메뉴 건너뛰기




Volumn 8, Issue 9, 2013, Pages 985-996

Genome-scale modeling of human metabolism - a systems biology approach

Author keywords

Genome scale metabolic models; Human Metabolic Reaction database; Personalized medicine; Systems biology; Whole body modeling

Indexed keywords

GENOME-SCALE METABOLIC MODELS; METABOLIC REACTIONS; PERSONALIZED MEDICINES; SYSTEMS BIOLOGY; WHOLE-BODY;

EID: 84883384697     PISSN: 18606768     EISSN: 18607314     Source Type: Journal    
DOI: 10.1002/biot.201200275     Document Type: Review
Times cited : (93)

References (94)
  • 1
    • 84862996501 scopus 로고    scopus 로고
    • De-meaning of metabolism.
    • Lazar, M. A., Birnbaum, M. J., De-meaning of metabolism. Science 2012, 336, 1651-1652.
    • (2012) Science , vol.336 , pp. 1651-1652
    • Lazar, M.A.1    Birnbaum, M.J.2
  • 2
    • 84858414020 scopus 로고    scopus 로고
    • Cellular metabolism and Disease: What do metabolic outliers teach us?
    • DeBerardinis, R. J., Thompson, C. B., Cellular metabolism and Disease: What do metabolic outliers teach us? Cell 2012, 148, 1132-1144.
    • (2012) Cell , vol.148 , pp. 1132-1144
    • DeBerardinis, R.J.1    Thompson, C.B.2
  • 3
    • 77949809397 scopus 로고    scopus 로고
    • Sugar-sweetened beverages, obesity, type 2 diabetes mellitus, and cardiovascular disease risk.
    • Malik, V. S., Popkin, B. M., Bray, G. A., Despres, J. P., Hu, F. B., Sugar-sweetened beverages, obesity, type 2 diabetes mellitus, and cardiovascular disease risk. Circulation 2010, 121, 1356-1364.
    • (2010) Circulation , vol.121 , pp. 1356-1364
    • Malik, V.S.1    Popkin, B.M.2    Bray, G.A.3    Despres, J.P.4    Hu, F.B.5
  • 4
    • 77957078371 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and inflammation in obesity and diabetes.
    • Hummasti, S., Hotamisligil, G. S., Endoplasmic reticulum stress and inflammation in obesity and diabetes. Circ. Res. 2010, 107, 579-591.
    • (2010) Circ. Res. , vol.107 , pp. 579-591
    • Hummasti, S.1    Hotamisligil, G.S.2
  • 5
    • 71149116560 scopus 로고    scopus 로고
    • Systems biology of lipid metabolism: from yeast to human.
    • Nielsen, J., Systems biology of lipid metabolism: from yeast to human. FEBS Lett. 2009, 583, 3905-3913.
    • (2009) FEBS Lett. , vol.583 , pp. 3905-3913
    • Nielsen, J.1
  • 6
    • 75149129569 scopus 로고    scopus 로고
    • A protocol for generating a high-quality genome-scale metabolic reconstruction.
    • Thiele, I., Palsson, B. O., A protocol for generating a high-quality genome-scale metabolic reconstruction. Nat. Protoc. 2010, 5, 93-121.
    • (2010) Nat. Protoc. , vol.5 , pp. 93-121
    • Thiele, I.1    Palsson, B.O.2
  • 7
    • 84855955467 scopus 로고    scopus 로고
    • Systems medicine and metabolic modelling.
    • Mardinoglu, A., Nielsen, J., Systems medicine and metabolic modelling. J. Intern. Med. 2012, 271, 142-154.
    • (2012) J. Intern. Med. , vol.271 , pp. 142-154
    • Mardinoglu, A.1    Nielsen, J.2
  • 8
    • 75749105082 scopus 로고    scopus 로고
    • Blueprint for antimicrobial hit discovery targeting metabolic networks.
    • Shen, Y., Liu, J., Estiu, G., Isin, B. et al., Blueprint for antimicrobial hit discovery targeting metabolic networks. Proc. Natl. Acad. Sci. USA 2010, 107, 1082-1087.
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 1082-1087
    • Shen, Y.1    Liu, J.2    Estiu, G.3    Isin, B.4
  • 9
    • 78650373804 scopus 로고    scopus 로고
    • Network medicine: A network-based approach to human disease.
    • Barabasi, A. L., Gulbahce, N., Loscalzo, J., Network medicine: A network-based approach to human disease. Nat. Rev. Genet. 2011, 12, 56-68.
    • (2011) Nat. Rev. Genet. , vol.12 , pp. 56-68
    • Barabasi, A.L.1    Gulbahce, N.2    Loscalzo, J.3
  • 10
    • 0036500993 scopus 로고    scopus 로고
    • Systems biology: A brief overview.
    • Kitano, H., Systems biology: A brief overview. Science 2002, 295, 1662-1664.
    • (2002) Science , vol.295 , pp. 1662-1664
    • Kitano, H.1
  • 11
    • 9544253891 scopus 로고    scopus 로고
    • Genome-scale models of microbial cells: Evaluating the consequences of constraints.
    • Price, N. D., Reed, J. L., Palsson, B. O., Genome-scale models of microbial cells: Evaluating the consequences of constraints. Nat. Rev. Microbiol. 2004, 2, 886-897.
    • (2004) Nat. Rev. Microbiol. , vol.2 , pp. 886-897
    • Price, N.D.1    Reed, J.L.2    Palsson, B.O.3
  • 12
    • 84858439602 scopus 로고    scopus 로고
    • Constraining the metabolic genotype-phenotype relationship using a phylogeny of in silico methods.
    • Lewis, N. E., Nagarajan, H., Palsson, B. O., Constraining the metabolic genotype-phenotype relationship using a phylogeny of in silico methods. Nat. Rev. Microbiol. 2012, 10, 291-305.
    • (2012) Nat. Rev. Microbiol. , vol.10 , pp. 291-305
    • Lewis, N.E.1    Nagarajan, H.2    Palsson, B.O.3
  • 13
    • 33846910173 scopus 로고    scopus 로고
    • Global reconstruction of the human metabolic network based on genomic and bibliomic data.
    • Duarte, N. C., Becker, S. A., Jamshidi, N., Thiele, I. et al., Global reconstruction of the human metabolic network based on genomic and bibliomic data. Proc. Natl. Acad. Sci. USA 2007, 104, 1777-1782.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 1777-1782
    • Duarte, N.C.1    Becker, S.A.2    Jamshidi, N.3    Thiele, I.4
  • 14
    • 34548860112 scopus 로고    scopus 로고
    • The Edinburgh human metabolic network reconstruction and its functional analysis.
    • Ma, H., Sorokin, A., Mazein, A., Selkov, A. et al., The Edinburgh human metabolic network reconstruction and its functional analysis. Mol. Syst. Biol. 2007, 3, 135.
    • (2007) Mol. Syst. Biol. , vol.3 , pp. 135
    • Ma, H.1    Sorokin, A.2    Mazein, A.3    Selkov, A.4
  • 15
    • 77954791900 scopus 로고    scopus 로고
    • Compartmentalization of the Edinburgh human metabolic network.
    • Hao, T., Ma, H. W., Zhao, X. M., Goryanin, I., Compartmentalization of the Edinburgh human metabolic network. BMC Bioinformatics 2010, 11, 393.
    • (2010) BMC Bioinformatics , vol.11 , pp. 393
    • Hao, T.1    Ma, H.W.2    Zhao, X.M.3    Goryanin, I.4
  • 16
    • 75549090213 scopus 로고    scopus 로고
    • KEGG for representation and analysis of molecular networks involving diseases and drugs.
    • Kanehisa, M., Goto, S., Furumichi, M., Tanabe, M., Hirakawa, M., KEGG for representation and analysis of molecular networks involving diseases and drugs. Nucleic Acids Res. 2010, 38, D355-D360.
    • (2010) Nucleic Acids Res. , vol.38
    • Kanehisa, M.1    Goto, S.2    Furumichi, M.3    Tanabe, M.4    Hirakawa, M.5
  • 17
    • 84863662483 scopus 로고    scopus 로고
    • Pornputtapong, N. , Reconstruction of genome-scale active metabolic metworks for 69 human cell types and 16 cancer types Using INIT.
    • Agren, R., Bordel, S., Mardinoglu, A., Pornputtapong, N. et al., Reconstruction of genome-scale active metabolic metworks for 69 human cell types and 16 cancer types Using INIT. PLOS Comput. Biol. 2012, 8, e1002518.
    • (2012) PLOS Comput. Biol. , vol.8
    • Agren, R.1    Bordel, S.2    Mardinoglu, A.3
  • 18
    • 84883787394 scopus 로고    scopus 로고
    • Integration of clinical data with a genome-scale metabolic model of the human adipocyte.
    • Mardinoglu, A., Agren, R., Kampf, C., Asplund, A. et al., Integration of clinical data with a genome-scale metabolic model of the human adipocyte. Mol. Syst. Biol. 2013, 9, 649.
    • (2013) Mol. Syst. Biol. , vol.9 , pp. 649
    • Mardinoglu, A.1    Agren, R.2    Kampf, C.3    Asplund, A.4
  • 19
    • 78651275182 scopus 로고    scopus 로고
    • Reactome: A database of reactions, pathways and biological processes.
    • Croft, D., O'Kelly, G., Wu, G. M., Haw, R. et al., Reactome: A database of reactions, pathways and biological processes. Nucleic Acids Res. 2011, 39, D691-D697.
    • (2011) Nucleic Acids Res. , vol.39
    • Croft, D.1    O'Kelly, G.2    Wu, G.M.3    Haw, R.4
  • 20
    • 77956407882 scopus 로고    scopus 로고
    • HepatoNet1: A comprehensive metabolic reconstruction of the human hepatocyte for the analysis of liver physiology.
    • Gille, C., Bolling, C., Hoppe, A., Bulik, S. et al., HepatoNet1: A comprehensive metabolic reconstruction of the human hepatocyte for the analysis of liver physiology. Mol. Syst. Biol. 2010, 6, 411.
    • (2010) Mol. Syst. Biol. , vol.6 , pp. 411
    • Gille, C.1    Bolling, C.2    Hoppe, A.3    Bulik, S.4
  • 21
    • 79959398473 scopus 로고    scopus 로고
    • Applications of mass spectrometry to lipids and membranes.
    • Harkewicz, R., Dennis, E. A., Applications of mass spectrometry to lipids and membranes. Ann. Rev. Biochem. 2010, 80, 301-325.
    • (2010) Ann. Rev. Biochem. , vol.80 , pp. 301-325
    • Harkewicz, R.1    Dennis, E.A.2
  • 22
    • 14844326483 scopus 로고    scopus 로고
    • Computational prediction of human metabolic pathways from the complete human genome.
    • Romero, P., Wagg, J., Green, M. L., Kaiser, D. et al., Computational prediction of human metabolic pathways from the complete human genome. Genome Biol. 2005, 6, R2.
    • (2005) Genome Biol. , vol.6
    • Romero, P.1    Wagg, J.2    Green, M.L.3    Kaiser, D.4
  • 23
    • 38549127678 scopus 로고    scopus 로고
    • ChEBI: A database and ontology for chemical entities of biological interest.
    • Degtyarenko, K., de Matos, P., Ennis, M., Hastings, J. et al., ChEBI: A database and ontology for chemical entities of biological interest. Nucleic Acids Res. 2008, 36, D344-350.
    • (2008) Nucleic Acids Res. , vol.36
    • Degtyarenko, K.1    de Matos, P.2    Ennis, M.3    Hastings, J.4
  • 24
    • 78651319979 scopus 로고    scopus 로고
    • Ongoing and future developments at the Universal Protein Resource.
    • Apweiler, R., Martin, M. J., O'Donovan, C. Magrane, M. et al., Ongoing and future developments at the Universal Protein Resource. Nucleic Acids Res. 2011, 39, D214-D219.
    • (2011) Nucleic Acids Res. , vol.39
    • Apweiler, R.1    Martin, M.J.2    O'Donovan, C.3    Magrane, M.4
  • 26
    • 78449277726 scopus 로고    scopus 로고
    • Creation of an antibody-based subcellular protein atlas.
    • Lundberg, E., Uhlen, M., Creation of an antibody-based subcellular protein atlas. Proteomics 2010, 10, 3984-3996.
    • (2010) Proteomics , vol.10 , pp. 3984-3996
    • Lundberg, E.1    Uhlen, M.2
  • 27
    • 34547676311 scopus 로고    scopus 로고
    • Optimization based automated curation of metabolic reconstructions.
    • Kumar, V. S., Dasika, M. S., Maranas, C. D., Optimization based automated curation of metabolic reconstructions. BMC Bioinformatics 2007, 8, 212.
    • (2007) BMC Bioinformatics , vol.8 , pp. 212
    • Kumar, V.S.1    Dasika, M.S.2    Maranas, C.D.3
  • 29
    • 6044265058 scopus 로고    scopus 로고
    • Integration of gene expression data into genome-scale metabolic models.
    • Akesson, M., Forster, J., Nielsen, J., Integration of gene expression data into genome-scale metabolic models. Metab. Eng. 2004, 6, 285-293.
    • (2004) Metab. Eng. , vol.6 , pp. 285-293
    • Akesson, M.1    Forster, J.2    Nielsen, J.3
  • 30
    • 44949225040 scopus 로고    scopus 로고
    • Context-specific metabolic networks are consistent with experiments.
    • Becker, S. A., Palsson, B. O., Context-specific metabolic networks are consistent with experiments. PLOS Comput. Biol. 2008, 4, e1000082.
    • (2008) PLOS Comput. Biol. , vol.4
    • Becker, S.A.1    Palsson, B.O.2
  • 31
    • 77956417789 scopus 로고    scopus 로고
    • Computational reconstruction of tissue-specific metabolic models: Application to human liver metabolism.
    • Jerby, L., Shlomi, T., Ruppin, E., Computational reconstruction of tissue-specific metabolic models: Application to human liver metabolism. Mol. Syst. Biol. 2010, 6, 401.
    • (2010) Mol. Syst. Biol. , vol.6 , pp. 401
    • Jerby, L.1    Shlomi, T.2    Ruppin, E.3
  • 32
    • 79951536020 scopus 로고    scopus 로고
    • Functional integration of a metabolic network model and expression data without arbitrary thresholding.
    • Jensen, P. A., Papin, J. A., Functional integration of a metabolic network model and expression data without arbitrary thresholding. Bioinformatics 2011, 27, 541-547.
    • (2011) Bioinformatics , vol.27 , pp. 541-547
    • Jensen, P.A.1    Papin, J.A.2
  • 34
    • 84863331725 scopus 로고    scopus 로고
    • Model-driven multi-omic data analysis elucidates metabolic immunomodulators of macrophage activation.
    • Bordbar, A., Mo, M. L., Nakayasu, E. S., Schrimpe-Rutledge, A. et al., Model-driven multi-omic data analysis elucidates metabolic immunomodulators of macrophage activation. Mol. Syst. Biol. 2012, 8, 558.
    • (2012) Mol. Syst. Biol. , vol.8 , pp. 558
    • Bordbar, A.1    Mo, M.L.2    Nakayasu, E.S.3    Schrimpe-Rutledge, A.4
  • 35
    • 84873093745 scopus 로고    scopus 로고
    • Mechanistic systems modeling to guide drug discovery and development.
    • Schmidt, B. J., Papin, J. A., Musante, C. J., Mechanistic systems modeling to guide drug discovery and development. Drug Discov. Today 2013, 18, 116-27.
    • (2013) Drug Discov. Today , vol.18 , pp. 116-127
    • Schmidt, B.J.1    Papin, J.A.2    Musante, C.J.3
  • 36
    • 11144358198 scopus 로고    scopus 로고
    • A gene atlas of the mouse and human protein-encoding transcriptomes.
    • Su, A. I., Wiltshire, T., Batalov, S., Lapp, H. et al., A gene atlas of the mouse and human protein-encoding transcriptomes. Proc. Natl. Acad. Sci. USA 2004, 101, 6062-6067.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 6062-6067
    • Su, A.I.1    Wiltshire, T.2    Batalov, S.3    Lapp, H.4
  • 38
    • 78049445175 scopus 로고    scopus 로고
    • Drug off-target effects predicted using structural analysis in the context of a metabolic network model.
    • Chang, R. L., Xie, L., Xie, L., Bourne, P. E., Palsson, B. O., Drug off-target effects predicted using structural analysis in the context of a metabolic network model. PLOS Comput. Biol. 2010, e1000938.
    • (2010) PLOS Comput. Biol.
    • Chang, R.L.1    Xie, L.2    Xie, L.3    Bourne, P.E.4    Palsson, B.O.5
  • 39
    • 78650002545 scopus 로고    scopus 로고
    • Large-scale in silico modeling of metabolic interactions between cell types in the human brain.
    • Lewis, N. E., Schramm, G., Bordbar, A., Schellenberger, J. et al., Large-scale in silico modeling of metabolic interactions between cell types in the human brain. Nat. Biotechnol. 2010, 28, 1279-1285.
    • (2010) Nat. Biotechnol. , vol.28 , pp. 1279-1285
    • Lewis, N.E.1    Schramm, G.2    Bordbar, A.3    Schellenberger, J.4
  • 40
    • 77958537509 scopus 로고    scopus 로고
    • Insight into human alveolar macrophage and M. tuberculosis interactions via metabolic reconstructions.
    • Bordbar, A., Lewis, N. E., Schellenberger, J., Palsson, B. O., Jamshidi, N., Insight into human alveolar macrophage and M. tuberculosis interactions via metabolic reconstructions. Mol. Syst. Biol. 2010, 6, 422.
    • (2010) Mol. Syst. Biol. , vol.6 , pp. 422
    • Bordbar, A.1    Lewis, N.E.2    Schellenberger, J.3    Palsson, B.O.4    Jamshidi, N.5
  • 41
    • 84865432555 scopus 로고    scopus 로고
    • CardioNet: A human metabolic network suited for the study of cardiomyocyte metabolism.
    • Karlstaedt, A., Fliegner, D., Kararigas, G., Ruderisch, H. S. et al., CardioNet: A human metabolic network suited for the study of cardiomyocyte metabolism. BMC Syst. Biol. 2012, 6, 114.
    • (2012) BMC Syst. Biol. , vol.6 , pp. 114
    • Karlstaedt, A.1    Fliegner, D.2    Kararigas, G.3    Ruderisch, H.S.4
  • 42
    • 80054969621 scopus 로고    scopus 로고
    • A multi-tissue type genome-scale metabolic network for analysis of whole-body systems physiology.
    • Bordbar, A., Feist, A. M., Usaite-Black, R., Woodcock, J. et al., A multi-tissue type genome-scale metabolic network for analysis of whole-body systems physiology. BMC Syst. Biol. 2011, 180.
    • (2011) BMC Syst. Biol. , pp. 180
    • Bordbar, A.1    Feist, A.M.2    Usaite-Black, R.3    Woodcock, J.4
  • 43
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation.
    • Hanahan, D., Weinberg, R. A., Hallmarks of cancer: The next generation. Cell 2011, 144, 646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 45
    • 84863661689 scopus 로고    scopus 로고
    • Therapeutic targets in cancer cell metabolism and autophagy.
    • Cheong, H., Lu, C., Lindsten, T., Thompson, C. B., Therapeutic targets in cancer cell metabolism and autophagy. Nat. Biotechnol. 2012, 30, 671-678.
    • (2012) Nat. Biotechnol. , vol.30 , pp. 671-678
    • Cheong, H.1    Lu, C.2    Lindsten, T.3    Thompson, C.B.4
  • 46
    • 84867554554 scopus 로고    scopus 로고
    • Predicting drug targets and biomarkers of cancer via genome-scale metabolic modeling.
    • Jerby, L., Ruppin, E., Predicting drug targets and biomarkers of cancer via genome-scale metabolic modeling. Clin. Cancer Res. 2012, 18, 5572-5584.
    • (2012) Clin. Cancer Res. , vol.18 , pp. 5572-5584
    • Jerby, L.1    Ruppin, E.2
  • 47
    • 84861422298 scopus 로고    scopus 로고
    • Cancer. Systems biology, metabolomics, and cancer metabolism.
    • Tomita, M., Kami, K., Cancer. Systems biology, metabolomics, and cancer metabolism. Science 2012, 336, 990-991.
    • (2012) Science , vol.336 , pp. 990-991
    • Tomita, M.1    Kami, K.2
  • 48
    • 79959621970 scopus 로고    scopus 로고
    • Gottlieb, E. , Predicting selective drug targets in cancer through metabolic networks.
    • Folger, O., Jerby, L., Frezza, C., Gottlieb, E. et al., Predicting selective drug targets in cancer through metabolic networks. Mol. Syst. Biol. 2011, 501.
    • (2011) Mol. Syst. Biol. , pp. 501
    • Folger, O.1    Jerby, L.2    Frezza, C.3
  • 49
    • 80052580351 scopus 로고    scopus 로고
    • Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase.
    • Frezza, C., Zheng, L., Folger, O., Rajagopalan, K. N. et al., Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase. Nature 2011, 477, 225-U132.
    • (2011) Nature , vol.477
    • Frezza, C.1    Zheng, L.2    Folger, O.3    Rajagopalan, K.N.4
  • 50
    • 84867527044 scopus 로고    scopus 로고
    • Metabolic associations of reduced proliferation and oxidative stress in advanced breast cancer.
    • Jerby, L., Wolf, L., Denkert, C., Stein, G. Y. et al., Metabolic associations of reduced proliferation and oxidative stress in advanced breast cancer. Cancer Res. 2012, 72, 5712-5720.
    • (2012) Cancer Res. , vol.72 , pp. 5712-5720
    • Jerby, L.1    Wolf, L.2    Denkert, C.3    Stein, G.Y.4
  • 51
    • 14544268137 scopus 로고    scopus 로고
    • Uncovering transcriptional regulation of metabolism by using metabolic network topology.
    • Patil, K. R., Nielsen, J., Uncovering transcriptional regulation of metabolism by using metabolic network topology. Proc. Natl. Acad. Sci. USA 2005, 102, 2685-2689.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 2685-2689
    • Patil, K.R.1    Nielsen, J.2
  • 52
    • 77958460555 scopus 로고    scopus 로고
    • The challenges of integrating multi-omic data sets.
    • Palsson, B., Zengler, K., The challenges of integrating multi-omic data sets. Nat. Chem. Biol. 2010, 6, 787-789.
    • (2010) Nat. Chem. Biol. , vol.6 , pp. 787-789
    • Palsson, B.1    Zengler, K.2
  • 53
    • 77954197778 scopus 로고    scopus 로고
    • Integrating quantitative proteomics and metabolomics with a genome-scale metabolic network model.
    • Yizhak, K., Benyamini, T., Liebermeister, W., Ruppin, E., Shlomi, T., Integrating quantitative proteomics and metabolomics with a genome-scale metabolic network model. Bioinformatics 2010, 26, i255-i260.
    • (2010) Bioinformatics , vol.26
    • Yizhak, K.1    Benyamini, T.2    Liebermeister, W.3    Ruppin, E.4    Shlomi, T.5
  • 54
    • 84856094560 scopus 로고    scopus 로고
    • Differential network biology.
    • Ideker, T., Krogan, N. J., Differential network biology. Mol. Syst. Biol. 2012, 8, 565.
    • (2012) Mol. Syst. Biol. , vol.8 , pp. 565
    • Ideker, T.1    Krogan, N.J.2
  • 55
    • 71149117622 scopus 로고    scopus 로고
    • Metabolic systems biology.
    • Palsson, B., Metabolic systems biology. FEBS Lett. 2009, 583, 3900-3904.
    • (2009) FEBS Lett. , vol.583 , pp. 3900-3904
    • Palsson, B.1
  • 56
    • 0344824417 scopus 로고    scopus 로고
    • Saccharomyces cerevisiae phenotypes can be predicted by using constraint-based analysis of a genome-scale reconstructed metabolic network.
    • Famili, I., Forster, J., Nielson, J., Palsson, B. O., Saccharomyces cerevisiae phenotypes can be predicted by using constraint-based analysis of a genome-scale reconstructed metabolic network. Proc. Natl. Acad. Sci. USA 2003, 100, 13134-13139.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 13134-13139
    • Famili, I.1    Forster, J.2    Nielson, J.3    Palsson, B.O.4
  • 57
    • 84866487453 scopus 로고    scopus 로고
    • Integration of expression data in genome-scale metabolic network reconstructions.
    • Blazier, A. S., Papin, J. A., Integration of expression data in genome-scale metabolic network reconstructions. Front. Physiol. 2012, 3, 299.
    • (2012) Front. Physiol. , vol.3 , pp. 299
    • Blazier, A.S.1    Papin, J.A.2
  • 59
    • 34447523907 scopus 로고    scopus 로고
    • Systematic evaluation of objective functions for predicting intracellular fluxes in Escherichia coli.
    • Schuetz, R., Kuepfer, L., Sauer, U., Systematic evaluation of objective functions for predicting intracellular fluxes in Escherichia coli. Mol. Syst. Biol. 2007, 119.
    • (2007) Mol. Syst. Biol. , pp. 119
    • Schuetz, R.1    Kuepfer, L.2    Sauer, U.3
  • 60
    • 45149111660 scopus 로고    scopus 로고
    • The growing scope of applications of genome-scale metabolic reconstructions using Escherichia coli.
    • Feist, A. M., Palsson, B. O., The growing scope of applications of genome-scale metabolic reconstructions using Escherichia coli. Nat. Biotechnol. 2008, 26, 659-667.
    • (2008) Nat. Biotechnol. , vol.26 , pp. 659-667
    • Feist, A.M.1    Palsson, B.O.2
  • 61
    • 33846061120 scopus 로고    scopus 로고
    • Metabolic networks in motion: C-13-based flux analysis.
    • Sauer, U., Metabolic networks in motion: C-13-based flux analysis. Mol. Syst. Biol. 2006, 2, 62.
    • (2006) Mol. Syst. Biol. , vol.2 , pp. 62
    • Sauer, U.1
  • 62
    • 84861420588 scopus 로고    scopus 로고
    • Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation.
    • Jain, M., Nilsson, R., Sharma, S., Madhusudhan, N. et al., Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation. Science 2012, 336, 1040-1044.
    • (2012) Science , vol.336 , pp. 1040-1044
    • Jain, M.1    Nilsson, R.2    Sharma, S.3    Madhusudhan, N.4
  • 63
    • 70449519259 scopus 로고    scopus 로고
    • Evaluation of C-13 isotopic tracers for metabolic flux analysis in mammalian cells.
    • Metallo, C. M., Walther, J. L., Stephanopoulos, G., Evaluation of C-13 isotopic tracers for metabolic flux analysis in mammalian cells. J. Biotechnol. 2009, 144, 167-174.
    • (2009) J. Biotechnol. , vol.144 , pp. 167-174
    • Metallo, C.M.1    Walther, J.L.2    Stephanopoulos, G.3
  • 64
    • 84862777903 scopus 로고    scopus 로고
    • Optimization of C-13 isotopic tracers for metabolic flux analysis in mammalian cells.
    • Walther, J. L., Metallo, C. M., Zhang, J., Stephanopoulos, G., Optimization of C-13 isotopic tracers for metabolic flux analysis in mammalian cells. Metab. Eng. 2012, 14, 162-171.
    • (2012) Metab. Eng. , vol.14 , pp. 162-171
    • Walther, J.L.1    Metallo, C.M.2    Zhang, J.3    Stephanopoulos, G.4
  • 65
    • 78049304837 scopus 로고    scopus 로고
    • Sampling the solution space in genome-scale metabolic networks reveals transcriptional regulation in key enzymes.
    • Bordel, S., Agren, R., Nielsen, J., Sampling the solution space in genome-scale metabolic networks reveals transcriptional regulation in key enzymes. PLOS Comput. Biol. 2010, 6, e1000859.
    • (2010) PLOS Comput. Biol. , vol.6
    • Bordel, S.1    Agren, R.2    Nielsen, J.3
  • 66
  • 67
    • 0347506028 scopus 로고    scopus 로고
    • It is all about metabolic fluxes.
    • Nielsen, J., It is all about metabolic fluxes. J. Bacteriol. 2003, 185, 7031-7035.
    • (2003) J. Bacteriol. , vol.185 , pp. 7031-7035
    • Nielsen, J.1
  • 68
    • 84858604270 scopus 로고    scopus 로고
    • Metabolic reprogramming: A cancer hallmark even Warburg did not anticipate.
    • Ward, P. S., Thompson, C. B., Metabolic reprogramming: A cancer hallmark even Warburg did not anticipate. Cancer Cell 2012, 21, 297-308.
    • (2012) Cancer Cell , vol.21 , pp. 297-308
    • Ward, P.S.1    Thompson, C.B.2
  • 69
    • 79959927716 scopus 로고    scopus 로고
    • Enzymatic features of the glucose metabolism in tumor cells.
    • Herling, A., Konig, M., Bulik, S., Holzhutter, H. G., Enzymatic features of the glucose metabolism in tumor cells. FEBS J. 2011, 278, 2436-2459.
    • (2011) FEBS J. , vol.278 , pp. 2436-2459
    • Herling, A.1    Konig, M.2    Bulik, S.3    Holzhutter, H.G.4
  • 70
    • 33751356224 scopus 로고    scopus 로고
    • Systems biology, metabolic modelling and metabolomics in drug discovery and development.
    • Kell, D. B., Systems biology, metabolic modelling and metabolomics in drug discovery and development. Drug Discov. Today 2006, 11, 1085-1092.
    • (2006) Drug Discov. Today , vol.11 , pp. 1085-1092
    • Kell, D.B.1
  • 72
    • 45949108082 scopus 로고    scopus 로고
    • The role of metabolic biomarkers in drug toxicity studies.
    • Schnackenberg, L. K., Beger, R. D., The role of metabolic biomarkers in drug toxicity studies. Toxicol. Mech. Meth. 2008, 18, 301-311.
    • (2008) Toxicol. Mech. Meth. , vol.18 , pp. 301-311
    • Schnackenberg, L.K.1    Beger, R.D.2
  • 73
    • 84867911343 scopus 로고    scopus 로고
    • Biomarkers and immune-modulating therapies for Type 2 diabetes.
    • Brooks-Worrell, B., Narla, R., Palmer, J. P., Biomarkers and immune-modulating therapies for Type 2 diabetes. Trends Immunol. 2012, 33, 546-553.
    • (2012) Trends Immunol. , vol.33 , pp. 546-553
    • Brooks-Worrell, B.1    Narla, R.2    Palmer, J.P.3
  • 74
    • 66249132328 scopus 로고    scopus 로고
    • Predicting metabolic biomarkers of human inborn errors of metabolism.
    • Shlomi, T., Cabili, M. N., Ruppin, E., Predicting metabolic biomarkers of human inborn errors of metabolism. Mol. Syst. Biol. 2009, 5.
    • (2009) Mol. Syst. Biol. , vol.5
    • Shlomi, T.1    Cabili, M.N.2    Ruppin, E.3
  • 75
    • 80052526020 scopus 로고    scopus 로고
    • Plasma free amino acid profiling of five types of cancer patients and its application for early detection.
    • Miyagi, Y., Higashiyama, M., Gochi, A., Akaike, M. et al., Plasma free amino acid profiling of five types of cancer patients and its application for early detection. PLOS One 2011, 6, e24143.
    • (2011) PLOS One , vol.6
    • Miyagi, Y.1    Higashiyama, M.2    Gochi, A.3    Akaike, M.4
  • 78
    • 84864818817 scopus 로고    scopus 로고
    • Revolutionizing medicine in the 21st century through systems approaches.
    • Hood, L., Balling, R., Auffray, C., Revolutionizing medicine in the 21st century through systems approaches. Biotechnol. J. 2012, 7, 992-1001.
    • (2012) Biotechnol. J. , vol.7 , pp. 992-1001
    • Hood, L.1    Balling, R.2    Auffray, C.3
  • 79
    • 62549110855 scopus 로고    scopus 로고
    • Personalizing medicine: A systems biology perspective.
    • Deisboeck, T. S., Personalizing medicine: A systems biology perspective. Mol. Syst. Biol. 2009, 5, 249.
    • (2009) Mol. Syst. Biol. , vol.5 , pp. 249
    • Deisboeck, T.S.1
  • 80
    • 67651152853 scopus 로고    scopus 로고
    • Individuality and epigenetics in obesity.
    • Campion, J., Milagro, F. I., Martinez, J. A., Individuality and epigenetics in obesity. Obes. Rev. 2009, 10, 383-392.
    • (2009) Obes. Rev. , vol.10 , pp. 383-392
    • Campion, J.1    Milagro, F.I.2    Martinez, J.A.3
  • 81
    • 84864807599 scopus 로고    scopus 로고
    • Personalized health care: From theory to practice.
    • Snyderman, R., Personalized health care: From theory to practice. Biotechnol. J. 2012, 7, 973-979.
    • (2012) Biotechnol. J. , vol.7 , pp. 973-979
    • Snyderman, R.1
  • 82
    • 84855929701 scopus 로고    scopus 로고
    • Systems cancer medicine: Towards realization of predictive, preventive, personalized and participatory (P4) medicine.
    • Tian, Q., Price, N. D., Hood, L., Systems cancer medicine: Towards realization of predictive, preventive, personalized and participatory (P4) medicine. J. Intern. Med. 2012, 271, 111-121.
    • (2012) J. Intern. Med. , vol.271 , pp. 111-121
    • Tian, Q.1    Price, N.D.2    Hood, L.3
  • 83
    • 84855933234 scopus 로고    scopus 로고
    • Translational and systems medicine introduction.
    • Nielsen, J., Translational and systems medicine introduction. J. Intern. Med. 2012, 271, 108-110.
    • (2012) J. Intern. Med. , vol.271 , pp. 108-110
    • Nielsen, J.1
  • 84
    • 84868112856 scopus 로고    scopus 로고
    • Integrating cellular metabolism into a multiscale whole-body model.
    • Krauss, M., Schaller, S., Borchers, S., Findeisen, R. et al., Integrating cellular metabolism into a multiscale whole-body model. PLOSComput. Biol. 2012, 8, e1002750.
    • (2012) PLOSComput. Biol. , vol.8
    • Krauss, M.1    Schaller, S.2    Borchers, S.3    Findeisen, R.4
  • 85
    • 0030819215 scopus 로고    scopus 로고
    • Basic concepts of pharmacokinetic/pharmacodynamic (PK/PD) modelling.
    • Meibohm, B., Derendorf, H., Basic concepts of pharmacokinetic/pharmacodynamic (PK/PD) modelling. Int. J. Clin. Pharm. Th. 1997, 35, 401-413.
    • (1997) Int. J. Clin. Pharm. Th. , vol.35 , pp. 401-413
    • Meibohm, B.1    Derendorf, H.2
  • 86
    • 78649736009 scopus 로고    scopus 로고
    • PBPK modelling of inter-individual variability in the pharmacokinetics of environmental chemicals.
    • Bois, F. Y., Jamei, M., Clewell, H. J., PBPK modelling of inter-individual variability in the pharmacokinetics of environmental chemicals. Toxicology 2010, 278, 256-267.
    • (2010) Toxicology , vol.278 , pp. 256-267
    • Bois, F.Y.1    Jamei, M.2    Clewell, H.J.3
  • 87
    • 79951765993 scopus 로고    scopus 로고
    • Physiologically-based [harmacokinetics in drug development and regulatory science.
    • Rowland, M., Peck, C., Tucker, G., Physiologically-based [harmacokinetics in drug development and regulatory science. Ann. Rev. Pharmacol. 2011, 51, 45-73.
    • (2011) Ann. Rev. Pharmacol. , vol.51 , pp. 45-73
    • Rowland, M.1    Peck, C.2    Tucker, G.3
  • 88
  • 89
    • 79953731940 scopus 로고    scopus 로고
    • A closer look at bacteroides: Phylogenetic relationship and genomic implications of a life in the human gut.
    • Karlsson, F. H., Ussery, D. W., Nielsen, J., Nookaew, I., A closer look at bacteroides: Phylogenetic relationship and genomic implications of a life in the human gut. Microb. Ecol. 2011, 61, 473-485.
    • (2011) Microb. Ecol. , vol.61 , pp. 473-485
    • Karlsson, F.H.1    Ussery, D.W.2    Nielsen, J.3    Nookaew, I.4
  • 90
    • 84871814687 scopus 로고    scopus 로고
    • Symptomatic atherosclerosis is associated with an altered gut metagenome.
    • Karlsson, F. H., Fak, F., Nookaew, I., Tremaroli, V. et al., Symptomatic atherosclerosis is associated with an altered gut metagenome. Nat. Commun. 2012, 3, 1245.
    • (2012) Nat. Commun. , vol.3 , pp. 1245
    • Karlsson, F.H.1    Fak, F.2    Nookaew, I.3    Tremaroli, V.4
  • 91
    • 84867074831 scopus 로고    scopus 로고
    • A metagenome-wide association study of gut microbiota in type 2 diabetes.
    • Qin, J. J., Li, Y. R., Cai, Z. M., Li, S. H. et al., A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature 2012, 490, 55-60.
    • (2012) Nature , vol.490 , pp. 55-60
    • Qin, J.J.1    Li, Y.R.2    Cai, Z.M.3    Li, S.H.4
  • 92
    • 33744804299 scopus 로고    scopus 로고
    • Metagenomic analysis of the human distal gut microbiome.
    • Gill, S. R., Pop, M., Deboy, R. T., Eckburg, P. B. et al., Metagenomic analysis of the human distal gut microbiome. Science 2006, 312, 1355-1359.
    • (2006) Science , vol.312 , pp. 1355-1359
    • Gill, S.R.1    Pop, M.2    Deboy, R.T.3    Eckburg, P.B.4
  • 93
    • 80051816997 scopus 로고    scopus 로고
    • Inclusion of interactions in mathematical modelling of implant assisted magnetic drug targeting.
    • Cregg, P. J., Murphy, K., Mardinoglu, A., Inclusion of interactions in mathematical modelling of implant assisted magnetic drug targeting. Appl. Math. Model. 2012, 36, 1-34.
    • (2012) Appl. Math. Model. , vol.36 , pp. 1-34
    • Cregg, P.J.1    Murphy, K.2    Mardinoglu, A.3
  • 94
    • 78049476143 scopus 로고    scopus 로고
    • Theoretical modelling of physiologically stretched vessel in magnetisable stent assisted magnetic drug targeting application.
    • Mardinoglu, A., Cregg, P. J., Murphy, K., Curtin, M., Prina-Mello, A., Theoretical modelling of physiologically stretched vessel in magnetisable stent assisted magnetic drug targeting application. J. Magn. Magn. Mater. 2011, 323, 324-329.
    • (2011) J. Magn. Magn. Mater. , vol.323 , pp. 324-329
    • Mardinoglu, A.1    Cregg, P.J.2    Murphy, K.3    Curtin, M.4    Prina-Mello, A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.