Carboxyl group footprinting mass spectrometry and molecular dynamics identify key interactions in the HER2-HER3 receptor tyrosine kinase interface

Journal of Biological Chemistry

Volumn 288, Issue 35, 2013, Pages 25254-25264

  Collier, Timothy S ^a   Diraviyam, Karthikeyan ^a   Monsey, John ^a   Shen, Wei ^a   Sept, David ^a   Bose, Ron ^a,b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION LOOPS; CARBOXYL GROUPS; DIMER INTERFACE; FOOTPRINTING; HETERODIMERS; RECEPTOR TYROSINE KINASE; SINGLE CONFIGURATION; STRUCTURAL CHARACTERIZATION;

AMINO ACIDS; DIMERS; ENZYMES; MASS SPECTROMETRY;

MOLECULAR DYNAMICS;

CARBOXYL GROUP; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR 3; HETERODIMER; PROTEIN TYROSINE KINASE;

AMINO TERMINAL SEQUENCE; ARTICLE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DIMERIZATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME PHOSPHORYLATION; IN VITRO STUDY; INTRACELLULAR SIGNALING; MASS SPECTROMETRY; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MUTATIONAL ANALYSIS; NUCLEOTIDE BINDING SITE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOOTPRINTING; PROTEIN INTERACTION; PROTEIN PROTEIN INTERACTION; STRUCTURE ANALYSIS;

EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR); MASS SPECTROMETRY (MS); MOLECULAR DYNAMICS; PROTEIN-PROTEIN INTERACTIONS; RECEPTOR TYROSINE KINASE;

ANIMALS; HUMANS; MASS SPECTROMETRY; MOLECULAR DYNAMICS SIMULATION; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; RECEPTOR, ERBB-2; RECEPTOR, ERBB-3; SF9 CELLS; SPODOPTERA;

EID: 84883374932     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.474882     Document Type: Article

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