메뉴 건너뛰기




Volumn 8, Issue 9, 2013, Pages

p21-Activated Kinase (PAK) Regulates Cytoskeletal Reorganization and Directional Migration in Human Neutrophils

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; CALCIUM ION; LEUCINE; METHIONINE; MYOSIN ADENOSINE TRIPHOSPHATASE; P21 ACTIVATED KINASE; PHENYLALANINE; PHOSPHOTRANSFERASE INHIBITOR; RAC PROTEIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN;

EID: 84883334122     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0073063     Document Type: Article
Times cited : (45)

References (50)
  • 1
    • 78649375771 scopus 로고    scopus 로고
    • Neutrophils, from marrow to microbes
    • Borregaard N, (2010) Neutrophils, from marrow to microbes. Immunity 33: 657-670.
    • (2010) Immunity , vol.33 , pp. 657-670
    • Borregaard, N.1
  • 2
    • 14744299030 scopus 로고    scopus 로고
    • Regulation of innate immunity by Rho GTPases
    • Bokoch GM, (2005) Regulation of innate immunity by Rho GTPases. Trends Cell Biol 15: 163-171.
    • (2005) Trends Cell Biol , vol.15 , pp. 163-171
    • Bokoch, G.M.1
  • 3
    • 84863299837 scopus 로고    scopus 로고
    • Group I and II mammalian PAKs have different modes of activation by Cdc42
    • Baskaran Y, Ng YW, Selamat W, Ling FT, Manser E, (2012) Group I and II mammalian PAKs have different modes of activation by Cdc42. EMBO Rep 13: 653-659.
    • (2012) EMBO Rep , vol.13 , pp. 653-659
    • Baskaran, Y.1    Ng, Y.W.2    Selamat, W.3    Ling, F.T.4    Manser, E.5
  • 4
    • 0031724925 scopus 로고    scopus 로고
    • Neutrophils stimulated with a variety of chemoattractants exhibit rapid activation of p21-activated kinases (Paks): separate signals are required for activation and inactivation of paks
    • Huang R, Lian JP, Robinson D, Badwey JA, (1998) Neutrophils stimulated with a variety of chemoattractants exhibit rapid activation of p21-activated kinases (Paks): separate signals are required for activation and inactivation of paks. Mol Cell Biol 18: 7130-7138.
    • (1998) Mol Cell Biol , vol.18 , pp. 7130-7138
    • Huang, R.1    Lian, J.P.2    Robinson, D.3    Badwey, J.A.4
  • 5
    • 0028998794 scopus 로고
    • Regulation of human leukocyte p21-activated kinases through G protein-coupled receptors
    • Knaus UG, Morris S, Dong HJ, Chernoff J, Bokoch GM, (1995) Regulation of human leukocyte p21-activated kinases through G protein-coupled receptors. Science 269: 221-223.
    • (1995) Science , vol.269 , pp. 221-223
    • Knaus, U.G.1    Morris, S.2    Dong, H.J.3    Chernoff, J.4    Bokoch, G.M.5
  • 6
    • 0032871296 scopus 로고    scopus 로고
    • Localization of p21-activated kinase 1 (PAK1) to pseudopodia, membrane ruffles, and phagocytic cups in activated human neutrophils
    • Dharmawardhane S, Brownson D, Lennartz M, Bokoch GM, (1999) Localization of p21-activated kinase 1 (PAK1) to pseudopodia, membrane ruffles, and phagocytic cups in activated human neutrophils. J Leukoc Biol 66: 521-527.
    • (1999) J Leukoc Biol , vol.66 , pp. 521-527
    • Dharmawardhane, S.1    Brownson, D.2    Lennartz, M.3    Bokoch, G.M.4
  • 7
    • 0041352963 scopus 로고    scopus 로고
    • Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of Cdc42
    • Li Z, Hannigan M, Mo Z, Liu B, Lu W, et al. (2003) Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of Cdc42. Cell 114: 215-227.
    • (2003) Cell , vol.114 , pp. 215-227
    • Li, Z.1    Hannigan, M.2    Mo, Z.3    Liu, B.4    Lu, W.5
  • 8
    • 59549099037 scopus 로고    scopus 로고
    • PAK1-mediated activation of ERK1/2 regulates lamellipodial dynamics
    • Smith SD, Jaffer ZM, Chernoff J, Ridley AJ, (2008) PAK1-mediated activation of ERK1/2 regulates lamellipodial dynamics. J Cell Sci 121: 3729-3736.
    • (2008) J Cell Sci , vol.121 , pp. 3729-3736
    • Smith, S.D.1    Jaffer, Z.M.2    Chernoff, J.3    Ridley, A.J.4
  • 9
    • 63849230362 scopus 로고    scopus 로고
    • p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics
    • Allen JD, Jaffer ZM, Park SJ, Burgin S, Hofmann C, et al. (2009) p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics. Blood 113: 2695-2705.
    • (2009) Blood , vol.113 , pp. 2695-2705
    • Allen, J.D.1    Jaffer, Z.M.2    Park, S.J.3    Burgin, S.4    Hofmann, C.5
  • 10
    • 82355184464 scopus 로고    scopus 로고
    • Inhibition or ablation of p21-activated kinase (PAK1) disrupts glucose homeostatic mechanisms in vivo
    • Wang Z, Oh E, Clapp DW, Chernoff J, Thurmond DC, (2011) Inhibition or ablation of p21-activated kinase (PAK1) disrupts glucose homeostatic mechanisms in vivo. J Biol Chem 286: 41359-41367.
    • (2011) J Biol Chem , vol.286 , pp. 41359-41367
    • Wang, Z.1    Oh, E.2    Clapp, D.W.3    Chernoff, J.4    Thurmond, D.C.5
  • 11
    • 80055121231 scopus 로고    scopus 로고
    • Ablation of p21-activated kinase-1 in mice promotes isoproterenol-induced cardiac hypertrophy in association with activation of Erk1/2 and inhibition of protein phosphatase 2A
    • Taglieri DM, Monasky MM, Knezevic I, Sheehan KA, Lei M, et al. (2011) Ablation of p21-activated kinase-1 in mice promotes isoproterenol-induced cardiac hypertrophy in association with activation of Erk1/2 and inhibition of protein phosphatase 2A. J Mol Cell Cardiol 51: 988-996.
    • (2011) J Mol Cell Cardiol , vol.51 , pp. 988-996
    • Taglieri, D.M.1    Monasky, M.M.2    Knezevic, I.3    Sheehan, K.A.4    Lei, M.5
  • 12
    • 84869225094 scopus 로고    scopus 로고
    • p21-Activated kinase 1 is required for efficient tumor formation and progression in a Ras-mediated skin cancer model
    • Chow HY, Jubb AM, Koch JN, Jaffer ZM, Stepanova D, et al. (2012) p21-Activated kinase 1 is required for efficient tumor formation and progression in a Ras-mediated skin cancer model. Cancer Res 72: 5966-5975.
    • (2012) Cancer Res , vol.72 , pp. 5966-5975
    • Chow, H.Y.1    Jubb, A.M.2    Koch, J.N.3    Jaffer, Z.M.4    Stepanova, D.5
  • 13
    • 84872299428 scopus 로고    scopus 로고
    • Pak2 Kinase Restrains Mast Cell Fc{epsilon}RI Receptor Signaling through Modulation of Rho Protein Guanine Nucleotide Exchange Factor (GEF) Activity
    • Kosoff R, Chow HY, Radu M, Chernoff J, (2013) Pak2 Kinase Restrains Mast Cell Fc{epsilon}RI Receptor Signaling through Modulation of Rho Protein Guanine Nucleotide Exchange Factor (GEF) Activity. J Biol Chem 288: 974-983.
    • (2013) J Biol Chem , vol.288 , pp. 974-983
    • Kosoff, R.1    Chow, H.Y.2    Radu, M.3    Chernoff, J.4
  • 14
    • 84878380745 scopus 로고    scopus 로고
    • The Rac GTPase effector p21 activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment
    • Dorrance AM, De Vita S, Radu M, Reddy PN, McGuinness MK, et al. (2013) The Rac GTPase effector p21 activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment. Blood 121: 2474-2482.
    • (2013) Blood , vol.121 , pp. 2474-2482
    • Dorrance, A.M.1    De Vita, S.2    Radu, M.3    Reddy, P.N.4    McGuinness, M.K.5
  • 15
    • 77952720804 scopus 로고    scopus 로고
    • Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth
    • Murray BW, Guo C, Piraino J, Westwick JK, Zhang C, et al. (2010) Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth. Proc Natl Acad Sci U S A 107: 9446-9451.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 9446-9451
    • Murray, B.W.1    Guo, C.2    Piraino, J.3    Westwick, J.K.4    Zhang, C.5
  • 16
    • 84879079136 scopus 로고    scopus 로고
    • p21 Activated Kinase Signaling Coordinates Glycoprotein Receptor VI-Mediated Platelet Aggregation, Lamellipodia Formation, and Aggregate Stability Under Shear
    • Aslan JE, Itakura A, Haley KM, Tormoen GW, Loren CP, et al. (2013) p21 Activated Kinase Signaling Coordinates Glycoprotein Receptor VI-Mediated Platelet Aggregation, Lamellipodia Formation, and Aggregate Stability Under Shear. Arterioscler Thromb Vasc Biol 33: 1544-1551.
    • (2013) Arterioscler Thromb Vasc Biol , vol.33 , pp. 1544-1551
    • Aslan, J.E.1    Itakura, A.2    Haley, K.M.3    Tormoen, G.W.4    Loren, C.P.5
  • 19
    • 80052938277 scopus 로고    scopus 로고
    • S6K1 and mTOR regulate Rac1-driven platelet activation and aggregation
    • Aslan JE, Tormoen GW, Loren CP, Pang J, McCarty OJ, (2011) S6K1 and mTOR regulate Rac1-driven platelet activation and aggregation. Blood 118: 3129-3136.
    • (2011) Blood , vol.118 , pp. 3129-3136
    • Aslan, J.E.1    Tormoen, G.W.2    Loren, C.P.3    Pang, J.4    McCarty, O.J.5
  • 20
    • 84883313334 scopus 로고    scopus 로고
    • Mouse models of PAK function
    • Kelly ML, Chernoff J, (2012) Mouse models of PAK function. Cell Logist 2: 84-88.
    • (2012) Cell Logist , vol.2 , pp. 84-88
    • Kelly, M.L.1    Chernoff, J.2
  • 22
    • 0032748298 scopus 로고    scopus 로고
    • Identification of a central phosphorylation site in p21-activated kinase regulating autoinhibition and kinase activity
    • Zenke FT, King CC, Bohl BP, Bokoch GM, (1999) Identification of a central phosphorylation site in p21-activated kinase regulating autoinhibition and kinase activity. J Biol Chem 274: 32565-32573.
    • (1999) J Biol Chem , vol.274 , pp. 32565-32573
    • Zenke, F.T.1    King, C.C.2    Bohl, B.P.3    Bokoch, G.M.4
  • 23
    • 84879101332 scopus 로고    scopus 로고
    • PAK family kinases: Physiological roles and regulation
    • Zhao ZS, Manser E, (2012) PAK family kinases: Physiological roles and regulation. Cell Logist 2: 59-68.
    • (2012) Cell Logist , vol.2 , pp. 59-68
    • Zhao, Z.S.1    Manser, E.2
  • 24
    • 0034082699 scopus 로고    scopus 로고
    • Interaction between PAK and nck: a template for Nck targets and role of PAK autophosphorylation
    • Zhao ZS, Manser E, Lim L, (2000) Interaction between PAK and nck: a template for Nck targets and role of PAK autophosphorylation. Mol Cell Biol 20: 3906-3917.
    • (2000) Mol Cell Biol , vol.20 , pp. 3906-3917
    • Zhao, Z.S.1    Manser, E.2    Lim, L.3
  • 25
    • 0038554077 scopus 로고    scopus 로고
    • Biology of the p21-activated kinases
    • Bokoch GM, (2003) Biology of the p21-activated kinases. Annu Rev Biochem 72: 743-781.
    • (2003) Annu Rev Biochem , vol.72 , pp. 743-781
    • Bokoch, G.M.1
  • 26
    • 0345731237 scopus 로고    scopus 로고
    • Cell migration: Rho GTPases lead the way
    • Raftopoulou M, Hall A, (2004) Cell migration: Rho GTPases lead the way. Dev Biol 265: 23-32.
    • (2004) Dev Biol , vol.265 , pp. 23-32
    • Raftopoulou, M.1    Hall, A.2
  • 27
    • 50149083752 scopus 로고    scopus 로고
    • Mammalian Rho GTPases: new insights into their functions from in vivo studies
    • Heasman SJ, Ridley AJ, (2008) Mammalian Rho GTPases: new insights into their functions from in vivo studies. Nat Rev Mol Cell Biol 9: 690-701.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 690-701
    • Heasman, S.J.1    Ridley, A.J.2
  • 28
    • 0036308972 scopus 로고    scopus 로고
    • A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity
    • Weiner OD, Neilsen PO, Prestwich GD, Kirschner MW, Cantley LC, et al. (2002) A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity. Nat Cell Biol 4: 509-513.
    • (2002) Nat Cell Biol , vol.4 , pp. 509-513
    • Weiner, O.D.1    Neilsen, P.O.2    Prestwich, G.D.3    Kirschner, M.W.4    Cantley, L.C.5
  • 29
    • 0037415640 scopus 로고    scopus 로고
    • Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis
    • Srinivasan S, Wang F, Glavas S, Ott A, Hofmann F, et al. (2003) Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis. J Cell Biol 160: 375-385.
    • (2003) J Cell Biol , vol.160 , pp. 375-385
    • Srinivasan, S.1    Wang, F.2    Glavas, S.3    Ott, A.4    Hofmann, F.5
  • 30
    • 15144353776 scopus 로고    scopus 로고
    • Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav
    • Han J, Luby-Phelps K, Das B, Shu X, Xia Y, et al. (1998) Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav. Science 279: 558-560.
    • (1998) Science , vol.279 , pp. 558-560
    • Han, J.1    Luby-Phelps, K.2    Das, B.3    Shu, X.4    Xia, Y.5
  • 31
    • 0037155727 scopus 로고    scopus 로고
    • P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac
    • Welch HC, Coadwell WJ, Ellson CD, Ferguson GJ, Andrews SR, et al. (2002) P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac. Cell 108: 809-821.
    • (2002) Cell , vol.108 , pp. 809-821
    • Welch, H.C.1    Coadwell, W.J.2    Ellson, C.D.3    Ferguson, G.J.4    Andrews, S.R.5
  • 32
    • 33947684328 scopus 로고    scopus 로고
    • Signaling requirements for translocation of P-Rex1, a key Rac2 exchange factor involved in chemoattractant-stimulated human neutrophil function
    • Zhao T, Nalbant P, Hoshino M, Dong X, Wu D, et al. (2007) Signaling requirements for translocation of P-Rex1, a key Rac2 exchange factor involved in chemoattractant-stimulated human neutrophil function. J Leukoc Biol 81: 1127-1136.
    • (2007) J Leukoc Biol , vol.81 , pp. 1127-1136
    • Zhao, T.1    Nalbant, P.2    Hoshino, M.3    Dong, X.4    Wu, D.5
  • 33
    • 5644222583 scopus 로고    scopus 로고
    • Involvement of phosphoinositide 3-kinase gamma, Rac, and PAK signaling in chemokine-induced macrophage migration
    • Weiss-Haljiti C, Pasquali C, Ji H, Gillieron C, Chabert C, et al. (2004) Involvement of phosphoinositide 3-kinase gamma, Rac, and PAK signaling in chemokine-induced macrophage migration. J Biol Chem 279: 43273-43284.
    • (2004) J Biol Chem , vol.279 , pp. 43273-43284
    • Weiss-Haljiti, C.1    Pasquali, C.2    Ji, H.3    Gillieron, C.4    Chabert, C.5
  • 34
    • 0035157971 scopus 로고    scopus 로고
    • Activation of Rhoa and ROCK are essential for detachment of migrating leukocytes
    • Alblas J, Ulfman L, Hordijk P, Koenderman L, (2001) Activation of Rhoa and ROCK are essential for detachment of migrating leukocytes. Mol Biol Cell 12: 2137-2145.
    • (2001) Mol Biol Cell , vol.12 , pp. 2137-2145
    • Alblas, J.1    Ulfman, L.2    Hordijk, P.3    Koenderman, L.4
  • 35
    • 0034107669 scopus 로고    scopus 로고
    • Ca2+-dependent myosin II activation is required for uropod retraction during neutrophil migration
    • Eddy RJ, Pierini LM, Matsumura F, Maxfield FR, (2000) Ca2+-dependent myosin II activation is required for uropod retraction during neutrophil migration. J Cell Sci 113 (Pt 7): 1287-1298.
    • (2000) J Cell Sci , vol.113 , Issue.PART 7 , pp. 1287-1298
    • Eddy, R.J.1    Pierini, L.M.2    Matsumura, F.3    Maxfield, F.R.4
  • 36
    • 0042354714 scopus 로고    scopus 로고
    • Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils
    • Xu J, Wang F, Van Keymeulen A, Herzmark P, Straight A, et al. (2003) Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils. Cell 114: 201-214.
    • (2003) Cell , vol.114 , pp. 201-214
    • Xu, J.1    Wang, F.2    Van Keymeulen, A.3    Herzmark, P.4    Straight, A.5
  • 38
    • 22144438655 scopus 로고    scopus 로고
    • TNF-alpha promotes a stop signal that inhibits neutrophil polarization and migration via a p38 MAPK pathway
    • Lokuta MA, Huttenlocher A, (2005) TNF-alpha promotes a stop signal that inhibits neutrophil polarization and migration via a p38 MAPK pathway. J Leukoc Biol 78: 210-219.
    • (2005) J Leukoc Biol , vol.78 , pp. 210-219
    • Lokuta, M.A.1    Huttenlocher, A.2
  • 39
    • 0034635221 scopus 로고    scopus 로고
    • Roles of PLC-beta2 and-beta3 and PI3Kgamma in chemoattractant-mediated signal transduction
    • Li Z, Jiang H, Xie W, Zhang Z, Smrcka AV, et al. (2000) Roles of PLC-beta2 and-beta3 and PI3Kgamma in chemoattractant-mediated signal transduction. Science 287: 1046-1049.
    • (2000) Science , vol.287 , pp. 1046-1049
    • Li, Z.1    Jiang, H.2    Xie, W.3    Zhang, Z.4    Smrcka, A.V.5
  • 40
    • 78649956469 scopus 로고    scopus 로고
    • mTORC2 regulates neutrophil chemotaxis in a cAMP- and RhoA-dependent fashion
    • Liu L, Das S, Losert W, Parent CA, (2010) mTORC2 regulates neutrophil chemotaxis in a cAMP- and RhoA-dependent fashion. Dev Cell 19: 845-857.
    • (2010) Dev Cell , vol.19 , pp. 845-857
    • Liu, L.1    Das, S.2    Losert, W.3    Parent, C.A.4
  • 41
    • 84861552972 scopus 로고    scopus 로고
    • Network crosstalk dynamically changes during neutrophil polarization
    • Ku CJ, Wang Y, Weiner OD, Altschuler SJ, Wu LF, (2012) Network crosstalk dynamically changes during neutrophil polarization. Cell 149: 1073-1083.
    • (2012) Cell , vol.149 , pp. 1073-1083
    • Ku, C.J.1    Wang, Y.2    Weiner, O.D.3    Altschuler, S.J.4    Wu, L.F.5
  • 42
    • 44949176114 scopus 로고    scopus 로고
    • Pak1 and Pak2 mediate tumor cell invasion through distinct signaling mechanisms
    • Coniglio SJ, Zavarella S, Symons MH, (2008) Pak1 and Pak2 mediate tumor cell invasion through distinct signaling mechanisms. Mol Cell Biol 28: 4162-4172.
    • (2008) Mol Cell Biol , vol.28 , pp. 4162-4172
    • Coniglio, S.J.1    Zavarella, S.2    Symons, M.H.3
  • 43
    • 0036898598 scopus 로고    scopus 로고
    • Spatial and temporal analysis of Rac activation during live neutrophil chemotaxis
    • Gardiner EM, Pestonjamasp KN, Bohl BP, Chamberlain C, Hahn KM, et al. (2002) Spatial and temporal analysis of Rac activation during live neutrophil chemotaxis. Curr Biol 12: 2029-2034.
    • (2002) Curr Biol , vol.12 , pp. 2029-2034
    • Gardiner, E.M.1    Pestonjamasp, K.N.2    Bohl, B.P.3    Chamberlain, C.4    Hahn, K.M.5
  • 44
    • 0038037737 scopus 로고    scopus 로고
    • RhoA and ROCK promote migration by limiting membrane protrusions
    • Worthylake RA, Burridge K, (2003) RhoA and ROCK promote migration by limiting membrane protrusions. J Biol Chem 278: 13578-13584.
    • (2003) J Biol Chem , vol.278 , pp. 13578-13584
    • Worthylake, R.A.1    Burridge, K.2
  • 45
    • 2442483847 scopus 로고    scopus 로고
    • p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factor
    • Zenke FT, Krendel M, DerMardirossian C, King CC, Bohl BP, et al. (2004) p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factor. J Biol Chem 279: 18392-18400.
    • (2004) J Biol Chem , vol.279 , pp. 18392-18400
    • Zenke, F.T.1    Krendel, M.2    DerMardirossian, C.3    King, C.C.4    Bohl, B.P.5
  • 46
    • 1242294384 scopus 로고    scopus 로고
    • Direct interaction of p21-activated kinase 4 with PDZ-RhoGEF, a G protein-linked Rho guanine exchange factor
    • Barac A, Basile J, Vazquez-Prado J, Gao Y, Zheng Y, et al. (2004) Direct interaction of p21-activated kinase 4 with PDZ-RhoGEF, a G protein-linked Rho guanine exchange factor. J Biol Chem 279: 6182-6189.
    • (2004) J Biol Chem , vol.279 , pp. 6182-6189
    • Barac, A.1    Basile, J.2    Vazquez-Prado, J.3    Gao, Y.4    Zheng, Y.5
  • 47
    • 0033605738 scopus 로고    scopus 로고
    • Inhibition of myosin light chain kinase by p21-activated kinase
    • Sanders LC, Matsumura F, Bokoch GM, de Lanerolle P, (1999) Inhibition of myosin light chain kinase by p21-activated kinase. Science 283: 2083-2085.
    • (1999) Science , vol.283 , pp. 2083-2085
    • Sanders, L.C.1    Matsumura, F.2    Bokoch, G.M.3    de Lanerolle, P.4
  • 48
    • 0031105660 scopus 로고    scopus 로고
    • Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells
    • Sells MA, Knaus UG, Bagrodia S, Ambrose DM, Bokoch GM, et al. (1997) Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells. Curr Biol 7: 202-210.
    • (1997) Curr Biol , vol.7 , pp. 202-210
    • Sells, M.A.1    Knaus, U.G.2    Bagrodia, S.3    Ambrose, D.M.4    Bokoch, G.M.5
  • 49
    • 0031036626 scopus 로고    scopus 로고
    • Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes
    • Manser E, Huang HY, Loo TH, Chen XQ, Dong JM, et al. (1997) Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes. Mol Cell Biol 17: 1129-1143.
    • (1997) Mol Cell Biol , vol.17 , pp. 1129-1143
    • Manser, E.1    Huang, H.Y.2    Loo, T.H.3    Chen, X.Q.4    Dong, J.M.5
  • 50
    • 79960228959 scopus 로고    scopus 로고
    • Pak1 regulates focal adhesion strength, myosin IIA distribution, and actin dynamics to optimize cell migration
    • Delorme-Walker VD, Peterson JR, Chernoff J, Waterman CM, Danuser G, et al. (2011) Pak1 regulates focal adhesion strength, myosin IIA distribution, and actin dynamics to optimize cell migration. J Cell Biol 193: 1289-1303.
    • (2011) J Cell Biol , vol.193 , pp. 1289-1303
    • Delorme-Walker, V.D.1    Peterson, J.R.2    Chernoff, J.3    Waterman, C.M.4    Danuser, G.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.