-
1
-
-
31044445108
-
Thrombus formation in vivo
-
Furie B, Furie BC. Thrombus formation in vivo. J Clin Invest. 2005;115:3355-3362.
-
(2005)
J Clin Invest
, vol.115
, pp. 3355-3362
-
-
Furie, B.1
Furie, B.C.2
-
2
-
-
0242300217
-
Antiplatelet therapy: In search of the 'magic bullet'
-
Jackson SP, Schoenwaelder SM. Antiplatelet therapy: in search of the 'magic bullet'. Nat Rev Drug Discov. 2003;2:775-789.
-
(2003)
Nat Rev Drug Discov
, vol.2
, pp. 775-789
-
-
Jackson, S.P.1
Schoenwaelder, S.M.2
-
4
-
-
34247604526
-
A major role for scar/wave-1 downstream of gpvi in platelets
-
Calaminus SD, McCarty OJ, Auger JM, Pearce AC, Insall RH, Watson SP, Machesky LM. A major role for Scar/WAVE-1 downstream of GPVI in platelets. J Thromb Haemost. 2007;5:535-541.
-
(2007)
J Thromb Haemost
, vol.5
, pp. 535-541
-
-
Calaminus, S.D.1
McCarty, O.J.2
Auger, J.M.3
Pearce, A.C.4
Insall, R.H.5
Watson, S.P.6
Machesky, L.M.7
-
5
-
-
0037097589
-
Arp2/3 complex is required for actin polymerization during platelet shape change
-
Li Z, Kim ES, Bearer EL. Arp2/3 complex is required for actin polymerization during platelet shape change. Blood. 2002;99:4466-4474.
-
(2002)
Blood
, vol.99
, pp. 4466-4474
-
-
Li, Z.1
Kim, E.S.2
Bearer, E.L.3
-
6
-
-
0037114750
-
Cdc42/rac1-dependent activation of the p21-activated kinase (pak) regulates human platelet lamellipodia spreading: Implication of the cortical-actin binding protein cortactin
-
Vidal C, Geny B, Melle J, Jandrot-Perrus M, Fontenay-Roupie M. Cdc42/Rac1-dependent activation of the p21-activated kinase (PAK) regulates human platelet lamellipodia spreading: implication of the cortical-actin binding protein cortactin. Blood. 2002;100:4462-4469.
-
(2002)
Blood
, vol.100
, pp. 4462-4469
-
-
Vidal, C.1
Geny, B.2
Melle, J.3
Jandrot-Perrus, M.4
Fontenay-Roupie, M.5
-
9
-
-
65649124530
-
Platelet activation by extracellular matrix proteins in haemostasis and thrombosis
-
Watson SP. Platelet activation by extracellular matrix proteins in haemostasis and thrombosis. Curr Pharm Des. 2009;15:1358-1372.
-
(2009)
Curr Pharm Des
, vol.15
, pp. 1358-1372
-
-
Watson, S.P.1
-
10
-
-
84879101332
-
Pak family kinases: Physiological roles and regulation
-
Zhao ZS, Manser E. PAK family kinases: physiological roles and regulation. Cell Logist. 2012;2:59-68.
-
(2012)
Cell Logist
, vol.2
, pp. 59-68
-
-
Zhao, Z.S.1
Manser, E.2
-
12
-
-
34249315804
-
Lim kinases, regulators of actin dynamics
-
Bernard O. Lim kinases, regulators of actin dynamics. Int J Biochem Cell Biol. 2007;39:1071-1076.
-
(2007)
Int J Biochem Cell Biol
, vol.39
, pp. 1071-1076
-
-
Bernard, O.1
-
13
-
-
0028842508
-
Identification and molecular cloning of a p21cdc42/rac1-activated serine/threonine kinase that is rapidly activated by thrombin in platelets
-
Teo M, Manser E, Lim L. Identification and molecular cloning of a p21cdc42/rac1-activated serine/threonine kinase that is rapidly activated by thrombin in platelets. J Biol Chem. 1995;270:26690-26697.
-
(1995)
J Biol Chem
, vol.270
, pp. 26690-26697
-
-
Teo, M.1
Manser, E.2
Lim, L.3
-
14
-
-
34447648178
-
Genetic and pharmacologic evidence that rac1 gtpase is involved in regulation of platelet secretion and aggregation
-
Akbar H, Kim J, Funk K, Cancelas JA, Shang X, Chen L, Johnson JF, Williams DA, Zheng Y. Genetic and pharmacologic evidence that Rac1 GTPase is involved in regulation of platelet secretion and aggregation. J Thromb Haemost. 2007;5:1747-1755.
-
(2007)
J Thromb Haemost
, vol.5
, pp. 1747-1755
-
-
Akbar, H.1
Kim, J.2
Funk, K.3
Cancelas, J.A.4
Shang, X.5
Chen, L.6
Johnson, J.F.7
Williams, D.A.8
Zheng, Y.9
-
15
-
-
79960567744
-
Gene targeting implicates cdc42 gtpase in gpvi and non-gpvi mediated platelet filopodia formation, secretion and aggregation
-
Akbar H, Shang X, Perveen R, Berryman M, Funk K, Johnson JF, Tandon NN, Zheng Y. Gene targeting implicates Cdc42 GTPase in GPVI and non-GPVI mediated platelet filopodia formation, secretion and aggregation. PLoS One. 2011;6:e22117.
-
(2011)
PLoS One
, vol.6
-
-
Akbar, H.1
Shang, X.2
Perveen, R.3
Berryman, M.4
Funk, K.5
Johnson, J.F.6
Tandon, N.N.7
Zheng, Y.8
-
16
-
-
0035895076
-
Rac, a small guanosine triphosphate-binding protein, and p21-activated kinase are activated during platelet spreading on collagen-coated surfaces: Roles of integrin alpha (2)beta( 1)
-
Suzuki-Inoue K, Yatomi Y, Asazuma N, Kainoh M, Tanaka T, Satoh K, Ozaki Y. Rac, a small guanosine triphosphate-binding protein, and p21-activated kinase are activated during platelet spreading on collagen-coated surfaces: roles of integrin alpha(2)beta(1). Blood. 2001;98:3708-3716.
-
(2001)
Blood
, vol.98
, pp. 3708-3716
-
-
Suzuki-Inoue, K.1
Yatomi, Y.2
Asazuma, N.3
Kainoh, M.4
Tanaka, T.5
Satoh, K.6
Ozaki, Y.7
-
17
-
-
58849159111
-
Activation of pak1/2 during the shedding of platelet microvesicles
-
Crespin M, Vidal C, Picard F, Lacombe C, Fontenay M. Activation of PAK1/2 during the shedding of platelet microvesicles. Blood Coagul Fibrinolysis. 2009;20:63-70.
-
(2009)
Blood Coagul Fibrinolysis
, vol.20
, pp. 63-70
-
-
Crespin, M.1
Vidal, C.2
Picard, F.3
Lacombe, C.4
Fontenay, M.5
-
18
-
-
30444460134
-
Regulation of lim-kinase 1 and cofilin in thrombin-stimulated platelets
-
Pandey D, Goyal P, Bamburg JR, Siess W. Regulation of LIM-kinase 1 and cofilin in thrombin-stimulated platelets. Blood. 2006;107:575-583.
-
(2006)
Blood
, vol.107
, pp. 575-583
-
-
Pandey, D.1
Goyal, P.2
Bamburg, J.R.3
Siess, W.4
-
19
-
-
0036333485
-
Rac-pak signaling stimulates extracellular signal-regulated kinase (erk) activation by regulating formation of mek1-erk complexes
-
Eblen ST, Slack JK, Weber MJ, Catling AD. Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEK1-ERK complexes. Mol Cell Biol. 2002;22:6023-6033.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 6023-6033
-
-
Eblen, S.T.1
Slack, J.K.2
Weber, M.J.3
Catling, A.D.4
-
20
-
-
34249282040
-
Mek1 activation by pak: A novel mechanism
-
Park ER, Eblen ST, Catling AD. MEK1 activation by PAK: a novel mechanism. Cell Signal. 2007;19:1488-1496.
-
(2007)
Cell Signal
, vol.19
, pp. 1488-1496
-
-
Park, E.R.1
Eblen, S.T.2
Catling, A.D.3
-
21
-
-
79952779502
-
Pases and their role in organizing the actin cytoskeleton
-
Sit ST, Manser E. Rho GTPases and their role in organizing the actin cytoskeleton. J Cell Sci. 2011;124:679-683.
-
(2011)
J Cell Sci
, vol.124
, pp. 679-683
-
-
Sit, S.T.1
Manser, E.2
Rho, G.T.3
-
22
-
-
41949100602
-
An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase
-
Deacon SW, Beeser A, Fukui JA, Rennefahrt UE, Myers C, Chernoff J, Peterson Jr. An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase. Chem Biol. 2008;15:322-331.
-
(2008)
Chem Biol
, vol.15
, pp. 322-331
-
-
Deacon, S.W.1
Beeser, A.2
Fukui, J.A.3
Rennefahrt, U.E.4
Myers, C.5
Chernoff, J.6
Peterson, J.R.7
-
23
-
-
70349484472
-
An allosteric kinase inhibitor binds the p21-activated kinase autoregulatory domain covalently
-
Viaud J, Peterson Jr. An allosteric kinase inhibitor binds the p21-activated kinase autoregulatory domain covalently. Mol Cancer Ther. 2009;8:2559-2565.
-
(2009)
Mol Cancer Ther
, vol.8
, pp. 2559-2565
-
-
Viaud, J.1
Peterson, J.R.2
-
24
-
-
80054772505
-
Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod-driven motility and cell-cycle progression
-
Li A, Ma Y, Yu X, Mort RL, Lindsay CR, Stevenson D, Strathdee D, Insall RH, Chernoff J, Snapper SB, Jackson IJ, Larue L, Sansom OJ, Machesky LM. Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod-driven motility and cell-cycle progression. Dev Cell. 2011;21:722-734.
-
(2011)
Dev Cell
, vol.21
, pp. 722-734
-
-
Li, A.1
Ma, Y.2
Yu, X.3
Mort, R.L.4
Lindsay, C.R.5
Stevenson, D.6
Strathdee, D.7
Insall, R.H.8
Chernoff, J.9
Snapper, S.B.10
Jackson, I.J.11
Larue, L.12
Sansom, O.J.13
Machesky, L.M.14
-
25
-
-
79955568142
-
Targeting p21-activated kinase 1 (pak1) to induce apoptosis of tumor cells
-
Ong CC, Jubb AM, Haverty PM, Zhou W, Tran V, Truong T, Turley H, O'Brien T, Vucic D, Harris AL, Belvin M, Friedman LS, Blackwood EM, Koeppen H, Hoeflich KP. Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells. Proc Natl Acad Sci U S A. 2011;108:7177-7182.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 7177-7182
-
-
Ong, C.C.1
Jubb, A.M.2
Haverty, P.M.3
Zhou, W.4
Tran, V.5
Truong, T.6
Turley, H.7
O'Brien, T.8
Vucic, D.9
Harris, A.L.10
Belvin, M.11
Friedman, L.S.12
Blackwood, E.M.13
Koeppen, H.14
Hoeflich, K.P.15
-
26
-
-
77951446656
-
Macropinocytotic uptake and infection of human epithelial cells with species b2 adenovirus type 35
-
Kälin S, Amstutz B, Gastaldelli M, Wolfrum N, Boucke K, Havenga M, DiGennaro F, Liska N, Hemmi S, Greber UF. Macropinocytotic uptake and infection of human epithelial cells with species B2 adenovirus type 35. J Virol. 2010;84:5336-5350.
-
(2010)
J Virol
, vol.84
, pp. 5336-5350
-
-
Kälin, S.1
Amstutz, B.2
Gastaldelli, M.3
Wolfrum, N.4
Boucke, K.5
Havenga, M.6
DiGennaro, F.7
Liska, N.8
Hemmi, S.9
Greber, U.F.10
-
27
-
-
72449202697
-
The small gtpase rac1 regulates auditory hair cell morphogenesis
-
Grimsley-Myers CM, Sipe CW, Géléoc GS, Lu X. The small GTPase Rac1 regulates auditory hair cell morphogenesis. J Neurosci. 2009;29:15859-15869.
-
(2009)
J Neurosci
, vol.29
, pp. 15859-15869
-
-
Grimsley-Myers, C.M.1
Sipe, C.W.2
Géléoc, G.S.3
Lu, X.4
-
28
-
-
84869225094
-
P21-activated kinase 1 is required for efficient tumor formation and progression in a ras-mediated skin cancer model
-
Chow HY, Jubb AM, Koch JN, Jaffer ZM, Stepanova D, Campbell DA, Duron SG, O'Farrell M, Cai KQ, Klein-Szanto AJ, Gutkind JS, Hoeflich KP, Chernoff J. p21-Activated kinase 1 is required for efficient tumor formation and progression in a Ras-mediated skin cancer model. Cancer Res. 2012;72:5966-5975.
-
(2012)
Cancer Res
, vol.72
, pp. 5966-5975
-
-
Chow, H.Y.1
Jubb, A.M.2
Koch, J.N.3
Jaffer, Z.M.4
Stepanova, D.5
Campbell, D.A.6
Duron, S.G.7
O'Farrell, M.8
Cai, K.Q.9
Klein-Szanto, A.J.10
Gutkind, J.S.11
Hoeflich, K.P.12
Chernoff, J.13
-
29
-
-
77952720804
-
Small-molecule p21-activated kinase inhibitor pf-3758309 is a potent inhibitor of oncogenic signaling and tumor growth
-
Murray BW, Guo C, Piraino J, et al. Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth. Proc Natl Acad Sci U S A. 2010;107:9446-9451.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 9446-9451
-
-
Murray, B.W.1
Guo, C.2
Piraino, J.3
-
30
-
-
38949200283
-
Regulation of akt/pkb activity by p21-activated kinase in cardiomyocytes
-
Mao K, Kobayashi S, Jaffer ZM, Huang Y, Volden P, Chernoff J, Liang Q. Regulation of Akt/PKB activity by P21-activated kinase in cardiomyocytes. J Mol Cell Cardiol. 2008;44:429-434.
-
(2008)
J Mol Cell Cardiol
, vol.44
, pp. 429-434
-
-
Mao, K.1
Kobayashi, S.2
Jaffer, Z.M.3
Huang, Y.4
Volden, P.5
Chernoff, J.6
Liang, Q.7
-
32
-
-
0036711657
-
Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1
-
Vadlamudi RK, Li F, Adam L, Nguyen D, Ohta Y, Stossel TP, Kumar R. Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1. Nat Cell Biol. 2002;4:681-690.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 681-690
-
-
Vadlamudi, R.K.1
Li, F.2
Adam, L.3
Nguyen, D.4
Ohta, Y.5
Stossel, T.P.6
Kumar, R.7
-
33
-
-
77956246333
-
A novel interaction between flna and syk regulates platelet itam-mediated receptor signaling and function
-
Falet H, Pollitt AY, Begonja AJ, Weber SE, Duerschmied D, Wagner DD, Watson SP, Hartwig JH. A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function. J Exp Med. 2010;207:1967-1979.
-
(2010)
J Exp Med
, vol.207
, pp. 1967-1979
-
-
Falet, H.1
Pollitt, A.Y.2
Begonja, A.J.3
Weber, S.E.4
Duerschmied, D.5
Wagner, D.D.6
Watson, S.P.7
Hartwig, J.H.8
-
35
-
-
84859029508
-
Regulation of the mtor-rac1 axis in platelet function
-
Aslan JE, McCarty OJ. Regulation of the mTOR-Rac1 axis in platelet function. Small GTPases. 2012;3:67-70.
-
(2012)
Small GTPases
, vol.3
, pp. 67-70
-
-
Aslan, J.E.1
McCarty, O.J.2
-
36
-
-
80052938277
-
S6k1 and mtor regulate rac1-driven platelet activation and aggregation
-
Aslan JE, Tormoen GW, Loren CP, Pang J, McCarty OJ. S6K1 and mTOR regulate Rac1-driven platelet activation and aggregation. Blood. 2011;118:3129-3136.
-
(2011)
Blood
, vol.118
, pp. 3129-3136
-
-
Aslan, J.E.1
Tormoen, G.W.2
Loren, C.P.3
Pang, J.4
McCarty, O.J.5
-
37
-
-
28244479366
-
Rac1 is essential for platelet lamellipodia formation and aggregate stability under flow
-
McCarty OJ, Larson MK, Auger JM, Kalia N, Atkinson BT, Pearce AC, Ruf S, Henderson RB, Tybulewicz VL, Machesky LM, Watson SP. Rac1 is essential for platelet lamellipodia formation and aggregate stability under flow. J Biol Chem. 2005;280:39474-39484.
-
(2005)
J Biol Chem
, vol.280
, pp. 39474-39484
-
-
McCarty, O.J.1
Larson, M.K.2
Auger, J.M.3
Kalia, N.4
Atkinson, B.T.5
Pearce, A.C.6
Ruf, S.7
Henderson, R.B.8
Tybulewicz, V.L.9
Machesky, L.M.10
Watson, S.P.11
-
38
-
-
33751187650
-
Continuous signaling via pi3k isoforms beta and gamma is required for platelet adp receptor function in dynamic thrombus stabilization
-
Cosemans JM, Munnix IC, Wetzker R, Heller R, Jackson SP, Heemskerk JW. Continuous signaling via PI3K isoforms beta and gamma is required for platelet ADP receptor function in dynamic thrombus stabilization. Blood. 2006;108:3045-3052.
-
(2006)
Blood
, vol.108
, pp. 3045-3052
-
-
Cosemans, J.M.1
Munnix, I.C.2
Wetzker, R.3
Heller, R.4
Jackson, S.P.5
Heemskerk, J.W.6
-
39
-
-
0028078824
-
A brain serine/threonine protein kinase activated by cdc42 and rac1
-
Manser E, Leung T, Salihuddin H, Zhao ZS, Lim L. A brain serine/threonine protein kinase activated by Cdc42 and Rac1. Nature. 1994;367:40-46.
-
(1994)
Nature
, vol.367
, pp. 40-46
-
-
Manser, E.1
Leung, T.2
Salihuddin, H.3
Zhao, Z.S.4
Lim, L.5
-
40
-
-
84863011162
-
Megakaryocyte-specific rhoa deficiency causes macrothrombocytopenia and defective platelet activation in hemostasis and thrombosis
-
Pleines I, Hagedorn I, Gupta S, May F, Chakarova L, van Hengel J, Offermanns S, Krohne G, Kleinschnitz C, Brakebusch C, Nieswandt B. Megakaryocyte-specific RhoA deficiency causes macrothrombocytopenia and defective platelet activation in hemostasis and thrombosis. Blood. 2012;119:1054-1063.
-
(2012)
Blood
, vol.119
, pp. 1054-1063
-
-
Pleines, I.1
Hagedorn, I.2
Gupta, S.3
May, F.4
Chakarova, L.5
Van Hengel, J.6
Offermanns, S.7
Krohne, G.8
Kleinschnitz, C.9
Brakebusch, C.10
Nieswandt, B.11
-
41
-
-
0037177816
-
Rhoa sustains integrin alpha iibbeta 3 adhesion contacts under high shear
-
Schoenwaelder SM, Hughan SC, Boniface K, Fernando S, Holdsworth M, Thompson PE, Salem HH, Jackson SP. RhoA sustains integrin alpha IIbbeta 3 adhesion contacts under high shear. J Biol Chem. 2002;277:14738-14746.
-
(2002)
J Biol Chem
, vol.277
, pp. 14738-14746
-
-
Schoenwaelder, S.M.1
Hughan, S.C.2
Boniface, K.3
Fernando, S.4
Holdsworth, M.5
Thompson, P.E.6
Salem, H.H.7
Jackson, S.P.8
-
42
-
-
77951459334
-
Multiple alterations of platelet functions dominated by increased secretion in mice lacking cdc42 in platelets
-
Pleines I, Eckly A, Elvers M, Hagedorn I, Eliautou S, Bender M, Wu X, Lanza F, Gachet C, Brakebusch C, Nieswandt B. Multiple alterations of platelet functions dominated by increased secretion in mice lacking Cdc42 in platelets. Blood. 2010;115:3364-3373.
-
(2010)
Blood
, vol.115
, pp. 3364-3373
-
-
Pleines, I.1
Eckly, A.2
Elvers, M.3
Hagedorn, I.4
Eliautou, S.5
Bender, M.6
Wu, X.7
Lanza, F.8
Gachet, C.9
Brakebusch, C.10
Nieswandt, B.11
-
43
-
-
0032101145
-
Effects of the mitogen-activated protein (map) kinase kinase inhibitor 2-(2'-amino-3'-methoxyphenyl)-oxanaphthalen-4-one (pd98059) on human platelet activation
-
McNicol A, Philpott CL, Shibou TS, Israels SJ. Effects of the mitogen-activated protein (MAP) kinase kinase inhibitor 2-(2'-amino-3'- methoxyphenyl)-oxanaphthalen-4-one (PD98059) on human platelet activation. Biochem Pharmacol. 1998;55:1759-1767.
-
(1998)
Biochem Pharmacol
, vol.55
, pp. 1759-1767
-
-
McNicol, A.1
Philpott, C.L.2
Shibou, T.S.3
Israels, S.J.4
-
45
-
-
0035834714
-
A mitogen-activated protein kinase-dependent signaling pathway in the activation of platelet integrin alpha iibbeta3
-
Li Z, Xi X, Du X. A mitogen-activated protein kinase-dependent signaling pathway in the activation of platelet integrin alpha IIbbeta3. J Biol Chem. 2001;276:42226-42232.
-
(2001)
J Biol Chem
, vol.276
, pp. 42226-42232
-
-
Li, Z.1
Xi, X.2
Du, X.3
-
46
-
-
27744525934
-
Src family kinase-mediated and erk-mediated thromboxane a2 generation are essential for vwf/gpib-induced fibrinogen receptor activation in human platelets
-
Garcia A, Quinton TM, Dorsam RT, Kunapuli SP. Src family kinase-mediated and Erk-mediated thromboxane A2 generation are essential for VWF/GPIb-induced fibrinogen receptor activation in human platelets. Blood. 2005;106:3410-3414.
-
(2005)
Blood
, vol.106
, pp. 3410-3414
-
-
Garcia, A.1
Quinton, T.M.2
Dorsam, R.T.3
Kunapuli, S.P.4
-
47
-
-
22544453045
-
Differential involvement of erk2 and p38 in platelet adhesion to collagen
-
Mazharian A, Roger S, Maurice P, Berrou E, Popoff MR, Hoylaerts MF, Fauvel-Lafeve F, Bonnefoy A, Bryckaert M. Differential Involvement of ERK2 and p38 in platelet adhesion to collagen. J Biol Chem. 2005;280:26002-26010.
-
(2005)
J Biol Chem
, vol.280
, pp. 26002-26010
-
-
Mazharian, A.1
Roger, S.2
Maurice, P.3
Berrou, E.4
Popoff, M.R.5
Hoylaerts, M.F.6
Fauvel-Lafeve, F.7
Bonnefoy, A.8
Bryckaert, M.9
|