Pak2 kinase restrains mast cell FcεRI receptor signaling through modulation of rho protein guanine nucleotide exchange factor (GEF) activity

Journal of Biological Chemistry

Volumn 288, Issue 2, 2013, Pages 974-983

  Kosoff, Rachelle ^a,b   Chows, Hoi Yee ^b   Radus, Maria ^b   Chernoffs, Jonathan ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b FOX CHASE CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MARROW-DERIVED MAST CELLS; CALCIUM INFLUX; CYTOKINE SECRETIONS; DEGRANULATION; EXTRACELLULAR; GUANINE NUCLEOTIDE EXCHANGE FACTORS; INHIBITORY SITES; ISOFORMS; KINASE FAMILY; MAST CELLS; MICROTUBULES; MYOSIN LIGHT CHAINS; RECEPTOR SIGNALING; RHO PROTEINS; SIGNALING ACTIVITY;

AMINO ACIDS; ANTIGENS; CYTOLOGY; ENZYME ACTIVITY; NUCLEOTIDES; PHOSPHORYLATION; POSITIVE IONS;

CELLS;

GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE TRIPHOSPHATASE; IMMUNOGLOBULIN E RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE P38; MYOSIN LIGHT CHAIN; P21 ACTIVATED KINASE 1; P21 ACTIVATED KINASE 2; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW; CALCIUM MOBILIZATION; CALCIUM TRANSPORT; CELL ADHESION; CELL STRAIN HEK293; CONTROLLED STUDY; CYTOKINE RELEASE; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENOTYPE; IN VITRO STUDY; MAST CELL; MAST CELL DEGRANULATION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; BASE SEQUENCE; BONE MARROW CELLS; CALCIUM; CELL ADHESION; CELLS, CULTURED; DNA PRIMERS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; MAST CELLS; MICE; MICE, INBRED C57BL; P21-ACTIVATED KINASES; POLYMERASE CHAIN REACTION; RECEPTORS, IGE; SIGNAL TRANSDUCTION;

MURINAE;

EID: 84872299428     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.422295     Document Type: Article

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