Pluronic-based core/shell nanoparticles for drug delivery and diagnosis

Current Medicinal Chemistry

Volumn 20, Issue 28, 2013, Pages 3488-3499

  Jung, Yong Woo ^a   Lee, Hwanbum ^a   Kim, Jae Yeon ^a   Koo, Eun Jin ^a   Oh, Keun Sang ^a   Yuk, Soon Hong ^a  

^a Korea University   (South Korea)

Author keywords

Antitumor efficacy; Cancer targetability; Chitosan heparin composite; Core shell nanoparticles; Enhanced permeability and retention effect; Layer by layer approach; Molecular imaging agent; Pluornics; Pluronic liposome composite nanoparticles; Polyethylene glycol; Protein drug; Self assembly; Temperature induced phase transition; Vesicle fusion

Indexed keywords

CARBOPLATIN; CHITOSAN; DOCETAXEL; DOXORUBICIN; MACROGOL; NANOPARTICLE; POLOXAMER; VASCULOTROPIN;

ANATOMICAL CONCEPTS; ANTINEOPLASTIC ACTIVITY; AQUEOUS SOLUTION; BIOCOMPATIBILITY; BIODEGRADABILITY; CELL MEMBRANE PERMEABILITY; CHEMICAL COMPOSITION; DRUG BIOAVAILABILITY; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG FORMULATION; DRUG HALF LIFE; DRUG UPTAKE; EMULSION; ENDOCYTOSIS; FREEZE DRYING; GELATION; GLASS TRANSITION TEMPERATURE; HUMAN; HYDROGEN BOND; HYDROPHILICITY; HYDROPHOBICITY; LIPID BILAYER; MELTING POINT; MICELLE; MOLECULAR IMAGING; MOLECULAR WEIGHT; MULTIDRUG RESISTANCE; NANOENCAPSULATION; NANOMEDICINE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PARTICLE SIZE; PH; PHASE TRANSITION; PHOTODYNAMIC THERAPY; REVIEW; SURFACE CHARGE; SUSTAINED DRUG RELEASE;

EID: 84883286953     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/09298673113209990036     Document Type: Review

References (123)

1. Hamley, I.W. The Physics of Block Copolymers, Oxford University Press; Oxford, 1998.
2. Mortensen, K; Pedersen J.S. Structural study on the micelle formation of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer in aqueous solution. Macromolecules, 1993, 26, 805-812.
3. Linse, P. Micellization of poly (ethylene oxide)-poly(propylene oxide) block copolymers in aqueous solution: effect of polymer polydispersity. Macromolecules, 1994, 27, 6404-6417.
4. Tiwari, A.; Prabaharan, M. An amphiphilic nanocarrier based on guar gum-graft-poly (ε-caprolactone) for potential drug-delivery applications. J. Biomaterials Sci., 2010, 21, 937-949.
5. Bockstahl, F; Duplaütre, G; Miguel, M. G.; Burrows, H. D. Probing the size of Pluronic P84 block copolymer micelles in aqueous solution by means of positron annihilation lifetime spectroscopy. Phys. Chem. Chem. Phys., 2000, 2, 4768-4771.
6. D'Errico, G.; Paduano, L.; Khan, A. Temperature and concentration effects on supramolecular aggregation and phase behavior for poly (propylene oxide)-b-poly(ethylene oxide)-b-poly(propylene oxide) copolymers of different composition in aqueous mixtures. J. Colloid. Interface Sci., 2004, 279, 379-390.
7. Nakashima, K; Bahadur, P. Aggregation of water-soluble block copolymers in aqueous solutions: Recent trends. Adv. Colloid Interface Sci., 2006, 123, 75-96.
8. Schillen, K.; Claesson, P. M.; Malmsten, M.; Linse, P.; Booth, C. Properties of Poly (ethylene oxide)-Poly(butylene oxide) Diblock Copolymers at the Interface between Hydrophobic Surfaces and Water. J. Phys. Chem., 1997, 101, 4238-4252.
9. Alexandridis, P.; Hatton, T.A. in: Pillai, V.; Shah, D.O. (Eds.), Dynamic Properties of Interfaces and Association Structures, AOCS Press, Champaign, IL, 1996, Ch. 12.
10. Alexandridis, P.; Holzwarth, J.F.; Hatton, T.A. Micellization of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymers in aqueous solutions: thermodynamics of copolymer association. Macromolecules, 1994, 27, 2414-2425.
11. Alexandridis, P. Poly (ethylene oxide)/poly(propylene oxide) block copolymer surfactants. Curr. Opin. Colloid Interface Sci., 1997, 2, 478-489.
12. Desai, P.R.; Jain, N.J.; Sharma, R.K.; Bahadur, P. Effect of additives on the micellization of PEO/PPO/PEO block copolymer F127 in aqueous solution. Colloid. Surface. A., 2001, 178, 57-69.
13. Ortona, O.; D'Errico, G.; Paduano, L.; Vitagliano, V. Interaction between cationic, anionic, and non-ionic surfactants with ABAblock copolymer Pluronic PE6200 and with BAB reverse block copolymer Pluronic 25R4. J. Colloid Interface Sci., 2006, 301, 63-77
14. Alakhov, V.Y.; Moskaleva, E.Y.; Batrakova, E.V.; Kabanov, A.V. Hypersensitization of multidrug resistant human ovarian carcinoma cells by Pluronic P85 block copolymer. Bioconjugate Chem., 1996, 7, 209-216.
15. Kabanov, A.V.; Batova, E.V.; Melik-Nubarov, N.S.; Fedoseev. N.A.; Dorodnich, T.; Alakhov, V.; Chekhonin, V.; Nazarova, I.R.; Kabanov, V.A. A new class of drug carriers: micelles of poly(oxyethylene)-poly(oxypropylene) block copolymers as microcontainers for drug targeting from blood in brain. J. Controlled Release, 1992, 22, 141-158.
16. Gabizon, A.; Catane, R.; Uziely, B.; Kaufman, B.; Safra, T.; Cohen, R.; Martin, F.; Huang, A.; Barenholz, Y. Prolonged circulation time and enhanced accumulation in malignant exudates of doxorubicin encapsulated in polyethylene-glycolcoated liposomes, Cancer Res., 1994, 54, 987-992.
17. Gabizon, A.; Goren, D.; Cohen, R.; Barentidz, Y. Development of liposomal anthracyclines: from basics to clinical applications. J. Control. Release, 1998, 53, 275-279.
18. Omelyanenko, V.; Kopecková, P.; Gentry, C.; Kopecek, J. Targetable HPMA copolymer-adriamycin conjugates. Recognition, internalization, and subcellular fate. J. Control. Release, 1988, 53, 25-37.
19. Jelínková, M.; Strohalm. J.; Plocová, D.; Subr, V.; St'astń, M.; Ulbrich. K.; Ríhová, B. Targeting of human and mouse Tlymphocytes by monoclonal antibody-HPMA copolymerdoxorubicin conjugates directed against different T-cell surface antigens. J. Control. Release, 1998, 52, 253-270.
20. Duncan. R.; Coatsworth, J. K.; Burtles, S. Preclinical toxicology of a novel polymeric antitumour agent: HPMA copolymerdoxorubicin (PK1). Hum. Exp. Toxicol., 1998, 17, 93-104.
21. Alakhov, V.; Klinski, E.; Li, S.; Pietrzynski, G.; Venne, A.; Batrakova, E.; Bronitch, T.; Kabanov, A. Block copolymer-based formulation of doxorubicin. From cell screen to clinical trials. Colloid. Surface. B., 1999, 16, 113-134.
22. Lyer, A.K.; Khaled, G.; Fang, J.; Maeda, H. Exploiting the enhanced permeability and retention effect for tumor targeting. Drug Discov. Today, 2006, 11, 812-818.
23. Exner, A.; Krupka, T.M.; Scherrer, K.; Teets, J.M. Enhancement of carboplatin toxicity by Pluronic block copolymers. J. Control. Release, 2005,106, 188-197.
24. Krylova, O.O.; Pohl, P. Ionophoric activity of pluronic block copolymers. Biochemistry, 2004, 43, 3696-3703.
25. Batrakova, E.V.; Li. S.; Vinogradov, S.V.; Alakhov, V.Y.; Miller D.W.; Kabanov, A.V. Mechanism of pluronic effect on Pglycoprotein efflux system in blood-brain barrier: contributions of energy depletion and membrane fluidization. J. Pharmacol. Exp. Ther., 2001, 299, 483-493.
26. Batrakova, E.V.; Li. S.; Elmquist, W.F.; Miller. D.W.; Alakhov. V.Y. Kabanov A.V. Mechanism of sensitization of MDR cancer cells by Pluronic block copolymers: selective energy depletion. Br. J. Cancer, 2001, 85, 1987-1997.
27. Boulikas, T.; Vougiouka, M. Cisplatin and platinum drugs at the molecular level. Oncol. Rep., 2003, 10, 1663-1683.
28. Daubeuf, S.; Balin, D.; Leroy, P.; Visvikis, A. Different mechanisms for gamma-glutamyltransferase-dependent resistance to carboplatin and cisplatin. Biochem. Pharmacol., 2003, 66, 595-604.
29. Adams, M.L.; Lavasanifar, A.; Kwon, G.S. Amphiphilic block copolymers for drug delivery. J. Pharm. Sci., 2003, 92, 1343-1355.
30. van Nostrum, C.F. Polymeric micelles to deliver photosensitizers for photodynamic therapy. Adv. Drug Deliv. Rev., 2004, 56, 9-16.
31. Husseini, G. A.; Rapoport, N.Y.; Christensen, D. A.; Pruitt, J. D.; Pitt, W.G. Kinetics of ultrasonic release of doxorubicin from pluronic P105 micelles. Colloid. Surface. B., 2002, 24, 253-264.
32. Munshi, N.; Rapoport, N.Y.; Pitt, W.G. Ultrasonic activated drug delivery from Pluronic P-105 micelles. Cancer Lett., 1997, 117, 13-19.
33. Rapoport, N.Y.; Herron, J.N.; Pitt, W.G.; Pitina, L. Micellar delivery of doxorubicin and its paramagnetic analogue, ruboxyl, to HL-60 cells: effect of micelle structure and in ultrasound on the intracellular drug uptake. J. Control. Release, 1999, 58, 153-162.
34. N.Y. Rapoport, Stabilization and acoustic activation of Pluronic micelles for tumor-targeted drug delivery. Colloid. Surface. B., 1999, 16, 93-111.
35. Husseini, G.A.; Myrup, G.D.; Pitt, W.G.; Christensen, D.A.; Rapoport, N.Y. Factors affecting acoustically triggered release of drugs from polymeric micelles. J. Control. Release, 2000, 69, 43-52.
36. Tachibana, K.; Uchida, T.; Ogawa, K.; Yamashita, N.; Tamura, K. Induction of cell-membrane porosity by ultrasound. Lancet, 1999, 353, 1409.
37. Ghoorchian, A.; Holland, N.B. Molecular architecture influences the thermally induced aggregation behavior of elastin-like polypeptides. Biomacromolecules, 2011, 12, 4022-4029.
38. Deng, W.; Yamaguchi, H.; Takashima, Y.; Harada, A. A chemicalresponsive supramolecular hydrogel from modified cyclodextrins. Angew. Chem. Int. Ed., 2007, 46, 5144-5147.
39. Matsen, M.W.; Thompson, R.B. Equilibrium behavior of asymmetric ABA triblock copolymer melts. J. Chem. Phys., 2000, 113, 5539-5546.
40. Mai, S.-M.; Mingvanish, W.; Turner, S.C.; Chaibundit, C.; Fairclough, J.P.A.; Heatley, F.; Matsen, M.W.; Ryan, A. J.; Booth, C. Microphase-separation behavior of triblock copolymer melts, comparison with diblock copolymer melts. Macromolecules, 2000, 33, 5124-5130.
41. Lee, K.E.; Kim, B.K.; Yuk, S.H. Biodegradable polymeric nanospheres formed by temperature-induced phase transition in a mixture of poly(lactide-co-glycolide) and poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer. Biomacromolecules, 2002, 3, 1116-1119.
42. Gautier, S.; Grudzielski, N.; Goffinet, G.; de Hassonville, S. H.; Delatti, J. R. Preparation of poly(D,L-lactide) nanoparticles assisted by amphiphilic poly(methyl methacrylate-co-methacrylic acid) copolymers J. Biomater. Sci., Polym. Ed., 2001, 12, 429-450.
43. Oh, K.S.; Song, J.Y.; Cho, S.H.; Lee, B.S.; Kim, S.Y.; Kim, K.; Jeon, H.; Kwon, I.C.; Yuk, S.H. Paclitaxel-loaded Pluronic nanoparticles formed by a temperature-induced phase transition for cancer therapy. J. Control. Release, 2010, 148, 344-350.
44. Yuk, S.H.; Oh, K.S.; Park, J.; Lee, E.H.; Kim, K.; Kwon, I.C. Docetaxel-loaded composite nanoparticles formed by a temperatureinduced phase transition for cancer therapy. J. Bioact. Compat. Pol., 2012, 27, 441-452.
45. Yuk, S.H.; Oh, K.S.; Cho, S.H.; Lee, B.S.; Kim, S.Y.; Kwak, B.-K.; Kim, K.; Kwon, I.C. Glycol chitosan/heparin immobilized iron oxide nanoparticles with a tumor-targeting characteristic for magnetic resonance imaging. Biomacromolecules, 2011, 12, 2335-2343.
46. Yuk, S.H.; Oh, K.S.; Cho, S.H.; Kim, S.Y.; Oh, S.; Lee, J.H.; Kim, K.; Kwon, I.C. Enhancement of the targeting capabilities of the paclitaxel-loaded pluronic nanoparticles with a glycol chitosan/heparin composite. Mol. Pharmaceut., 2012, 9, 230-236.
47. Choi, K.Y.; Chung, H.; Min, K.H.;Yoon, H.Y.; Kim, K.; Park, J.H.; Kwon, I.C.; Jeong, S.Y. Self-assembled hyaluronic acid nanoparticles for active tumor targeting. Biomaterials, 2010, 31, 106-114.
48. Mugabe, C.; Matsui, Y.; So, A.I.; Gleave, M.E.; Baker, J.H.E.; Minchinton, A.I.; Manisali, I.; Liggins, R.; Brooks, D. E.; Burt, H.M. In vivo evaluation of mucoadhesive nanoparticulate docetaxel for intravesical treatment of non-muscle-invasive bladder cancer. Clin. Cancer Res., 2011, 17, 2788-2798.
49. Vaidya, A.; Sun, Y.; Feng, Y.; Emerson, L.; Jeong, E.-K.; Lu, Z.-R. Contrast-enhanced MRI-guided photodynamic cancer therapy with a pegylated bifunctional polymer conjugate. Pharm. Res., 2008, 25, 2002-2011.
50. Koffie, R.M.; Farrar, C.T.; Saidi, L.J.; William, C.M.; Hyman, B.T.; Spires-Jones, T.L. Nanoparticles enhance brain delivery of blood-brain barrier-impermeable probes for in vivo optical and magnetic resonance imaging. Proc. Natl. Acad. Sci. USA, 2011, 108, 18837-18842.
51. Kim, D.; Jeong, Y.Y.; Jon, S. A drug-loaded aptamer-gold nanoparticle bioconjugate for combined CT imaging and therapy of prostate cancer. ACS Nano, 2010, 4, 3689-3696.
52. Lee, B.S.; Park, K.; Park, S.; Kim, G.C.; Kim, H.J.; Lee, S.; Kil, H.; Oh, S.J.; Chi, D.; Kim, K.; Choi, K.; Kwon, I.C.; Kim, S.Y. Tumor targeting efficiency of bare nanoparticles does not mean the efficacy of loaded anticancer drugs: importance of radionuclide imaging for optimization of highly selective tumor targeting polymeric nanoparticles with or without drug. J. Control. Release, 2010, 147, 253-260.
53. Ling, Y.; Wei, K.; Luo, Y.; Gao, X.; Zhong, S. Dual docetaxel/ superparamagnetic iron oxide loaded nanoparticles for both targeting magnetic resonance imaging and cancer therapy. Biomaterials, 2011, 32, 7139-7150.
54. Park, S.; Kim, S.H.; Kim, W.J.; Yoo, H.S. Pluronic@Fe3O4 nanoparticles with robust incorporation of doxorubicin by thermoresponsiveness. Int. J. Pharm., 2012, 424, 107-114.
55. Rapoport, N.; Gao, Z.; Kennedy, A. Multifunctional nanoparticles for combining ultrasonic tumor imaging and targeted chemotherapy. J. Natl. Cancer Inst., 2007, 99, 1095-1106.
56. Wang, C.; Tao, H.; Cheng, L.; Liu, Z. Near-infrared light induced in vivo photodynamic therapy of cancer based on upconversion nanoparticles. Biomaterials, 2011, 32, 6145-6154.
57. Godin, B.; Driessen, W.H.; Proneth, B.; Lee, S.Y.; Srinivasan, S.; Rumbaut, R.; Arap, W.; Pasqualini, R.; Ferrari, M.; Decuzzi, P. An integrated approach for the rational design of nanovectors for biomedical imaging and therapy. Adv. Genet., 2010, 69, 31-64.
58. He, C.; Hu, Y.; Yin, L.; Tang, C.; Yin, C. Effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles. Biomaterials, 2010, 31, 3657-3666.
59. Park, K.; Kim, J.H.; Nam, Y.S.; Lee, S.; Nam, H.Y.; Kim, K.; Park, J.H.; Kim, I.S.; Choi, K.; Kim, S.Y.; Kwon, I.C. Effect of polymer molecular weight on the tumor targeting characteristics of selfassembled glycol chitosan nanoparticles. J. Control. Release, 2007, 122, 305-314.
60. Sheng, Y.; Liu, C.; Yuan, Y.; Tao, X.; Yang, F.; Shan, X., Zhou, H.; Xu, F. Long-circulating polymeric nanoparticles bearing a combinatorial coating of PEG and water-soluble chitosan. Biomaterials, 2009, 30, 2340-2348.
61. Wang, M.; Thanou, M. Targeting nanoparticles to cancer. Pharmacol. Res., 2010, 62, 90-99.
62. Maeda, H.; Wu, J.; Sawa, T.; Matsumura, Y.; Hori, K. Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review. J. Control Release, 2000, 65, 271-284.
63. Mouritsen, O.G.; Jørgensen, K. A new look at lipid-membrane structure in relation to drug research. Pharm Res., 1998, 15, 1507-1519.
64. Inoh, Y., Kitamoto, D., Hirashima, N., Nakanishi, M. Biosurfactant MEL-A dramatically increases gene transfection via membrane fusion. J. Control. Release, 2004, 94, 423-431.
65. Dos Santos, N.; Waterhouse, D.; Masin, D.; Tardi, P.G.; Karlsson, G.; Edwards, K.; Bally, M.B.; Substantial increases in idarubicin plasma concentration by liposome encapsulation mediates improved antitumor activity. J. Control. Release, 2005, 105, 89-105.
66. Wang, X.-X.; Li, Y.-B.; Yao, H.-J.; Ju, R.-J.; Zhang, Y.; Li, R.-J.; Yu, Y.; Zhang, L.; Lu, W,-L. The use of mitochondrial targeting resveratrol liposomes modified with a dequalinium polyethylene glycol distearoylphosphatidyl ethanolamine conjugate to induce apoptosis in resistant lung cancer cells. Biomaterials, 2011, 32, 5673-5687.
67. Barenholz, Y. Liposome application: problems and prospects. Curr. Opin. Colloid Interface Sci., 2001, 65, 66-77.
68. Mouristen O.G.; Jorgenson, K. Dynamical order and disorder in lipid bilayers. Chem. Phys. Lipids, 1993, 73, 3-25.
69. Roger, J.A.; Anderson, K. E. The potential of liposomes in oral drug delivery system. Crit. Rev. Ther. Drug Carrier. Syst., 1998, 15, 421-480.
70. O'Brien, D.F.; Armitage, B.; Benedicto, A.; Bennett, D. E.; Lamparski, H. G.; Lee, Y. S.; Srisiri. W.; Sission, T. M. Polymerization of preformed self-organized assemblies. Acc. Chem. Res., 1998, 31, 861-868.
71. Okada, J.; Cohen, S.; Langer R. In vitro evaluation of polymerized liposomes as an oral drug delivery system. Pharm. Res., 1995, 12, 576-582.
72. Steneke, R. J. H.; Loebis, A.E.; Fernandes, C.M.; Crommelin, D.J.A, Hennink, W. Controlled release of liposomes from biodegradable dextran microspheres: A novel delivery concept. Pharm. Res., 2001, 7, 690-695.
73. Feng, S. S.; Ruan, G.; Li, Q. T. Fabrication and characterizations of a novel drug delivery devices liposomes-in-microsphere (LIM). Biomaterials, 2004, 25, 5181-5189.
74. Machluf. M.; Arte. R.; Regev, O.; Cohen, S. Enhancing the immunogenicity of liposomal hepatitis B surface antigen (HBsAg) by controlling its delivery from polymeric microspheres. J. Pharm. Sci., 2000, 89, 1550-1557.
75. Yuk, S.H.; Oh, K.S.; Koo, H. Jeon, H.; Kim, K.; Kwon, I.C. Multicore vesicle nanoparticles based on vesicle fusion for delivery of chemotherapic drugs. Biomaterials, 2011, 32, 7924-7931.
76. Liu, J.; Jiang, X.; Ashley, C.; Brinker, C.J. Electrostatically mediated liposome fusion and lipid exchange with a nanoparticlesupported bilayer for control of surface charge, drug containment, and delivery. J. Am. Chem. Soc., 2009, 131, 7567-7569.
77. Lei, G.; MacDonald, R.C. Lipid bilayer vesicle fusion: intermediates captured by high-speed microfluorescence spectroscopy. Biophys. J., 2003, 85, 1585-1599.
78. Wang, B.; Zhang, L.; Bae. S.C.; Granick, S. Nanoparticle-induced surface reconstruction of phospholipid membranes. Proc. Natl. Acad. Sci. USA, 2008,105, 18171-18175.
79. Zhang. L.; Hong. L.; Yu, Y.; Bae, S.C.; Granick, S. Nanoparticleassisted surface immobilization of phospholipid liposomes. J. Am. Chem. Soc., 2006, 128, 9026-9027.
80. Liu, J.; Stace-Naughton, A.; Jiang, X.; Brinker, C.J. Porous nanoparticle supported lipid bilayers (protocells) as delivery vehicles. J. Am. Chem. Soc., 2009, 131, 1354-1355.
81. Smith, K.A.; Jasnow, D.; Balazs, A.C. Designing synthetic vesicles that engulf nanoscopic particles. J. Chem. Phys., 2007, 127, 084703-1-10.
82. Carr, R.; Weinstock, I.A.; Sivaprasadarao, A.; Müller, A.; Aksimentiev, A. Synthetic ion channels via self-assembly: a route for embedding porous polyoxometalate nanocapsules in lipid bilayer membranes. Nano Lett., 2008, 8, 3916-3921.
83. Pornpattananangkul, D.; Olson, S.; Aryal, S.; Sartor, M.; Huang, C.; Vecchio, K.; Zhang, L. Stimuli-responsive liposome fusion mediated by gold nanoparticles. ACS Nano, 2010, 4, 1935-1942.
84. Crowe, J.H.; Carpenter, J.F.; Crowe. L.M. The role of vitrification in anhydrobiosis. Ann. Rev. Physiol., 1998, 60, 73103.
85. Kaushik, J.K.; Bhat, R. Why is trehalose an exceptional protein stabilizer? J. Biol. Chem., 2003, 278, 26458-26465.
86. Yang, L; Alexandridis, P. Physicochemical aspects of drug delivery and release from polymer based colloids. Curr. Opin. Colloid Interface Sci., 2000, 5, 132-143.
87. Firestone, M.A.; Wolf, A.C.; Seifert, S. Small-angle X-ray scattering study of the interaction of poly(ethylene oxide)-bpoly (propylene oxide)-b-poly(ethylene oxide) triblock copolymer with lipid bilayers. Biomacromolecules, 2003, 4, 15393-15497.
88. Oh, K.S.; Lee, H.; Kim, J.Y.; Koo, E.J.; Lee, E.H.; Park, J.H.; Kim, S.Y.; Kim, K.; Kwon, I.C.; Yuk, S.H. The multilayer nanoparticles formed by layer by layer approach for cancer-targeting therapy, J. Control. Release, 2013, 165, 9-15.
89. Lu, R.M.; Chang, Y.L.; Chen, M.S.; Wu, H.C. Single chain anti-c-Met antibody conjugated nanoparticles for in vivo tumor-targeted imaging and drug delivery. Biomaterials, 2011, 32, 3265-3274.
90. Peer, D.; Karp, J.M.; Hong, S.; Farokhzad, O.C.; Margalit, R.; Langer, R. Nanocarriers as an emerging platform for cancer therapy. Nat. Nanotechnol., 2007, 2, 751-760.
91. Manning, M.C.; Patel, K.; Borchardt, R.T. Stability of protein pharmaceuticals. Pharm. Res., 1989, 6, 903-918.
92. Prokop, A.; Holland, C.A.; Kozlov, E.; Moore, B., Tanner, R.D. Water-based nanoparticulate polymeric system for protein delivery. Biotechnol. Bioeng., 2001, 75, 228-232.
93. Tabata, Y.; Nagano, A.; Ikada, Y. Biodegradation of hydrogel carrier incorporating fibroblast growth factor. Tissue Eng., 1999, 5, 127-138.
94. Fattal, E.; Vauthier, C.; Aynie, I.; Nakada, Y.; Lambert, G.; Malvy, C.; Convreur, P. Biodegradable polyalkylcyanoacrylate nanoparticles for the delivery of oligonucleotides. J. Control. Release, 1998, 53, 137-143.
95. Hans, M.L.; Maxwell, C.; Ehrlichman, R.S.; Metzger, K.; Liang, Y.; Siegel, S.J.; Lowman, A.M. Evaluation of in vitro release and in vivo efficacy of mPEG-PLA-haloperidol conjugate micelle-like structures. J. Biomed Mater. Res. B Appl. Biomater., 2007, 83, 422-430.
96. Lee, K.Y.; Yuk, S.H. Polymeric protein delivery systems. Prog. Polym. Sci., 2007, 32, 669-697.
97. Redhead, H.M.; Davis, S.S.; Illum, L. Drug delivery in poly(lactide-co-glycolide) nanoparticles surface modified with poloxamer 407 and poloxamine 908: in vitro characterisation and in vivo evaluation. J. Control. Release, 2001, 70, 353-363.
98. Dai, C.; Wang, B.; Zhao, H. Microencapsulation peptide and protein drugs delivery system. Colloid. Surface. B., 2005, 41, 117-120.
99. Sinha, V.R.; Trehan, A. Biodegradable microspheres for protein delivery. J. Control. Release, 2003, 90, 261-280.
100. Anderson, P.M.; Hanson, D.C.; Hasz, D.E.; Halet, M.R.; Blazar, B.R.; Ochoa, A.C. Cytokines in liposomes: preliminary studies with IL-1, IL-2, IL-6, GM-CSF and interferon-gamma. Cytokine, 1994, 6, 92-101.
101. Ye, Q.; Asherman, J.; Stevenson, M.; Brownson, E.; Katre, N.V. DepoFoam technology: a vehicle for controlled delivery of protein and peptide drugs. J. Control. Release, 2000, 64, 155-166.
102. Mayer, L. D.; Hope, M. J.; Cullis, P. R. Vesicles of variable sizes produced by a rapid extrusion procedure. Biochim. Biophys. Acta, 1986, 858, 161-168.
103. Fidler, I. J.; Raz, A.; Folger, W. E.; Kirsh, R.; Bugelski, P.; Poste, G. Design of liposomes to improve delivery of macrophageaugmenting agents to alveolar macrophages. Cancer Res., 1980, 40, 4460-4466.
104. Poste, G.; Bucana, C.; Raz, A.; Bugelski, P.; Kirsh, R.; Fidler, I. J. Analysis of the fate of systemically administered liposomes and implications for their use in drug delivery. Cancer Res., 1982, 42, 1412-1422.
105. Fonseca, M.J., Alsina, M.A.; Reig, F. Coating liposomes with collagen (Mr 50000) increases uptake into liver. Biochim. Biophys. Acta -Biomembranes, 1996, 1279, 259-265.
106. Anderson, P.M.; Hanson, D.C.; Hasz, D. E.; Halet, M. R.; Blazar, B.R.; Ochoa, A.C. Cytokines in liposomes; preliminary studies with IL-1, IL-2, IL-6, GM-CSF and Interferon - γ. Cytokine, 1994, 6, 92-101.
107. Meyer, J.; Whitcomb, L.; Collins, D. Efficient encapsulation of proteins within liposomes for slow release in vivo. Biochem. Biophys. Res. Commun., 1994,199, 433-438.
108. Coeshott, C. M.; Smithson, S. L.; Verderber, E.; Samaniego, A.; Blonder, J. M.; Rosenthal, G. J.; Westerink, M.A.J. Pluronic® F127-based systemic vaccine delivery systems. Vaccine, 2004, 22, 2396-2405.
109. Oh, K.S.; Lee, K.Y.; Han, S.K.; Cho, S.H.; Kim, D.; Yuk, S.H. Formation of core/shell nanoparticles with a lipid core and their application as a drug delivery system. Biomacromolecules, 2005, 6, 1062-1067.
110. Oh, K.S.; Han, S.K.; Lee, H.S.; Koo. H.M.; Kim, R.S.; Lee, K.Y., Han, S.K., Cho, S.H.; Yuk, S.H. Core/shell nanoparticles with lecithin lipid cores for protein delivery. Biomacromolecules, 2006, 7, 2363-2367.
111. Lopez, J.J.; Laham, R.J.; Stamler, A.; Pearlman, J.D.; Bunting, S.; Kaplan, A.; Carrozza, J.P.; Sellke, F.W. Simons, M. VEGF administration in chronic myocardial ischemia in pigs. Cardiovasc. Res., 1998, 40, 272-281.
112. Oh, K.S.; Song, J.Y.; Yoon, S.J.; Park, Y.; Kim, D.; Yuk, S.H. Temperature-induced gel formation of core/shell nanoparticles for the regeneration of ischemic heart. J. Control. Release, 2010, 146, 207-211.
113. Jørgensen, J.O.; Møller, N.; Lauritzen, T.; Christiansen, J.S. Pulsatile versus continuous intravenous administration of growth hormone (GH) in GH-deficient patients: effects on circulating insulin-like growth factor-I and metabolic indices. J. Clin. Endocrinol. Metab., 1990, 70, 1616 -1623.
114. Laursen, T.; Jørgensen, J.O.; Christiansen, J.S. Pharmacokinetics and metabolic effects of growth hormone injected subcutaneously in growth hormone deficient patients: thigh versus abdomen. Clin. Endocrinol. (Oxf)., 1994, 40, 373-378.
115. Laursen, T.; Jørgensen, J.O.; Jakobsen, G.; Hansen, B.L.; Christiansen, J.S. Continuous infusion versus daily injections of growth hormone (GH) for 4 weeks in GH-deficient patients. J. Clin. Endocrinol. Metab., 1995, 80, 2410-2418.
116. Jostel, A.; Mukherjee, A.; Alenfall, J.; Smethurst, L.; Shalet, S.M. A new sustained-release preparation of human growth hormone and its pharmacokinetic, pharmacodynamic and safety profile. Clin. Endocrinol., 2005, 62, 623-627 .
117. Vlugt-Wensink K.D.; de Vrueh, R.; Gresnigt, M.G.; Hoogerbrugge, C.M.; van Buul-Offers, S.C.; de Leede L.G.; Sterkman, L.G.; Crommelin, D.J.; Hennink, W.E.; Verrijk, R. Pharm. Res., 2007, 24, 2239-2248.
118. Whitaker, M.J.; Hao, J.; Davies, O.R.; Serhatkulu, G.; Stolnik-Trenkic, S.; Howdle, S.M.; Shakesheff, K.M. The production of protein-loaded microparticles by supercritical fluid enhanced mixing and spraying. J. Control. Release, 2005, 101, 85-92.
119. Jordan, F.; Naylor, A.; Kelly, C.A.; Howdle, S.M.; Lewis, A.; Illum, L. Sustained release hGH microsphere formulation produced by a novel supercritical fluid technology: in vivo studies. J. Control. Release, 2010, 141, 153-160.
120. Yuk, S. H.; Oh, K. S.; Kim, S. K.; Lee, J. H.; Cho, S. H.; Kim, K.; Jeon, H.; Kwon, I.C. Multi-Core Vesicle Nanoparticles for Controlled Delivery of Protein Drug. Macromol. Res., 2012, 20, 309-312.
121. Tiwari, A; Mishra, A.K.; Kobayashi, H.; Turner, A.P.F. (Eds), Intelligent Nanomaterials, Scrivener Publishing; Bevely, 2012.
122. Lee, H.; Kim, J. Y.; Lee, E.H.; Park, Y.I.; Oh, K.S. Kim, K.; Kwon, I.C. Yuk, S. H. in: Tiwari, A.; Tiwari, A. (Eds.), Nanomaterials in Drug Delivery, Imaging and Tissue Engineering, Scrivener Publishing; Beverly, 2013. Ch. 9.
123. Ge, Y.; Tiwari, A.; Li, S. Nanomedicine - bridging the gap between nanotechnology and medicine. Adv. Mat. Lett., 2011, 2, 1-2.