The use of mitochondrial targeting resveratrol liposomes modified with a dequalinium polyethylene glycol-distearoylphosphatidyl ethanolamine conjugate to induce apoptosis in resistant lung cancer cells

Biomaterials

Volumn 32, Issue 24, 2011, Pages 5673-5687

  Wang, Xiao Xing ^a   Li, Yang Bing ^a   Yao, Hong Juan ^a   Ju, Rui Jun ^a   Zhang, Yan ^a   Li, Ruo Jing ^a   Yu, Yang ^a   Zhang, Liang ^a   Lu, Wan Liang ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

DQA PEG2000 DSPE conjugate; Intrinsic multidrug resistance; Lung cancer; Mitochondria signaling pathway; Mitochondrial targeting resveratrol liposomes

Indexed keywords

A549 CELLS; ANTI-TUMOR EFFICACY; APOPTOSIS; CANCER CELLS; CASPASES; CELLULAR UPTAKE; CYTOCHROME C; DQA-PEG2000-DSPE CONJUGATE; ETHANOLAMINES; FLUORESCENT PROBES; HUMAN LUNG; INDUCED APOPTOSIS; LUNG CANCER; LUNG CANCER CELLS; MEMBRANE POTENTIALS; MITOCHONDRIAL TARGETING RESVERATROL LIPOSOMES; MULTIDRUG RESISTANCE; NUDE MICE; RESVERATROL; SIGNALING PATHWAYS; TUMOR SPHEROID; VINORELBINE;

BIOLOGICAL ORGANS; CELL DEATH; CHEMOTHERAPY; DISEASES; DRUG PRODUCTS; ENZYME INHIBITION; GLYCOLS; LIPOSOMES; PHOSPHOLIPIDS; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; POLYETHYLENES; SIGNALING; SYNTHESIS (CHEMICAL); THERMOPLASTICS; TUMORS;

MITOCHONDRIA;

CASPASE 3; CASPASE 9; CISPLATIN; COUMARIN; CYTOCHROME C; DEQUALINIUM; DEQUALINIUM POLYETHYLENE GLYCOL DISTEAROYLPHOSPHATIDYLETHANOLAMINE CONJUGATE; DRUG CARRIER; FLUORESCENT DYE; MACROGOL; NAVELBINE; PHOSPHATIDYLETHANOLAMINE; RESVERATROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CANCER RESISTANCE; CHEMICAL MODIFICATION; CONCENTRATION RESPONSE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFICACY; ENZYME ACTIVITY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; LIPOSOMAL DELIVERY; LUNG ADENOCARCINOMA; LUNG CANCER; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL TARGETING; MITOCHONDRIAL TARGETING SIGNAL; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SYNTHESIS; TARGET CELL DESTRUCTION; TUMOR XENOGRAFT; ZETA POTENTIAL;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; CYTOCHROMES C; DEQUALINIUM; FEMALE; HUMANS; LIPOSOMES; LUNG NEOPLASMS; MICE; MICE, INBRED BALB C; MICE, NUDE; MITOCHONDRIA; PHOSPHATIDYLETHANOLAMINES; POLYETHYLENE GLYCOLS; STILBENES;

MUS MUSCULUS;

EID: 79957908426     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2011.04.029     Document Type: Article

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