Evaluation of in vitro release and in vivo efficacy of mPEG-PLA-haloperidol conjugate micelle-like structures

Journal of Biomedical Materials Research - Part B Applied Biomaterials

Volumn 83, Issue 2, 2007, Pages 422-430

  Hans, Meredith L ^a   Maxwell, Christina ^b   Ehrlichman, Richard S ^b   Metzger, Kayla ^b   Liang, Yuling ^b   Siegel, Steven J ^b   Lowman, Anthony M ^a  

^a Drexel University   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Drug delivery release; Nanotechnology; Polymer; Stability

Indexed keywords

HALOPERIDOL INJECTION; HALOPERIDOLS; HYPERLOCOMOTION; KETAMINE;

AMINES; DRUG DELIVERY; MICELLES; NANOTECHNOLOGY; POLYETHYLENE GLYCOLS; STABILITY CRITERIA;

DRUG PRODUCTS;

HALOPERIDOL; KETAMINE; MACROGOL; METHOXYPOLY(ETHYLENE GLYCOL) BLOCK POLY(LACTIC ACID); UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AQUEOUS SOLUTION; ARTICLE; CONJUGATION; CONTROLLED STUDY; COVALENT BOND; CRITICAL MICELLE CONCENTRATION; DIALYSIS MEMBRANE; DRUG ACTIVITY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG RELEASE; DRUG STABILITY; DRUG STRUCTURE; EVALUATION; HYDROLYSIS; IN VITRO STUDY; IN VIVO STUDY; LOCOMOTION; MALE; MICELLE; MOLECULAR WEIGHT; MOUSE; NANOTECHNOLOGY; NONHUMAN; SEDATION; TRANSMISSION ELECTRON MICROSCOPY;

ANIMALS; ANTI-DYSKINESIA AGENTS; DELAYED-ACTION PREPARATIONS; DRUG DELIVERY SYSTEMS; DYSKINESIA, DRUG-INDUCED; DYSKINESIAS; HALOPERIDOL; KETAMINE; MALE; MICE; MICE, INBRED C57BL; MICELLES; POLYESTERS; POLYETHYLENE GLYCOLS;

EID: 35548937895     PISSN: 15524973     EISSN: 15524981     Source Type: Journal    
DOI: 10.1002/jbm.b.30812     Document Type: Article

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