HIV: A new role for Nef in the spread of HIV

Current Biology

Volumn 9, Issue 12, 1999, Pages

  Harris, Mark ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0033578024     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(99)80282-6     Document Type: Note

References (12)

1. Kestler HW, Ringler DJ, Mori K, Panicali DL, Sehgal PK, Daniel MD, Desrosiers RC: Importance of the nef gene for maintenance of high virus loads and for development of AIDS. Cell 1991, 65:651-662.
2. Hanna Z, Kay DG, Rebai N, Guimond A, Jothy S, Jolicoeur P: Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice. Cell 1998, 95:163-175.
3. Ross TM, Oran AE, Cullen BR: Inhibition of HIV-1 progeny virion release by cell-surface CD4 is relieved by expression of the viral Nef protein. Curr Biol 1999, 9:613-621.
4. Lama J, Mangasarian A, Trono D: Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef-and Vpu-inhibitable manner. Curr Biol 1999, 9:622-631.
5. Harris M: From negative factor to a critical role in virus pathogenesis - the changing fortunes of Nef. J Gen Virol 1996, 77:2379-2392.
6. Harris MPG, Neil JC: Myristoylation-dependent binding of HIV-1 Nef to CD4. J Mol Biol 1994, 241:136-142.
7. LeGall S, Erdtmann L, Benichou S, Berlioz-Torrent C, Liu LX, Benarous R, Heard JM, Schwartz O: Nef interacts with the Mu subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I molecules. Immunity 1998, 8:483-495.
8. Lu XB, Yu HF, Liu SH, Brodsky FM, Peterlin BM: Interactions between HIV1 Nef and vacuolar ATPase facilitate the internalization of CD4. Immunity 1998, 8:647-656.
9. lck complex in the endoplasmic reticulum. J Virol 1992, 66:2296-2301.
10. Schubert U, Anton LC, Bacik I, Cox JH, Bour S, Bennink JR, Orlowski M, Strebel K, Yewdell JW: CD4 glycoprotein degradation induced by human immunodeficiency virus type 1 Vpu protein requires the function of proteasomes and the ubiquitin-conjugating pathway. J Virol 1998, 72:2280-2288.
11. Benkirane M, Schmid-Antomarchi H, Littman DR, Hirn M, Rossi B, Devaux C: The cytoplasmic tail of CD4 is required for inhibition of human immunodeficiency virus type 1 replication by antibodies that bind to the immunoglobulin CDR3-like region in domain 1 of CD4. J Virol 1995, 69:6904-6910.
12. Center DM, Kornfeld H, Cruikshank WW: Interleukin 16 and its function as a CD4 ligand. Immunol Today 1996, 17:476-481.