C-Abl-dependent molecular circuitry involving Smad5 and phosphatidylinositol 3-kinase regulates bone morphogenetic protein-2-induced osteogenesis

Journal of Biological Chemistry

Volumn 288, Issue 34, 2013, Pages 24503-24517

  Ghosh Choudhury, Nandini ^a,c   Mandal, Chandi C ^c   Das, Falguni ^d   Ganapathy, Suthakar ^c   Ahuja, Seema ^a,d   Choudhury, Goutam Ghosh ^a,b,d  

^a Veterans Affairs Research   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c University of Texas Health Science Center   (United States)

^d UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AKT PHOSPHORYLATION; ALKALINE PHOSPHATASE; CHRONIC MYELOID LEUKEMIAS; DOMINANT-NEGATIVE MUTANTS; OSTEOBLAST DIFFERENTIATION; OSTEOCLAST DIFFERENTIATION; PHARMACOLOGICAL INHIBITORS; PHOSPHATIDYLINOSITOL 3-KINASE;

ACTIVATION ANALYSIS; AMINO ACIDS; BONE; PHOSPHATASES; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

OSTEOBLASTS;

ABELSON KINASE; ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN RECEPTOR 1A; COLONY STIMULATING FACTOR 1; MUTANT PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN TYROSINE KINASE INHIBITOR; SMAD5 PROTEIN; TRANSCRIPTION FACTOR OSTERIX;

ANIMAL CELL; ARTICLE; AUTOREGULATION; BONE DEVELOPMENT; BONE REMODELING; CELL DIFFERENTIATION; CELL MATURATION; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME REPRESSION; MOUSE; MULTINUCLEAR CELL; NONHUMAN; OSTEOBLAST; OSTEOCLAST; OSTEOCLASTOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

BONE MORPHOGENETIC PROTEIN (BMP); C-ABL; COLONY-STIMULATING FACTOR-1 (CSF-1); OSTEOBLASTS; OSTEOCLAST; PI 3-KINASE; SMAD TRANSCRIPTION FACTOR;

ALKALINE PHOSPHATASE; ANIMALS; BONE MORPHOGENETIC PROTEIN 2; CELL LINE; GENE EXPRESSION REGULATION; MACROPHAGE COLONY-STIMULATING FACTOR; MICE; OSTEOBLASTS; OSTEOGENESIS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-ABL; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; SKULL; SMAD5 PROTEIN; TRANSCRIPTION FACTORS;

EID: 84883163204     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.455733     Document Type: Article

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