Bone development: Overview of bone cells and signaling

Current Osteoporosis Reports

Volumn 9, Issue 4, 2011, Pages 264-273

  Teti, Anna ^a  

^a UNIVERSITY OF L'AQUILA   (Italy)

Author keywords

Bone development; Bone turnover; Cell signaling; Hormonal regulation; Osteoblast; Osteoclast; Osteocyte

Indexed keywords

DENTIN MATRIX PROTEIN 1; ESTROGEN; FIBROBLAST GROWTH FACTOR 23; GROWTH HORMONE; HYPOPHYSIS HORMONE; OSTEOCALCIN; SOMATOMEDIN C; TESTOSTERONE; THYROID HORMONE;

ACTIVATION PHASE; BONE CELL; BONE DEVELOPMENT; BONE GROWTH; BONE METABOLISM; BONE MODELING; BONE REMODELING; ENCHONDRAL OSSIFICATION; ENDOCRINE GLAND; ENERGY METABOLISM; HOMEOSTASIS; HORMONAL REGULATION; HUMAN; INTRACELLULAR SIGNALING; INTRAMEMBRANOUS OSSIFICATION; KIDNEY FUNCTION; MALE FERTILITY; MOLECULAR INTERACTION; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOCLAST; OSTEOLYSIS; QUIESCENCE PHASE; RESORPTION PHASE; REVERSAL PHASE; REVIEW;

ANIMALS; BONE AND BONES; BONE DEVELOPMENT; BONE REMODELING; HOMEOSTASIS; HUMANS; MODELS, ANIMAL; OSTEOBLASTS; OSTEOCLASTS; SIGNAL TRANSDUCTION;

EID: 81255142013     PISSN: 15441873     EISSN: 15442241     Source Type: Journal    
DOI: 10.1007/s11914-011-0078-8     Document Type: Review

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72. VK Yadav JH Ryu N Suda KF Tanaka JA Gingrich G Schütz FH Glorieux CY Chiang JD Zajac KL Insogna JJ Mann R Hen P Ducy G Karsenty 2008 Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum Cell 135 825 837 19041748 10.1016/j.cell.2008.09.059 1:CAS:528:DC%2BD1cXhsV2jtr%2FP This article, along with that by Cui et al. [73••], is very controversial. This paper supports the concept that the effect of LPRP5 in bone is not direct but rather mediated by gut serotonin, with a mechanism independent of brain serotonin that does not cross the blood-brain barrier. The paper by Cui et al. [73••] confutes this hypothesis and supports the concept of a direct role of LRP5 in bone cells. Both studies make use of genetic approaches and complex animal models and also allude to human diseases. This is one of the most powerful controversies in the bone field in recent years and will require further studies, preferably conducted by independent groups
73. Y Cui PJ Niziolek BT Macdonald CR Zylstra N Alenina DR Robinson Z Zhong S Matthes CM Jacobsen RA Conlon R Brommage Q Liu F Mseeh DR Powell QM Yang B Zambrowicz H Gerrits JA Gossen X He M Bader BO Williams ML Warman AG Robling 2011 Lrp5 functions in bone to regulate bone mass Nat Med 17 684 691 21602802 10.1038/nm.2388 1:CAS:528:DC%2BC3MXmsVGmsLY%3D This article, along with that by Yadav et al, [72••], is very controversial. This paper confutes the hypothesis by Yadav et al. [72••] and supports the concept of a direct role of LRP5 in bone cells. Both studies make use of genetic approaches and complex animal models and also allude to human diseases
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