-
1
-
-
36749022214
-
The DNA damage response: Ten years after
-
Harper, J. W., and Elledge, S. J. (2007) The DNA damage response: ten years after. Mol. Cell 28, 739-745
-
(2007)
Mol. Cell
, vol.28
, pp. 739-745
-
-
Harper, J.W.1
Elledge, S.J.2
-
2
-
-
70350504453
-
The DNA-damage response in human biology and disease
-
Jackson, S. P., and Bartek, J. (2009) The DNA-damage response in human biology and disease. Nature 461, 1071-1078
-
(2009)
Nature
, vol.461
, pp. 1071-1078
-
-
Jackson, S.P.1
Bartek, J.2
-
3
-
-
34249947699
-
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
-
Matsuoka, S., Ballif, B. A., Smogorzewska, A., McDonald, E. R., 3rd, Hurov, K. E., Luo, J., Bakalarski, C. E., Zhao, Z., Solimini, N., Lerenthal, Y., Shiloh, Y., Gygi, S. P., and Elledge, S. J. (2007) ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 316, 1160-1166
-
(2007)
Science
, vol.316
, pp. 1160-1166
-
-
Matsuoka, S.1
Ballif, B.A.2
Smogorzewska, A.3
McDonald III, E.R.4
Hurov, K.E.5
Luo, J.6
Bakalarski, C.E.7
Zhao, Z.8
Solimini, N.9
Lerenthal, Y.10
Shiloh, Y.11
Gygi, S.P.12
Elledge, S.J.13
-
4
-
-
0032489520
-
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
-
Rogakou, E. P., Pilch, D. R., Orr, A. H., Ivanova, V. S., and Bonner, W. M. (1998) DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J. Biol. Chem. 273, 5858-5868
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 5858-5868
-
-
Rogakou, E.P.1
Pilch, D.R.2
Orr, A.H.3
Ivanova, V.S.4
Bonner, W.M.5
-
5
-
-
36949026694
-
Activation and regulation of ATMkinase activity in response to DNA double-strand breaks
-
Lee, J. H., and Paull, T. T. (2007) Activation and regulation of ATMkinase activity in response to DNA double-strand breaks. Oncogene 26, 7741-7748
-
(2007)
Oncogene
, vol.26
, pp. 7741-7748
-
-
Lee, J.H.1
Paull, T.T.2
-
6
-
-
30744465308
-
MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNAdamage signals
-
Lou, Z., Minter-Dykhouse, K., Franco, S., Gostissa, M., Rivera, M. A., Celeste, A., Manis, J. P., van Deursen, J., Nussenzweig, A., Paull, T. T., Alt, F. W., and Chen, J. (2006) MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNAdamage signals. Mol. Cell 21, 187-200
-
(2006)
Mol. Cell
, vol.21
, pp. 187-200
-
-
Lou, Z.1
Minter-Dykhouse, K.2
Franco, S.3
Gostissa, M.4
Rivera, M.A.5
Celeste, A.6
Manis, J.P.7
Van Deursen, J.8
Nussenzweig, A.9
Paull, T.T.10
Alt, F.W.11
Chen, J.12
-
7
-
-
0037468192
-
MDC1 is a mediator of the mammalian DNA damage checkpoint
-
Stewart, G. S., Wang, B., Bignell, C. R., Taylor, A. M., and Elledge, S. J. (2003) MDC1 is a mediator of the mammalian DNA damage checkpoint. Nature 421, 961-966
-
(2003)
Nature
, vol.421
, pp. 961-966
-
-
Stewart, G.S.1
Wang, B.2
Bignell, C.R.3
Taylor, A.M.4
Elledge, S.J.5
-
8
-
-
29244434544
-
MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks
-
Stucki, M., Clapperton, J. A., Mohammad, D., Yaffe, M. B., Smerdon, S. J., and Jackson, S. P. (2005) MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. Cell 123, 1213-1226
-
(2005)
Cell
, vol.123
, pp. 1213-1226
-
-
Stucki, M.1
Clapperton, J.A.2
Mohammad, D.3
Yaffe, M.B.4
Smerdon, S.J.5
Jackson, S.P.6
-
9
-
-
46649116785
-
RNF8-dependent and RNF8-independent regulation of 53BP1 in response to DNA damage
-
Sakasai, R., and Tibbetts, R. (2008) RNF8-dependent and RNF8-independent regulation of 53BP1 in response to DNA damage. J. Biol. Chem. 283, 13549-13555
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 13549-13555
-
-
Sakasai, R.1
Tibbetts, R.2
-
10
-
-
36248966246
-
RNF8 ubiquitylates histones at DNA doublestrand breaks and promotes assembly of repair proteins
-
Mailand, N., Bekker-Jensen, S., Faustrup, H., Melander, F., Bartek, J., Lukas, C., and Lukas, J. (2007) RNF8 ubiquitylates histones at DNA doublestrand breaks and promotes assembly of repair proteins. Cell 131, 887-900
-
(2007)
Cell
, vol.131
, pp. 887-900
-
-
Mailand, N.1
Bekker-Jensen, S.2
Faustrup, H.3
Melander, F.4
Bartek, J.5
Lukas, C.6
Lukas, J.7
-
11
-
-
36749025467
-
Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage
-
Wang, B., and Elledge, S. J. (2007) Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage. Proc. Natl. Acad. Sci. U.S.A. 104, 20759-20763
-
(2007)
Proc. Natl. Acad. Sci. U.S.A.
, vol.104
, pp. 20759-20763
-
-
Wang, B.1
Elledge, S.J.2
-
12
-
-
59049103900
-
The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage
-
Stewart, G. S., Panier, S., Townsend, K., Al-Hakim, A. K., Kolas, N. K., Miller, E. S., Nakada, S., Ylanko, J., Olivarius, S., Mendez, M., Oldreive, C., Wildenhain, J., Tagliaferro, A., Pelletier, L., Taubenheim, N., Durandy, A., Byrd, P. J., Stankovic, T., Taylor, A. M., and Durocher, D. (2009) The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage. Cell 136, 420-434
-
(2009)
Cell
, vol.136
, pp. 420-434
-
-
Stewart, G.S.1
Panier, S.2
Townsend, K.3
Al-Hakim, A.K.4
Kolas, N.K.5
Miller, E.S.6
Nakada, S.7
Ylanko, J.8
Olivarius, S.9
Mendez, M.10
Oldreive, C.11
Wildenhain, J.12
Tagliaferro, A.13
Pelletier, L.14
Taubenheim, N.15
Durandy, A.16
Byrd, P.J.17
Stankovic, T.18
Taylor, A.M.19
Durocher, D.20
more..
-
13
-
-
59049091728
-
RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins
-
Doil, C., Mailand, N., Bekker-Jensen, S., Menard, P., Larsen, D. H., Pepperkok, R., Ellenberg, J., Panier, S., Durocher, D., Bartek, J., Lukas, J., and Lukas, C. (2009) RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins. Cell 136, 435-446
-
(2009)
Cell
, vol.136
, pp. 435-446
-
-
Doil, C.1
Mailand, N.2
Bekker-Jensen, S.3
Menard, P.4
Larsen, D.H.5
Pepperkok, R.6
Ellenberg, J.7
Panier, S.8
Durocher, D.9
Bartek, J.10
Lukas, J.11
Lukas, C.12
-
14
-
-
36749084931
-
Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase
-
Kolas, N. K., Chapman, J. R., Nakada, S., Ylanko, J., Chahwan, R., Sweeney, F. D., Panier, S., Mendez, M., Wildenhain, J., Thomson, T. M., Pelletier, L., Jackson, S. P., and Durocher, D. (2007) Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase. Science 318, 1637-1640
-
(2007)
Science
, vol.318
, pp. 1637-1640
-
-
Kolas, N.K.1
Chapman, J.R.2
Nakada, S.3
Ylanko, J.4
Chahwan, R.5
Sweeney, F.D.6
Panier, S.7
Mendez, M.8
Wildenhain, J.9
Thomson, T.M.10
Pelletier, L.11
Jackson, S.P.12
Durocher, D.13
-
15
-
-
84865364870
-
Playing the end game: DNA double-strand break repair pathway choice
-
Chapman, J. R., Taylor, M. R., and Boulton, S. J. (2012) Playing the end game: DNA double-strand break repair pathway choice. Mol. Cell 47, 497-510
-
(2012)
Mol. Cell
, vol.47
, pp. 497-510
-
-
Chapman, J.R.1
Taylor, M.R.2
Boulton, S.J.3
-
16
-
-
84860806404
-
Structural basis for DNA damage-dependent poly(ADP-ribosyl)ation by human PARP-1
-
Langelier, M. F., Planck, J. L., Roy, S., and Pascal, J. M. (2012) Structural basis for DNA damage-dependent poly(ADP-ribosyl)ation by human PARP-1. Science 336, 728-732
-
(2012)
Science
, vol.336
, pp. 728-732
-
-
Langelier, M.F.1
Planck, J.L.2
Roy, S.3
Pascal, J.M.4
-
17
-
-
79952008439
-
The DNA-binding domain of human PARP-1 interacts with DNA single-strand breaks as a monomer through its second zinc finger
-
Eustermann, S., Videler, H., Yang, J. C., Cole, P. T., Gruszka, D., Veprintsev, D., and Neuhaus, D. (2011) The DNA-binding domain of human PARP-1 interacts with DNA single-strand breaks as a monomer through its second zinc finger. J. Mol. Biol. 407, 149-170
-
(2011)
J. Mol. Biol.
, vol.407
, pp. 149-170
-
-
Eustermann, S.1
Videler, H.2
Yang, J.C.3
Cole, P.T.4
Gruszka, D.5
Veprintsev, D.6
Neuhaus, D.7
-
18
-
-
3242891383
-
PARP-1, PARP-2 and ATM in the DNA damage response: Functional synergy in mouse development
-
Huber, A., Bai, P., de Murcia, J. M., and de Murcia, G. (2004) PARP-1, PARP-2 and ATM in the DNA damage response: functional synergy in mouse development. DNA Repair 3, 1103-1108
-
(2004)
DNA Repair
, vol.3
, pp. 1103-1108
-
-
Huber, A.1
Bai, P.2
De Murcia, J.M.3
De Murcia, G.4
-
19
-
-
33845657443
-
PARP-1 and Ku compete for repair of DNAdouble strand breaks by distinct NHEJ pathways
-
Wang, M., Wu, W., Wu, W., Rosidi, B., Zhang, L., Wang, H., and Iliakis, G. (2006) PARP-1 and Ku compete for repair of DNAdouble strand breaks by distinct NHEJ pathways. Nucleic Acids Res. 34, 6170-6182
-
(2006)
Nucleic Acids Res.
, vol.34
, pp. 6170-6182
-
-
Wang, M.1
Wu, W.2
Wu, W.3
Rosidi, B.4
Zhang, L.5
Wang, H.6
Iliakis, G.7
-
20
-
-
84861231399
-
The diverse roles and clinical relevance of PARPs in DNAdamage repair: Current state of the art
-
De Vos, M., Schreiber, V., and Dantzer, F. (2012) The diverse roles and clinical relevance of PARPs in DNAdamage repair: current state of the art. Biochem. Pharmacol. 84, 137-146
-
(2012)
Biochem. Pharmacol.
, vol.84
, pp. 137-146
-
-
De Vos, M.1
Schreiber, V.2
Dantzer, F.3
-
21
-
-
77956870690
-
Regulation of DNA-damage responses and cell cycle progression by the chromatin remodelling factor CHD4
-
Polo, S. E., Kaidi, A., Baskcomb, L., Galanty, Y., and Jackson, S. P. (2010) Regulation of DNA-damage responses and cell cycle progression by the chromatin remodelling factor CHD4. EMBO J. 29, 3130-3139
-
(2010)
EMBO J.
, vol.29
, pp. 3130-3139
-
-
Polo, S.E.1
Kaidi, A.2
Baskcomb, L.3
Galanty, Y.4
Jackson, S.P.5
-
22
-
-
78649349810
-
A chromatin localization screen reveals poly(ADP ribose)-regulated recruitment of the repressive Polycomb and Nu RD complexes to sites of DNA damage
-
Chou, D. M., Adamson, B., Dephoure, N. E., Tan, X., Nottke, A. C., Hurov, K. E., Gygi, S. P., Colaiácovo, M. P., and Elledge, S. J. (2010) A chromatin localization screen reveals poly(ADP ribose)-regulated recruitment of the repressive Polycomb and Nu RD complexes to sites of DNA damage. Proc. Natl. Acad. Sci. U.S.A. 107, 18475-18480
-
(2010)
Proc. Natl. Acad. Sci. U.S.A.
, vol.107
, pp. 18475-18480
-
-
Chou, D.M.1
Adamson, B.2
Dephoure, N.E.3
Tan, X.4
Nottke, A.C.5
Hurov, K.E.6
Gygi, S.P.7
Colaiácovo, M.P.8
Elledge, S.J.9
-
23
-
-
77956387556
-
The NuRD chromatin-remodeling complex regulates signaling and repair of DNA damage
-
Smeenk, G., Wiegant, W. W., Vrolijk, H., Solari, A. P., Pastink, A., and van Attikum, H. (2010) The NuRD chromatin-remodeling complex regulates signaling and repair of DNA damage. J. Cell Biol. 190, 741-749
-
(2010)
J. Cell Biol.
, vol.190
, pp. 741-749
-
-
Smeenk, G.1
Wiegant, W.W.2
Vrolijk, H.3
Solari, A.P.4
Pastink, A.5
Van Attikum, H.6
-
24
-
-
79960844248
-
Cancer biology and NuRD: A multifac-eted chromatin remodelling complex
-
Lai, A. Y., and Wade, P. A. (2011) Cancer biology and NuRD: a multifac-eted chromatin remodelling complex. Nat. Rev. Cancer 11, 588-596
-
(2011)
Nat. Rev. Cancer
, vol.11
, pp. 588-596
-
-
Lai, A.Y.1
Wade, P.A.2
-
25
-
-
0029812470
-
HTAF(II)68, a novel RNA/ssDNA-binding protein with homology to the pro-oncoproteins TLS/FUS and EWS is associated with both TFIID and RNA polymerase II
-
Bertolotti, A., Lutz, Y., Heard, D. J., Chambon, P., and Tora, L. (1996) hTAF(II)68, a novel RNA/ssDNA-binding protein with homology to the pro-oncoproteins TLS/FUS and EWS is associated with both TFIID and RNA polymerase II. EMBO J. 15, 5022-5031
-
(1996)
EMBO J.
, vol.15
, pp. 5022-5031
-
-
Bertolotti, A.1
Lutz, Y.2
Heard, D.J.3
Chambon, P.4
Tora, L.5
-
26
-
-
0028968330
-
Cabeza, a Drosophila gene encoding a novel RNA-binding protein, shares homology with EWS and TLS, two genes involved in human sarcoma formation
-
Stolow, D. T., and Haynes, S. R. (1995) Cabeza, a Drosophila gene encoding a novel RNA-binding protein, shares homology with EWS and TLS, two genes involved in human sarcoma formation. Nucleic Acids Res. 23, 835-843
-
(1995)
Nucleic Acids Res.
, vol.23
, pp. 835-843
-
-
Stolow, D.T.1
Haynes, S.R.2
-
27
-
-
0027227651
-
Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma
-
Crozat, A., Aman, P., Mandahl, N., and Ron, D. (1993) Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma. Nature 363, 640-644
-
(1993)
Nature
, vol.363
, pp. 640-644
-
-
Crozat, A.1
Aman, P.2
Mandahl, N.3
Ron, D.4
-
28
-
-
0027276357
-
Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma
-
Rabbitts, T. H., Forster, A., Larson, R., and Nathan, P. (1993) Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma. Nat. Genet. 4, 175-180
-
(1993)
Nat. Genet.
, vol.4
, pp. 175-180
-
-
Rabbitts, T.H.1
Forster, A.2
Larson, R.3
Nathan, P.4
-
29
-
-
33745945163
-
TLS, EWS and TAF15: A model for transcriptional integration of gene expression
-
Law, W. J., Cann, K. L., and Hicks, G. G. (2006) TLS, EWS and TAF15: a model for transcriptional integration of gene expression. Brief Funct. Genomic Proteomic 5, 8-14
-
(2006)
Brief Funct. Genomic Proteomic
, vol.5
, pp. 8-14
-
-
Law, W.J.1
Cann, K.L.2
Hicks, G.G.3
-
30
-
-
80052802585
-
RNA-binding proteins with prion-like domains in ALS and FTLD-U
-
Gitler, A. D., and Shorter, J. (2011) RNA-binding proteins with prion-like domains in ALS and FTLD-U. Prion 5, 179-187
-
(2011)
Prion
, vol.5
, pp. 179-187
-
-
Gitler, A.D.1
Shorter, J.2
-
31
-
-
7244242399
-
Domain architectures and characterization of an RNA-binding protein, TLS
-
Iko, Y., Kodama, T. S., Kasai, N., Oyama, T., Morita, E. H., Muto, T., Okumura, M., Fujii, R., Takumi, T., Tate, S., and Morikawa, K. (2004) Domain architectures and characterization of an RNA-binding protein, TLS. J. Biol. Chem. 279, 44834-44840
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 44834-44840
-
-
Iko, Y.1
Kodama, T.S.2
Kasai, N.3
Oyama, T.4
Morita, E.H.5
Muto, T.6
Okumura, M.7
Fujii, R.8
Takumi, T.9
Tate, S.10
Morikawa, K.11
-
32
-
-
0027948152
-
TLS/FUS fusion domain of TLS/FUS-erg chimeric protein resulting from the t(16;21) chromosomal translocation in human myeloid leukemia functions as a transcriptional activation domain
-
Prasad, D. D., Ouchida, M., Lee, L., Rao, V. N., and Reddy, E. S. (1994) TLS/FUS fusion domain of TLS/FUS-erg chimeric protein resulting from the t(16;21) chromosomal translocation in human myeloid leukemia functions as a transcriptional activation domain. Oncogene 9, 3717-3729
-
(1994)
Oncogene
, vol.9
, pp. 3717-3729
-
-
Prasad, D.D.1
Ouchida, M.2
Lee, L.3
Rao, V.N.4
Reddy, E.S.5
-
33
-
-
0030746523
-
TLS (FUS) binds RNA in vivo and engages in nucleo-cytoplasmic shuttling
-
Zinszner, H., Sok, J., Immanuel, D., Yin, Y., and Ron, D. (1997) TLS (FUS) binds RNA in vivo and engages in nucleo-cytoplasmic shuttling. J. Cell Sci. 110, 1741-1750
-
(1997)
J. Cell Sci.
, vol.110
, pp. 1741-1750
-
-
Zinszner, H.1
Sok, J.2
Immanuel, D.3
Yin, Y.4
Ron, D.5
-
34
-
-
0033607753
-
Human 75-kDa DNA-pairing protein is identical to the prooncoprotein TLS/FUS and is able to promote D-loop formation
-
Baechtold, H., Kuroda, M., Sok, J., Ron, D., Lopez, B. S., and Akhmedov, A. T. (1999) Human 75-kDa DNA-pairing protein is identical to the prooncoprotein TLS/FUS and is able to promote D-loop formation. J. Biol. Chem. 274, 34337-34342
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 34337-34342
-
-
Baechtold, H.1
Kuroda, M.2
Sok, J.3
Ron, D.4
Lopez, B.S.5
Akhmedov, A.T.6
-
35
-
-
0032479980
-
TLS/FUS, a pro-oncogene involved in multiple chromosomal translocations, is a novel regulator of BCR/ABL-mediated leukemogenesis
-
Perrotti, D., Bonatti, S., Trotta, R., Martinez, R., Skorski, T., Salomoni, P., Grassilli, E., Lozzo, R. V., Cooper, D. R., and Calabretta, B. (1998) TLS/FUS, a pro-oncogene involved in multiple chromosomal translocations, is a novel regulator of BCR/ABL-mediated leukemogenesis. EMBO J. 17, 4442-4455
-
(1998)
EMBO J.
, vol.17
, pp. 4442-4455
-
-
Perrotti, D.1
Bonatti, S.2
Trotta, R.3
Martinez, R.4
Skorski, T.5
Salomoni, P.6
Grassilli, E.7
Lozzo, R.V.8
Cooper, D.R.9
Calabretta, B.10
-
36
-
-
77953890823
-
TDP-43 and FUS/TLS: Emerging roles in RNA processing and neurodegeneration
-
Lagier-Tourenne, C., Polymenidou, M., and Cleveland, D. W. (2010) TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration. Hum. Mol. Genet. 19, R46-64
-
(2010)
Hum. Mol. Genet.
, vol.19
-
-
Lagier-Tourenne, C.1
Polymenidou, M.2
Cleveland, D.W.3
-
37
-
-
84871590658
-
FUS binds the CTDof RNApolymerase II and regulates its phosphorylation at Ser-2
-
Schwartz, J. C., Ebmeier, C. C., Podell, E. R., Heimiller, J., Taatjes, D. J., and Cech, T. R. (2012) FUS binds the CTDof RNApolymerase II and regulates its phosphorylation at Ser-2. Genes Dev. 26, 2690-2695
-
(2012)
Genes Dev.
, vol.26
, pp. 2690-2695
-
-
Schwartz, J.C.1
Ebmeier, C.C.2
Podell, E.R.3
Heimiller, J.4
Taatjes, D.J.5
Cech, T.R.6
-
38
-
-
61349162349
-
Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6
-
Vance, C., Rogelj, B., Hortobágyi, T., De Vos, K. J., Nishimura, A. L., Sreedharan, J., Hu, X., Smith, B., Ruddy, D., Wright, P., Ganesalingam, J., Williams, K. L., Tripathi, V., Al-Saraj, S., Al-Chalabi, A., Leigh, P. N., Blair, I. P., Nicholson, G., de Belleroche, J., Gallo, J. M., Miller, C. C., and Shaw, C. E. (2009) Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6. Science 323, 1208-1211
-
(2009)
Science
, vol.323
, pp. 1208-1211
-
-
Vance, C.1
Rogelj, B.2
Hortobágyi, T.3
De Vos, K.J.4
Nishimura, A.L.5
Sreedharan, J.6
Hu, X.7
Smith, B.8
Ruddy, D.9
Wright, P.10
Ganesalingam, J.11
Williams, K.L.12
Tripathi, V.13
Al-Saraj, S.14
Al-Chalabi, A.15
Leigh, P.N.16
Blair, I.P.17
Nicholson, G.18
De Belleroche, J.19
Gallo, J.M.20
Miller, C.C.21
Shaw, C.E.22
more..
-
39
-
-
61349156118
-
Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis
-
Kwiatkowski, T. J., Jr., Bosco, D. A., Leclerc, A. L., Tamrazian, E., Vanderburg, C. R., Russ, C., Davis, A., Gilchrist, J., Kasarskis, E. J., Munsat, T., Valdmanis, P., Rouleau, G. A., Hosler, B. A., Cortelli, P., de Jong, P. J., Yoshinaga, Y., Haines, J. L., Pericak-Vance, M. A., Yan, J., Ticozzi, N., Siddique, T., McKenna-Yasek, D., Sapp, P. C., Horvitz, H. R., Landers, J. E., and Brown, R. H., Jr. (2009) Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis. Science 323, 1205-1208
-
(2009)
Science
, vol.323
, pp. 1205-1208
-
-
Kwiatkowski Jr., T.J.1
Bosco, D.A.2
Leclerc, A.L.3
Tamrazian, E.4
Vanderburg, C.R.5
Russ, C.6
Davis, A.7
Gilchrist, J.8
Kasarskis, E.J.9
Munsat, T.10
Valdmanis, P.11
Rouleau, G.A.12
Hosler, B.A.13
Cortelli, P.14
De Jong, P.J.15
Yoshinaga, Y.16
Haines, J.L.17
Pericak-Vance, M.A.18
Yan, J.19
Ticozzi, N.20
Siddique, T.21
McKenna-Yasek, D.22
Sapp, P.C.23
Horvitz, H.R.24
Landers, J.E.25
Brown Jr., R.H.26
more..
-
40
-
-
0034142209
-
-/- mice
-
-/- mice. EMBO J. 19, 453-462
-
(2000)
EMBO J.
, vol.19
, pp. 453-462
-
-
Kuroda, M.1
Sok, J.2
Webb, L.3
Baechtold, H.4
Urano, F.5
Yin, Y.6
Chung, P.7
De Rooij, D.G.8
Akhmedov, A.9
Ashley, T.10
Ron, D.11
-
41
-
-
0033968408
-
Fus deficiency in mice results in defective B-lymphocyte development and activation, high levels of chromosomal instability and perinatal death
-
Hicks, G. G., Singh, N., Nashabi, A., Mai, S., Bozek, G., Klewes, L., Arapovic, D., White, E. K., Koury, M. J., Oltz, E. M., Van Kaer, L., and Ruley, H. E. (2000) Fus deficiency in mice results in defective B-lymphocyte development and activation, high levels of chromosomal instability and perinatal death. Nat. Genet. 24, 175-179
-
(2000)
Nat. Genet.
, vol.24
, pp. 175-179
-
-
Hicks, G.G.1
Singh, N.2
Nashabi, A.3
Mai, S.4
Bozek, G.5
Klewes, L.6
Arapovic, D.7
White, E.K.8
Koury, M.J.9
Oltz, E.M.10
Van Kaer, L.11
Ruley, H.E.12
-
42
-
-
84865620494
-
Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: The molecular choreography
-
Thompson, L. H. (2012) Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: the molecular choreography. Mutat. Res. 751, 158-246
-
(2012)
Mutat. Res.
, vol.751
, pp. 158-246
-
-
Thompson, L.H.1
-
43
-
-
46649093597
-
Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription
-
Wang, X., Arai, S., Song, X., Reichart, D., Du, K., Pascual, G., Tempst, P., Rosenfeld, M. G., Glass, C. K., and Kurokawa, R. (2008) Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription. Nature 454, 126-130
-
(2008)
Nature
, vol.454
, pp. 126-130
-
-
Wang, X.1
Arai, S.2
Song, X.3
Reichart, D.4
Du, K.5
Pascual, G.6
Tempst, P.7
Rosenfeld, M.G.8
Glass, C.K.9
Kurokawa, R.10
-
44
-
-
54049138797
-
Identification and characterization of FUS/TLS as a new target of ATM
-
Gardiner, M., Toth, R., Vandermoere, F., Morrice, N. A., and Rouse, J. (2008) Identification and characterization of FUS/TLS as a new target of ATM. Biochem. J. 415, 297-307
-
(2008)
Biochem. J.
, vol.415
, pp. 297-307
-
-
Gardiner, M.1
Toth, R.2
Vandermoere, F.3
Morrice, N.A.4
Rouse, J.5
-
45
-
-
0033569684
-
XRCC3 promotes homology-directed repair of DNA damage in mammalian cells
-
Pierce, A. J., Johnson, R. D., Thompson, L. H., and Jasin, M. (1999) XRCC3 promotes homology-directed repair of DNA damage in mammalian cells. Genes Dev. 13, 2633-2638
-
(1999)
Genes Dev.
, vol.13
, pp. 2633-2638
-
-
Pierce, A.J.1
Johnson, R.D.2
Thompson, L.H.3
Jasin, M.4
-
46
-
-
46249131123
-
Alternative-NHEJ is a mechanistically distinct pathway of mammalian chromosome break repair
-
Bennardo, N., Cheng, A., Huang, N., and Stark, J. M. (2008) Alternative-NHEJ is a mechanistically distinct pathway of mammalian chromosome break repair. PLoS Genet. 4, e1000110
-
(2008)
PLoS Genet.
, vol.4
-
-
Bennardo, N.1
Cheng, A.2
Huang, N.3
Stark, J.M.4
-
47
-
-
67649219195
-
Computational analysis of the human HSPH/HSPA/DNAJ family and cloning of a human HSPH/HSPA/DNAJ expression library
-
Hageman, J., and Kampinga, H. H. (2009) Computational analysis of the human HSPH/HSPA/DNAJ family and cloning of a human HSPH/HSPA/DNAJ expression library. Cell Stress Chaperones 14, 1-21
-
(2009)
Cell Stress Chaperones
, vol.14
, pp. 1-21
-
-
Hageman, J.1
Kampinga, H.H.2
-
48
-
-
82955236089
-
RNA targets of wild-type and mutant FET family proteins
-
Hoell, J. I., Larsson, E., Runge, S., Nusbaum, J. D., Duggimpudi, S., Farazi, T. A., Hafner, M., Borkhardt, A., Sander, C., and Tuschl, T. (2011) RNA targets of wild-type and mutant FET family proteins. Nat. Struct. Mol. Biol. 18, 1428-1431
-
(2011)
Nat. Struct. Mol. Biol.
, vol.18
, pp. 1428-1431
-
-
Hoell, J.I.1
Larsson, E.2
Runge, S.3
Nusbaum, J.D.4
Duggimpudi, S.5
Farazi, T.A.6
Hafner, M.7
Borkhardt, A.8
Sander, C.9
Tuschl, T.10
-
49
-
-
0344375083
-
Lentivirus-delivered stable gene silencing by RNAi in primary cells
-
Stewart, S. A., Dykxhoorn, D. M., Palliser, D., Mizuno, H., Yu, E. Y., An, D. S., Sabatini, D. M., Chen, I. S., Hahn, W. C., Sharp, P. A., Weinberg, R. A., and Novina, C. D. (2003) Lentivirus-delivered stable gene silencing by RNAi in primary cells. RNA 9, 493-501
-
(2003)
RNA
, vol.9
, pp. 493-501
-
-
Stewart, S.A.1
Dykxhoorn, D.M.2
Palliser, D.3
Mizuno, H.4
Yu, E.Y.5
An, D.S.6
Sabatini, D.M.7
Chen, I.S.8
Hahn, W.C.9
Sharp, P.A.10
Weinberg, R.A.11
Novina, C.D.12
-
50
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
Sarbassov, D. D., Guertin, D. A., Ali, S. M., and Sabatini, D. M. (2005) Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307, 1098-1101
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
51
-
-
84857781943
-
A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response
-
Adamson, B., Smogorzewska, A., Sigoillot, F. D., King, R. W., and Elledge, S. J. (2012) A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response. Nat. Cell Biol. 14, 318-328
-
(2012)
Nat. Cell Biol.
, vol.14
, pp. 318-328
-
-
Adamson, B.1
Smogorzewska, A.2
Sigoillot, F.D.3
King, R.W.4
Elledge, S.J.5
-
52
-
-
84869024542
-
PARP activation regulates the RNA-binding protein NONOin the DNAdamage response to DNA double-strand breaks
-
Krietsch, J., Caron, M. C., Gagné, J. P., Ethier, C., Vignard, J., Vincent, M., Rouleau, M., Hendzel, M. J., Poirier, G. G., and Masson, J. Y. (2012) PARP activation regulates the RNA-binding protein NONOin the DNAdamage response to DNA double-strand breaks. Nucleic Acids Res. 40, 10287-10301
-
(2012)
Nucleic Acids Res.
, vol.40
, pp. 10287-10301
-
-
Krietsch, J.1
Caron, M.C.2
Gagné, J.P.3
Ethier, C.4
Vignard, J.5
Vincent, M.6
Rouleau, M.7
Hendzel, M.J.8
Poirier, G.G.9
Masson, J.Y.10
-
53
-
-
84860325854
-
Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response
-
Beli, P., Lukashchuk, N., Wagner, S. A., Weinert, B. T., Olsen, J. V., Baskcomb, L., Mann, M., Jackson, S. P., and Choudhary, C. (2012) Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response. Mol. Cell 46, 212-225
-
(2012)
Mol. Cell
, vol.46
, pp. 212-225
-
-
Beli, P.1
Lukashchuk, N.2
Wagner, S.A.3
Weinert, B.T.4
Olsen, J.V.5
Baskcomb, L.6
Mann, M.7
Jackson, S.P.8
Choudhary, C.9
-
54
-
-
84863415403
-
Regulation of DNA-end resection by hnRNPU-like proteins promotes DNA double-strand break signaling and repair
-
Polo, S. E., Blackford, A. N., Chapman, J. R., Baskcomb, L., Gravel, S., Rusch, A., Thomas, A., Blundred, R., Smith, P., Kzhyshkowska, J., Dobner, T., Taylor, A. M., Turnell, A. S., Stewart, G. S., Grand, R. J., and Jackson, S. P. (2012) Regulation of DNA-end resection by hnRNPU-like proteins promotes DNA double-strand break signaling and repair. Mol. Cell 45, 505-516
-
(2012)
Mol. Cell
, vol.45
, pp. 505-516
-
-
Polo, S.E.1
Blackford, A.N.2
Chapman, J.R.3
Baskcomb, L.4
Gravel, S.5
Rusch, A.6
Thomas, A.7
Blundred, R.8
Smith, P.9
Kzhyshkowska, J.10
Dobner, T.11
Taylor, A.M.12
Turnell, A.S.13
Stewart, G.S.14
Grand, R.J.15
Jackson, S.P.16
-
55
-
-
41949119043
-
TDP-43 A315T mutation in familial motor neuron disease
-
Gitcho, M. A., Baloh, R. H., Chakraverty, S., Mayo, K., Norton, J. B., Levitch, D., Hatanpaa, K. J., White, C. L., 3rd, Bigio, E. H., Caselli, R., Baker, M., Al-Lozi, M. T., Morris, J. C., Pestronk, A., Rademakers, R., Goate, A. M., and Cairns, N. J. (2008) TDP-43 A315T mutation in familial motor neuron disease. Ann. Neurol. 63, 535-538
-
(2008)
Ann. Neurol.
, vol.63
, pp. 535-538
-
-
Gitcho, M.A.1
Baloh, R.H.2
Chakraverty, S.3
Mayo, K.4
Norton, J.B.5
Levitch, D.6
Hatanpaa, K.J.7
White III, C.L.8
Bigio, E.H.9
Caselli, R.10
Baker, M.11
Al-Lozi, M.T.12
Morris, J.C.13
Pestronk, A.14
Rademakers, R.15
Goate, A.M.16
Cairns, N.J.17
-
56
-
-
41149180753
-
TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis
-
Sreedharan, J., Blair, I. P., Tripathi, V. B., Hu, X., Vance, C., Rogelj, B., Ackerley, S., Durnall, J. C., Williams, K. L., Buratti, E., Baralle, F., de Belleroche, J., Mitchell, J. D., Leigh, P. N., Al-Chalabi, A., Miller, C. C., Nicholson, G., and Shaw, C. E. (2008) TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis. Science 319, 1668-1672
-
(2008)
Science
, vol.319
, pp. 1668-1672
-
-
Sreedharan, J.1
Blair, I.P.2
Tripathi, V.B.3
Hu, X.4
Vance, C.5
Rogelj, B.6
Ackerley, S.7
Durnall, J.C.8
Williams, K.L.9
Buratti, E.10
Baralle, F.11
De Belleroche, J.12
Mitchell, J.D.13
Leigh, P.N.14
Al-Chalabi, A.15
Miller, C.C.16
Nicholson, G.17
Shaw, C.E.18
-
57
-
-
80052374038
-
FUS and TARDBP but not SOD1 interact in genetic models of amyotrophic lateral sclerosis
-
Kabashi, E., Bercier, V., Lissouba, A., Liao, M., Brustein, E., Rouleau, G. A., and Drapeau, P. (2011) FUS and TARDBP but not SOD1 interact in genetic models of amyotrophic lateral sclerosis. PLoS Genet. 7, e1002214
-
(2011)
PLoS Genet.
, vol.7
-
-
Kabashi, E.1
Bercier, V.2
Lissouba, A.3
Liao, M.4
Brustein, E.5
Rouleau, G.A.6
Drapeau, P.7
-
58
-
-
42949094584
-
TDP-43 mutation in familial amyotrophic lateral sclerosis
-
Yokoseki, A., Shiga, A., Tan, C. F., Tagawa, A., Kaneko, H., Koyama, A., Eguchi, H., Tsujino, A., Ikeuchi, T., Kakita, A., Okamoto, K., Nishizawa, M., Takahashi, H., and Onodera, O. (2008) TDP-43 mutation in familial amyotrophic lateral sclerosis. Ann. Neurol. 63, 538-542
-
(2008)
Ann. Neurol.
, vol.63
, pp. 538-542
-
-
Yokoseki, A.1
Shiga, A.2
Tan, C.F.3
Tagawa, A.4
Kaneko, H.5
Koyama, A.6
Eguchi, H.7
Tsujino, A.8
Ikeuchi, T.9
Kakita, A.10
Okamoto, K.11
Nishizawa, M.12
Takahashi, H.13
Onodera, O.14
-
59
-
-
41949100148
-
TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: A genetic and histopathological analysis
-
Van Deerlin, V. M., Leverenz, J. B., Bekris, L. M., Bird, T. D., Yuan, W., Elman, L. B., Clay, D., Wood, E. M., Chen-Plotkin, A. S., Martinez-Lage, M., Steinbart, E., McCluskey, L., Grossman, M., Neumann, M., Wu, I. L., Yang, W. S., Kalb, R., Galasko, D. R., Montine, T. J., Trojanowski, J. Q., Lee, V. M., Schellenberg, G. D., and Yu, C. E. (2008) TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: a genetic and histopathological analysis. Lancet Neurol. 7, 409-416
-
(2008)
Lancet Neurol.
, vol.7
, pp. 409-416
-
-
Van Deerlin, V.M.1
Leverenz, J.B.2
Bekris, L.M.3
Bird, T.D.4
Yuan, W.5
Elman, L.B.6
Clay, D.7
Wood, E.M.8
Chen-Plotkin, A.S.9
Martinez-Lage, M.10
Steinbart, E.11
McCluskey, L.12
Grossman, M.13
Neumann, M.14
Wu, I.L.15
Yang, W.S.16
Kalb, R.17
Galasko, D.R.18
Montine, T.J.19
Trojanowski, J.Q.20
Lee, V.M.21
Schellenberg, G.D.22
Yu, C.E.23
more..
-
60
-
-
51649124062
-
Two German kindreds with familial amyotrophic lateral sclerosis due to TARDBP mutations
-
Kühnlein, P., Sperfeld, A. D., Vanmassenhove, B., Van Deerlin, V., Lee, V. M., Trojanowski, J. Q., Kretzschmar, H. A., Ludolph, A. C., and Neumann, M. (2008) Two German kindreds with familial amyotrophic lateral sclerosis due to TARDBP mutations. Arch. Neurol. 65, 1185-1189
-
(2008)
Arch. Neurol.
, vol.65
, pp. 1185-1189
-
-
Kühnlein, P.1
Sperfeld, A.D.2
Vanmassenhove, B.3
Van Deerlin, V.4
Lee, V.M.5
Trojanowski, J.Q.6
Kretzschmar, H.A.7
Ludolph, A.C.8
Neumann, M.9
-
61
-
-
84863507711
-
Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis
-
Couthouis, J., Hart, M. P., Erion, R., King, O. D., Diaz, Z., Nakaya, T., Ibrahim, F., Kim, H. J., Mojsilovic-Petrovic, J., Panossian, S., Kim, C. E., Frackelton, E. C., Solski, J. A., Williams, K. L., Clay-Falcone, D., Elman, L., McCluskey, L., Greene, R., Hakonarson, H., Kalb, R. G., Lee, V. M., Trojanowski, J. Q., Nicholson, G. A., Blair, I. P., Bonini, N. M., Van Deerlin, V. M., Mourelatos, Z., Shorter, J., and Gitler, A. D. (2012) Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis. Hum. Mol. Genet. 21, 2899-2911
-
(2012)
Hum. Mol. Genet.
, vol.21
, pp. 2899-2911
-
-
Couthouis, J.1
Hart, M.P.2
Erion, R.3
King, O.D.4
Diaz, Z.5
Nakaya, T.6
Ibrahim, F.7
Kim, H.J.8
Mojsilovic-Petrovic, J.9
Panossian, S.10
Kim, C.E.11
Frackelton, E.C.12
Solski, J.A.13
Williams, K.L.14
Clay-Falcone, D.15
Elman, L.16
McCluskey, L.17
Greene, R.18
Hakonarson, H.19
Kalb, R.G.20
Lee, V.M.21
Trojanowski, J.Q.22
Nicholson, G.A.23
Blair, I.P.24
Bonini, N.M.25
Van Deerlin, V.M.26
Mourelatos, Z.27
Shorter, J.28
Gitler, A.D.29
more..
-
62
-
-
84874531814
-
RNA binding ability of FUS regulates neurodegeneration, cytoplasmic mislocalization and incorporation into stress granules associated with FUS carrying ALS-linked mutations
-
Daigle, J. G., Lanson, N. A., Smith, R. B., Casci, I., Maltare, A., Monaghan, J., Nichols, C. D., Kryndushkin, D., Shewmaker, F., and Pandey, U. B. (2013) RNA binding ability of FUS regulates neurodegeneration, cytoplasmic mislocalization and incorporation into stress granules associated with FUS carrying ALS-linked mutations. Hum. Mol. Genet. 22, 1193-1205
-
(2013)
Hum. Mol. Genet.
, vol.22
, pp. 1193-1205
-
-
Daigle, J.G.1
Lanson, N.A.2
Smith, R.B.3
Casci, I.4
Maltare, A.5
Monaghan, J.6
Nichols, C.D.7
Kryndushkin, D.8
Shewmaker, F.9
Pandey, U.B.10
-
63
-
-
79955502687
-
Molecular determinants and genetic modifiers of aggregation and toxicity for the ALS disease protein FUS/TLS
-
Sun, Z., Diaz, Z., Fang, X., Hart, M. P., Chesi, A., Shorter, J., and Gitler, A. D. (2011) Molecular determinants and genetic modifiers of aggregation and toxicity for the ALS disease protein FUS/TLS. PLoS Biol. 9, e1000614
-
(2011)
PLoS Biol.
, vol.9
-
-
Sun, Z.1
Diaz, Z.2
Fang, X.3
Hart, M.P.4
Chesi, A.5
Shorter, J.6
Gitler, A.D.7
-
64
-
-
79952317624
-
Characterization of a family of RanBP2-type zinc fingers that can recognize single-stranded RNA
-
Nguyen, C. D., Mansfield, R. E., Leung, W., Vaz, P. M., Loughlin, F. E., Grant, R. P., and Mackay, J. P. (2011) Characterization of a family of RanBP2-type zinc fingers that can recognize single-stranded RNA. J. Mol. Biol. 407, 273-283
-
(2011)
J. Mol. Biol.
, vol.407
, pp. 273-283
-
-
Nguyen, C.D.1
Mansfield, R.E.2
Leung, W.3
Vaz, P.M.4
Loughlin, F.E.5
Grant, R.P.6
MacKay, J.P.7
-
65
-
-
78649336706
-
The DNA damage response: Making it safe to play with knives
-
Ciccia, A., and Elledge, S. J. (2010) The DNA damage response: making it safe to play with knives. Mol. Cell 40, 179-204
-
(2010)
Mol. Cell
, vol.40
, pp. 179-204
-
-
Ciccia, A.1
Elledge, S.J.2
-
66
-
-
84860863700
-
Cell-free formation of RNA granules: Bound RNAs identify features and components of cellular assemblies
-
Han, T. W., Kato, M., Xie, S., Wu, L. C., Mirzaei, H., Pei, J., Chen, M., Xie, Y., Allen, J., Xiao, G., and McKnight, S. L. (2012) Cell-free formation of RNA granules: bound RNAs identify features and components of cellular assemblies. Cell 149, 768-779
-
(2012)
Cell
, vol.149
, pp. 768-779
-
-
Han, T.W.1
Kato, M.2
Xie, S.3
Wu, L.C.4
Mirzaei, H.5
Pei, J.6
Chen, M.7
Xie, Y.8
Allen, J.9
Xiao, G.10
McKnight, S.L.11
-
67
-
-
77951498531
-
High-resolution profiling of γh2AX around DNA double strand breaks in the mammalian genome
-
Iacovoni, J. S., Caron, P., Lassadi, I., Nicolas, E., Massip, L., Trouche, D., and Legube, G. (2010) High-resolution profiling of γH2AX around DNA double strand breaks in the mammalian genome. EMBO J. 29, 1446-1457
-
(2010)
EMBO J.
, vol.29
, pp. 1446-1457
-
-
Iacovoni, J.S.1
Caron, P.2
Lassadi, I.3
Nicolas, E.4
Massip, L.5
Trouche, D.6
Legube, G.7
-
68
-
-
0038583869
-
Spatial and temporal cellular responses to single-strand breaks in human cells
-
Okano, S., Lan, L., Caldecott, K. W., Mori, T., and Yasui, A. (2003) Spatial and temporal cellular responses to single-strand breaks in human cells. Mol. Cell. Biol. 23, 3974-3981
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 3974-3981
-
-
Okano, S.1
Lan, L.2
Caldecott, K.W.3
Mori, T.4
Yasui, A.5
-
69
-
-
77956341931
-
Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining
-
Miller, K. M., Tjeertes, J. V., Coates, J., Legube, G., Polo, S. E., Britton, S., and Jackson, S. P. (2010) Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining. Nat. Struct. Mol. Biol. 17, 1144-1151
-
(2010)
Nat. Struct. Mol. Biol.
, vol.17
, pp. 1144-1151
-
-
Miller, K.M.1
Tjeertes, J.V.2
Coates, J.3
Legube, G.4
Polo, S.E.5
Britton, S.6
Jackson, S.P.7
-
70
-
-
34548771748
-
Phospho-epitope binding by the BRCT domains of hPTIP controls multiple aspects of the cellular response to DNA damage
-
Munoz, I. M., Jowsey, P. A., Toth, R., and Rouse, J. (2007) Phospho-epitope binding by the BRCT domains of hPTIP controls multiple aspects of the cellular response to DNA damage. Nucleic Acids Res. 35, 5312-5322
-
(2007)
Nucleic Acids Res.
, vol.35
, pp. 5312-5322
-
-
Munoz, I.M.1
Jowsey, P.A.2
Toth, R.3
Rouse, J.4
-
71
-
-
0034641724
-
Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro
-
Matsuoka, S., Rotman, G., Ogawa, A., Shiloh, Y., Tamai, K., and Elledge, S. J. (2000) Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro. Proc. Natl. Acad. Sci. U.S.A. 97, 10389-10394
-
(2000)
Proc. Natl. Acad. Sci. U.S.A.
, vol.97
, pp. 10389-10394
-
-
Matsuoka, S.1
Rotman, G.2
Ogawa, A.3
Shiloh, Y.4
Tamai, K.5
Elledge, S.J.6
-
72
-
-
0034306332
-
Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1
-
Melchionna, R., Chen, X. B., Blasina, A., and McGowan, C. H. (2000) Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1. Nat. Cell Biol. 2, 762-765
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 762-765
-
-
Melchionna, R.1
Chen, X.B.2
Blasina, A.3
McGowan, C.H.4
-
73
-
-
0034326802
-
Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation
-
Ahn, J. Y., Schwarz, J. K., Piwnica-Worms, H., and Canman, C. E. (2000) Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation. Cancer Res. 60, 5934-5936
-
(2000)
Cancer Res.
, vol.60
, pp. 5934-5936
-
-
Ahn, J.Y.1
Schwarz, J.K.2
Piwnica-Worms, H.3
Canman, C.E.4
-
74
-
-
36549060102
-
Human CtIP promotes DNA end resection
-
Sartori, A. A., Lukas, C., Coates, J., Mistrik, M., Fu, S., Bartek, J., Baer, R., Lukas, J., and Jackson, S. P. (2007) Human CtIP promotes DNA end resection. Nature 450, 509-514
-
(2007)
Nature
, vol.450
, pp. 509-514
-
-
Sartori, A.A.1
Lukas, C.2
Coates, J.3
Mistrik, M.4
Fu, S.5
Bartek, J.6
Baer, R.7
Lukas, J.8
Jackson, S.P.9
-
75
-
-
84875918552
-
The role of hnRPUL1 involved in DNA damage response is related to PARP1
-
Hong, Z., Jiang, J., Ma, J., Dai, S., Xu, T., Li, H., and Yasui, A. (2013) The role of hnRPUL1 involved in DNA damage response is related to PARP1. PLoS One 8, e60208
-
(2013)
PLoS One
, vol.8
-
-
Hong, Z.1
Jiang, J.2
Ma, J.3
Dai, S.4
Xu, T.5
Li, H.6
Yasui, A.7
-
76
-
-
58749112769
-
Proteome-wide identification of poly(ADP-ribose)-binding proteins and poly(ADP-ribose)-associated protein complexes
-
Gagné, J. P., Isabelle, M., Lo, K. S., Bourassa, S., Hendzel, M. J., Dawson, V. L., Dawson, T. M., and Poirier, G. G. (2008) Proteome-wide identification of poly(ADP-ribose)-binding proteins and poly(ADP-ribose)- associated protein complexes. Nucleic Acids Res. 36, 6959-6976
-
(2008)
Nucleic Acids Res.
, vol.36
, pp. 6959-6976
-
-
Gagné, J.P.1
Isabelle, M.2
Lo, K.S.3
Bourassa, S.4
Hendzel, M.J.5
Dawson, V.L.6
Dawson, T.M.7
Poirier, G.G.8
-
77
-
-
84881244327
-
Reprogramming cellular events by poly(ADP-ribose)-binding proteins
-
00139-2
-
Krietsch, J., Rouleau, M., Pic, E., Ethier, C., Dawson, T. M., Dawson, V. L., Masson, J. Y., Poirier, G. G., and Gagné, J. P. (2012) Reprogramming cellular events by poly(ADP-ribose)-binding proteins. Mol. Aspects Med. S0098-2997, 00139-2
-
(2012)
Mol. Aspects Med.
-
-
Krietsch, J.1
Rouleau, M.2
Pic, E.3
Ethier, C.4
Dawson, T.M.5
Dawson, V.L.6
Masson, J.Y.7
Poirier, G.G.8
Gagné, J.P.9
-
78
-
-
84860872161
-
Cell-free formation of RNA granules: Low complexity sequence domains form dynamic fibers within hydrogels
-
Kato, M., Han, T. W., Xie, S., Shi, K., Du, X., Wu, L. C., Mirzaei, H., Goldsmith, E. J., Longgood, J., Pei, J., Grishin, N. V., Frantz, D. E., Schneider, J. W., Chen, S., Li, L., Sawaya, M. R., Eisenberg, D., Tycko, R., and McKnight, S. L. (2012) Cell-free formation of RNA granules: low complexity sequence domains form dynamic fibers within hydrogels. Cell 149, 753-767
-
(2012)
Cell
, vol.149
, pp. 753-767
-
-
Kato, M.1
Han, T.W.2
Xie, S.3
Shi, K.4
Du, X.5
Wu, L.C.6
Mirzaei, H.7
Goldsmith, E.J.8
Longgood, J.9
Pei, J.10
Grishin, N.V.11
Frantz, D.E.12
Schneider, J.W.13
Chen, S.14
Li, L.15
Sawaya, M.R.16
Eisenberg, D.17
Tycko, R.18
McKnight, S.L.19
-
79
-
-
77149134314
-
Ebp1 sumoylation, regulated by TLS/FUS E3 ligase, is required for its anti-proliferative activity
-
Oh, S. M., Liu, Z., Okada, M., Jang, S. W., Liu, X., Chan, C. B., Luo, H., and Ye, K. (2010) Ebp1 sumoylation, regulated by TLS/FUS E3 ligase, is required for its anti-proliferative activity. Oncogene 29, 1017-1030
-
(2010)
Oncogene
, vol.29
, pp. 1017-1030
-
-
Oh, S.M.1
Liu, Z.2
Okada, M.3
Jang, S.W.4
Liu, X.5
Chan, C.B.6
Luo, H.7
Ye, K.8
-
80
-
-
72449175818
-
Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks
-
Galanty, Y., Belotserkovskaya, R., Coates, J., Polo, S., Miller, K. M., and Jackson, S. P. (2009) Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks. Nature 462, 935-939
-
(2009)
Nature
, vol.462
, pp. 935-939
-
-
Galanty, Y.1
Belotserkovskaya, R.2
Coates, J.3
Polo, S.4
Miller, K.M.5
Jackson, S.P.6
-
81
-
-
4544376045
-
Radiation response: An additional unique signature of myxoid liposarcoma
-
Pitson, G., Robinson, P., Wilke, D., Kandel, R. A., White, L., Griffin, A. M., Bell, R. S., Catton, C. N., Wunder, J. S., and O'Sullivan, B. (2004) Radiation response: an additional unique signature of myxoid liposarcoma. Int. J. Radiat. Oncol. Biol. Phys. 60, 522-526
-
(2004)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.60
, pp. 522-526
-
-
Pitson, G.1
Robinson, P.2
Wilke, D.3
Kandel, R.A.4
White, L.5
Griffin, A.M.6
Bell, R.S.7
Catton, C.N.8
Wunder, J.S.9
O'Sullivan, B.10
-
82
-
-
34248203558
-
Ewing sarcoma gene EWS is essential for meiosis and B lymphocyte development
-
Li, H., Watford, W., Li, C., Parmelee, A., Bryant, M. A., Deng, C., O'Shea, J., and Lee, S. B. (2007) Ewing sarcoma gene EWS is essential for meiosis and B lymphocyte development. J. Clin. Invest. 117, 1314-1323
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 1314-1323
-
-
Li, H.1
Watford, W.2
Li, C.3
Parmelee, A.4
Bryant, M.A.5
Deng, C.6
O'Shea, J.7
Lee, S.B.8
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