Design, synthesis, docking study and biological evaluation of some novel tetrahydrochromeno [3′,4′:5,6]pyrano[2,3-b]quinolin-6(7H)-one derivatives against acetyl- and butyrylcholinesterase

European Journal of Medicinal Chemistry

Volumn 68, Issue , 2013, Pages 291-300

  Khoobi, Mehdi ^a   Alipour, Masoumeh ^b   Moradi, Alireza ^c   Sakhteman, Amirhossein ^c   Nadri, Hamid ^c   Razavi, Seyyede Faeze ^a   Ghandi, Mehdi ^b   Foroumadi, Alireza ^a,d   Shafiee, Abbas ^a  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b UNIVERSITY OF TEHRAN   (Iran)

^c SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d KERMAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Alzheimer's disease; Cholinesterase inhibitor; Coumarin; Docking study; Tacrine

Indexed keywords

8 AMINO 7 (2 CHLOROPHENYL) 9,10,11,12 TETRAHYDROCHROMENO[3',4':5,6] PYRANO[2,3 B]QUINOLIN 6(7H) ONE; 8 AMINO 7 (2,4 DICHLOROPHENYL) 9,10,11,12 TETRAHYDROCHROMENO[3',4':5,6] PYRANO[2,3 B]QUINOLIN 6(7H) ONE; 8 AMINO 7 (3 CHLOROPHENYL) 9,10,11,12 TETRAHYDROCHROMENO[3',4':5,6] PYRANO[2,3 B]QUINOLIN 6(7H) ONE; 8 AMINO 7 (3 FLUOROPHENYL) 9,10,11,12 TETRAHYDROCHROMENO[3',4':5,6] PYRANO[2,3 B]QUINOLIN 6(7H) ONE; 8 AMINO 7 (3 NITROPHENYL) 9,10,11,12 TETRAHYDROCHROMENO[3',4':5,6] PYRANO[2,3 B]QUINOLIN 6(7H) ONE; 8 AMINO 7 (3,4 DIMETHOXYPHENYL) 9,10,11,12 TETRAHYDROCHROMENO[3',4':5,6] PYRANO[2,3 B]QUINOLIN 6(7H) ONE; 8 AMINO 7 (3,4,5 TRIMETHOXYPHENYL) 9,10,11,12 TETRAHYDROCHROMENO[3',4':5,6] PYRANO[2,3 B]QUINOLIN 6(7H) ONE; 8 AMINO 7 (4 CHLOROPHENYL) 9,10,11,12 TETRAHYDROCHROMENO[3',4':5,6] PYRANO[2,3 B]QUINOLIN 6(7H) ONE; 8 AMINO 7 (4 FLUOROPHENYL) 9,10,11,12 TETRAHYDROCHROMENO[3',4':5,6] PYRANO[2,3 B]QUINOLIN 6(7H) ONE; 8 AMINO 7 (4 METHOXYPHENYL) 9,10,11,12 TETRAHYDROCHROMENO[3',4':5,6] PYRANO[2,3 B]QUINOLIN 6(7H) ONE; 8 AMINO 7 (BENZO[D][1,3]DIOXOL 5 YL) 9,10,11,12 TETRAHYDROCHROMENO[3',4':5,6] PYRANO[2,3 B]QUINOLIN 6(7H) ONE; 8 AMINO 7 (P TOLYL) 9,10,11,12 TETRAHYDROCHROMENO[3',4':5,6] PYRANO[2,3 B]QUINOLIN 6(7H) ONE; 8 AMINO 7 (PYRIDIN 4 YL) 9,10,11,12 TETRAHYDROCHROMENO[3',4':5,6] PYRANO[2,3 B]QUINOLIN 6(7H) ONE; 8 AMINO 7 (THIOPHEN 2 YL) 9,10,11,12 TETRAHYDROCHROMENO[3',4':5,6] PYRANO[2,3 B]QUINOLIN 6(7H) ONE; 8 AMINO 7 BUTHYL 9,10,11,12 TETRAHYDROCHROMENO[3',4':5,6] PYRANO[2,3 B]QUINOLIN 6(7H) ONE; 8 AMINO 7 ETHYL 9,10,11,12 TETRAHYDROCHROMENO[3',4':5,6] PYRANO[2,3 B]QUINOLIN 6(7H) ONE; 8 AMINO 7 METHYL 9,10,11,12 TETRAHYDROCHROMENO[3',4':5,6] PYRANO[2,3 B]QUINOLIN 6(7H) ONE; 8 AMINO 7 PHENYL 9,10,11,12 TETRAHYDROCHROMENO[3',4':5,6] PYRANO[2,3 B]QUINOLIN 6(7H) ONE; ACETYLCHOLINESTERASE; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; COUMARIN DERIVATIVE; QUINOLINE DERIVATIVE; TACRINE; TETRAHYDROCHROMENO [3',4':5,6]PYRANO[2,3 B]QUINOLIN 6(7H) ONE; UNCLASSIFIED DRUG;

ARTICLE; CHOLINESTERASE INHIBITION; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME ACTIVITY; HYDROGEN BOND; MOLECULAR DOCKING; NANOCATALYST; REACTION TIME;

ALZHEIMER'S DISEASE; CHOLINESTERASE INHIBITOR; COUMARIN; DOCKING STUDY; TACRINE;

ACETYLCHOLINESTERASE; BENZOPYRANS; BINDING SITES; BUTYRYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; COUMARINS; DRUG DESIGN; ENZYME ACTIVATION; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MOLECULAR DOCKING SIMULATION; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; TACRINE;

EID: 84883100909     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.07.045     Document Type: Article

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