Synthesis and evaluation of 4-substituted coumarins as novel acetylcholinesterase inhibitors

European Journal of Medicinal Chemistry

Volumn 64, Issue , 2013, Pages 252-259

  Razavi, Seyyede Faeze ^a   Khoobi, Mehdi ^b   Nadri, Hamid ^c   Sakhteman, Amirhossein ^c   Moradi, Alireza ^c   Emami, Saeed ^d   Foroumadi, Alireza ^b   Shafiee, Abbas ^b  

^a UNIVERSITY OF ZANJAN   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Acetylcholinesterase; Alzheimer's disease; Coumarins; Docking study

Indexed keywords

2 (2 OXO 2H CHROMEN 4 YLOXY)ACETIC ACID; 4 (2 OXO 2H CHROMEN 4 YLOXY)BUTANOIC ACID; 4 [2 (4 BENZYLPIPERIDIN 1 YL) 2 OXOETHOXY) 2H CHROMEN 2 ONE; 4 [2 [4 (2 FLUOROPHENYL)PIPERAZIN 1 YL] 2 OXOETHOXY) 2H CHROMEN 2 ONE; 4 [2 [4 (2 HYDROXYPHENYL)PIPERAZIN 1 YL] 2 OXOETHOXY] 2H CHROMEN 2 ONE; 4 [2 [4 (3,4 DICHLOROPHENYL)PIPERAZIN 1 YL] 2 OXOETHOXY 2H CHROMEN 2 ONE; 4 [2 [4 (4 BROMOPHENYL) 4 HYDROXYPIPERIDIN 1 YL] 2 OXOETHOXY] 2H CHROMEN 2 ONE; 4 [2 [4 (4 CHLOROPHENYL) 4 HYDROXYPIPERIDIN 1 YL] 2 OXOETHOXY] 2H CHROMEN 2 ONE; 4 [2 [4 (4 FLUOROPHENYL)PIPERAZIN 1 YL] 2 OXOETHOXY] 2H CHROMEN 2 ONE; 4 [2 OXO 2 (4 PHENYLPIPERAZIN 1 YL)ETHOXY)] 2H CHROMEN 2 ONE; 4 [4 (4 BENZYLPIPERIDIN 1 YL) 4 OXOBUTOXY] 2H CHROMEN 2 ONE; 4 [4 [4 (2 FLUOROPHENYL)PIPERAZIN 1 YL] 4 OXOBUTOXY] 2H CHROMEN 2 ONE; 4 [4 [4 (2 HYDROXYPHENYL)PIPERAZIN 1 YL] 4 OXOBUTOXY] 2H CHROMEN 2 ONE; 4 [4 [4 (3,4 DICHLOROPHENYL)PIPERAZIN 1 YL] 4 OXOBUTOXY] 2H CHROMEN 2 ONE; 4 [4 [4 (4 BROMOPHENYL) 4 HYDROXYPIPERIDIN 1 YL] 4 OXOBUTOXY] 2H CHROMEN 2 ONE; 4 [4 [4 (4 CHLOROPHENYL) 4 HYDROXYPIPERIDIN 1 YL] 4 OXOBUTOXY] 2H CHROMEN 2 ONE; 4 [4 [4 (4 FLUOROPHENYL)PIPERAZIN 1 YL] 4 OXOBUTOXY] 2H CHROMEN 2 ONE; 4 [4 OXO 4 (4 PHENYLPIPERAZIN 1 YL)BUTOXY] 2H CHROMEN 2 ONE; ACETYLCHOLINESTERASE; AP 2238; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; COUMARIN DERIVATIVE; ENSACULINE; ENZYME INHIBITOR; N(1 BENZYLPIPERIDIN 4 YL) 2 (2 OXO 2H CHROMEN 4 YLOXY)ACETAMIDE; N(1 BENZYLPIPERIDIN 4 YL) 4 (2 OXO 2H CHROMEN 4 YLOXY)BUTANAMIDE; N(3,4 DIMETHOXYPHENETHYL) 4 (2 OXO 2H CHROMEN 4 YLOXY)BUTANAMIDE; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; ARTICLE; DRUG DESIGN; DRUG SELECTIVITY; DRUG SYNTHESIS; ELECTROPHORUS; ENZYME INHIBITION; EVALUATION; HORSE; IC 50; MOLECULAR DOCKING; MOLECULAR RECOGNITION; NONHUMAN; SUBSTITUTION REACTION;

ACETYLCHOLINESTERASE; ANIMALS; BUTYRYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; COUMARINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORUS; HORSES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84877026618     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.03.021     Document Type: Article

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