Establishing catalytic activity on an artificial (βα) 8-barrel protein designed from identical half-barrels

FEBS Letters

Volumn 587, Issue 17, 2013, Pages 2798-2805

  Sperl, Josef M ^a   Rohweder, Bettina ^a   Rajendran, Chitra ^a   Sterner, Reinhard ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

( ) 8 Barrel; Artificial enzyme; Enzyme design; Enzyme evolution

Indexed keywords

SCAFFOLD PROTEIN; SYM2 PROTEIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENZYME MECHANISM; ENZYME STABILITY; GENE DUPLICATION; GENE EXPRESSION REGULATION; GENE LIBRARY; GENE MUTATION; GENETIC VARIABILITY; ISOMERIZATION; MOLECULAR EVOLUTION; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN SECONDARY STRUCTURE; STRUCTURE ANALYSIS; SYM2 GENE; TAUTOMERIZATION;

(ΒΑ)(8)-BARREL; ARTIFICIAL ENZYME; ENZYME DESIGN; ENZYME EVOLUTION;

AMINOHYDROLASES; CATALYTIC DOMAIN; CLONING, MOLECULAR; CRYSTALLOGRAPHY, X-RAY; ENZYME STABILITY; ESCHERICHIA COLI; ISOMERISM; KINETICS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN ENGINEERING; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT FUSION PROTEINS;

EID: 84883049489     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2013.06.022     Document Type: Article

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