Mimicking enzyme evolution by generating new (βα) 8-barrels from (βα)4-half-barrels

Proceedings of the National Academy of Sciences of the United States of America

Volumn 101, Issue 47, 2004, Pages 16448-16453

  Höcker, Birte ^a,c   Claren, Jörg ^a,b   Sterner, Reinhard ^a,b  

^a UNIVERSITY OF COLOGNE   (Germany)

^b UNIVERSITY OF REGENSBURG   (Germany)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Chimeric proteins; Gene duplication; Histidine biosynthesis; TIM barrel

Indexed keywords

AMINO ACID; CHIMERIC PROTEIN; ENZYME; HISTIDINE; ISOMERASE; PROTEIN; SYNTHETASE;

AMINO ACID SEQUENCE; ARTICLE; BIOSYNTHESIS; CIRCULAR DICHROISM; ENZYME ACTIVITY; EVOLUTION; FLUORESCENCE SPECTROSCOPY; GENE; GENE DUPLICATION; GENE FUSION; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

ALDOSE-KETOSE ISOMERASES; AMINOHYDROLASES; BASE SEQUENCE; CLONING, MOLECULAR; DNA, BACTERIAL; EVOLUTION, MOLECULAR; GENE DUPLICATION; GENES, BACTERIAL; MODELS, MOLECULAR; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; THERMOTOGA MARITIMA;

EID: 9344235017     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0405832101     Document Type: Article

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