The activation of P2Y6 receptor in cultured spinal microglia induces the production of CCL2 through the MAP kinases-NF-κB pathway

Neuropharmacology

Volumn 75, Issue , 2013, Pages 116-125

  Morioka, Norimitsu ^a   Tokuhara, Masato ^a   Harano, Sakura ^a   Nakamura, Yoki ^a   Hisaoka Nakashima, Kazue ^a   Nakata, Yoshihiro ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

Author keywords

CCL2; MAP kinases; NF B; P2Y6; Spinal microglia; UTP

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; ADENOSINE TRIPHOSPHATE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; PHOSPHOLIPASE C; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; PURINERGIC P2Y RECEPTOR; PURINERGIC P2Y2 RECEPTOR; PURINERGIC P2Y4 RECEPTOR; PURINERGIC P2Y6 RECEPTOR; SURAMIN; SYNAPTOPHYSIN; URIDINE TRIPHOSPHATE; DRUG DERIVATIVE; ENZYME INHIBITOR; ISOTHIOCYANIC ACID DERIVATIVE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE KINASE; N,N'' 1,4 BUTANEDIYLBIS(N' (3 ISOTHIOCYANATOPHENYL))THIOUREA; N,N''-1,4-BUTANEDIYLBIS(N'-(3-ISOTHIOCYANATOPHENYL))THIOUREA; PURINERGIC P2 RECEPTOR; PURINERGIC P2Y RECEPTOR ANTAGONIST; THIOUREA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; IN VITRO STUDY; MICROGLIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; SPINAL CORD; ANIMAL; CCL2; CYTOLOGY; DOSE RESPONSE; DRUG EFFECT; GENETICS; MAP KINASES; METABOLISM; NF-ΚB; P2Y(6); PHYSIOLOGY; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SPINAL MICROGLIA; TIME;

CCL2; MAP KINASES; NF-ΚB; P2Y(6); SPINAL MICROGLIA; UTP;

ANIMALS; CELLS, CULTURED; CHEMOKINE CCL2; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; ISOTHIOCYANATES; MICROGLIA; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; NF-KAPPA B; PURINERGIC P2Y RECEPTOR ANTAGONISTS; RATS; RECEPTORS, PURINERGIC P2; RNA INTERFERENCE; RNA, MESSENGER; SIGNAL TRANSDUCTION; SPINAL CORD; THIOUREA; TIME FACTORS; URIDINE TRIPHOSPHATE;

EID: 84883028142     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2013.07.017     Document Type: Article

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