Retro-inversion of certain cell-penetrating peptides causes severe cellular toxicity

Biochimica et Biophysica Acta - Biomembranes

Volumn 1808, Issue 6, 2011, Pages 1544-1551

  Holm, Tina ^a   Räägel, Helin ^b   Andaloussi, Samir El ^a   Hein, Margot ^b   Mäe, Maarja ^a   Pooga, Margus ^b   Langel, Ülo ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b UNIVERSITY OF TARTU   (Estonia)

Author keywords

Apoptosis; Cell penetrating peptide; Cytotoxicity; Hydrophobicity; Retro inverso

Indexed keywords

ACTIN; CASPASE 3; CELL PENETRATING PEPTIDE; PEPTIDE NUCLEIC ACID; STAUROSPORINE; TRYPSIN;

APOPTOSIS; ARTICLE; CELL LINE; CELL METABOLISM; CELL NUCLEUS; CELL PROLIFERATION; CELL STRAIN MCF 7; CELL STRUCTURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOSKELETON; CYTOTOXICITY; ENZYME ACTIVATION; FLUORESCENCE MICROSCOPY; FOCAL ADHESION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN STABILITY;

AMINO ACID SEQUENCE; APOPTOSIS; CARRIER PROTEINS; CASPASE 3; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; FLUORESCEINS; GENE PRODUCTS, TAT; HELA CELLS; HUMANS; MICROSCOPY, FLUORESCENCE; MOLECULAR SEQUENCE DATA; PEPTIDES;

EID: 79954690910     PISSN: 00052736     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamem.2010.10.019     Document Type: Article

References (36)

1. S. EL Andaloussi, T. Holm, and Ü. Langel Cell-penetrating peptides: mechanisms and applications Curr. Pharm. Des. 11 2005 3597 3611 (Pubitemid 41630987)
2. M. Mäe, S. EL Andaloussi, P. Lundin, N. Oskolkov, H.J. Johansson, P. Guterstam, and Ü. Langel A stearylated CPP for delivery of splice correcting oligonucleotides using a non-covalent co-incubation strategy J. Control. Release 134 2009 221 227
3. J.S. Wadia, R.V. Stan, and S.F. Dowdy Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion proteins after lipid raft macropinocytosis Nat. Med. 10 2004 310 315 (Pubitemid 38667624)
4. P.A. Wender, D.J. Mitchell, K. Pattabiraman, E.T. Pelkey, L. Steinman, and J.B. Rothbard The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: peptoid molecular transporters Proc. Natl Acad. Sci. USA 97 2000 13003 13008
5. D. Derossi, S. Calvet, A. Trembleau, A. Brunissen, G. Chassaing, and A. Prochiantz Cell internalization of the third helix of the Antennapedia homeodomain is receptor-independent J. Biol. Chem. 271 1996 18188 18193 (Pubitemid 26250811)
6. M. Chorev, and M. Goodman Recent developments in retro peptides and proteins-an ongoing topochemical exploration Trends Biotechnol. 13 1995 438 445
7. M. Chorev The partial retro-inverso modification: a road traveled together Biopolymers 80 2005 67 84 (Pubitemid 40791045)
8. P.M. Fischer The design, synthesis and application of stereochemical and directional peptide isomers: a critical review Curr. Protein Pept. Sci. 4 2003 339 356 (Pubitemid 37236348)
9. C. Li, M. Pazgier, J. Li, C. Li, M. Liu, G. Zou, Z. Li, J. Chen, S.G. Tarasov, W.Y. Lu, and W. Lu Limitations of peptide retro-inverso isomerization in molecular mimicry J. Biol. Chem. 285 2010 19572 19581
10. E.L. Snyder, B.R. Meade, C.C. Saenz, and S.F. Dowdy Treatment of terminal peritoneal carcinomatosis by a transducible p53-activating peptide PLoS Biol. 2 2004 E36
11. J. Brugidou, C. Legrand, J. Mery, and A. Rabie The retro-inverso form of a homeobox-derived short peptide is rapidly internalised by cultured neurones: a new basis for an efficient intracellular delivery system Biochem. Biophys. Res. Commun. 214 1995 685 693
12. S. EL Andaloussi, H.J. Johansson, T. Holm, and Ü. Langel A novel cell-penetrating peptide, M918, for efficient delivery of proteins and peptide nucleic acids Mol. Ther. 15 2007 1820 1826 (Pubitemid 47434189)
13. H.J. Johansson, S. EL Andaloussi, T. Holm, M. Mäe, J. Jänes, T. Maimets, and Ü. Langel Characterization of a novel cytotoxic cell-penetrating peptide derived from p14ARF protein Mol. Ther. 16 2008 115 123
14. S. EL Andaloussi, P. Guterstam, and Ü. Langel Assessing the delivery efficacy and internalization route of cell-penetrating peptides Nat. Protoc. 2 2007 2043 2047 (Pubitemid 47308144)
15. S.H. Kang, M.J. Cho, and R. Kole Up-regulation of luciferase gene expression with antisense oligonucleotides: implications and applications in functional assay development Biochemistry 37 1998 6235 6239 (Pubitemid 28213640)
16. C. Albiges-Rizo, O. Destaing, B. Fourcade, E. Planus, and M.R. Block Actin machinery and mechanosensitivity in invadopodia, podosomes and focal adhesions J. Cell Sci. 122 2009 3037 3049
17. J.L. Vayssiere, P.X. Petit, Y. Risler, and B. Mignotte Commitment to apoptosis is associated with changes in mitochondrial biogenesis and activity in cell lines conditionally immortalized with simian virus 40 Proc. Natl Acad. Sci. USA 91 1994 11752 11756 (Pubitemid 24356423)
18. A.G. Porter, and R.U. Janicke Emerging roles of caspase-3 in apoptosis Cell Death Differ. 6 1999 99 104 (Pubitemid 29082297)
19. H.J. Lee, and W.M. Pardridge Pharmacokinetics and delivery of tat and tat-protein conjugates to tissues in vivo Bioconjug. Chem. 12 2001 995 999 (Pubitemid 33136870)
20. Y.P. Jarajapu, J. Baltunis, H.J. Knot, and S.M. Sullivan Biological evaluation of penetration domain and killing domain peptides J. Gene Med. 7 2005 908 917 (Pubitemid 41015539)
21. D. Delaroche, F.X. Cantrelle, F. Subra, C. Van Heijenoort, E. Guittet, C.Y. Jiao, L. Blanchoin, G. Chassaing, S. Lavielle, C. Auclair, and S. Sagan Cell-penetrating peptides with intracellular actin remodeling activity in malignant fibroblasts J. Biol. Chem. 2009
22. S. Etienne-Manneville, and A. Hall Rho GTPases in cell biology Nature 420 2002 629 635 (Pubitemid 36764489)
23. A.S. Maddox, and K. Burridge RhoA is required for cortical retraction and rigidity during mitotic cell rounding J. Cell Biol. 160 2003 255 265 (Pubitemid 36254959)
24. D.A. Starr Communication between the cytoskeleton and the nuclear envelope to position the nucleus Mol. Biosyst. 3 2007 583 589 (Pubitemid 47258223)
25. S.S. Martin, and P. Leder Human MCF10A mammary epithelial cells undergo apoptosis following actin depolymerization that is independent of attachment and rescued by Bcl-2 Mol. Cell. Biol. 21 2001 6529 6536 (Pubitemid 32927420)
26. D.J. Mitchell, D.T. Kim, L. Steinman, C.G. Fathman, and J.B. Rothbard Polyarginine enters cells more efficiently than other polycationic homopolymers J. Pept. Res. 56 2000 318 325
27. U. Soomets, M. Lindgren, X. Gallet, M. Hällbrink, A. Elmquist, L. Balaspiri, M. Zorko, M. Pooga, R. Brasseur, and Ü. Langel Deletion analogues of transportan Biochim. Biophys. Acta 1467 2000 165 176 (Pubitemid 30621595)
28. A. Scheller, J. Oehlke, B. Wiesner, M. Dathe, E. Krause, M. Beyermann, M. Melzig, and M. Bienert Structural requirements for cellular uptake of alpha-helical amphipathic peptides J. Pept. Sci. 5 1999 185 194 (Pubitemid 29224610)
29. S. EL Andaloussi, P. Järver, H.J. Johansson, and Ü. Langel Cargo-dependent cytotoxicity and delivery efficacy of cell-penetrating peptides: a comparative study Biochem. J. 407 2007 285 292 (Pubitemid 47556993)
30. C.Y. Jiao, D. Delaroche, F. Burlina, I.D. Alves, G. Chassaing, and S. Sagan Translocation and endocytosis for cell-penetrating peptide internalization J. Biol. Chem. 284 2009 33957 33965
31. S.W. Jones, R. Christison, K. Bundell, C.J. Voyce, S.M. Brockbank, P. Newham, and M.A. Lindsay Characterisation of cell-penetrating peptide-mediated peptide delivery Br. J. Pharmacol. 145 2005 1093 1102 (Pubitemid 43079982)
32. J. Mueller, I. Kretzschmar, R. Volkmer, and P. Boisguerin Comparison of cellular uptake using 22 CPPs in 4 different cell lines Bioconjug. Chem. 19 2008 2363 2374
33. S.W. Tait, and D.R. Green Caspase-independent cell death: leaving the set without the final cut Oncogene 27 2008 6452 6461
34. N.J. McCarthy, M.K. Whyte, C.S. Gilbert, and G.I. Evan Inhibition of Ced-3/ICE-related proteases does not prevent cell death induced by oncogenes, DNA damage, or the Bcl-2 homologue Bak J. Cell Biol. 136 1997 215 227 (Pubitemid 27044816)
35. J. Xiang, D.T. Chao, and S.J. Korsmeyer BAX-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases Proc. Natl Acad. Sci. USA 93 1996 14559 14563 (Pubitemid 26419006)
36. A. Elmquist, and Ü. Langel In vitro uptake and stability study of pVEC and its all-D analog Biol. Chem. 384 2003 387 393 (Pubitemid 36527645)