Probing the S1′ site for the identification of non-zinc-binding MMP-2 inhibitors

ChemMedChem

Volumn 8, Issue 9, 2013, Pages 1475-1482

  Pizio, Antonella Di ^a   Laghezza, Antonio ^b   Tortorella, Paolo ^b   Agamennone, Mariangela ^a  

^a UNIVERSITY OF CHIETI   (Italy)

^b UNIVERSITY OF BARI   (Italy)

Author keywords

Inhibitors; Matrix metalloproteinases; Metalloenzymes; Non zinc binding; Virtual screening

Indexed keywords

COLLAGENASE 3; GELATINASE A; GELATINASE A INHIBITOR; GELATINASE INHIBITOR; INTERSTITIAL COLLAGENASE; LIGAND; MATRILYSIN; NEUTROPHIL COLLAGENASE; UNCLASSIFIED DRUG; ZINC; ISOPROTEIN; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE INHIBITOR;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG IDENTIFICATION; DRUG SAFETY; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; ENERGY; ENZYME ACTIVE SITE; ENZYME STRUCTURE; HYDROGEN BOND; IC 50; LIGAND BINDING; MOLECULAR DOCKING; MOLECULAR MODEL; PHARMACOPHORE; PRIORITY JOURNAL; PROCESS OPTIMIZATION; STRUCTURE ACTIVITY RELATION; VIRTUAL REALITY; BINDING SITE; CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; INHIBITORS; KINETICS; METABOLISM; METALLOENZYMES; NON-ZINC BINDING; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; THERMODYNAMICS; VIRTUAL SCREENING;

INHIBITORS; MATRIX METALLOPROTEINASES; METALLOENZYMES; NON-ZINC BINDING; VIRTUAL SCREENING;

BINDING SITES; DRUG DESIGN; KINETICS; LIGANDS; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE INHIBITORS; MOLECULAR DOCKING SIMULATION; PROTEIN BINDING; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; THERMODYNAMICS; ZINC;

EID: 84882969349     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201300186     Document Type: Article

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