Biphenyl Sulfonylamino Methyl Bisphosphonic Acids as Inhibitors of Matrix Metalloproteinases and Bone Resorption

ChemMedChem

Volumn 6, Issue 7, 2011, Pages 1258-1268

  Rubino, Maria Teresa ^a   Agamennone, Mariangela ^b   Campestre, Cristina ^b   Campiglia, Pietro ^c   Cremasco, Viviana ^a   Faccio, Roberta ^a   Laghezza, Antonio ^a   Loiodice, Fulvio ^a   Maggi, Dariana ^a   Panza, Emilia ^a   Rossello, Armando ^d   Tortorella, Paolo ^a,e  

^a UNIVERSITY OF BARI   (Italy)

^b UNIVERSITY OF CHIETI   (Italy)

^c UNIVERSITY OF SALERNO   (Italy)

^d WASHINGTON UNIVERSITY   (United States)

^e UNIVERSITY OF PISA   (Italy)

Author keywords

Bisphosphonates; Inhibitors; Matrix metalloproteinases; Metalloproteins; Zinc binding groups

Indexed keywords

( BIPHENYL 4 SULFONYLAMINO)METHYL 1,1 BISPHOSPHONIC ACID; (3 NITRO PHENYLSULFONYLAMINO)METHYL 1,1 BISPHOSPHONIC ACID; (4 BROMO PHENYLCARBOXYAMIDO)METHYL 1,1 BISPHOSPHONIC ACID; (4 BROMO PHENYLSULFONYL)METHYL 1,1 BISPHOSPHONIC ACID; (4 BROMO PHENYLSULFONYLAMINO)METHYL 1,1 BISPHOSPHONIC ACID; (4 CHLORO PHENYLSULFONYLAMINO)METHYL 1,1 BISPHOSPHONIC ACID; (4 METHOXY PHENYLSULFONYLAMINO)METHYL 1,1 BISPHOSPHONIC ACID; (4 METHYL PHENYLSULFONYLAMINO)METHYL 1,1 BISPHOSPHONIC ACID; (4 NITRO PHENYLSULFONYLAMINO)METHYL 1,1 BISPHOSPHONIC ACID; (4' CHLORO BIPHENYL 4 SULFONYLAMINO)METHYL 1,1 BISPHOSPHONIC ACID; (4' METHOXY BIPHENYL 4 SULFONYLAMINO)METHYL 1,1 BISPHOSPHONIC ACID; (4' NITRO BIPHENYL 4 SULFONYLAMINO)METHYL 1,1 BISPHOSPHONIC ACID; (BENZENSULFONYLAMINO)METHYL 1,1 BISPHOSPHONIC ACID; [2 (4 BROMO PHENYLSULFONYL)ETHYL] 1,1 BISPHOSPHONIC ACID; [4 (2 THIENYL)PHENYLSULFONYLAMINO]METHYL 1,1 BISPHOSPHONIC; ALENDRONIC ACID; BIPHENYL SULFONYLAMINO METHYL BISPHOSPHONIC ACID; BISPHOSPHONIC ACID DERIVATIVE; ETIDRONIC ACID; GELATINASE A; GELATINASE B; MACROPHAGE ELASTASE; MATRIX METALLOPROTEINASE 14; MATRIX METALLOPROTEINASE INHIBITOR; NEUTROPHIL COLLAGENASE; PAMIDRONIC ACID; TILUDRONIC ACID; UNCLASSIFIED DRUG; ZINC BINDING PROTEIN; ZOLEDRONIC ACID;

ANIMAL CELL; ARTICLE; BONE DISEASE; CANCER CELL; CHELATION; DRUG STRUCTURE; IN VITRO STUDY; MOUSE; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; PRIORITY JOURNAL; PROTEIN DEGRADATION;

BINDING SITES; BONE DENSITY CONSERVATION AGENTS; CELL LINE, TUMOR; COMPUTER SIMULATION; DIPHOSPHONATES; HUMANS; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASES; PROTEASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79959748552     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201000540     Document Type: Article

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