The PIKK Family of Protein Kinases

Handbook of Cell Signaling, Second Edition

Volumn 2, Issue , 2009, Pages 575-580

  Smith, Graeme C M ^a   Jackson, Stephen P ^b  

^a KuDOS Pharmaceuticals Ltd   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84882818868     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-374145-5.00077-2     Document Type: Chapter

References (51)

1. VA Zakian (1995) ATM-related genes: what do they tell us about functions of the human gene? Cell 82 685-687.
2. T Hunter (1995) When is a lipid kinase not a lipid kinase? When it is a protein kinase. Cell 83 1-4.
3. A Toker and LC Cantley (1997) Signalling through the lipid products of phosphoinositide-3-OH kinase. Nature 387 673-676.
4. GCM Smith and SP Jackson (1999) The DNA-dependent protein kinase. Genes Dev 13 916-934.
5. Y Shiloh (2001) ATM and ATR: networking cellular responses to DNA damage. Curr Opin Genet Dev 11 71-77.
6. RT Abraham (2001) Cell cycle checkpoint signalling through the ATM and ATR kinases. Genes Dev 15 2177-2196.
7. KK Khanna and SP Jackson (2001) DNA double-strand breaks: signalling, repair and the cancer connection. Nat Genet 27 247-254.
8. A Yamashita, T Ohnishi, I Kashina, Y Taya and S Ohno (2001) Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay. Genes Dev 15 2215-2228.
9. T Schmelzle and MN Hall (2000) TOR, a central controller of cell growth. Cell 103 253-262.
10. B Raught, A-C Gingras and N Sonenberg (2001) The target of rapamycin (TOR) proteins. Proc Natl Acad Sci USA 98 7037-7044.
11. SB McMahon, HA Van Buskirk, KA Dugan, TD Copeland and MD Cole (1998) The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins. Cell 94 363-374.
12. PA Grant, D Schieltz, MG Pray-Grant, JRR Yates and JL Workman (1998) The ATM related cofactor Tra1 is a component of the purified SAGA complex. Mol Cell 2 863-867.
13. A Vassilev, J Yamauchi, T Kotani, C Prives, ML Avantaggiati, J Qin and Y Nakatani (1998) The 400kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily. Mol Cell 2 869-875.
14. A Saleh, D Schieltz, N Ting, SB McMahon, DW Litchfield, JR Yates, SP Lees-Miller, MD Cole and CJ Brandl (1998) Tra1p is a component of the yeast ADA/SPT transcriptional regulatory complexes. J Biol Chem 273 26,559-26,570.
15. EH Walker, O Perisic, C Ried, L Stephens and RL Williams (1999) Structural insights into phosphoinositide 3-kinase catalysis and signalling. Nature 402 313-320.
16. R Bosotti, A Isacchi and EL Sonnhammer (2000) FAT: a novel domain in PIK-related kinases. Trends Biochem Sci 25 225-227.
17. MA Andrade and P Bork (1995) HEAT repeats in the Huntington’s disease protein. Nat Genet 11 115-116.
18. J Choi, J Chen, SL Schreiber and J Clardy (1996) Structure of the FKB12-rapamycin complex interacting with the binding domain of human FRAP. Science 273 239-242.
19. J Kunz, R Henriquez, U Schneider, M Deuter-Reinhard, NR Movva and MN Hall (1993) Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression. Cell 73 585-596.
20. EJ Brown, MW Albers, TB Shin, K Ichikawa, CT Keith, WS Lane and SL Schreiber (1994) A mammalian protein targeted by G1-arresting rapamycin-receptor complex. Nature 369 756-758.
21. MI Chiu, H Katz and V Berlin (1994) RAPT1, a mammalian homolog of yeast TOR, interacts with the FKBP12/rapamycin complex. Proc Natl Acad Sci USA 91 12,574-12,576.
22. DM Sabatini, H Erdjument-Bromage, M Lui, P Tempst and SH Snyder (1994) RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs. Cell 78 35-43.
23. CJ Sabers, MM Martin, GJ Brunn, JM Williams, FJ Dumont, G Weiderrecht and RT Abraham (1995) Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells. J Biol Chem 270 815-822.
24. M Hidalgo and EK Rowinsky (2000) The rapamycin-sensitive signal transduction pathway as a target for cancer therapy. Oncogene 19 6680-6686.
25. TM Gottlieb and SP Jackson (1993) The DNA-dependent protein kinase requirement for DNA ends and association with Ku antigen. Cell 72 131-142.
26. PA Jeggo (1998) Identification of genes involved in repair of DNA double-strand breaks in mammalian cells. Radiat Res 150 S80-S91.
27. SP Jackson and PA Jeggo (1995) DNA double strand break repair and V(D)J recombination: involvement of DNA-PK. Trends Biochem Sci 20 412-415.
28. D Gilley, H Tanaka, MP Hande, A Kurimasa, GC Li, M Oshimura and DJ Chen (2001) DNA-PKcs is critical for telo mere capping. Proc Natl Acad Sci USA 98 15,084-15,088.
29. A Kurimasa, S Kumano, NV Boubnov, MD Story, CS Tung, SR Peterson and DJ Chen (1999) Requirement for the kinase activity of human DNA-dependent protein kinase catalytic subunit in DNA strand break rejoining. Mol Cell Biol 19 3877-3884.
30. Critchlow, S. and Jackson, S. P. DNA end joining: from yeast to man. Trends Biochem. Sci. 23, 394–398.
31. Y Ma, U Pannicke, K Schwarz and MR Lieber (2002) Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination. Cell 108 781-794.
32. AY Karpova, M Trost, JM Murray, LC Cantley and PM Howly (2002) Interferon regulatory factor-3 is an in vivo target of DNA-PK. Proc Natl Acad Sci USA 99 2818-2823.
33. MF Lavin and Y Shiloh (1997) The genetic defect in ataxia-telang iectasia. Annu Rev Immunol 15 177-202.
34. WA Cliby, CJ Roberts, KA Cimprich, CM Stringer, JR Lamb, SL Schreiber and SH Friend (1998) Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints. EMBO J 17 159-169.
35. P Nghiem, PK Park, Y Kim, C Vaziri and SL Schreiber (2001) ATR inhibition selectively sensitizes G1 checkpoint-deficient cells to lethal premature chromatin condensation. Proc Natl Acad Sci USA 98 9092-9097.
36. NF Lowndes and JR Murguia (2000) Sensing and responding to DNA damage. Curr Opin Genet Dev 10 7-25.
37. G Denning, L Jamieson, LE Maquat, EA Thompson and AP Fields (2001) Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein. J Biol Chem 276 22,709-22,714.
38. LE Macquat and GG Carmichael (2001) Quality control of mRNA function. Cell 104 173-176.
39. J Park, S Kunjibettu, SB McMahon and MD Cole (2001) The ATM-related domain of TRRAP is required for histone acetyltransferase recruitment and Myc-dependent oncogenesis. Genes Dev 15 1619-1624.
40. Z Herceg, W Hulla, D Gell, C Cuenin, M Lleonart, S Jackson and ZQ Wang (2001) Disruption of Trrap causes early embryonic lethality and defects in cell cycle progression. Nat Genet 29 206-211.
41. FG Kruvilla and SL Schreiber (1999) The PIK-related kinases intercept conventional signaling pathways. Chem Biol 6 R129-R136.
42. D Durocher and SP Jackson (2001) DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme? Curr Opin Cell Biol 13 225-231.
43. GCM Smith, RB Cary, ND Lakin, BC Hann, SH Teo, DJ Chen and SP Jackson (1999) Purification and DNA binding properties of the ataxia-telangiectasia gene product ATM. Proc Natl Acad Sci USA 96 11,134-11,139.
44. K Suzuki, S Kodama and M Watanabe (1999) Recruitment of ATM protein to double strand DNA irradiated with ionizing radiation. J Biol Chem 274 25,571-25,575.
45. S Banin, L Moyal, S Shieh, Y Taya, CW Anderson, L Chessa, NI Smorodinsky, C Prives, Y Reiss, Y Shiloh and Y Ziv (1998) Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science 281 1674-1677.
46. CE Canman, BS Lim, KA Cimprich, Y Taya, K Tamai, K Sakaguchi, E Appella, MB Kastan and J Siliciano (1998) Activation of the ATM kinase by ionizing radiation and phosphorylation of p 53. Science 281 1677-1679.
47. Y Andegeko, L Moyal, L Mittelman, I Tsarfaty, Y Shiloh and G Rotman (2001) Nuclear retention of ATM at sites of DNA double strand breaks. J Biol Chem 12 38,224-38,230.
48. ND Lakin, BC Hann and SP Jackson (1999) The ataxia-telang iectasia mutated protein ATR mediates DNA-dependent phosphorylation of p53. Oncogene 18 3989-3995.
49. Z Guo, A Kumagai, SX Wang and WG Dunphy (2000) Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts. Genes Dev 14 2745-2756.
50. D Cortez, S Guntuku, J Qin and SJ Elledge (2001) ATR and ATRIP: partners in checkpoint signaling. Science 294 1713-1716.
51. J Rouse and SP Jackson (2002) Lcd1p recruits Mec1p to DNA lesions in vitro and in vivo. Mol Cell 9 857-869.