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Volumn 6, Issue 2, 2013, Pages 170-177

Is high oral dose L-arginine intake effective in leukoaraiosis? Preliminary data, study protocol and expert's opinion

Author keywords

Cognitive decline; Gait imbalance; L arginine; Leukoaraiosis; Magnetic resonance; Neuropsychological assessment

Indexed keywords

ARGININE;

EID: 84882785203     PISSN: 18746098     EISSN: 18746128     Source Type: Journal    
DOI: 10.2174/1874609811306020005     Document Type: Article
Times cited : (10)

References (59)
  • 1
    • 0032773252 scopus 로고    scopus 로고
    • White matter changes in stroke patients. Relationship with stroke subtype and outcome
    • Leys D, Englund E, Del Ser T, et al. White matter changes in stroke patients. Relationship with stroke subtype and outcome. Eur Neurol 1999; 42(2): 67-75.
    • (1999) Eur Neurol , vol.42 , Issue.2 , pp. 67-75
    • Leys, D.1    Englund, E.2    Del, S.T.3
  • 2
    • 0037014581 scopus 로고    scopus 로고
    • Cerebral white matter lesions, retinopathy, and incident clinical stroke
    • Wong TY, Klein R, Sharrett AR, et al. Cerebral white matter lesions, retinopathy, and incident clinical stroke. JAMA 2002; 288: 67-74.
    • (2002) JAMA , vol.288 , pp. 67-74
    • Wong, T.Y.1    Klein, R.2    Sharrett, A.R.3
  • 5
    • 67449113713 scopus 로고    scopus 로고
    • Severity of leukoaraiosis correlates with clinical outcome after ischemic stroke
    • Arsava EM, Rahman R, Rosand J, et al. Severity of leukoaraiosis correlates with clinical outcome after ischemic stroke. Neurology 2009; 72: 1403-1410.
    • (2009) Neurology , vol.72 , pp. 1403-1410
    • Arsava, E.M.1    Rahman, R.2    Rosand, J.3
  • 6
    • 44449135131 scopus 로고    scopus 로고
    • Severity of leukoaraiosis and susceptibility to infarct growth in acute stroke
    • Ay H, Arsava EM, Rosand J, et al. Severity of leukoaraiosis and susceptibility to infarct growth in acute stroke. Stroke 2008; 39: 1409-1413.
    • (2008) Stroke , vol.39 , pp. 1409-1413
    • Ay, H.1    Arsava, E.M.2    Rosand, J.3
  • 7
    • 33947131632 scopus 로고    scopus 로고
    • Is leukoaraiosis on CT an accurate surrogate marker for the presence of microbleeds in acute stroke patients?
    • Görner A, Lemmens R, Schrooten M, Thijs V. Is leukoaraiosis on CT an accurate surrogate marker for the presence of microbleeds in acute stroke patients? J Neurol 2007; 254: 284-289.
    • (2007) J Neurol , vol.254 , pp. 284-289
    • Görner, A.1    Lemmens, R.2    Schrooten, M.3    Thijs, V.4
  • 8
    • 67650076525 scopus 로고    scopus 로고
    • Cerebral white matter lesions are associated with the risk of stroke but not with other vascular events: The 3-City Dijon Study
    • Buyck JF, Dufouil C, Mazoyer B, et al. Cerebral white matter lesions are associated with the risk of stroke but not with other vascular events: the 3-City Dijon Study. Stroke 2009; 40: 2327-2331.
    • (2009) Stroke , vol.40 , pp. 2327-2331
    • Buyck, J.F.1    Dufouil, C.2    Mazoyer, B.3
  • 9
    • 5344253243 scopus 로고    scopus 로고
    • Cerebral white matter lesions and the risk of dementia
    • Prins ND, van Dijk EJ, den Heijer T, et al. Cerebral white matter lesions and the risk of dementia. Arch Neurol 2004; 61:1531-1534.
    • (2004) Arch Neurol , vol.61 , pp. 1531-1534
    • Prins, N.D.1    van Dijk, E.J.2    den Heijer, T.3
  • 10
  • 11
    • 33751075727 scopus 로고    scopus 로고
    • Pathomechanism of laukoarariosis: A Molecular Bridge Between the Genetic, Biochemical, and Clinical Processes (a Mitochondrial Hypothesis)
    • Szolnoki Z. Pathomechanism of laukoarariosis: A Molecular Bridge Between the Genetic, Biochemical, and Clinical Processes (a Mitochondrial Hypothesis). Neuromol Med 2007; 9: 21-34.
    • (2007) Neuromol Med , vol.9 , pp. 21-34
    • Szolnoki, Z.1
  • 12
    • 0037338557 scopus 로고    scopus 로고
    • Is breakdown of the blood-brain barrier responsible for lacunar stroke, leukoaraiosis, and dementia?
    • Wardlaw JM, Sandercock PA, Dennis MS, Starr J. Is breakdown of the blood-brain barrier responsible for lacunar stroke, leukoaraiosis, and dementia? Stroke 2003; 34: 806-812.
    • (2003) Stroke , vol.34 , pp. 806-812
    • Wardlaw, J.M.1    Sandercock, P.A.2    Dennis, M.S.3    Starr, J.4
  • 14
    • 0031908926 scopus 로고    scopus 로고
    • Nitric oxide synthase inhibition in humans reduces cerebral blood flow but not the hyperaemic response to hypercapnia
    • White RP, Deane C, Vallance P, Markus HS. Nitric oxide synthase inhibition in humans reduces cerebral blood flow but not the hyperaemic response to hypercapnia. Stroke 1998; 29: 467-472.
    • (1998) Stroke , vol.29 , pp. 467-472
    • White, R.P.1    Deane, C.2    Vallance, P.3    Markus, H.S.4
  • 16
    • 49949087968 scopus 로고    scopus 로고
    • New indications and controversies in arginine therapy
    • Coman D, Yaplito-Lee J, Boneh A. New indications and controversies in arginine therapy. Clin Nutr 2008; 27: 489-496.
    • (2008) Clin Nutr , vol.27 , pp. 489-496
    • Coman, D.1    Yaplito-Lee, J.2    Boneh, A.3
  • 18
    • 0342991848 scopus 로고    scopus 로고
    • Restoring vascular nitric oxide formation by L-arginine improves the symptoms of intermittent claudication in patients with peripheral arterial occlusive disease
    • Böger RH, Bode-Böger SM, Thiele W, Creutzig A, Alexander K, Frölich JC. Restoring vascular nitric oxide formation by L-arginine improves the symptoms of intermittent claudication in patients with peripheral arterial occlusive disease. J Am Coll Cardiol 1998; 32:1336-1344.
    • (1998) J Am Coll Cardiol , vol.32 , pp. 1336-1344
    • Böger, R.H.1    Bode-Böger, S.M.2    Thiele, W.3    Creutzig, A.4    Alexander, K.5    Frölich, J.C.6
  • 19
    • 84882779124 scopus 로고    scopus 로고
    • Effect of oral administration of high-dose nitric oxide donor Larginine in men with organic erectile dysfunction: Results of a double-blind, randomized, placebo-controlled study
    • Chen J, Wollman Y, Chernichovsky T, Iaina A, Sofer M, Matzkin H. Effect of oral administration of high-dose nitric oxide donor Larginine in men with organic erectile dysfunction: results of a double-blind, randomized, placebo-controlled study. BJU Int 1999; 63: 220-223.
    • (1999) BJU Int , vol.63 , pp. 220-223
    • Chen, J.1    Wollman, Y.2    Chernichovsky, T.3    Iaina, A.4    Sofer, M.5    Matzkin, H.6
  • 20
    • 33847643298 scopus 로고    scopus 로고
    • MELAS and L-arginine therapy
    • Koga Y, Akita Y, Nishioka J, et al. MELAS and L-arginine therapy. Mitochondrion 2007; 7(1-2): 133-139.
    • (2007) Mitochondrion , vol.7 , Issue.1-2 , pp. 133-139
    • Koga, Y.1    Akita, Y.2    Nishioka, J.3
  • 21
    • 34547406118 scopus 로고    scopus 로고
    • Treatment of leukoaraiosis: A futuristic view
    • Helenius J, Tatlisumak T. Treatment of leukoaraiosis: a futuristic view. Curr Drug Targets 2007; 8: 839-845.
    • (2007) Curr Drug Targets , vol.8 , pp. 839-845
    • Helenius, J.1    Tatlisumak, T.2
  • 22
    • 0344464903 scopus 로고    scopus 로고
    • Brain diffusion changes in carotid occlusive disease treated with endarterectomy
    • Soinne L, Helenius J, Saimanen E, et al. Brain diffusion changes in carotid occlusive disease treated with endarterectomy. Neurology 2003; 61: 1061-1065.
    • (2003) Neurology , vol.61 , pp. 1061-1065
    • Soinne, L.1    Helenius, J.2    Saimanen, E.3
  • 23
    • 0033047493 scopus 로고    scopus 로고
    • A 24-month, double-blind, placebo-controlled multicentre pilot study of the efficacy and safety of nicergoline 60 mg per day in elderly hypertensive patients with leukoaraiosis
    • Bès A, Orgogozo JM, Poncet M, et al. A 24-month, double-blind, placebo-controlled multicentre pilot study of the efficacy and safety of nicergoline 60 mg per day in elderly hypertensive patients with leukoaraiosis. Eur J Neurol 1999; 6: 313-322.
    • (1999) Eur J Neurol , vol.6 , pp. 313-322
    • Bès, A.1    Orgogozo, J.M.2    Poncet, M.3
  • 24
    • 0029821586 scopus 로고    scopus 로고
    • A preliminary open trial with nimodipine in patients with cognitive impairment and leukoaraiosis
    • Pantoni L, Carosi M, Amigoni S, Mascalchi M, Inzitari D. A preliminary open trial with nimodipine in patients with cognitive impairment and leukoaraiosis. Clin Neuropharmacol 1996; 19: 497-506.
    • (1996) Clin Neuropharmacol , vol.19 , pp. 497-506
    • Pantoni, L.1    Carosi, M.2    Amigoni, S.3    Mascalchi, M.4    Inzitari, D.5
  • 25
    • 34249817585 scopus 로고    scopus 로고
    • The Pharmacodynamics of L-Arginine
    • Böger RH. The Pharmacodynamics of L-Arginine. J Nutr 2007; 137: 1650S-1655S.
    • (2007) J Nutr , vol.137
    • Böger, R.H.1
  • 26
    • 80052628813 scopus 로고    scopus 로고
    • Does L-arginine supplementation play a role in cerebral small vessels disease? Implication in the treatment of leukoaraiosis
    • Calabrò RS, Gervasi G, Bramanti P. Does L-arginine supplementation play a role in cerebral small vessels disease? Implication in the treatment of leukoaraiosis. Med Hypotheses 2011; 77: 671-673.
    • (2011) Med Hypotheses , vol.77 , pp. 671-673
    • Calabrò, R.S.1    Gervasi, G.2    Bramanti, P.3
  • 28
    • 0036742197 scopus 로고    scopus 로고
    • Accurate, robust, and automated longitudinal and cross-sectional brain change analysis
    • Smith SM, Zhang Y, Jenkinson M, et al. Accurate, robust, and automated longitudinal and cross-sectional brain change analysis. Neuroimage 2002; 17: 479-489.
    • (2002) Neuroimage , vol.17 , pp. 479-489
    • Smith, S.M.1    Zhang, Y.2    Jenkinson, M.3
  • 29
    • 0016823810 scopus 로고
    • Mini-mental state. A practical method for grading the cognitive state of patients for the clinician
    • Folstein MF, Folstein SE, McHugh PR. Mini-mental state. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12: 189-198.
    • (1975) J Psychiatr Res , vol.12 , pp. 189-198
    • Folstein, M.F.1    Folstein, S.E.2    McHugh, P.R.3
  • 33
    • 33749169804 scopus 로고
    • A simple objective technique for measuring flexibility in thinking
    • Berg EA. A simple objective technique for measuring flexibility in thinking. J Gen Psychol 1948; 39: 15-22.
    • (1948) J Gen Psychol , vol.39 , pp. 15-22
    • Berg, E.A.1
  • 34
    • 0002603228 scopus 로고
    • Standardizzazione e taratura italiana di Test neuropsicologici
    • Spinnler H, Tognoni G. Standardizzazione e taratura italiana di Test neuropsicologici. Ital J Neurol Sci 1987; (suppl 8): 6.
    • (1987) Ital J Neurol Sci , Issue.SUPPL. 8 , pp. 6
    • Spinnler, H.1    Tognoni, G.2
  • 35
    • 0036225711 scopus 로고    scopus 로고
    • Rey-Osterrieth complex figure: Normative values in an Italian population sample
    • Caffarra P, Vezzadini G, Dieci F, Zonato F, Venneri A. Rey-Osterrieth complex figure: normative values in an Italian population sample. Neurol Sci 2002; 22: 443-447.
    • (2002) Neurol Sci , vol.22 , pp. 443-447
    • Caffarra, P.1    Vezzadini, G.2    Dieci, F.3    Zonato, F.4    Venneri, A.5
  • 36
    • 0000719740 scopus 로고
    • Tre test clinici di ricerca e produzione lessicale. Taratura su soggetti normali. Archivio di Psicologia
    • Novelli G, Papagno C, Capitani E, Laiacona N, Vallar G, Cappa SF. Tre test clinici di ricerca e produzione lessicale. Taratura su soggetti normali. Archivio di Psicologia, Neurologia e Psichiatria 1986; 47: 447-506.
    • (1986) Neurologia E Psichiatria , vol.47 , pp. 447-506
    • Novelli, G.1    Papagno, C.2    Capitani, E.3    Laiacona, N.4    Vallar, G.5    Cappa, S.F.6
  • 39
    • 51549099524 scopus 로고
    • The assessment of anxiety states by rating
    • Hamilton M. The assessment of anxiety states by rating. Br J Med Psychol 1959; 32: 50-55.
    • (1959) Br J Med Psychol , vol.32 , pp. 50-55
    • Hamilton, M.1
  • 41
    • 1642572165 scopus 로고
    • Jaffe MW. Studies of illness in the aged. The index of ADL: A standardized measure of biological and psychosocial function
    • Katz S, Ford AB, Moskowitz RW, Jackson BA, Jaffe MW. Studies of illness in the aged. The index of ADL: A standardized measure of biological and psychosocial function. JAMA 1963; 185: 914-919.
    • (1963) JAMA , vol.185 , pp. 914-919
    • Katz, S.1    Ford, A.B.2    Moskowitz, R.W.3    Jackson, B.A.4
  • 42
    • 0014579432 scopus 로고
    • Assessment of older people: Selfmaintaining and instrumental activities of daily living
    • Lawton MP, Brody EM. Assessment of older people: selfmaintaining and instrumental activities of daily living. Gerontologist 1969; 9: 179-186.
    • (1969) Gerontologist , vol.9 , pp. 179-186
    • Lawton, M.P.1    Brody, E.M.2
  • 44
    • 44449149915 scopus 로고    scopus 로고
    • Leukoaraiosis: From an ancient term to an actual marker of poor prognosis
    • Pantoni L. Leukoaraiosis: from an ancient term to an actual marker of poor prognosis. Stroke 2008; 39:1401-1413.
    • (2008) Stroke , vol.39 , pp. 1401-1413
    • Pantoni, L.1
  • 45
    • 33745618970 scopus 로고    scopus 로고
    • Leukoaraiosis predicts hidden global functioning impairment in nondisabled older people: The LADIS (Leukoaraiosis and Disability in the Elderly) Study
    • Pantoni L, Poggesi A, Basile AM, et al. Leukoaraiosis predicts hidden global functioning impairment in nondisabled older people: the LADIS (Leukoaraiosis and Disability in the Elderly) Study. J Am Geriatr Soc 2006; 54:1095-1101.
    • (2006) J Am Geriatr Soc , vol.54 , pp. 1095-1101
    • Pantoni, L.1    Poggesi, A.2    Basile, A.M.3
  • 46
    • 61649123570 scopus 로고    scopus 로고
    • Longitudinal cognitive decline in subcortical ischemic vascular disease--the LADIS Study
    • Jokinen H, Kalska H, Ylikoski R, et al. Longitudinal cognitive decline in subcortical ischemic vascular disease--the LADIS Study. Cerebrovasc Dis 2009; 27: 384-391.
    • (2009) Cerebrovasc Dis , vol.27 , pp. 384-391
    • Jokinen, H.1    Kalska, H.2    Ylikoski, R.3
  • 47
    • 68149108650 scopus 로고    scopus 로고
    • Changes in white matter as determinant of global functional decline in older independent outpatients: Three year follow-up of LADIS (leukoaraiosis and disability) study cohort
    • Inzitari D, Pracucci G, Poggesi A, et al. Changes in white matter as determinant of global functional decline in older independent outpatients: three year follow-up of LADIS (leukoaraiosis and disability) study cohort. BMJ 2009; 339: b2477.
    • (2009) BMJ , vol.339
    • Inzitari, D.1    Pracucci, G.2    Poggesi, A.3
  • 49
    • 84874230749 scopus 로고    scopus 로고
    • Leukoaraiosis, a common brain magnetic resonance imaging finding, as a predictor of traffic crashes
    • Park K, Nakagawa Y, Kumagai Y, Nagahara M. Leukoaraiosis, a common brain magnetic resonance imaging finding, as a predictor of traffic crashes. PLoS One 2013; 8: e57255.
    • (2013) PLoS One , vol.8
    • Park, K.1    Nakagawa, Y.2    Kumagai, Y.3    Nagahara, M.4
  • 50
    • 84858177941 scopus 로고    scopus 로고
    • White matter damage along the uncinate fasciculus contributes to cognitive decline in AD and DLB
    • Serra L, Cercignani M, Basile B, et al. White matter damage along the uncinate fasciculus contributes to cognitive decline in AD and DLB. Curr Alzheimer Res 2012; 9: 326-333.
    • (2012) Curr Alzheimer Res , vol.9 , pp. 326-333
    • Serra, L.1    Cercignani, M.2    Basile, B.3
  • 51
    • 84882739919 scopus 로고    scopus 로고
    • Leukoaraiosis is associated with short-and long-term mortality in patients with Intracerebral Hemorrhage
    • doi:pii: S1052-3057(13)00023-2.10.1016/j.jstrokecerebrovasdis.2013.01.017
    • Tveiten A, Ljøstad U, Mygland A, Naess H. Leukoaraiosis is associated with short-and long-term mortality in patients with Intracerebral Hemorrhage. J Stroke Cerebrovasc Dis 2013. doi:pii: S1052-3057(13)00023-2.10.1016/j.jstrokecerebrovasdis.2013.01.017.
    • (2013) J Stroke Cerebrovasc Dis
    • Tveiten, A.1    Ljøstad, U.2    Mygland, A.3    Naess, H.4
  • 52
    • 84876273287 scopus 로고    scopus 로고
    • Leukoaraiosis on magnetic resonance imaging correlates with worse outcomes after spontaneous intracerebral hemorrhage
    • Caprio FZ, Maas MB, Rosenberg NF, et al. Leukoaraiosis on magnetic resonance imaging correlates with worse outcomes after spontaneous intracerebral hemorrhage. Stroke 2013; 44: 642-646.
    • (2013) Stroke , vol.44 , pp. 642-646
    • Caprio, F.Z.1    Maas, M.B.2    Rosenberg, N.F.3
  • 53
    • 84874911379 scopus 로고    scopus 로고
    • Magnetic resonance imaging in Alzheimer's disease: From diagnosis to monitoring treatment effect
    • Filippi M, Agosta F, Frisoni GB, et al. Magnetic resonance imaging in Alzheimer's disease: from diagnosis to monitoring treatment effect. Curr Alzheimer Res 2012; 9: 1198-1209.
    • (2012) Curr Alzheimer Res , vol.9 , pp. 1198-1209
    • Filippi, M.1    Agosta, F.2    Frisoni, G.B.3
  • 54
    • 84882786556 scopus 로고    scopus 로고
    • L-arginine-nitric oxide pathway and oxidative stress in plasma and platelets of patients with pre-eclampsia
    • doi: 10.1038/hr.2013.34
    • Pimentel AM, Pereira NR, Costa CA, et al. L-arginine-nitric oxide pathway and oxidative stress in plasma and platelets of patients with pre-eclampsia. Hypertens Res 2013; doi: 10.1038/hr.2013.34.
    • (2013) Hypertens Res
    • Pimentel, A.M.1    Pereira, N.R.2    Costa, C.A.3
  • 55
    • 49949087968 scopus 로고    scopus 로고
    • New indications and controversies in arginine therapy
    • Coman D, Yaplito-Lee J, Boneh A. New indications and controversies in arginine therapy. Clin Nutr 2008; 27: 489-496.
    • (2008) Clin Nutr , vol.27 , pp. 489-496
    • Coman, D.1    Yaplito-Lee, J.2    Boneh, A.3
  • 56
    • 84878607703 scopus 로고    scopus 로고
    • Effects of L-arginine and N_-nitro-L-arginine methylester on learning and memory and _7 nAChR expression in the prefrontal cortex and hippocampus of rats
    • Wei XM, Yang W, Liu LX, Qi WX. Effects of L-arginine and N_-nitro-L-arginine methylester on learning and memory and _7 nAChR expression in the prefrontal cortex and hippocampus of rats. Neurosci Bull 2013; 29(3): 303-310.
    • (2013) Neurosci Bull , vol.29 , Issue.3 , pp. 303-310
    • Wei, X.M.1    Yang, W.2    Liu, L.X.3    Qi, W.X.4
  • 57
    • 84860527408 scopus 로고    scopus 로고
    • Lifestyle and genetic contributions to cognitive decline and hippocampal structure and function in healthy aging
    • Woodard JL, Sugarman MA, Nielson KA, et al. Lifestyle and genetic contributions to cognitive decline and hippocampal structure and function in healthy aging. Curr Alzheimer Res 2012; 9: 436-446.
    • (2012) Curr Alzheimer Res , vol.9 , pp. 436-446
    • Woodard, J.L.1    Sugarman, M.A.2    Nielson, K.A.3
  • 58
    • 84870946741 scopus 로고    scopus 로고
    • Physical activity prevents progression for cognitive impairment and vascular dementia: Results from the LADIS (Leukoaraiosis and Disability) study
    • Verdelho A, Madureira S, Ferro JM, et al. Physical activity prevents progression for cognitive impairment and vascular dementia: results from the LADIS (Leukoaraiosis and Disability) study. Stroke 2012; 43: 3331-3335.
    • (2012) Stroke , vol.43 , pp. 3331-3335
    • Verdelho, A.1    Madureira, S.2    Ferro, J.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.