New indications and controversies in arginine therapy

Clinical Nutrition

Volumn 27, Issue 4, 2008, Pages 489-496

  Coman, David ^a   Yaplito Lee, Joy ^a   Boneh, Avihu ^a,b  

^a MURDOCH CHILDREN'S RESEARCH INSTITUTE   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Arginine; Asthma; Citrulline; Creatine; Glutaric aciduria type I; MELAS; Nitric oxide; Urea cycle

Indexed keywords

AMMONIA; ARGININE; CITRULLINE; CREATINE; NITRIC OXIDE; UREA;

AMINO ACID METABOLISM; AMINO ACID TRANSPORT; ASTHMA; CREATINE DEFICIENCY; DIET RESTRICTION; DIET SUPPLEMENTATION; DRUG OVERDOSE; DRUG SAFETY; GLUTARIC ACIDURIA TYPE 1; HUMAN; MELAS SYNDROME; METABOLIC DISORDER; NECROTIZING ENTEROCOLITIS; NONHUMAN; PERSISTENT PULMONARY HYPERTENSION; PROTEIN INTOLERANCE; REVIEW; UREA CYCLE DEFECT;

ACIDOSIS, LACTIC; AMINO ACID METABOLISM, INBORN ERRORS; ARGININE; CENTRAL NERVOUS SYSTEM; CREATINE; DIETARY SUPPLEMENTS; HUMANS; MELAS SYNDROME; MITOCHONDRIAL MYOPATHIES; NITRIC OXIDE; VASCULAR DISEASES;

EID: 49949087968     PISSN: 02615614     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clnu.2008.05.007     Document Type: Review

References (85)

1. Flynn N.E., Meininger C.J., Haynes T.E., and Wu G. The metabolic basis of arginine nutrition and pharmacotherapy. Biomed Pharmacother 56 (2002) 427-438
2. Morris Jr. S.M. Enzymes of arginine metabolism. J Nutr 134 (2004) 2743S-2747S [discussion: 2765S-7S]
3. Castillo L., Chapman T.E., Sanchez M., et al. Plasma arginine and citrulline kinetics in adults given adequate and arginine-free diets. Proc Natl Acad Sci U S A 90 (1993) 7749-7753
4. Castillo L., Chapman T.E., Yu Y.M., Ajami A., Burke J.F., and Young V.R. Dietary arginine uptake by the splanchnic region in adult humans. Am J Physiol 265 (1993) E532-E539
5. Castillo L., DeRojas-Walker T., Yu Y.M., et al. Whole body arginine metabolism and nitric oxide synthesis in newborns with persistent pulmonary hypertension. Pediatr Res 38 (1995) 17-24
6. Johnson J.D., Albritton W.L., and Sunshine P. Hyperammonemia accompanying parenteral nutrition in newborn infants. J Pediatr 81 (1972) 154-161
7. Wu G., and Meininger C.J. Arginine nutrition and cardiovascular function. J Nutr 130 (2000) 2626-2629
8. Wu G. Synthesis of citrulline and arginine from proline in enterocytes of postnatal pigs. Am J Physiol 272 (1997) G1382-G1390
9. De Jonge W.J., Dingemanse M.A., de Boer P.A., Lamers W.H., and Moorman A.F. Arginine-metabolizing enzymes in the developing rat small intestine. Pediatr Res 43 (1998) 442-451
10. Morris Jr. S.M., Sweeney Jr. W.E., Kepka D.M., O'Brien W.E., and Avner E.D. Localization of arginine biosynthetic enzymes in renal proximal tubules and abundance of mRNA during development. Pediatr Res 29 (1991) 151-154
11. Meijer A.J., Lamers W.H., and Chamuleau R.A. Nitrogen metabolism and ornithine cycle function. Physiol Rev 70 (1990) 701-748
12. Jenkinson C.P., Grody W.W., and Cederbaum S.D. Comparative properties of arginases. Comp Biochem Physiol B Biochem Mol Biol 114 (1996) 107-132
13. Morris Jr. S.M. Regulation of enzymes of urea and arginine synthesis. Annu Rev Nutr 12 (1992) 81-101
14. Gotoh T., Sonoki T., Nagasaki A., Terada K., Takiguchi M., and Mori M. Molecular cloning of cDNA for nonhepatic mitochondrial arginase (arginase II) and comparison of its induction with nitric oxide synthase in a murine macrophage-like cell line. FEBS Lett 395 (1996) 119-122
15. Nissim I., Daikhin Y., Luhovyy B., Horyn O., Wehkli S.L., and Yudkoff M. Agmatine stimulates hepatic fatty acid oxidation: a possible mechanism for up-regulation of ureagenesis. J Biol Chem 281 (2006) 8486-8496 Epub 2006 Feb 8481
16. Reis D.J., and Regunathan S. Is agmatine a novel neurotransmitter in brain?. Trends Pharmacol Sci 21 (2000) 187-193
17. Satriano J., Matsufuji S., Murakami Y., et al. Agmatine suppresses proliferation by frameshift induction of antizyme and attenuation of cellular polyamine levels. J Biol Chem 273 (1998) 15313-15316
18. Galea E., Regunathan S., Eliopoulos V., Feinstein D.L., and Reis D.J. Inhibition of mammalian nitric oxide synthases by agmatine, an endogenous polyamine formed by decarboxylation of arginine. Biochem J 316 Pt. 1 (1996) 247-249
19. Closs E.I. Expression, regulation and function of carrier proteins for cationic amino acids. Curr Opin Nephrol Hypertens 11 (2002) 99-107
20. Grillo M.A., and Colombatto S. Arginine revisited: minireview article. Amino Acids 26 (2004) 345-351
21. Bachmann C., Braissant O., Villard A.M., Boulat O., and Henry H. Ammonia toxicity to the brain and creatine. Mol Genet Metab 81 Suppl. 1 (2004) S52-S57
22. Fiermonte G., Dolce V., David L., et al. The mitochondrial ornithine transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution of two human isoforms. J Biol Chem 278 (2003) 32778-32783
23. Nakamura H., Saheki T., and Nakagawa S. Differential cellular localization of enzymes of l-arginine metabolism in the rat brain. Brain Res 530 (1990) 108-112
24. Braissant O., Gotoh T., Loup M., Mori M., and Bachmann C. l-arginine uptake, the citrulline-NO cycle and arginase II in the rat brain: an in situ hybridization study. Brain Res Mol Brain Res 70 (1999) 231-241
25. Braissant O., Honegger P., Loup M., Mori M., and Bachmann C. Hyperammonemia: regulation of argininosuccinate synthetase and argininosuccinate lyase genes in aggregating cell cultures of fetal rat brain. Neurosci Lett 266 (1999) 89-92
26. Wiesinger H. Arginine metabolism and the synthesis of nitric oxide in the nervous system. Prog Neurobiol 64 (2001) 365-391
27. Kline J.J., Hug G., Schubert W.K., and Berry H. Arginine deficiency syndrome. Its occurrence in carbamyl phosphate synthetase deficiency. Am J Dis Child 135 (1981) 437-442
28. Wilcken B. Problems in the management of urea cycle disorders. Mol Genet Metab 81 Suppl. 1 (2004) S86-S91
29. Nissim I., Horyn O., Daikhin Y., Lazarow A., and Yudkoff M. Regulation of urea synthesis by agmatine in the perfused liver: studies with 15N. Am J Physiol Endocrinol Metab 283 (2002) E1123-E1134 [Epub 2002 Aug 13]
30. Nissim I., Luhovyy B., Horyn O., Daikhin Y., and Yudkoff M. The role of mitochondrially bound arginase in the regulation of urea synthesis: studies with [U-15N4]arginine, isolated mitochondria, and perfused rat liver. J Biol Chem 280 (2005) 17715-17724 [Epub 2005 Mar 7]
31. Huynh N.N., and Chin-Dusting J. Amino acids, arginase and nitric oxide in vascular health. Clin Exp Pharmacol Physiol 33 (2006) 1-8
32. Berka V., Wu G., Yeh H.C., Palmer G., and Tsai A.L. Three different oxygen-induced radical species in endothelial nitric-oxide synthase oxygenase domain under regulation by l-arginine and tetrahydrobiopterin. J Biol Chem 279 (2004) 32243-32251
33. Moncada S., Palmer R.M., and Higgs E.A. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 43 (1991) 109-142
34. Wyss M., and Kaddurah-Daouk R. Creatine and creatinine metabolism. Physiol Rev 80 (2000) 1107-1213
35. Braissant O., Henry H., Villard A.M., Speer O., Wallimann T., and Bachmann C. Creatine synthesis and transport during rat embryogenesis: spatiotemporal expression of AGAT, GAMT and CT1. BMC Dev Biol 5 (2005) 9
36. Braissant O., Henry H., Villard A.M., et al. Ammonium-induced impairment of axonal growth is prevented through glial creatine. J Neurosci 22 (2002) 9810-9820
37. Ratnakumari L., Qureshi I.A., Butterworth R.F., Marescau B., and De Deyn P.P. Arginine-related guanidino compounds and nitric oxide synthase in the brain of ornithine transcarbamylase deficient spf mutant mouse: effect of metabolic arginine deficiency. Neurosci Lett 215 (1996) 153-156
38. Braissant O., Henry H., Loup M., Eilers B., and Bachmann C. Endogenous synthesis and transport of creatine in the rat brain: an in situ hybridization study. Brain Res Mol Brain Res 86 (2001) 193-201
39. Schimke R.T. Enzymes of arginine metabolism in cell culture: studies on enzyme induction and repression. Natl Cancer Inst Monogr 13 (1964) 197-216
40. Jackson M.J., Allen S.J., Beaudet A.L., and O'Brien W.E. Metabolite regulation of argininosuccinate synthetase in cultured human cells. J Biol Chem 263 (1988) 16388-16394
41. Lee J., Ryu H., Ferrante R.J., Morris Jr. S.M., and Ratan R.R. Translational control of inducible nitric oxide synthase expression by arginine can explain the arginine paradox. Proc Natl Acad Sci U S A 100 (2003) 4843-4848
42. El-Gayar S., Thuring-Nahler H., Pfeilschifter J., Rollinghoff M., and Bogdan C. Translational control of inducible nitric oxide synthase by IL-13 and arginine availability in inflammatory macrophages. J Immunol 171 (2003) 4561-4568
43. Fernandez J., Lopez A.B., Wang C., et al. Transcriptional control of the arginine/lysine transporter, cat-1, by physiological stress. J Biol Chem 278 (2003) 50000-50009
44. Batshaw M.L., Wachtel R.C., Thomas G.H., Starrett A., and Brusilow S.W. Arginine-responsive asymptomatic hyperammonemia in the premature infant. J Pediatr 105 (1984) 86-91
45. Summar M.L., Hall L., Christman B., et al. Environmentally determined genetic expression: clinical correlates with molecular variants of carbamyl phosphate synthetase I. Mol Genet Metab 81 Suppl. 1 (2004) S12-S19
46. Luiking Y.C., Poeze M., Dejong C.H., Ramsay G., and Deutz N.E. Sepsis: an arginine deficiency state?. Crit Care Med 32 (2004) 2135-2145
47. Pearson D.L., Dawling S., Walsh W.F., et al. Neonatal pulmonary hypertension-urea-cycle intermediates, nitric oxide production, and carbamoyl-phosphate synthetase function. N Engl J Med 344 (2001) 1832-1838
48. Saudubray J.M., Touati G., Delonlay P., et al. Liver transplantation in urea cycle disorders. Eur J Pediatr 158 Suppl. 2 (1999) S55-S59
49. + LAT-1, as the lysinuric protein intolerance gene. Nat Genet 21 (1999) 293-296
50. Leonard J.V. The nutritional management of urea cycle disorders. J Pediatr 138 (2001) S40-S44 [discussion S44-5]
51. Lee B., Yu H., Jahoor F., O'Brien W., Beaudet A.L., and Reeds P. In vivo urea cycle flux distinguishes and correlates with phenotypic severity in disorders of the urea cycle. Proc Natl Acad Sci U S A 97 (2000) 8021-8026
52. Arias A., Garcia-Villoria J., and Ribes A. Guanidinoacetate and creatine/creatinine levels in controls and patients with urea cycle defects. Mol Genet Metab 82 (2004) 220-223
53. Nagasaka H., Yorifuji T., Murayama K., et al. Effects of arginine treatment on nutrition, growth and urea cycle function in seven Japanese boys with late-onset ornithine transcarbamylase deficiency. Eur J Pediatr 165 (2006) 618-624 Epub 2006 May 16
54. Walser M., Batshaw M., Sherwood G., Robinson B., and Brusilow S. Nitrogen metabolism in neonatal citrullinaemia. Clin Sci Mol Med 53 (1977) 173-181
55. Brusilow S.W., Valle D.L., and Batshaw M. New pathways of nitrogen excretion in inborn errors of urea synthesis. Lancet 2 (1979) 452-454
56. Batshaw M.L., Brusilow S., Waber L., et al. Treatment of inborn errors of urea synthesis: activation of alternative pathways of waste nitrogen synthesis and excretion. N Engl J Med 306 (1982) 1387-1392
57. Summar M. Current strategies for the management of neonatal urea cycle disorders. J Pediatr 138 (2001) S30-S39
58. Kolker S., Sauer S.W., Okun J.G., Hoffmann G.F., and Koeller D.M. Lysine intake and neurotoxicity in glutaric aciduria type I: towards a rationale for therapy?. Brain 129 (2006) e54
59. Kolker S., Sauer S.W., Surtees R.A., and Leonard J.V. The aetiology of neurological complications of organic acidaemias-a role for the blood-brain barrier. J Inherit Metab Dis 29 (2006) 701-704 [discussion 705-6] Epub 2006 Oct 14
60. Sijens P.E., Reijngoud D.J., Soorani-Lunsing R.J., Oudkerk M., and van Spronsen F.J. Cerebral 1H MR spectroscopy showing elevation of brain guanidinoacetate in argininosuccinate lyase deficiency. Mol Genet Metab 88 (2006) 100-102
61. Schulze A., Ebinger F., Rating D., and Mayatepek E. Improving treatment of guanidinoacetate methyltransferase deficiency: reduction of guanidinoacetic acid in body fluids by arginine restriction and ornithine supplementation. Mol Genet Metab 74 (2001) 413-419
62. Newnham T.H., Allen W., Wellard K., Hamilton R.M., Jones C., and Boneh R. A liver transplantation for argininosuccinic aciduria: clinical, biochemical and metabolic outcome. Liver Transpl 14 (2008) 41-45
63. Iyer R., Jenkinson C.P., Vockley J.G., Kern R.M., Grody W.W., and Cederbaum S. The human arginases and arginase deficiency. J Inherit Metab Dis 21 Suppl. 1 (1998) 86-100
64. Cederbaum S.D., Yu H., Grody W.W., Kern R.M., Yoo P., and Iyer R.K. Arginases I and II: do their functions overlap?. Mol Genet Metab 81 Suppl. 1 (2004) S38-S44
65. Scaglia F., and Lee B. Clinical, biochemical, and molecular spectrum of hyperargininemia due to arginase I deficiency. Am J Med Genet C Semin Med Genet 142 (2006) 113-120
66. Amin H.J., Zamora S.A., McMillan D.D., et al. Arginine supplementation prevents necrotizing enterocolitis in the premature infant. J Pediatr 140 (2002) 425-431
67. McCaffrey M.J., Bose C.L., Reiter P.D., and Stiles A.D. Effect of l-arginine infusion on infants with persistent pulmonary hypertension of the newborn. Biol Neonate 67 (1995) 240-243
68. Baggio R., Emig F.A., Christianson D.W., Ash D.E., Chakder S., and Rattan S. Biochemical and functional profile of a newly developed potent and isozyme-selective arginase inhibitor. J Pharmacol Exp Ther 290 (1999) 1409-1416
69. Kim N.N., Cox J.D., Baggio R.F., et al. Probing erectile function: S-(2-boronoethyl)-l-cysteine binds to arginase as a transition state analogue and enhances smooth muscle relaxation in human penile corpus cavernosum. Biochemistry 40 (2001) 2678-2688
70. Wilson A.M., Harada R., Nair N., Balasubramanian N., and Cooke J.P. l-arginine supplementation in peripheral arterial disease: no benefit and possible harm. Circulation 116 (2007) 188-195 Epub 2007 Jun 25
71. Koga Y., Ishibashi M., Ueki I., et al. Effects of l-arginine on the acute phase of strokes in three patients with MELAS. Neurology 58 (2002) 827-828
72. Kubota M., Sakakihara Y., Mori M., Yamagata T., and Momoi-Yoshida M. Beneficial effect of l-arginine for stroke-like episode in MELAS. Brain Dev 26 (2004) 481-483 [discussion 480]
73. Koga Y., Akita Y., Nishioka J., et al. l-arginine improves the symptoms of stroke-like episodes in MELAS. Neurology 64 (2005) 710-712
74. Koga Y., Akita Y., Junko N., et al. Endothelial dysfunction in MELAS improved by l-arginine supplementation. Neurology 66 (2006) 1766-1769
75. Vega-Agapito V., Almeida A., Hatzoglou M., and Bolanos J.P. Peroxynitrite stimulates l-arginine transport system y(+) in glial cells. A potential mechanism for replenishing neuronal l-arginine. J Biol Chem 277 (2002) 29753-29759 Epub 2002 Jun 10
76. Zimmermann N., King N.E., Laporte J., et al. Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis. J Clin Invest 111 (2003) 1863-1874
77. Vercelli D. Arginase: marker, effector, or candidate gene for asthma?. J Clin Invest 111 (2003) 1815-1817
78. Morris C.R., Poljakovic M., Lavrisha L., Mahcado L., Kuypers F.A., and Morris Jr. S.M. Decreased arginine bioavailability and increased serum arginase activity in asthma. Am J Respir Crit Care Med 170 (2004) 148-153
79. Meurs H., Maarsingh H., and Zaagsma J. Arginase and asthma: novel insights into nitric oxide homeostasis and airway hyperresponsiveness. Trends Pharmacol Sci 24 (2003) 450-455
80. Maarsingh H., Leusink J., Bos I.S., Zaagsma J., and Meurs H. Arginase strongly impairs neuronal nitric oxide-mediated airway smooth muscle relaxation in allergic asthma. Respir Res 7 (2006) 6
81. deGrauw T.J., Cecil K.M., Byars A.W., Salomons G.S., Ball W.S., and Jakobs C. The clinical syndrome of creatine transporter deficiency. Mol Cell Biochem 244 (2003) 45-48
82. Summar M., Pietsch J., Deshpande J., and Schulman G. Effective hemodialysis and hemofiltration driven by an extracorporeal membrane oxygenation pump in infants with hyperammonemia. J Pediatr 128 (1996) 379-382
83. Nakano D., Pollock J.S., and Pollock D.M. Renal medullary ETB receptors produce diuresis and natriuresis via NOS1. Am J Physiol Renal Physiol 294 (2008) F1205-F1211
84. Gerard J.M., and Luisiri A. A fatal overdose of arginine hydrochloride. J Toxicol Clin Toxicol 35 (1997) 621-625
85. Kato T., Mizutani N., and Ban M. Hyperammonemia in lysinuric protein intolerance. Pediatrics 73 (1984) 489-492