Leukoaraiosis predicts hidden global functioning impairment in nondisabled older people: The LADIS (Leukoaraiosis and Disability in the Elderly) study

Journal of the American Geriatrics Society

Volumn 54, Issue 7, 2006, Pages 1095-1101

  Pantoni, Leonardo ^a   Poggesi, Anna ^a   Basile, Anna Maria ^a   Pracucci, Giovanni ^a   Barkhof, Frederik ^b   Chabriat, Hugues ^c   Erkinjuntti, Timo ^d   Ferro, José M ^e   Hennerici, Michael ^f   O'Brien, John ^g   Schmidt, Reinhold ^h   Visser, Marieke C ^b   Wahlund, Lars Olof ⁱ   Waldemar, Gunhild ^j   Wallin, Anders ^k   Inzitari, Domenico ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c HÔPITAL LARIBOISIÈRE   (France)

^d UNIVERSITY OF HELSINKI   (Finland)

^e Centro de Estudos Egas Moniz   (Portugal)

^f UNIVERSITY OF HEIDELBERG   (Germany)

^g NEWCASTLE UNIVERSITY   (United Kingdom)

^h MEDICAL UNIVERSITY OF GRAZ   (Austria)

ⁱ KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^j Mental Health Services CPH   (Denmark)

^k UNIVERSITY OF GOTHENBURG   (Sweden)

more..

Author keywords

Disability; Executive functions; Functional assessment; MRI; White matter changes

Indexed keywords

AGED; ARTICLE; BRAIN DAMAGE; CEREBROVASCULAR DISEASE; COGNITIVE DEFECT; CONTROLLED STUDY; DISABILITY; DISABILITY ASSESSMENT FOR DEMENTIA SCALE; DISEASE ASSOCIATION; DISEASE SEVERITY; FAZEKAS SCALE; FEMALE; FUNCTIONAL DISEASE; GERIATRIC DISORDER; HUMAN; LEUKOARAIOSIS; MAJOR CLINICAL STUDY; MALE; MENTAL FUNCTION; MOOD DISORDER; MOTOR DYSFUNCTION; MULTIPLE LINEAR REGRESSION ANALYSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; RATING SCALE; WHITE MATTER;

ACTIVITIES OF DAILY LIVING; AGED; AGED, 80 AND OVER; COGNITION DISORDERS; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; LEUKOARAIOSIS; MAGNETIC RESONANCE IMAGING; MALE; MOTOR SKILLS; TELENCEPHALON;

EID: 33745618970     PISSN: 00028614     EISSN: 15325415     Source Type: Journal    
DOI: 10.1111/j.1532-5415.2006.00798.x     Document Type: Article

References (27)

1. Hachinski VC, Potter P, Merskey H. Leuko-araiosis. Arch Neurol 1987;44:21-23.
2. Pantoni L, Garcia JH. The significance of cerebral white matter abnormalities 100 years after Binswanger's report. A review. Stroke 1995;26:1293-1301.
3. Longstreth WT, Manolio TA, Arnold A et al. Clinical correlates of white matter findings on cranial magnetic resonance imaging of 3302 elderly people. The Cardiovascular Health Study. Stroke 1996;27:1274-1282.
4. Liao D, Cooper L, Cai J et al. Presence and severity of cerebral white matter lesions and hypertension, its treatment, and its control. The ARIC Study. Atherosclerosis Risk in Communities Study. Stroke 1996;27:2262-2270.
5. De Leeuw FE, de Groot JC, Achten E et al. Prevalence of cerebral white matter lesions in elderly people: A population based magnetic resonance imaging study. The Rotterdam Scan Study. J Neurol Neurosurg Psychiatry 2001;70:9-14.
6. Pantoni L, Garcia JH. Pathogenesis of leukoaraiosis: A review. Stroke 1997;28:652-659.
7. Tell GS, Lefkowitz DS, Diehr P et al. Relationship between balance and abnormalities in cerebral magnetic resonance imaging in older adults. Arch Neurol 1998;55:73-79.
8. Sakakibara R, Hattori T, Uchiyama T et al. Urinary function in elderly people with and without leukoaraiosis: Relation to cognitive and gait function. J Neurol Neurosurg Psychiatry 1999;67:658-660.
9. Schmidt R, Fazekas F, Offenbacher H et al. Neuropsychologic correlates of MRI white matter hyperintensities: A study of 150 normal volunteers. Neurology 1993;43:2490-2494.
10. Ylikoski R, Ylikoski A, Erkinjuntti T et al. White matter changes in healthy elderly persons correlate with attention and speed of mental processing. Arch Neurol 1993;50:818-824.
11. Breteler MM, van Amerongen NM, van Swieten JC et al. Cognitive correlates of ventricular enlargement and cerebral white matter lesions on magnetic resonance imaging. The Rotterdam Study. Stroke 1994;25:1109-1115.
12. O'Brien J, Ames D, Chiu E et al. Severe deep white matter lesions and outcome in elderly patients with major depressive disorder: Follow up study. BMJ 1998;317:982-984.
13. O'Brien J, Desmond P, Ames D et al. A magnetic resonance imaging study of white matter lesions in depression and Alzheimer's disease. Br J Psychiatry 1996;168:477-485.
14. Steingart A, Hachinski VC, Lau C et al. Cognitive and neurologic findings in subjects with diffuse white matter lucencies on computed tomographic scan (leuko-araiosis). Arch Neurol 1987;44:32-35.
15. Masdeu JC, Wolfson L, Lantos G et al. Brain white-matter changes in the elderly prone to falling. Arch Neurol 1989;46:1292-1296.
16. Kerber KA, Enrietto JA, Jacobson KM et al. Disequilibrium in older people: A prospective study. Neurology 1998;51:574-580.
17. Baloh RW, Ying SH, Jacobson KM. A longitudinal study of gait and balance dysfunction in normal older people. Arch Neurol 2003;60:835-839.
18. Pantoni L, Basile AM, Pracucci G et al. Impact of age-related cerebral white matter changes on the transition to disability - the LADIS study: Rationale, design and methodology. Neuroepidemiology 2005;24:51-62.
19. Fazekas F, Chawluk JB, Alavi A et al. MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging. AJNR Am J Neuroradiol 1987;8:421-426.
20. Lawton MP, Brody EM. Assessment of older people: Self-maintaining and instrumental activities of daily living. Gerontologist 1969;9:179-186.
21. Gelinàs I, Gauthier L, McIntyre M et al. Development of a functional measure for persons with Alzheimer's disease: The disability assessment for dementia. Am J Occup Ther 1999;53:471-481.
22. McLeod CM. Half a century of research on the Stroop effect: An integrative review. Psychol Bull 1991;109:163-203.
23. Reitan RM. Validity of the Trail Making Test as an indicator of organic brain damage. Percept Mot Skills 1958;8:271-276.
24. Ferris SH. General measures of cognition. Int Psychogeriatr 2003;15(Suppl 1):215-217.
25. van der Flier WM, van Straaten EC, Barkhof F et al. Small vessel disease and general cognitive function in nondisabled elderly. The LADIS Study. Stroke 2005;36:2116-2120.
26. Feldman H, Sauter A, Donald A et al. The disability assessment for dementia scale: A 12-month study of functional ability in mild to moderate severity Alzheimer disease. Alzheimer Dis Assoc Disord 2001;15:89-95.
27. Rosano C, Kuller LH, Chung H et al. Subclinical brain magnetic resonance imaging abnormalities predict physical functional decline in high-functioning older adults. J Am Geriatr Soc 2005;53:649-654.