Is Leukoaraiosis on CT an accurate surrogate marker for the presence of microbleeds in acute stroke patients?

Journal of Neurology

Volumn 254, Issue 3, 2007, Pages 284-289

  Görner, Astrid ^a   Lemmens, Robin ^a   Schrooten, Maarten ^a   Thijs, Vincent ^a  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

Anticoagulants; Cerebrovascular; Computerized tomography and magnetic resonance imaging; Microbleeds; Small vessel disease; Thrombolysis

Indexed keywords

ANTICOAGULANT AGENT;

ACUTE DISEASE; ADULT; AGED; ANTICOAGULANT THERAPY; AREA UNDER THE CURVE; ARTICLE; BLOOD CLOT LYSIS; BRAIN HEMORRHAGE; CEREBROVASCULAR ACCIDENT; CLINICAL TRIAL; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DISEASE MARKER; EMERGENCY WARD; FEMALE; FIBRINOLYTIC THERAPY; HUMAN; LEUKOARAIOSIS; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RISK FACTOR; STATISTICAL MODEL; STATISTICAL SIGNIFICANCE; STROKE; STROKE PATIENT; TRANSIENT ISCHEMIC ATTACK; WHITE MATTER;

AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; CEREBRAL HEMORRHAGE; CEREBROVASCULAR ACCIDENT; FEMALE; HUMANS; LEUKOARAIOSIS; LOGISTIC MODELS; MAGNETIC RESONANCE IMAGING; MALE; PREDICTIVE VALUE OF TESTS; PROSPECTIVE STUDIES; RETROSPECTIVE STUDIES; RISK FACTORS; ROC CURVE; STATISTICS, NONPARAMETRIC; TOMOGRAPHY, X-RAY COMPUTED;

EID: 33947131632     PISSN: 03405354     EISSN: 14321459     Source Type: Journal    
DOI: 10.1007/s00415-006-0311-z     Document Type: Article

References (22)

1. Greenberg SM, Finklestein SP, Schaefer PW (1996) Petechial hemorrhages accompanying lobar hemorrhage: detection by gradient-echo MRI. Neurology 46:1751-1754
2. Kwa VI, Franke CL, Verbeeten B Jr, Stam J (1998) Silent intracerebral microhemorrhages in patients with ischemic stroke. Amsterdam Vascular Medicine Group. Ann Neurol 44:372-377
3. Jeerakathil T, Wolf PA, Beiser A, Hald JK, Au R, Kase CS, et al. (2004) Cerebral microbleeds: prevalence and associations with cardiovascular risk factors in the Framingham Study. Stroke 35:1831-1835
4. Lee SH, Park JM, Kwon SJ, Kim H, Kim YH, Roh JK, et al. (2004) Left ventricular hypertrophy is associated with cerebral microbleeds in hypertensive patients. Neurology 63:16-21
5. Roob G, Schmidt R, Kapeller P, Lechner A, Hartung HP, Fazekas F (1999) MRI evidence of past cerebral microbleeds in a healthy elderly population. Neurology 52:991-994
6. Kidwell CS, Saver JL, Villablanca JP, Duckwiler G, Fredieu A, Gough K, et al. (2002) Magnetic resonance imaging detection of microbleeds before thrombolysis: an emerging application. Stroke 33:95-98
7. A randomized trial of anticoagulants versus aspirin after cerebral ischemia of presumed arterial origin. The Stroke Prevention in Reversible Ischemia Trial (SPIRIT) Study Group. Ann Neurol (1997);42:857-865
8. Bamford J, Sandercock P, Dennis M, Burn J, Warlow C (1991) Classification and natural history of clinically identifiable subtypes of cerebral infarction. Lancet 337(8756):1521-1526
9. van Swieten JC, Hijdra A, Koudstaal PJ, van Gijn J (1990) Grading white matter lesions on CT and MRI: a simple scale. J Neurol Neurosurg Psychiatry 53:1080-1083
10. Fazekas F, Chawluk JB, Alavi A, Hurtig HI, Zimmerman RA (1987) MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging. AJR Am J Roentgenol 149:351-356
11. Fan YH, Zhang L, Lam WW, Mok VC, Wong KS (2003) Cerebral microbleeds as a risk factor for subsequent intracerebral hemorrhages among patients with acute ischemic stroke. Stroke 34:2459-2462
12. Awad IA, Spetzler RF, Hodak JA, Awad CA, Carey R (1986) Incidental subcortical lesions identified on magnetic resonance imaging in the elderly. I. Correlation with age and cerebrovascular risk factors. Stroke 17:1084-1089
13. Breteler MM, van Swieten JC, Bots ML, Grobbee DE, Claus JJ, van den Hout JH, et al. (1994) Cerebral white matter lesions, vascular risk factors, and cognitive function in a population-based study: the Rotterdam Study. Neurology 44:1246-1252
14. Kato H, Izumiyama M, Izumiyama K, Takahashi A, Itoyama Y (2002) Silent cerebral microbleeds on T2*-weighted MRI: correlation with stroke subtype, stroke recurrence, and leukoaraiosis. Stroke 33:1536-1540
15. Lee SH, Bae HJ, Ko SB, Kim H, Yoon BW, Roh JK (2004) Comparative analysis of the spatial distribution and severity of cerebral microbleeds and old lacunes. J Neurol Neurosurg Psychiatry 75:423-427
16. Nighoghossian N, Hermier M, Adeleine P, Blanc-Lasserre K, Derex L, Honnorat J, et al. (2002) Old microbleeds are a potential risk factor for cerebral bleeding after ischemic stroke: a gradient-echo T2*-weighted brain MRI study. Stroke 33:735-742
17. Chalela JA, Kang DW, Warach S (2004) Multiple cerebral microbleeds: MRI marker of a diffuse hemorrhage-prone state. J Neuroimaging 14:54-57
18. Derex L, Nighoghossian N, Hermier M, Adeleine P, Philippeau F, Honnorat J, et al. (2004) Thrombolysis for ischemic stroke in patients with old microbleeds on pretreatment MRI. Cerebrovasc Dis 17:238-241
19. Kakuda W, Thijs VN, Lansberg MG, Bammer R, Wechsler L, Kemp S, et al. (2005) Clinical importance of microbleeds in patients receiving IV thrombolysis. Neurology 65:1175-1178
20. Wintermark M, Reichhart M, Thiran JP, Maeder P, Chalaron M, Schnyder P, et al. (2002) Prognostic accuracy of cerebral blood flow measurement by perfusion computed tomography, at the time of emergency room admission, in acute stroke patients. Ann Neurol 51:417-432
21. Ezzeddine MA, Lev MH, McDonald CT, Rordorf G, Oliveira-Filho J, Aksoy FG, et al. (2002) CT angiography with whole brain perfused blood volume imaging: added clinical value in the assessment of acute stroke. Stroke 33:959-966
22. Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. N Engl J Med 333:1581-1587