Nitric oxide synthase inhibition in humans reduces cerebral blood flow but not the hyperemic response to hypercapnia

Stroke

Volumn 29, Issue 2, 1998, Pages 467-472

  White, Richard P ^a   Deane, Colin ^a   Vallance, Patrick ^b   Markus, Hugh S ^a,c  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Cerebrovascular circulation; Nitric oxide; Noradrenaline; Ultrasonography, Doppler

Indexed keywords

ARGININE; N(G) METHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NORADRENALIN;

ADULT; ARTICLE; BLOOD BRAIN BARRIER; BLOOD PRESSURE; BRAIN BLOOD FLOW; BRAIN CIRCULATION; COLOR ULTRASOUND FLOWMETRY; COMMON CAROTID ARTERY; DOSE RESPONSE; FEMALE; HUMAN; HUMAN EXPERIMENT; HYPERCAPNIA; HYPEREMIA; INTERNAL CAROTID ARTERY; MALE; MIDDLE CEREBRAL ARTERY; PRIORITY JOURNAL; VASODILATATION;

EID: 0031908926     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.STR.29.2.467     Document Type: Article

References (31)

1. McPherson RW, Kirsch JR, Ghaly RF, Traystman RJ. Effect of nitric oxide synthase inhibition on the cerebral vascular response to hypercapnia in primates. Stroke. 1995;26:682-687.
2. Iadecola C, Pelligrino DA, Moskowitz MA, Lassen NA. Nitric oxide synthase inhibition and cerebrovascular regulation. J Cereb Blood Flow Metab. 1994;14:175-192.
3. G-nitro-L-arginine and L-arginine on regional cerebral blood flow in the cat. J Physiol (Lond). 1992;449:183-196.
4. Buchanan JE, Phillis JW. The role of nitric oxide in the regulation of cerebral blood flow. Brain Res. 1993;610:248-255.
5. Fernandez N, Garcia JL, Garcia Villalon AL, Monge L, Gomez B, Dieguez G. Cerebral blood flow and cerebrovascular reactivity after inhibition of nitric oxide synthesis in conscious goats. Br J Pharmacol. 1993;110: 428-434.
6. G-nitro-L-arginine methyl ester. Neuroscience. 1994;59:13-20.
7. Egberongbe YI, Gentleman SM, Falkai P, Bogerts B, Polak JM, Roberts GW. The distribution of nitric oxide synthase immunoreactivity in the human brain. Neuroscience. 1994;59:561-578.
8. Tomimoto H, Nishimura M, Suenaga T, Nakamura S, Akiguchi I, Wakita H, Kimura J, Mayer B. Distribution of nitric oxide synthase in the human cerebral blood vessels and brain tissues. J Cereb Blood Flow Metab. 1994;14: 930-938.
9. Ayata C, Ma JY, Meng W, Huang PL, Moskowitz MA. L-NA-sensitive rCBF augmentation during vibrissal stimulation in type-III nitric-oxide synthase mutant mice. J Cereb Blood Flow Metab. 1996;16:539-541.
10. Iadecola C, Zhang F. Nitric oxide-dependent and -independent components of cerebrovasodilation elicited by hypercapnia. Am J Physiol. 1994; 266:R546-R552.
11. Wang Q, Pelligrino DA, Baughman VL, Koenig HM, Albrecht RF. The role of neuronal nitric oxide synthase in regulation of cerebral blood flow in normocapnia and hypercapnia in rats. J Cereb Blood Flow Metab. 1995; 15:774-778.
12. Bonvento G, Seylaz J, Lacombe P. Widespread attenuation of the cerebrovascular reactivity to hypercapnia following inhibition of nitric oxide synthase in the conscious rat. J Cereb Blood Flow Metab. 1994;14:699-703.
13. G-nitro-L-arginine and indomethacin on the hypercapnic cerebral blood flow increase in rats. Brain Res. 1994;641:257-264.
14. Thompson BG, Pluta RM, Girton ME, Oldfield EH. Nitric oxide mediation of chemoregulation but not autoregulation of cerebral blood flow in primates. J Neurosurg. 1996;84:71-78.
15. Goadsby PJ. Nitric oxide is not the sole determinant of hypercapnic or metabolically driven vasodilation in the cerebral circulation. J Auton Nerv Syst. 1994;49(suppl):S67-S72.
16. Aldaraso M, Martinez C, Vila JM, Medina P, Lluch S. Influence of endothelial nitric-oxide on adrenergic responses of human cerebral arteries. J Cereb Blood Flow Metab. 1996;16:623-628.
17. Toda N. Mediation by nitric oxide of neurally induced human cerebral artery relaxation. Experientia. 1993;49:51-53.
18. Vallance P, Collier J, Moncada S. Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man. Lancet. 1989;2:997-1000.
19. Pickard JD, Mackenzie ET. Inhibition of prostaglandin synthesis and the response of baboon cerebral circulation to carbon dioxide. Nature. 1973; 245:187-188.
20. Markus HS, Vallance P, Brown MM. Differential effect of three cyclooxygenase inhibitors on human cerebral blood flow velocity and carbon dioxide reactivity. Stroke. 1994;25:1760-1764.
21. Eicke BM, Tegeler CH. Ultrasonic quantitative flow volumetry of the carotid arteries: initial experience with a color-flow M-mode system. Cerebrovasc Dis. 1995;5:145-149.
22. Deane C, Markus HS. Colour velocity flow measurement: in vitro validation and application to human carotid arteries. Ultrasound Med Biol. 1997;23:447-452.
23. 2-induced cerebral vasomotor response in normal individuals and patients with internal carotid artery occlusions. Stroke. 1988; 19:963-969.
24. Huang PL, Huang Z, Mashimo H, Bloch KD, Moskowitz MA, Bevan JA, Fishman MC. Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature. 1995;377:239-242.
25. Zuckerman SL, Armstead WM, Hsu P, Shibata M, Leffler CW. Age dependence of cerebrovascular response mechanisms in domestic pigs. Am J Physiol. 1996;271:H535-H540.
26. Sahai S, Rajamani K, Correale J, Mohler JG, Azen C, Qian GD, Stark C, Ismail Y, Abdelmessih NK, Chandraratna PAN, Ameriso SF. Effect of nitric oxide synthase inhibition on human cerebral vasomotor reactivity. Stroke. 1997;28:256. Abstract.
27. Dahl A, Russell D, Nyberg-Hansen R, Rootwelt K. Effect of nitroglycerin on cerebral circulation measured by transcranial Doppler and SPECT. Stroke. 1989;20:1733-1736.
28. Eicke BM, Tegeler C. Ultrasonic quantification of blood flow volume. In: Tegeler CH, Babikian VL, Gomez CR, eds. Neurosonology. St Louis, Mo: Mosby; 1996:101-110.
29. Calver A, Collier J, Vallance P. Inhibition and stimulation of nitric oxide synthesis in the human forearm arterial bed of patients with insulin-dependent diabetes. J Clin Invest. 1992;90:2548-2554.
30. Calver A, Collier J, Vallance P. Forearm blood flow responses to a nitric oxide synthase inhibitor in patients with treated essential hypertension. Cardiovasc Res. 1994;28:1720-1725.
31. Huang Z, Huang PL, Panahian N, Dalkara T, Fishman MC, Moskowitz MA. Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase. Science. 1994;265:1883-1885.