Physical activity prevents progression for cognitive impairment and vascular dementia: Results from the LADIS (Leukoaraiosis and Disability) study

Stroke

Volumn 43, Issue 12, 2012, Pages 3331-3335

  Verdelho, Ana ^a   Madureira, Sofia ^a   Ferro, José M ^a   Baezner, Hansjörg ^b   Blahak, Christian ^b   Poggesi, Anna ^c   Hennerici, Michael ^b   Pantoni, Leonardo ^c   Fazekas, Franz ^d   Scheltens, Philip ^e   Waldemar, Gunhild ^f   Wallin, Anders ^g   Erkinjuntti, Timo ^h   Inzitari, Domenico ^c  

^a UNIVERSITY OF LISBON   (Portugal)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c UNIVERSITY OF FLORENCE   (Italy)

^d UNIVERSITY OF GRAZ   (Austria)

^e VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^f Mental Health Center Glostrup   (Denmark)

^g UNIVERSITY OF GOTHENBURG   (Sweden)

^h UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Cognition; Cognitive impairment; Dementia; Magnetic resonance; Physical activity; White matter disease

Indexed keywords

AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN CORTEX ATROPHY; CLINICAL ASSESSMENT; CLINICAL PROTOCOL; COGNITIVE DEFECT; DIABETES MELLITUS; DISEASE COURSE; EDUCATIONAL STATUS; EUROPE; FEMALE; FOLLOW UP; FRONTOTEMPORAL DEMENTIA; HAZARD RATIO; HUMAN; INTERVIEW; LEUKOARAIOSIS; MAJOR CLINICAL STUDY; MALE; MINI MENTAL STATE EXAMINATION; MULTIINFARCT DEMENTIA; NAMED INVENTORIES, QUESTIONNAIRES AND RATING SCALES; NUCLEAR MAGNETIC RESONANCE IMAGING; PHYSICAL ACTIVITY; PRIORITY JOURNAL; PROPORTIONAL HAZARDS MODEL; VASCULAR DEMENTIA ASSESSMENT SCALE; WHITE MATTER;

ACTIVITIES OF DAILY LIVING; AGED; ALZHEIMER DISEASE; COGNITION DISORDERS; DEMENTIA, VASCULAR; DIABETES MELLITUS; DISABILITY EVALUATION; DISEASE PROGRESSION; FEMALE; HUMANS; INCIDENCE; INTERVIEWS AS TOPIC; LEUKOENCEPHALOPATHIES; MAGNETIC RESONANCE IMAGING; MALE; MOTOR ACTIVITY; NEUROPSYCHOLOGICAL TESTS; PROSPECTIVE STUDIES; RISK FACTORS; STROKE; TEMPORAL LOBE;

EID: 84870946741     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.112.661793     Document Type: Article

References (29)

1. Larson EB, Wang L, Bowen JD, McCormick WC, Teri L, Crane P, Kukull W. Exercise is associated with reduced risk for incident dementia among persons 65 years of age and older. Ann Intern Med. 2006;144:73-81.
2. Weuve J, Kang JH, Manson JE, Breteler MM, Ware JH, Grodstein F. Physical activity, including walking, and cognitive function in older women. JAMA. 2004;292:1454-1461.
3. Rovio S, Kåreholt I, Helkala EL, Viitanen M, Winblad B, Tuomilehto J, Soininen H, Nissinen A, Kivipelto M. Leisure-time physical activity at midlife and the risk of dementia and Alzheimer's disease. Lancet Neurol. 2005;4:705-711.
4. Wang L, Larson EB, Bowen JD, van Belle G. Performance-based physical function and future dementia in older people. Arch Intern Med. 2006;166:1115-1120.
5. Forbes D, Forbes S, Morgan DG, Markle-Reid M, Wood J, Culum I. Physical activity programs for persons with dementia. Cochrane Database Syst Rev. 2008;3: CD006489.
6. Scarmeas N, Luchsinger JA, Schupf N, Brickman AM, Cosentino S, Tang MX, Stern Y. Physical activity, diet, and risk of Alzheimer disease. JAMA. 2009;302:627-637.
7. Miller DI, Taler V, Davidson PS, Messier C. Measuring the impact of exercise on cognitive aging: methodological issues. Neurobiol Aging. 2012;33:622.e29-622.e43.
8. Fratiglioni L, Paillard-Borg S, Winblad B. An active and socially integrated lifestyle in late life might protect against dementia. Lancet Neurol. 2004;3:343-353.
9. Kramer AF, Colcombe SJ, McAuley E, Scalf PE, Erickson KI. Fitness, aging and neurocognitive function. Neurobiol Aging. 2005;26(suppl 1):124-127.
10. Clarkson P, Montgomery HE, Mullen MJ, Donald AE, Powe AJ, Bull T, Jubb M, World M, Deanfield JE. Exercise training enhances endothelial function in young men. J Am Coll Cardiol. 1999;33:1379-1385.
11. Vona M, Codeluppi GM, Iannino T, Ferrari E, Bogousslavsky J, von Segesser LK. Effects of different types of exercise training followed by detraining on endothelium-dependent dilation in patients with recent myocardial infarction. Circulation. 2009;119:1601-1608.
12. Seals DR, Desouza CA, Donato AJ, Tanaka H. Habitual exercise and arterial aging. J Appl Physiol. 2008;105:1323-1332.
13. Pantoni L, Basile AM, Pracucci G, Asplund K, Bogousslavsky J, Chabriat H, Erkinjuntti T, Fazekas F, Ferro JM, Hennerici M, O'brien J, Scheltens P, Visser MC, Wahlund LO, Waldemar G, Wallin A, Inzitari D. Impact of age-related cerebral white matter changes on the transition to disability - the LADIS study: rationale, design and methodology. Neuroepidemiology. 2005;24:51-62.
14. Madureira S, Verdelho A, Ferro J, Basile AM, Chabriat H, Erkinjuntti T, Fazekas F, Hennerici M, O'Brien J, Pantoni L, Salvadori E, Scheltens P, Visser MC, Wahlund LO, Waldemar G, Wallin A, Inzitari D; LADIS Study Group. Development of a neuropsychological battery for the Leukoaraiosis and Disability in the Elderly Study (LADIS): experience and baseline data. Neuroepidemiology. 2006;27:101-116.
15. Fazekas F, Chawluk JB, Alavi A, Hurtig HI, Zimmerman RA. MR signal abnormalities at 1.5T in Alzheimer's dementia and normal aging. AJNR Am J Neuroradiol. 1987;8:421-426.
16. Lawton MP, Brody EM. Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist. 1969;9:179-186.
17. Fletcher GF, Balady G, Blair SN, Blumenthal J, Caspersen C, Chaitman B, Epstein S, Sivarajan Froelicher ES, Froelicher VF, Pina IL, Pollock ML. Statement on exercise: benefits and recommendations for physical activity programs for all Americans. A statement for health professionals by the Committee on Exercise and Cardiac Rehabilitation of the Council on Clinical Cardiology, American Heart Association. Circulation. 1996;94:857-862.
18. Scheltens P, Leys D, Barkhof F, Huglo D, Weinstein HC, Vermersch P, Kuiper M, Steinling M, Wolters EC, Valk J. Atrophy of medial temporal lobes on MRI in 'probable' Alzheimer's disease and normal ageing: diagnostic value and neuropsychological correlates. J Neurol Neurosurg Psychiatry. 1992;55:967-972.
19. Verdelho A, Madureira S, Moleiro C, Ferro JM, Santos CO, Erkinjuntti T, Pantoni L, Fazekas F, Visser M, Waldemar G, Wallin A, Hennerici M, Inzitari D; LADIS Study. White matter changes and diabetes predict cognitive decline in the elderly: the LADIS study. Neurology. 2010;75:160-167.
20. Madureira S, Verdelho A, Moleiro C, Ferro JM, Erkinjuntti T, Jokinen H, Pantoni L, Fazekas F, Van der Flier W, Visser M, Waldemar G, Wallin A, Hennerici M, Inzitari D. Neuropsychological predictors of dementia in a three-year follow-up period: data from the LADIS study. Dement Geriatr Cogn Disord. 2010;29:325-334.
21. Daviglus ML, Plassman BL, Pirzada A, Bell CC, Bowen PE, Burke JR, Connolly ES Jr, Dunbar-Jacob JM, Granieri EC, McGarry K, Patel D, Trevisan M, Williams JW Jr. Risk factors and preventive interventions for Alzheimer disease: state of the science. Arch Neurol. 2011;68:1185-1190.
22. Aarsland D, Sardahaee FS, Anderssen S, Ballard C; Alzheimer's Society Systematic Review group. Is physical activity a potential preventive factor for vascular dementia? A systematic review. Aging Ment Health. 2010;14:386-395.
23. Podewils LJ, Guallar E, Kuller LH, Fried LP, Lopez OL, Carlson M, Lyketsos CG. Physical activity, APOE genotype, and dementia risk: findings from the Cardiovascular Health Cognition Study. Am J Epidemiol. 2005;161:639-651.
24. Abbott RD, White LR, Ross GW, Masaki KH, Curb JD, Petrovitch H. Walking and dementia in physically capable elderly men. JAMA. 2004;292:1447-1453.
25. Laurin D, Verreault R, Lindsay J, MacPherson K, Rockwood K. Physical activity and risk of cognitive impairment and dementia in elderly persons. Arch Neurol. 2001;58:498-504.
26. Ravaglia G, Forti P, Lucicesare A, Pisacane N, Rietti E, Bianchin M, Dalmonte E. Physical activity and dementia risk in the elderly: findings from a prospective Italian study. Neurology. 2008;70:1786-1794.
27. Yoshitake T, Kiyohara Y, Kato I, Ohmura T, Iwamoto H, Nakayama K, Ohmori S, Nomiyama K, Kawano H, Ueda K. Incidence and risk factors of vascular dementia and Alzheimer's disease in a defined elderly Japanese population: the Hisayama Study. Neurology. 1995;45:1161-1168.
28. Baezner H, Blahak C, Poggesi A, Pantoni L, Inzitari D, Chabriat H, Erkinjuntti T, Fazekas F, Ferro JM, Langhorne P, O'Brien J, Scheltens P, Visser MC, Wahlund LO, Waldemar G, Wallin A, Hennerici MG; LADIS Study Group. Association of gait and balance disorders with age-related white matter changes: the LADIS study. Neurology. 2008;70:935-942.
29. Blahak C, Baezner H, Pantoni L, Poggesi A, Chabriat H, Erkinjuntti T, Fazekas F, Ferro JM, Langhorne P, O'Brien J, Visser MC, Wahlund LO, Waldemar G, Wallin A, Inzitari D, Hennerici MG; LADIS Study Group. Deep frontal and periventricular age related white matter changes but not basal ganglia and infratentorial hyperintensities are associated with falls: cross sectional results from the LADIS study. J Neurol Neurosurg Psychiatry. 2009;80:608-613.