메뉴 건너뛰기




Volumn 142-143, Issue , 2013, Pages 1-16

Toxicological evaluation of microcystins in aquatic fish species: Current knowledge and future directions

Author keywords

Biomonitoring; Cyanobacterial blooms; Fish; Microcystins; Omics

Indexed keywords

ALPHA ACTININ; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; LACTATE DEHYDROGENASE; MICROCYSTIN; MICROCYSTIN LR; MICROCYSTIN RR; NATURAL ORGANIC MATTER; PHOSPHOPROTEIN PHOSPHATASE 1; PHOSPHOPROTEIN PHOSPHATASE 2A; TALIN;

EID: 84882785055     PISSN: 0166445X     EISSN: 18791514     Source Type: Journal    
DOI: 10.1016/j.aquatox.2013.07.010     Document Type: Review
Times cited : (76)

References (186)
  • 1
    • 60049093587 scopus 로고    scopus 로고
    • A method to measure total antioxidant capacity against peroxyl radicals in aquatic organisms: application to evaluate microcystins toxicity
    • Amado L.L., Garcia M.L., Ramos P.B., Freitas R.F., Zafalon B., Ferreira J.L.R., Yunes J.S., Monserrat J.M. A method to measure total antioxidant capacity against peroxyl radicals in aquatic organisms: application to evaluate microcystins toxicity. Sci. Total Environ. 2009, 407:2115-2123.
    • (2009) Sci. Total Environ. , vol.407 , pp. 2115-2123
    • Amado, L.L.1    Garcia, M.L.2    Ramos, P.B.3    Freitas, R.F.4    Zafalon, B.5    Ferreira, J.L.R.6    Yunes, J.S.7    Monserrat, J.M.8
  • 2
    • 73249127370 scopus 로고    scopus 로고
    • Oxidative stress generation by microcystins in aquatic animals: Why and How
    • Amado L.L., Monserrat J.M. Oxidative stress generation by microcystins in aquatic animals: Why and How. Environ. Int. 2010, 36:226-235.
    • (2010) Environ. Int. , vol.36 , pp. 226-235
    • Amado, L.L.1    Monserrat, J.M.2
  • 3
    • 47849104282 scopus 로고    scopus 로고
    • Dose-dependent antioxidant responses and pathological changes in tenca (Tinca tinca) after acute oral exposure to Microcystis under laboratory conditions
    • 1-1
    • Atencio L., Moreno I., Jos A., Pichardo S., Moyano R., Blanco A., Cameán A.M. Dose-dependent antioxidant responses and pathological changes in tenca (Tinca tinca) after acute oral exposure to Microcystis under laboratory conditions. Toxicon 2008, 52. 1-1.
    • (2008) Toxicon , vol.52
    • Atencio, L.1    Moreno, I.2    Jos, A.3    Pichardo, S.4    Moyano, R.5    Blanco, A.6    Cameán, A.M.7
  • 5
    • 0028045464 scopus 로고
    • 1st Report of microcystins from a Brazilian Isolate of the cyanobacterium Microcystis aeruginosa
    • Azevedo S.M.F.O., Evans W.R., Carmichael W.W., Namikoshi M. 1st Report of microcystins from a Brazilian Isolate of the cyanobacterium Microcystis aeruginosa. J. App. Phycol. 1994, 6(3):261-265.
    • (1994) J. App. Phycol. , vol.6 , Issue.3 , pp. 261-265
    • Azevedo, S.M.F.O.1    Evans, W.R.2    Carmichael, W.W.3    Namikoshi, M.4
  • 6
    • 9244223606 scopus 로고    scopus 로고
    • Comparative study of microcystin- LR-induced behavioral changes of two fish species, Danio rerio and Leucaspius delineatus
    • Baganz D., Staaks G., Pflugmacher S., Steinberg C.E.W. Comparative study of microcystin- LR-induced behavioral changes of two fish species, Danio rerio and Leucaspius delineatus. Environ. Toxicol. 2004, 19:564-567.
    • (2004) Environ. Toxicol. , vol.19 , pp. 564-567
    • Baganz, D.1    Staaks, G.2    Pflugmacher, S.3    Steinberg, C.E.W.4
  • 7
    • 0037202005 scopus 로고    scopus 로고
    • Effects of enteric bacterial and cyanobacterial lipopolysaccharides, and of microcystin-LR, on glutathione S-transferase activities in zebra fish (Danio rerio)
    • Best J., Pflugmacher S., Wiegand C., Eddy F., Metcalf J., Codd G. Effects of enteric bacterial and cyanobacterial lipopolysaccharides, and of microcystin-LR, on glutathione S-transferase activities in zebra fish (Danio rerio). Aquat. Toxicol. 2002, 60:223-231.
    • (2002) Aquat. Toxicol. , vol.60 , pp. 223-231
    • Best, J.1    Pflugmacher, S.2    Wiegand, C.3    Eddy, F.4    Metcalf, J.5    Codd, G.6
  • 8
    • 0035722640 scopus 로고    scopus 로고
    • Effects of purified MC-LR and cell extracts of Microcystis strains PCC 7813 and CYA 43 on cardiac function in brown trout (Salmo trutta) alevins
    • Best J.H., Eddy F.B., Codd G.A. Effects of purified MC-LR and cell extracts of Microcystis strains PCC 7813 and CYA 43 on cardiac function in brown trout (Salmo trutta) alevins. Fish Physiol. Biochem. 2001, 24:171-178.
    • (2001) Fish Physiol. Biochem. , vol.24 , pp. 171-178
    • Best, J.H.1    Eddy, F.B.2    Codd, G.A.3
  • 9
    • 0037700501 scopus 로고    scopus 로고
    • Effects of Microcystis cells, cell extracts and lipopolysaccharide on drinking and liver function in rainbow trout Oncorhynchus mykiss Walbaum
    • Best J.H., Eddy F.B., Codd G.A. Effects of Microcystis cells, cell extracts and lipopolysaccharide on drinking and liver function in rainbow trout Oncorhynchus mykiss Walbaum. Aquat. Toxicol. 2003, 64:419-426.
    • (2003) Aquat. Toxicol. , vol.64 , pp. 419-426
    • Best, J.H.1    Eddy, F.B.2    Codd, G.A.3
  • 10
    • 34249337761 scopus 로고    scopus 로고
    • Perceptions of epigenetics
    • Bird A. Perceptions of epigenetics. Nature 2007, 447(7143):396-398.
    • (2007) Nature , vol.447 , Issue.7143 , pp. 396-398
    • Bird, A.1
  • 11
    • 29244445465 scopus 로고    scopus 로고
    • Microcystin-LR induced cellular effects in mammalian and fish primary hepatocyte cultures and cell lines: a comparative study
    • Boaru D.A., Dragos N., Schirmer K. Microcystin-LR induced cellular effects in mammalian and fish primary hepatocyte cultures and cell lines: a comparative study. Toxicol. 2006, 218(2-3):134-148.
    • (2006) Toxicol. , vol.218 , Issue.2-3 , pp. 134-148
    • Boaru, D.A.1    Dragos, N.2    Schirmer, K.3
  • 12
    • 79951771713 scopus 로고    scopus 로고
    • The fragility of omics risk and benefit perceptions
    • Borner F.U., Schutz H., Wiedemann P. The fragility of omics risk and benefit perceptions. Toxicol. Lett. 2011, 201:249-257.
    • (2011) Toxicol. Lett. , vol.201 , pp. 249-257
    • Borner, F.U.1    Schutz, H.2    Wiedemann, P.3
  • 13
    • 0141626442 scopus 로고    scopus 로고
    • Health hazards for terrestrial vertebrates from toxic cyanobacteria in surface water ecosystems
    • Briand J.F., Jacquet S., Bernard C., Humbert J.F. Health hazards for terrestrial vertebrates from toxic cyanobacteria in surface water ecosystems. Vet. Res. 2003, 34(4):361-377.
    • (2003) Vet. Res. , vol.34 , Issue.4 , pp. 361-377
    • Briand, J.F.1    Jacquet, S.2    Bernard, C.3    Humbert, J.F.4
  • 14
    • 0028833936 scopus 로고
    • The effects of the cyanobacterium Microcystis aeruginosa, the cyanobacterial hepatotoxin microcystin-LR, and ammonia on growth rate and ionic regulation of brown trout
    • Bury N.R., Eddy F.B., Codd G.A. The effects of the cyanobacterium Microcystis aeruginosa, the cyanobacterial hepatotoxin microcystin-LR, and ammonia on growth rate and ionic regulation of brown trout. J. Fish Biol. 1995, 46:1042-1054.
    • (1995) J. Fish Biol. , vol.46 , pp. 1042-1054
    • Bury, N.R.1    Eddy, F.B.2    Codd, G.A.3
  • 15
    • 0029786485 scopus 로고    scopus 로고
    • Stress responses of brown trout, Salmo trutta L., to the cyanobacterium, Microcystis aeruginosa
    • Bury N.R., Eddy F.B., Codd G.A. Stress responses of brown trout, Salmo trutta L., to the cyanobacterium, Microcystis aeruginosa. Environ. Toxicol. Water Qual. 1997, 11:187-193.
    • (1997) Environ. Toxicol. Water Qual. , vol.11 , pp. 187-193
    • Bury, N.R.1    Eddy, F.B.2    Codd, G.A.3
  • 16
    • 0029831638 scopus 로고    scopus 로고
    • The effects ofcyanobacteria and the cyanobacterial toxin MC-LR on Ca21 transport and Na1/K1-ATPase in tilapia gills
    • Bury N.R., Flik G., Eddy F.B., Codd G.A. The effects ofcyanobacteria and the cyanobacterial toxin MC-LR on Ca21 transport and Na1/K1-ATPase in tilapia gills. J. Exp. Biol. 1996, 199:1319-1326.
    • (1996) J. Exp. Biol. , vol.199 , pp. 1319-1326
    • Bury, N.R.1    Flik, G.2    Eddy, F.B.3    Codd, G.A.4
  • 18
    • 34250106069 scopus 로고
    • Problems associated with selecting the most sensitive species for toxicity testing
    • Cairns, Niederlehner B.R. Problems associated with selecting the most sensitive species for toxicity testing. Hydrobiologia 1987, 153(1):87-94.
    • (1987) Hydrobiologia , vol.153 , Issue.1 , pp. 87-94
    • Cairns1    Niederlehner, B.R.2
  • 19
    • 33845416939 scopus 로고    scopus 로고
    • Highly sensitive amperometric immunosensors for microcystin detection in algae
    • Campas M., Marty J.L. Highly sensitive amperometric immunosensors for microcystin detection in algae. Biosens. Bioelectron. 2007, 22:1034-1040.
    • (2007) Biosens. Bioelectron. , vol.22 , pp. 1034-1040
    • Campas, M.1    Marty, J.L.2
  • 20
    • 0002304119 scopus 로고    scopus 로고
    • The histopathology of carp, Cyprinus carpio L., exposed to MCs by gavage, immersion and intraperitoneal administration
    • Carbis C.R., Rawlin G.T., Mitchell G.F., Anderson J.W., McCauley I. The histopathology of carp, Cyprinus carpio L., exposed to MCs by gavage, immersion and intraperitoneal administration. J. Fish Dis. 1996, 19:199-207.
    • (1996) J. Fish Dis. , vol.19 , pp. 199-207
    • Carbis, C.R.1    Rawlin, G.T.2    Mitchell, G.F.3    Anderson, J.W.4    McCauley, I.5
  • 21
  • 23
    • 28744446756 scopus 로고    scopus 로고
    • Differential detoxification and antioxidant response in diverse organs of Corydoras paleatus experimentally exposed to microcystin-RR
    • Cazenave J., Bistoni MdlA., Pesce S.F., Wunderlin D.A. Differential detoxification and antioxidant response in diverse organs of Corydoras paleatus experimentally exposed to microcystin-RR. Aquat. Toxicol. 2006, 76:1-12.
    • (2006) Aquat. Toxicol. , vol.76 , pp. 1-12
    • Cazenave, J.1    Bistoni, M.2    Pesce, S.F.3    Wunderlin, D.A.4
  • 24
    • 33244491934 scopus 로고    scopus 로고
    • Attenuating effects of natural organic matter on microcystin toxicity in zebra fish (Danio rerio) embryos benefits and costs of microcystin detoxication
    • Cazenave J., Bistoni MdlA., Zwirnmann E., Wunderlin D.A., Wiegand C. Attenuating effects of natural organic matter on microcystin toxicity in zebra fish (Danio rerio) embryos benefits and costs of microcystin detoxication. Environ. Toxicol. 2006, 21:22-32.
    • (2006) Environ. Toxicol. , vol.21 , pp. 22-32
    • Cazenave, J.1    Bistoni, M.2    Zwirnmann, E.3    Wunderlin, D.A.4    Wiegand, C.5
  • 25
    • 38949106886 scopus 로고    scopus 로고
    • Changes in the swimming activity and the glutathione S-transferase activity of Jenynsia multidentata fed with microcystin-RR
    • Cazenave J., Nores M.L., Miceli M., Díaz M.P., Wunderlin D.A., Bistoni M.A. Changes in the swimming activity and the glutathione S-transferase activity of Jenynsia multidentata fed with microcystin-RR. Water Res. 2008, 42:1299-1307.
    • (2008) Water Res. , vol.42 , pp. 1299-1307
    • Cazenave, J.1    Nores, M.L.2    Miceli, M.3    Díaz, M.P.4    Wunderlin, D.A.5    Bistoni, M.A.6
  • 26
    • 24944453273 scopus 로고    scopus 로고
    • Induction of apoptosis in mouse liver by microcystin-LR: A combined transcriptomic, proteomic, and simulation strategy
    • Chen T., Wang Q., Cui J., Yang W. Induction of apoptosis in mouse liver by microcystin-LR: A combined transcriptomic, proteomic, and simulation strategy. Mol. Cell. Proteomics 2005, 4:958-974.
    • (2005) Mol. Cell. Proteomics , vol.4 , pp. 958-974
    • Chen, T.1    Wang, Q.2    Cui, J.3    Yang, W.4
  • 27
    • 0036523388 scopus 로고    scopus 로고
    • MIP-based solid phase extraction cartridges combined with MIP-based sensors for the detection of microcystin-LR
    • Chianella I., Piletsky S.A., Tothill I.E., Chen B., Turner A.P.F. MIP-based solid phase extraction cartridges combined with MIP-based sensors for the detection of microcystin-LR. Biosens. Bioelectron. 2003, 18:119-127.
    • (2003) Biosens. Bioelectron. , vol.18 , pp. 119-127
    • Chianella, I.1    Piletsky, S.A.2    Tothill, I.E.3    Chen, B.4    Turner, A.P.F.5
  • 29
    • 0029823235 scopus 로고    scopus 로고
    • The effect of microcystin on growth of single species and on mixed natural populations of heterotrophic nanoflagellates
    • Christofferson K. The effect of microcystin on growth of single species and on mixed natural populations of heterotrophic nanoflagellates. Nat. Toxins 1996, 4(5):215-220.
    • (1996) Nat. Toxins , vol.4 , Issue.5 , pp. 215-220
    • Christofferson, K.1
  • 30
    • 18944388783 scopus 로고    scopus 로고
    • Growing pains for metabolomics
    • Daviss B. Growing pains for metabolomics. The Scientist 2005, 19(8):25-28.
    • (2005) The Scientist , vol.19 , Issue.8 , pp. 25-28
    • Daviss, B.1
  • 31
    • 0032124844 scopus 로고    scopus 로고
    • The toxicology of microcystins
    • Dawson R.M. The toxicology of microcystins. Toxicon 1998, 36:953-962.
    • (1998) Toxicon , vol.36 , pp. 953-962
    • Dawson, R.M.1
  • 33
    • 0036709597 scopus 로고    scopus 로고
    • Cellular glutathione and thiols metabolism
    • Dickinson D.A., Forman H.J. Cellular glutathione and thiols metabolism. Biochem. Pharmacol. 2002, 64:1019-1026.
    • (2002) Biochem. Pharmacol. , vol.64 , pp. 1019-1026
    • Dickinson, D.A.1    Forman, H.J.2
  • 34
    • 0037436437 scopus 로고    scopus 로고
    • Role of oxidative stress and mitochondrial changes in cyanobacteria induced apoptosis and hepatotoxicity
    • Ding W-X., Ong C.N. Role of oxidative stress and mitochondrial changes in cyanobacteria induced apoptosis and hepatotoxicity. FEMS Microbiol. Lett. 2003, 220:1-7.
    • (2003) FEMS Microbiol. Lett. , vol.220 , pp. 1-7
    • Ding, W.-X.1    Ong, C.N.2
  • 35
    • 0033844686 scopus 로고    scopus 로고
    • Critical role of reactive oxygen species and mitochondrial permeability transition in microcystin-induced rapid apoptosis in rat hepatocytes
    • Ding W-X., Shen H-M., Ong C-N. Critical role of reactive oxygen species and mitochondrial permeability transition in microcystin-induced rapid apoptosis in rat hepatocytes. Hepatology 2000, 32:547-555.
    • (2000) Hepatology , vol.32 , pp. 547-555
    • Ding, W.-X.1    Shen, H.-M.2    Ong, C.-N.3
  • 36
    • 0036299222 scopus 로고    scopus 로고
    • Calpain activation after mitochondrial permeability transition in microcystin-induced cell death in rat hepatocytes
    • Ding W-X., Shen H-M., Ong C-N. Calpain activation after mitochondrial permeability transition in microcystin-induced cell death in rat hepatocytes. Biochem. Biophys. Res. Commun. 2002, 291:321-331.
    • (2002) Biochem. Biophys. Res. Commun. , vol.291 , pp. 321-331
    • Ding, W.-X.1    Shen, H.-M.2    Ong, C.-N.3
  • 37
    • 2642531973 scopus 로고    scopus 로고
    • Epigenetics in human disease and prospects for epigenetic therapy
    • Egger G., Liang G., Aparicio A., Jones P.A. Epigenetics in human disease and prospects for epigenetic therapy. Nature 2004, 429(6990):457-463.
    • (2004) Nature , vol.429 , Issue.6990 , pp. 457-463
    • Egger, G.1    Liang, G.2    Aparicio, A.3    Jones, P.A.4
  • 39
    • 0035204961 scopus 로고    scopus 로고
    • Presence of Planktothrix sp. and cyanobacterial toxins in Lake Ammersee, Germany and their impact on whitefish (Coregonus lavaretus L.)
    • Ernst B., Hitzfeld B., Dietrich D. Presence of Planktothrix sp. and cyanobacterial toxins in Lake Ammersee, Germany and their impact on whitefish (Coregonus lavaretus L.). Environ. Toxicol. 2001, 16:483-488.
    • (2001) Environ. Toxicol. , vol.16 , pp. 483-488
    • Ernst, B.1    Hitzfeld, B.2    Dietrich, D.3
  • 40
    • 0023160937 scopus 로고
    • The fish gill: site of action and model for toxic effects of environmental pollutants
    • Evans D.H. The fish gill: site of action and model for toxic effects of environmental pollutants. Environ. Health Perspect. 1987, 71:47-58.
    • (1987) Environ. Health Perspect. , vol.71 , pp. 47-58
    • Evans, D.H.1
  • 41
    • 0033034114 scopus 로고    scopus 로고
    • An overview of problems caused by toxic blue-green algae (cyanobacteria) in drinking and recreational water
    • Falconer I.R. An overview of problems caused by toxic blue-green algae (cyanobacteria) in drinking and recreational water. Environ. Toxicol. 1999, 14:5-12.
    • (1999) Environ. Toxicol. , vol.14 , pp. 5-12
    • Falconer, I.R.1
  • 42
    • 34548441589 scopus 로고    scopus 로고
    • Cyanobacterial toxins present in Microcystis aeruginosa extracts-more than microcystins!
    • Falconer I.R. Cyanobacterial toxins present in Microcystis aeruginosa extracts-more than microcystins!. Toxicon 2007, 50(4):585-588.
    • (2007) Toxicon , vol.50 , Issue.4 , pp. 585-588
    • Falconer, I.R.1
  • 43
    • 84970582448 scopus 로고
    • Liver pathology in mice in poisening by the blue-green alga microcystis aeruginosa
    • Falconer I.R., Jackson A.R.B., Langley J. Liver pathology in mice in poisening by the blue-green alga microcystis aeruginosa. Aust. J. Diol. Sci. 1981, 34:179-187.
    • (1981) Aust. J. Diol. Sci. , vol.34 , pp. 179-187
    • Falconer, I.R.1    Jackson, A.R.B.2    Langley, J.3
  • 44
    • 0036390216 scopus 로고    scopus 로고
    • An international intercomparison exercise for the determination of purified microcystin-LR and microcystins in cyanobacterial field material
    • Fastner J., Codd G.A., Metcalf J.S., Woitke P., Wiedner C., Utkilen H. An international intercomparison exercise for the determination of purified microcystin-LR and microcystins in cyanobacterial field material. Anal. Bioanal. Chem. 2002, 374(3):437-444.
    • (2002) Anal. Bioanal. Chem. , vol.374 , Issue.3 , pp. 437-444
    • Fastner, J.1    Codd, G.A.2    Metcalf, J.S.3    Woitke, P.4    Wiedner, C.5    Utkilen, H.6
  • 46
    • 0034176293 scopus 로고    scopus 로고
    • Pathological and biochemical characterization of MC-induced hepatopancreas and kidney damage in carp (Cyprinus carpio)
    • Fischer W.J., Dietrich D.R. Pathological and biochemical characterization of MC-induced hepatopancreas and kidney damage in carp (Cyprinus carpio). Toxicol. Appl. Pharmacol. 2000, 16:73-81.
    • (2000) Toxicol. Appl. Pharmacol. , vol.16 , pp. 73-81
    • Fischer, W.J.1    Dietrich, D.R.2
  • 47
    • 0034106372 scopus 로고    scopus 로고
    • MC-LR toxicodynamics, induced pathology, and immunohistochemical localization in livers of blue-green algae exposed rainbow trout (Oncorhynchus mykiss)
    • Fischer W.J., Hitzfeld B.C., Tencalla F., Eriksson J.E., Mikhailov A., Dietrich D.R. MC-LR toxicodynamics, induced pathology, and immunohistochemical localization in livers of blue-green algae exposed rainbow trout (Oncorhynchus mykiss). Toxicol. Sci. 2000, 54:365-373.
    • (2000) Toxicol. Sci. , vol.54 , pp. 365-373
    • Fischer, W.J.1    Hitzfeld, B.C.2    Tencalla, F.3    Eriksson, J.E.4    Mikhailov, A.5    Dietrich, D.R.6
  • 49
    • 0036955909 scopus 로고    scopus 로고
    • Histopathological evidence of regeneration following hepatotoxic effects of the cyanotoxin MCLR in the hardhead catfish and Gulf killifish
    • Fournie J.W., Courtney L.A. Histopathological evidence of regeneration following hepatotoxic effects of the cyanotoxin MCLR in the hardhead catfish and Gulf killifish. J. Aquat. Anim. Health 2002, 14:273-280.
    • (2002) J. Aquat. Anim. Health , vol.14 , pp. 273-280
    • Fournie, J.W.1    Courtney, L.A.2
  • 50
    • 0000966573 scopus 로고
    • Toxic and inhibitory effects of the green alga Microcystis aeruginosa on herbivorous zooplankton
    • Fulton R.S., Pearl H.W. Toxic and inhibitory effects of the green alga Microcystis aeruginosa on herbivorous zooplankton. J. Plankton. Res. 1987, 9:837-855.
    • (1987) J. Plankton. Res. , vol.9 , pp. 837-855
    • Fulton, R.S.1    Pearl, H.W.2
  • 51
    • 0028012794 scopus 로고
    • Inhibitory effects of Microcystis aeruginosa toxin on ion pumps of the gill of freshwater fish
    • Gaete V., Canelo E., Lagos N., Zambrano F. Inhibitory effects of Microcystis aeruginosa toxin on ion pumps of the gill of freshwater fish. Toxicon 1994, 32:121-127.
    • (1994) Toxicon , vol.32 , pp. 121-127
    • Gaete, V.1    Canelo, E.2    Lagos, N.3    Zambrano, F.4
  • 52
    • 0028799190 scopus 로고
    • Effects of microcystin-LR on actin and actin-associated protein a-actinin and talin in hepatocytes
    • Ghosh S., Khan S.A., Wickstrom M., Beasley V. Effects of microcystin-LR on actin and actin-associated protein a-actinin and talin in hepatocytes. Nat. Toxin 1995, 3:405-414.
    • (1995) Nat. Toxin , vol.3 , pp. 405-414
    • Ghosh, S.1    Khan, S.A.2    Wickstrom, M.3    Beasley, V.4
  • 54
    • 0343570140 scopus 로고    scopus 로고
    • Distinct role of protein phosphatase 2A subunit C[alpha] in the regulation of E-cadherin and [beta]-catenin during development
    • Gotz J., Probst A., Mistl C., Nitsch R.M., Ehler E. Distinct role of protein phosphatase 2A subunit C[alpha] in the regulation of E-cadherin and [beta]-catenin during development. Mech. Develop. 2000, 93(1-2):83-93.
    • (2000) Mech. Develop. , vol.93 , Issue.1-2 , pp. 83-93
    • Gotz, J.1    Probst, A.2    Mistl, C.3    Nitsch, R.M.4    Ehler, E.5
  • 55
    • 4644262109 scopus 로고    scopus 로고
    • Metabolomics: its potential as a tool in toxicology for safety assessment and data integration
    • Griffin J.L., Bollard M.E. Metabolomics: its potential as a tool in toxicology for safety assessment and data integration. Curr. Drug Metab. 2004, 5:389-398.
    • (2004) Curr. Drug Metab. , vol.5 , pp. 389-398
    • Griffin, J.L.1    Bollard, M.E.2
  • 57
    • 0037723070 scopus 로고    scopus 로고
    • Comparative toxicity evaluation of cyanobacterial cyclic peptide toxin microcystin variants (LR, RR, YR) in mice
    • Gupta N., Pant S.C., Vijayaraghavan R., Rao P.V. Comparative toxicity evaluation of cyanobacterial cyclic peptide toxin microcystin variants (LR, RR, YR) in mice. Toxicol. 2003, 188:285-296.
    • (2003) Toxicol. , vol.188 , pp. 285-296
    • Gupta, N.1    Pant, S.C.2    Vijayaraghavan, R.3    Rao, P.V.4
  • 58
    • 0003536299 scopus 로고    scopus 로고
    • Oxford University Press, New York, B. Halliwell, J.M.C. Gutteridge (Eds.)
    • Free Radicals in Biology and Medicine 2007, Oxford University Press, New York. fourth ed. B. Halliwell, J.M.C. Gutteridge (Eds.).
    • (2007) Free Radicals in Biology and Medicine
  • 59
    • 0002371358 scopus 로고    scopus 로고
    • Stability of microcystins from cyanobacteria-III. Effect of pH and temperature
    • Harada K.-I., Tsuji K., Watanabe M.F., Kondo F. Stability of microcystins from cyanobacteria-III. Effect of pH and temperature. Phycologia 1996, 36(6):83-88.
    • (1996) Phycologia , vol.36 , Issue.6 , pp. 83-88
    • Harada, K.-I.1    Tsuji, K.2    Watanabe, M.F.3    Kondo, F.4
  • 60
  • 62
    • 0033794092 scopus 로고    scopus 로고
    • Fulminant hepatocyte apoptosis in vivo following microcystin-LR administration to rats
    • Hooser S.B. Fulminant hepatocyte apoptosis in vivo following microcystin-LR administration to rats. Toxicol. Pathol. 2000, 28(5):726-733.
    • (2000) Toxicol. Pathol. , vol.28 , Issue.5 , pp. 726-733
    • Hooser, S.B.1
  • 63
    • 40049111056 scopus 로고    scopus 로고
    • A novel chemiluminescent immunoassay for microcystin (MC) detection based on gold nanoparticles label and its application to MC analysis in aquatic environmental samples
    • Hu C., Gan N., He Z., Song L. A novel chemiluminescent immunoassay for microcystin (MC) detection based on gold nanoparticles label and its application to MC analysis in aquatic environmental samples. Int. J. Environ. Anal. Chem. 2008, 88:267-277.
    • (2008) Int. J. Environ. Anal. Chem. , vol.88 , pp. 267-277
    • Hu, C.1    Gan, N.2    He, Z.3    Song, L.4
  • 65
    • 71249160290 scopus 로고    scopus 로고
    • Cyanobacterial toxins: a qualitative meta-analysis of concentrations, dosage and effects in freshwater, estuarine and marine biota
    • H.H. Kenneth (Ed.)
    • Ibelings B.W., Havens K.E. Cyanobacterial toxins: a qualitative meta-analysis of concentrations, dosage and effects in freshwater, estuarine and marine biota. International Symposium on Cyanobacterial Harmful Algal Blooms (ISOC-HAB) 2007, 685-744. H.H. Kenneth (Ed.).
    • (2007) International Symposium on Cyanobacterial Harmful Algal Blooms (ISOC-HAB) , pp. 685-744
    • Ibelings, B.W.1    Havens, K.E.2
  • 67
    • 79960332444 scopus 로고    scopus 로고
    • Time-dependent oxidative stress and histopathological changes in Cyprinus carpio L. exposed to microcystin-LR
    • Jinlin J., Xueyuan G., Rui S., Qian Z., Jinju G., Xiaorong W., Liuyan Y. Time-dependent oxidative stress and histopathological changes in Cyprinus carpio L. exposed to microcystin-LR. Ecotoxicol. 2011, 20(5):1000-1009.
    • (2011) Ecotoxicol. , vol.20 , Issue.5 , pp. 1000-1009
    • Jinlin, J.1    Xueyuan, G.2    Rui, S.3    Qian, Z.4    Jinju, G.5    Xiaorong, W.6    Liuyan, Y.7
  • 69
    • 33744962865 scopus 로고    scopus 로고
    • Redefining oxidative stress
    • Jones D.P. Redefining oxidative stress. Antioxid. Redox Signal. 2006, 8:1865-1879.
    • (2006) Antioxid. Redox Signal. , vol.8 , pp. 1865-1879
    • Jones, D.P.1
  • 70
    • 16844374445 scopus 로고    scopus 로고
    • Toxic cyanobacterial cells containing microcystins induce oxidative stress in exposed tilapia fish (Oreochromis sp.) under laboratory conditions
    • Jos Á., Pichardo S., Prieto A.I., Repetto G., Vázquez C.M., Morenoa I. Toxic cyanobacterial cells containing microcystins induce oxidative stress in exposed tilapia fish (Oreochromis sp.) under laboratory conditions. Aquat. Toxicol. 2005, 72:261-271.
    • (2005) Aquat. Toxicol. , vol.72 , pp. 261-271
    • Jos, Á.1    Pichardo, S.2    Prieto, A.I.3    Repetto, G.4    Vázquez, C.M.5    Morenoa, I.6
  • 71
    • 0036492207 scopus 로고    scopus 로고
    • Assimilation of different cyanobacteria as food and the consequences for internal energy stores of juvenile roach
    • Kamjunke N., Mendonca R., Hardewig I., Mehner T. Assimilation of different cyanobacteria as food and the consequences for internal energy stores of juvenile roach. J. Fish Biol. 2002, 60:731-738.
    • (2002) J. Fish Biol. , vol.60 , pp. 731-738
    • Kamjunke, N.1    Mendonca, R.2    Hardewig, I.3    Mehner, T.4
  • 72
    • 0033771658 scopus 로고    scopus 로고
    • Role of chemical and physical variables in regulating microcystin-LR concentration in phytoplankton of eutrophic lakes
    • Kotak B.G., Lam A.K.-Y., Prepas E.E., Hrudey S.E. Role of chemical and physical variables in regulating microcystin-LR concentration in phytoplankton of eutrophic lakes. Can. J. Fish. Aquat. Sci. 2000, 57:1584-1593.
    • (2000) Can. J. Fish. Aquat. Sci. , vol.57 , pp. 1584-1593
    • Kotak, B.G.1    Lam, A.K.-Y.2    Prepas, E.E.3    Hrudey, S.E.4
  • 73
    • 0029945765 scopus 로고    scopus 로고
    • Hepatic and renal pathology of intraperitoneally administered MC-LR in rainbow trout (Oncorhynchus mykiss)
    • Kotak B.G., Semalulu S., Fritz D.L., Prepas E.E., Hrudey S.E., Coppock R.W. Hepatic and renal pathology of intraperitoneally administered MC-LR in rainbow trout (Oncorhynchus mykiss). Toxicon. 1996, 34:517-525.
    • (1996) Toxicon. , vol.34 , pp. 517-525
    • Kotak, B.G.1    Semalulu, S.2    Fritz, D.L.3    Prepas, E.E.4    Hrudey, S.E.5    Coppock, R.W.6
  • 74
    • 84863214404 scopus 로고    scopus 로고
    • Removal of cyanotoxins from surface water resources using reusable molecularly imprinted polymer adsorbents
    • Krupadam R.J., Patel G.P., Balasubramanian R. Removal of cyanotoxins from surface water resources using reusable molecularly imprinted polymer adsorbents. Environ. Sci. Poll. Res. 2013, 19:1841-1851.
    • (2013) Environ. Sci. Poll. Res. , vol.19 , pp. 1841-1851
    • Krupadam, R.J.1    Patel, G.P.2    Balasubramanian, R.3
  • 75
    • 23844494323 scopus 로고    scopus 로고
    • The effects of harmful algal blooms on aquatic organisms
    • Landsberg J.H. The effects of harmful algal blooms on aquatic organisms. Rev. Fish. Sci. 2002, 10(2):113-390.
    • (2002) Rev. Fish. Sci. , vol.10 , Issue.2 , pp. 113-390
    • Landsberg, J.H.1
  • 76
    • 37049080007 scopus 로고
    • Extraction and highperformance liquid chromatographic method for the determination of microcystins in raw and treated waters
    • Lawton L., Edwards C., Codd G.A. Extraction and highperformance liquid chromatographic method for the determination of microcystins in raw and treated waters. Analyst 1994, 119:1525-1530.
    • (1994) Analyst , vol.119 , pp. 1525-1530
    • Lawton, L.1    Edwards, C.2    Codd, G.A.3
  • 78
    • 33845309486 scopus 로고    scopus 로고
    • Effect of process variables and natural organic matter on removal of microcystin-LR by PAC-UF
    • Lee J., Walker H.W. Effect of process variables and natural organic matter on removal of microcystin-LR by PAC-UF. Environ. Sci. Technol. 2006, 40:7336-7342.
    • (2006) Environ. Sci. Technol. , vol.40 , pp. 7336-7342
    • Lee, J.1    Walker, H.W.2
  • 79
    • 55649091225 scopus 로고    scopus 로고
    • Changes in plasma thyroid hormones and cortisol levels in crucian carp (Carassius auratus) exposed to the extracted microcystins
    • Li D., Xie P., Zhang X. Changes in plasma thyroid hormones and cortisol levels in crucian carp (Carassius auratus) exposed to the extracted microcystins. Chemosphere 2008, 74:13-18.
    • (2008) Chemosphere , vol.74 , pp. 13-18
    • Li, D.1    Xie, P.2    Zhang, X.3
  • 80
    • 79955770951 scopus 로고    scopus 로고
    • Protein expression profiling in the zebrafish (Danio rerio) embryos exposed to the microcystin-LR
    • Li G., Chen J., Xie P., Jiang Y., Wu L., Zhang X. Protein expression profiling in the zebrafish (Danio rerio) embryos exposed to the microcystin-LR. Proteomics 2011, 11(10):2003-2018.
    • (2011) Proteomics , vol.11 , Issue.10 , pp. 2003-2018
    • Li, G.1    Chen, J.2    Xie, P.3    Jiang, Y.4    Wu, L.5    Zhang, X.6
  • 81
    • 43049164115 scopus 로고    scopus 로고
    • Microcystin-induced variations in transcription of GSTs in an omnivorous freshwater fish, goldfish
    • Li G., Xie P., Fu J., Hao L., Xiong Q., Li H. Microcystin-induced variations in transcription of GSTs in an omnivorous freshwater fish, goldfish. Aquat. Toxicol. 2008, 88:75-80.
    • (2008) Aquat. Toxicol. , vol.88 , pp. 75-80
    • Li, G.1    Xie, P.2    Fu, J.3    Hao, L.4    Xiong, Q.5    Li, H.6
  • 82
    • 62649150146 scopus 로고    scopus 로고
    • The first study on the effects of microcystin-RR on gene expression profiles of antioxidant enzymes and heat shock protein-70 in Synechocystis sp. PCC6803
    • Li H., Xie P., Zhang D., Chen J. The first study on the effects of microcystin-RR on gene expression profiles of antioxidant enzymes and heat shock protein-70 in Synechocystis sp. PCC6803. Toxicon. 2009, 53:595-601.
    • (2009) Toxicon. , vol.53 , pp. 595-601
    • Li, H.1    Xie, P.2    Zhang, D.3    Chen, J.4
  • 83
    • 34548301253 scopus 로고    scopus 로고
    • Evaluation of dietary supplementation of β-hydroxy-β-methylbutyrate for hybrid striped bass Morone chrysops X Morone saxatilis
    • Li P., Gatlin D.M. Evaluation of dietary supplementation of β-hydroxy-β-methylbutyrate for hybrid striped bass Morone chrysops X Morone saxatilis. J. Appl. Aquac. 2007, 19:77-88.
    • (2007) J. Appl. Aquac. , vol.19 , pp. 77-88
    • Li, P.1    Gatlin, D.M.2
  • 84
    • 0032845313 scopus 로고    scopus 로고
    • Development of a capillary zone electrophoretic method for the rapid separation and detection of hepatotoxic microcystins
    • Li P.C.H., Hu S., Lam P.K.S. Development of a capillary zone electrophoretic method for the rapid separation and detection of hepatotoxic microcystins. Mar. Pollut. Bull. 1999, 39:250-254.
    • (1999) Mar. Pollut. Bull. , vol.39 , pp. 250-254
    • Li, P.C.H.1    Hu, S.2    Lam, P.K.S.3
  • 85
    • 0141543868 scopus 로고    scopus 로고
    • Responses of antioxidant systems in the hepatocytes of common carp (Cyprinus carpio L.) to the toxicity of microcystin-LR
    • Li X., Liu Y., Song L., Liu J. Responses of antioxidant systems in the hepatocytes of common carp (Cyprinus carpio L.) to the toxicity of microcystin-LR. Toxicon 2003, 42:85-89.
    • (2003) Toxicon , vol.42 , pp. 85-89
    • Li, X.1    Liu, Y.2    Song, L.3    Liu, J.4
  • 86
    • 8644230019 scopus 로고    scopus 로고
    • Subchronic oral toxicity of microcystin in common carp (Cyprinus carpio L.) exposed to Microcystis under laboratory conditions
    • Li X.-Y., Chung I.-K., Kim J.-I., Lee J.-A. Subchronic oral toxicity of microcystin in common carp (Cyprinus carpio L.) exposed to Microcystis under laboratory conditions. Toxicon 2004, 44:821-827.
    • (2004) Toxicon , vol.44 , pp. 821-827
    • Li, X.-Y.1    Chung, I.-K.2    Kim, J.-I.3    Lee, J.-A.4
  • 87
    • 23944517789 scopus 로고    scopus 로고
    • Oral exposure to Microcystis increases activityaugmented antioxidant enzymes in the liver of loach (Misgurnus mizolepis) and has no effect on lipid peroxidation
    • Li X-Y., Chung I-K., Kim J-I., Lee J-A. Oral exposure to Microcystis increases activityaugmented antioxidant enzymes in the liver of loach (Misgurnus mizolepis) and has no effect on lipid peroxidation. Comp. Biochem. Physiol. C 2005, 141:292-296.
    • (2005) Comp. Biochem. Physiol. C , vol.141 , pp. 292-296
    • Li, X.-Y.1    Chung, I.-K.2    Kim, J.-I.3    Lee, J.-A.4
  • 89
    • 0031897675 scopus 로고    scopus 로고
    • Can ingested cyanobacteria be harmful to the signal crayfish (Pacifastacus leniusculus)
    • Liras V., Lindberg M., Nystrom P., Annadotter H., Lawton L., Graf B. Can ingested cyanobacteria be harmful to the signal crayfish (Pacifastacus leniusculus). Freshwater Biol. 1998, 39:233-242.
    • (1998) Freshwater Biol. , vol.39 , pp. 233-242
    • Liras, V.1    Lindberg, M.2    Nystrom, P.3    Annadotter, H.4    Lawton, L.5    Graf, B.6
  • 90
    • 0036136599 scopus 로고    scopus 로고
    • The toxic effects of MC-LR on embryo-larval and juvenile development of loach, Misguruns mizolepis Gunthe
    • Liu Y., Song L., Li X., Liu T. The toxic effects of MC-LR on embryo-larval and juvenile development of loach, Misguruns mizolepis Gunthe. Toxicon 2002, 40:395-399.
    • (2002) Toxicon , vol.40 , pp. 395-399
    • Liu, Y.1    Song, L.2    Li, X.3    Liu, T.4
  • 91
    • 0035158449 scopus 로고    scopus 로고
    • Cellular microcystin content in N-limited Microcystis aeruginosa can be predicted from growth rate
    • Long B.M., Jones G.J., Orr P.T. Cellular microcystin content in N-limited Microcystis aeruginosa can be predicted from growth rate. Appl. Environ. Microbiol. 2001, 67(1):278-283.
    • (2001) Appl. Environ. Microbiol. , vol.67 , Issue.1 , pp. 278-283
    • Long, B.M.1    Jones, G.J.2    Orr, P.T.3
  • 92
    • 0025333146 scopus 로고
    • Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants
    • Mackintosh C., Beattie K.A., Klumpp S., Cohen P., Codd G.A. Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants. FEBS Lett. 1990, 264:187-192.
    • (1990) FEBS Lett. , vol.264 , pp. 187-192
    • Mackintosh, C.1    Beattie, K.A.2    Klumpp, S.3    Cohen, P.4    Codd, G.A.5
  • 93
    • 0029088182 scopus 로고
    • The cyanobacterial toxin microcystin binds covalently to cysteine-273 on protein phosphatase 1
    • MacKintosh R.W., Dalby K.N., Campbell D.G., Cohen P.T., Cohen P., MacKintosh C. The cyanobacterial toxin microcystin binds covalently to cysteine-273 on protein phosphatase 1. FEBS Lett. 1995, 371(3):236-240.
    • (1995) FEBS Lett. , vol.371 , Issue.3 , pp. 236-240
    • MacKintosh, R.W.1    Dalby, K.N.2    Campbell, D.G.3    Cohen, P.T.4    Cohen, P.5    MacKintosh, C.6
  • 94
  • 95
    • 0035401328 scopus 로고    scopus 로고
    • Microcystin contamination in fish from the Jacarapaguã Lagoon (RJ, Brazil): Ecological implication and human health risk
    • Magalhães V.F., Soares R.M., Azevedo S.M.F.O. Microcystin contamination in fish from the Jacarapaguã Lagoon (RJ, Brazil): Ecological implication and human health risk. Toxicon 2001, 39:1077-1108.
    • (2001) Toxicon , vol.39 , pp. 1077-1108
    • Magalhães, V.F.1    Soares, R.M.2    Azevedo, S.M.F.O.3
  • 96
    • 23644432822 scopus 로고    scopus 로고
    • The effects of stress and aging on glutathione metabolism
    • Maher P. The effects of stress and aging on glutathione metabolism. Ageing Res. Rev. 2005, 4:288-314.
    • (2005) Ageing Res. Rev. , vol.4 , pp. 288-314
    • Maher, P.1
  • 99
    • 0037674832 scopus 로고    scopus 로고
    • Hepatic accumulation and effects of MC-LR on juvenile goldfish Carassius auratus L
    • Malbrouck C., Trausch G., Devos P., Kestemont P. Hepatic accumulation and effects of MC-LR on juvenile goldfish Carassius auratus L. Comp. Biochem. Physiol. C 2003, 135:39-48.
    • (2003) Comp. Biochem. Physiol. C , vol.135 , pp. 39-48
    • Malbrouck, C.1    Trausch, G.2    Devos, P.3    Kestemont, P.4
  • 100
    • 68249107159 scopus 로고    scopus 로고
    • Proteomic study of the effects of microcystin-LR on organelle and membrane proteins in medaka fish liver
    • Malécot M., Mezhoud K., Marie A., Praseuth D., Puiseux-Dao S., Edery M. Proteomic study of the effects of microcystin-LR on organelle and membrane proteins in medaka fish liver. Aquat. Toxicol. 2009, 94(2):153-161.
    • (2009) Aquat. Toxicol. , vol.94 , Issue.2 , pp. 153-161
    • Malécot, M.1    Mezhoud, K.2    Marie, A.3    Praseuth, D.4    Puiseux-Dao, S.5    Edery, M.6
  • 102
    • 14644396569 scopus 로고    scopus 로고
    • Detection of the cyanobacterial hepatotoxins microcystins
    • McElhiney J., Lawton L.A. Detection of the cyanobacterial hepatotoxins microcystins. Toxicol. Appl. Pharmacol. 2005, 203:219-230.
    • (2005) Toxicol. Appl. Pharmacol. , vol.203 , pp. 219-230
    • McElhiney, J.1    Lawton, L.A.2
  • 103
  • 104
    • 0037328127 scopus 로고    scopus 로고
    • Analysis of cyanobacterial toxins by immunological methods
    • Metcalf J.S., Codd G.A. Analysis of cyanobacterial toxins by immunological methods. Chem. Res. Toxicol. 2003, 16:103-112.
    • (2003) Chem. Res. Toxicol. , vol.16 , pp. 103-112
    • Metcalf, J.S.1    Codd, G.A.2
  • 106
    • 38749111845 scopus 로고    scopus 로고
    • Global quantitative analysis of protein expression, and phosphorylation status in the liver of the medaka fish (Oryzias latipes) exposed to microcystin-LR I. Bathing study
    • Mezhoud K., Praseuth D., Puiseux-Dao S., François J.C., Bernard C., Edery M. Global quantitative analysis of protein expression, and phosphorylation status in the liver of the medaka fish (Oryzias latipes) exposed to microcystin-LR I. Bathing study. Aquat. Toxicol. 2008, 86(2):166-175.
    • (2008) Aquat. Toxicol. , vol.86 , Issue.2 , pp. 166-175
    • Mezhoud, K.1    Praseuth, D.2    Puiseux-Dao, S.3    François, J.C.4    Bernard, C.5    Edery, M.6
  • 108
    • 0242334129 scopus 로고    scopus 로고
    • Nephrotoxic effects of chronic administration of microcystins-LR and-YR
    • Milutinovic A., Zivin M., Zorc-Pleskovic R., Sedmak B., Suput D. Nephrotoxic effects of chronic administration of microcystins-LR and-YR. Toxicon 2003, 42:281-288.
    • (2003) Toxicon , vol.42 , pp. 281-288
    • Milutinovic, A.1    Zivin, M.2    Zorc-Pleskovic, R.3    Sedmak, B.4    Suput, D.5
  • 109
    • 0026100142 scopus 로고
    • Hepatotoxicity of MCLR in fed and fasted rats
    • Miura G.A., Robinson N.A., Lawrence W.B., Pace J.G. Hepatotoxicity of MCLR in fed and fasted rats. Toxicon 1991, 29(3):337-346.
    • (1991) Toxicon , vol.29 , Issue.3 , pp. 337-346
    • Miura, G.A.1    Robinson, N.A.2    Lawrence, W.B.3    Pace, J.G.4
  • 110
    • 33644518736 scopus 로고    scopus 로고
    • Depuration of microcystins in tilapia fish exposed to natural populations of toxic cyanobacteria: a laboratory study
    • Mohamed Z.A., Hussein A.A. Depuration of microcystins in tilapia fish exposed to natural populations of toxic cyanobacteria: a laboratory study. Ecotoxicol. Environ. Saf. 2006, 63(3):424-429.
    • (2006) Ecotoxicol. Environ. Saf. , vol.63 , Issue.3 , pp. 424-429
    • Mohamed, Z.A.1    Hussein, A.A.2
  • 111
    • 17744419000 scopus 로고    scopus 로고
    • The effects of pure MC-LR and biomass of blue-green algae on blood indices of carp (Cyprinus carpio L.)
    • Navratil S., Palikova M., Vajcova V. The effects of pure MC-LR and biomass of blue-green algae on blood indices of carp (Cyprinus carpio L.). Acta Vet. Brno. 1998, 67:273-279.
    • (1998) Acta Vet. Brno. , vol.67 , pp. 273-279
    • Navratil, S.1    Palikova, M.2    Vajcova, V.3
  • 112
    • 0033924249 scopus 로고    scopus 로고
    • Co-occurrence of non-toxic (cyanopeptolin) and toxic (microcystin) peptides in a bloom of Microcystis sp from a Chilean Lake
    • Neumann U., Campos V., Cantarero S., Urrutia H., Heinze R., Weckesser J., Erhard M. Co-occurrence of non-toxic (cyanopeptolin) and toxic (microcystin) peptides in a bloom of Microcystis sp from a Chilean Lake. Syst. Appl. Microbiol. 2000, 23(2):191-197.
    • (2000) Syst. Appl. Microbiol. , vol.23 , Issue.2 , pp. 191-197
    • Neumann, U.1    Campos, V.2    Cantarero, S.3    Urrutia, H.4    Heinze, R.5    Weckesser, J.6    Erhard, M.7
  • 113
    • 0022823554 scopus 로고
    • Acute toxic effects of the cyanobacteria Microcystis aeruginosa on Daphnia magna
    • Nizan S., Dimentman C., Shilo M. Acute toxic effects of the cyanobacteria Microcystis aeruginosa on Daphnia magna. Limnol. Oceanogr. 1986, 31:497-502.
    • (1986) Limnol. Oceanogr. , vol.31 , pp. 497-502
    • Nizan, S.1    Dimentman, C.2    Shilo, M.3
  • 114
    • 84856101477 scopus 로고    scopus 로고
    • The rise of harmful cyanobacteria blooms: The potential roles of eutrophication and climate change
    • O'Neil J.M., Davis T.W., Burford M.A., Gobler C.J. The rise of harmful cyanobacteria blooms: The potential roles of eutrophication and climate change. Harmful Algae 2012, 14:313-334.
    • (2012) Harmful Algae , vol.14 , pp. 313-334
    • O'Neil, J.M.1    Davis, T.W.2    Burford, M.A.3    Gobler, C.J.4
  • 115
    • 0032992309 scopus 로고    scopus 로고
    • Effects of cyanobacterial toxins and aqueous crude extracts on the development of fish and amphibians
    • Oberemm A., Becker J., Codd G., Steinberg C. Effects of cyanobacterial toxins and aqueous crude extracts on the development of fish and amphibians. Environ. Toxicol. 1999, 14:77-88.
    • (1999) Environ. Toxicol. , vol.14 , pp. 77-88
    • Oberemm, A.1    Becker, J.2    Codd, G.3    Steinberg, C.4
  • 116
    • 0031281308 scopus 로고    scopus 로고
    • Effects of MC-LR and cyanobacterial crude extracts on embryo-larval development of zebrafish
    • Oberemm A., Fastner J., Steinberg C. Effects of MC-LR and cyanobacterial crude extracts on embryo-larval development of zebrafish. Water Res. 1997, 31:2918-2921.
    • (1997) Water Res. , vol.31 , pp. 2918-2921
    • Oberemm, A.1    Fastner, J.2    Steinberg, C.3
  • 118
    • 84856645166 scopus 로고    scopus 로고
    • Climate change: Links to global expansion of harmful cyanobacteria
    • Paerl H.W., Paul V.J. Climate change: Links to global expansion of harmful cyanobacteria. Wat. Res. 2012, 46:1349-1363.
    • (2012) Wat. Res. , vol.46 , pp. 1349-1363
    • Paerl, H.W.1    Paul, V.J.2
  • 119
    • 0032265404 scopus 로고    scopus 로고
    • The effects of pure MC LR and biomass of blue-green algae on selected immunological indices of carp (Cyprinus carpio L.) and silver carp (Hypophthalmichthys molitrix Val.)
    • Palikova M., Kovaru F., Navratil S., Kubala L., Pesak S., Vajcova V. The effects of pure MC LR and biomass of blue-green algae on selected immunological indices of carp (Cyprinus carpio L.) and silver carp (Hypophthalmichthys molitrix Val.). Acta Vet. Brno. 1998, 67:265-272.
    • (1998) Acta Vet. Brno. , vol.67 , pp. 265-272
    • Palikova, M.1    Kovaru, F.2    Navratil, S.3    Kubala, L.4    Pesak, S.5    Vajcova, V.6
  • 120
    • 4444376889 scopus 로고    scopus 로고
    • Histopathology of carp (Cyprinus carpio L.) larvae exposed to cyanobacteria extract
    • Palikova M., Navratil S., Tichy F., Sterba F., Marsalek B., Blaha L. Histopathology of carp (Cyprinus carpio L.) larvae exposed to cyanobacteria extract. Acta Vet. Brno. 2004, 73:253-257.
    • (2004) Acta Vet. Brno. , vol.73 , pp. 253-257
    • Palikova, M.1    Navratil, S.2    Tichy, F.3    Sterba, F.4    Marsalek, B.5    Blaha, L.6
  • 121
    • 84455167759 scopus 로고    scopus 로고
    • Biochemical response of diverse organs in adult Danio rerio (zebrafish) exposed to sub-lethal concentrations of microcystin-LR and microcystin-RR: A balneation study
    • Pavagadhi S., Gong Z., Hande M.P., Dionysiou D.D., de la Cruz A.A., Balasubramanian R. Biochemical response of diverse organs in adult Danio rerio (zebrafish) exposed to sub-lethal concentrations of microcystin-LR and microcystin-RR: A balneation study. Aquat. Toxicol. 2012, 109:1-10.
    • (2012) Aquat. Toxicol. , vol.109 , pp. 1-10
    • Pavagadhi, S.1    Gong, Z.2    Hande, M.P.3    Dionysiou, D.D.4    de la Cruz, A.A.5    Balasubramanian, R.6
  • 122
    • 84878694484 scopus 로고    scopus 로고
    • Toxicological implications of microcystins on zebrafish embryos in the presence of other environmental pollutants
    • Pavagadhi S., Zhiyuan G., Balasubramanian R. Toxicological implications of microcystins on zebrafish embryos in the presence of other environmental pollutants. Environ. Toxicol. Chem. (accepted manuscript) 2013, 10.1002/etc.2203.
    • (2013) Environ. Toxicol. Chem. (accepted manuscript)
    • Pavagadhi, S.1    Zhiyuan, G.2    Balasubramanian, R.3
  • 123
    • 84857199671 scopus 로고    scopus 로고
    • Use of chlorophyll a fluorescence to detect the effect of microcystins on photosynthesis and photosystem II energy fluxes of green algae
    • Perron M.-C., Qiu B., Boucher N., Bellemare F., Juneau P. Use of chlorophyll a fluorescence to detect the effect of microcystins on photosynthesis and photosystem II energy fluxes of green algae. Toxicon 2012, 59:567-577.
    • (2012) Toxicon , vol.59 , pp. 567-577
    • Perron, M.-C.1    Qiu, B.2    Boucher, N.3    Bellemare, F.4    Juneau, P.5
  • 124
    • 0031788805 scopus 로고    scopus 로고
    • Identification of an enzymatically formed glutathione conjugate of the cyanobacterial hepatotoxin MC-LR: The first step of detoxication
    • Pflugmacher S., Wiegand C., Oberemm A., Beattie K.A., Krause E., Codd G.A., Steinberg C.E.W. Identification of an enzymatically formed glutathione conjugate of the cyanobacterial hepatotoxin MC-LR: The first step of detoxication. Biochim. Biophys. Acta 1998, 1425:527-533.
    • (1998) Biochim. Biophys. Acta , vol.1425 , pp. 527-533
    • Pflugmacher, S.1    Wiegand, C.2    Oberemm, A.3    Beattie, K.A.4    Krause, E.5    Codd, G.A.6    Steinberg, C.E.W.7
  • 126
    • 0021368649 scopus 로고
    • First-pass elimination- Basic concepts and clinical consequences
    • Pond S.M., Tozer T.N. First-pass elimination- Basic concepts and clinical consequences. Clin. Pharmacokinet. 1984, 9(1):1-25.
    • (1984) Clin. Pharmacokinet. , vol.9 , Issue.1 , pp. 1-25
    • Pond, S.M.1    Tozer, T.N.2
  • 127
    • 33646114525 scopus 로고    scopus 로고
    • Differential oxidative stress responses to microcystins LR and RR in intraperitoneally exposed tilapia fish (Oreochromis sp.)
    • Prieto A.I., Jos A., Pichardo S., Moreno I., Cameán A.M. Differential oxidative stress responses to microcystins LR and RR in intraperitoneally exposed tilapia fish (Oreochromis sp.). Aquat. Toxicol. 2006, 77:314-321.
    • (2006) Aquat. Toxicol. , vol.77 , pp. 314-321
    • Prieto, A.I.1    Jos, A.2    Pichardo, S.3    Moreno, I.4    Cameán, A.M.5
  • 128
    • 34547880740 scopus 로고    scopus 로고
    • Time-dependent oxidative stress responses after acute exposure to toxic cyanobacterial cells containing microcystins in tilapia fish (Oreochromis niloticus) under laboratory conditions
    • Prieto A.I., Pichardo S., Jos Á., Moreno I., Cameán A.M. Time-dependent oxidative stress responses after acute exposure to toxic cyanobacterial cells containing microcystins in tilapia fish (Oreochromis niloticus) under laboratory conditions. Aquat. Toxicol. 2007, 84:337-345.
    • (2007) Aquat. Toxicol. , vol.84 , pp. 337-345
    • Prieto, A.I.1    Pichardo, S.2    Jos, Á.3    Moreno, I.4    Cameán, A.M.5
  • 129
    • 62949106984 scopus 로고    scopus 로고
    • Plasma biochemical responses of the planktivorous filterfeeding silver carp (Hypophthalmichthys molitrix) and bighead carp (Aristichthysn nobilis) to prolonged toxic cyanobacterial blooms in natural waters
    • Qiu T., Xie P., Guo L., Zhang D. Plasma biochemical responses of the planktivorous filterfeeding silver carp (Hypophthalmichthys molitrix) and bighead carp (Aristichthysn nobilis) to prolonged toxic cyanobacterial blooms in natural waters. Environ. Toxicol. Pharmacol. 2009, 27:350-356.
    • (2009) Environ. Toxicol. Pharmacol. , vol.27 , pp. 350-356
    • Qiu, T.1    Xie, P.2    Guo, L.3    Zhang, D.4
  • 130
    • 0025733722 scopus 로고
    • Histopathological effects of microcystin LR, a cyclic peptide toxin from the cyanobacterium (blue-green alga) Microcystis aeruginosa on common carp (Cyprinus carpio L.)
    • Rabergh C.M.I., Bylund G., Eriksson J.E. Histopathological effects of microcystin LR, a cyclic peptide toxin from the cyanobacterium (blue-green alga) Microcystis aeruginosa on common carp (Cyprinus carpio L.). Aquat. Toxicol. 1991, 20:131-214.
    • (1991) Aquat. Toxicol. , vol.20 , pp. 131-214
    • Rabergh, C.M.I.1    Bylund, G.2    Eriksson, J.E.3
  • 131
    • 0037183453 scopus 로고    scopus 로고
    • Detection of microcystins with protein phosphatase inhibition assay, highperformance liquid chromatography-UV detection and enzymelinked immunosorbent assay-Comparison of methods
    • Rapala J., Erkomaa K., Kukkonen J., Sivonen K., Lahti K. Detection of microcystins with protein phosphatase inhibition assay, highperformance liquid chromatography-UV detection and enzymelinked immunosorbent assay-Comparison of methods. Anal. Chim. Acta 2002, 466:213-231.
    • (2002) Anal. Chim. Acta , vol.466 , pp. 213-231
    • Rapala, J.1    Erkomaa, K.2    Kukkonen, J.3    Sivonen, K.4    Lahti, K.5
  • 132
    • 0030994088 scopus 로고    scopus 로고
    • Variation of microcystins, cyanobacterial hepatotoxins, in Anabaena spp. As a function of growth stimuli
    • Rapala J., Sivonen K., Lyra C., Niemelä S.I. Variation of microcystins, cyanobacterial hepatotoxins, in Anabaena spp. As a function of growth stimuli. Appl. Environ. Microbiol. 1997, 63(6):2206-2212.
    • (1997) Appl. Environ. Microbiol. , vol.63 , Issue.6 , pp. 2206-2212
    • Rapala, J.1    Sivonen, K.2    Lyra, C.3    Niemelä, S.I.4
  • 134
    • 0023556755 scopus 로고
    • Temperature effects on photosynthetic capacity, respiration, and growth rates of bloom-forming cyanobacteria
    • Robarts R.D., Zohary T. Temperature effects on photosynthetic capacity, respiration, and growth rates of bloom-forming cyanobacteria. N.Z. J. Mar. Freshwat. Res. 1987, 21:391-399.
    • (1987) N.Z. J. Mar. Freshwat. Res. , vol.21 , pp. 391-399
    • Robarts, R.D.1    Zohary, T.2
  • 135
    • 0034663830 scopus 로고    scopus 로고
    • Hepatotoxins production kinetics of the cyanobacterium Microcystis aeruginosa PCC 7820, as determined by HPLC-mass spectrometry and protein phosphatase bioassay
    • Robillot C., Vinh J., Puiseux-Dao S., Hennion M.C. Hepatotoxins production kinetics of the cyanobacterium Microcystis aeruginosa PCC 7820, as determined by HPLC-mass spectrometry and protein phosphatase bioassay. Environ. Sci. Technol. 2000, 34:3372-3378.
    • (2000) Environ. Sci. Technol. , vol.34 , pp. 3372-3378
    • Robillot, C.1    Vinh, J.2    Puiseux-Dao, S.3    Hennion, M.C.4
  • 137
    • 79952180931 scopus 로고    scopus 로고
    • Global gene expression profiling in larval zebrafish exposed to microcystin-LR and microcystis reveals endocrine disrupting effects of cyanobacteria
    • Rogers E.D., Henry T.B., Twiner M.J., Gouffon J.S., McPherson J.T., Boyer G.L., Sayler G.S., Wilhelm S.W. Global gene expression profiling in larval zebrafish exposed to microcystin-LR and microcystis reveals endocrine disrupting effects of cyanobacteria. Environ. Sci. Technol. 2011, 45:1962-1969.
    • (2011) Environ. Sci. Technol. , vol.45 , pp. 1962-1969
    • Rogers, E.D.1    Henry, T.B.2    Twiner, M.J.3    Gouffon, J.S.4    McPherson, J.T.5    Boyer, G.L.6    Sayler, G.S.7    Wilhelm, S.W.8
  • 138
    • 0037290663 scopus 로고    scopus 로고
    • Fish bioaccumulation and biomarkers in environmental risk assessment: a review
    • Ron V.D.O., Jonny B., Nico P.E.V. Fish bioaccumulation and biomarkers in environmental risk assessment: a review. Envrion. Toxicol. Phar. 2003, 13:57-149.
    • (2003) Envrion. Toxicol. Phar. , vol.13 , pp. 57-149
    • Ron, V.D.O.1    Jonny, B.2    Nico, P.E.V.3
  • 139
    • 20344397404 scopus 로고    scopus 로고
    • Characterizing the metabolic actions of natural stresses in the california red abalone, haliotis rufescens using 1H NMR metabolomics
    • Rosenblum E.S., Viant M.R., Braid B.M., Moore J.D., Friedman C.S., Tjeerdema R.S. Characterizing the metabolic actions of natural stresses in the california red abalone, haliotis rufescens using 1H NMR metabolomics. Metabolomics 2005, 1:199-209.
    • (2005) Metabolomics , vol.1 , pp. 199-209
    • Rosenblum, E.S.1    Viant, M.R.2    Braid, B.M.3    Moore, J.D.4    Friedman, C.S.5    Tjeerdema, R.S.6
  • 140
    • 84874533779 scopus 로고    scopus 로고
    • Electrochemical immunosensor for ultrasensitive detection of microcystin-LR based on graphene-gold nanocomposite/functional conducting polymer/gold nanoparticle/ionic liquid composite film with electrodeposition
    • Ruiyi L., Qianfang X., Zaijun L., Xiulan S., Junkang L. Electrochemical immunosensor for ultrasensitive detection of microcystin-LR based on graphene-gold nanocomposite/functional conducting polymer/gold nanoparticle/ionic liquid composite film with electrodeposition. Biosens. Bioelectron. 2013, 44:235-240.
    • (2013) Biosens. Bioelectron. , vol.44 , pp. 235-240
    • Ruiyi, L.1    Qianfang, X.2    Zaijun, L.3    Xiulan, S.4    Junkang, L.5
  • 141
    • 0028806986 scopus 로고
    • Microcystin uptake and inhibition of protein phosphatases: effects of chemoprotectants and self-inhibition in relation to known hepatic transporters
    • Runnegar M., Berndt N., Kaplowitz N. Microcystin uptake and inhibition of protein phosphatases: effects of chemoprotectants and self-inhibition in relation to known hepatic transporters. Toxicol. Appl. Pharmacol. 1995, 134:264-272.
    • (1995) Toxicol. Appl. Pharmacol. , vol.134 , pp. 264-272
    • Runnegar, M.1    Berndt, N.2    Kaplowitz, N.3
  • 142
    • 0025966237 scopus 로고
    • The uptake of the cyanobacterial hepatotoxin microcystin by isolated rat hepatocytes
    • Runnegar M.T., Gerdes R.G., Falconer I.R. The uptake of the cyanobacterial hepatotoxin microcystin by isolated rat hepatocytes. Toxicon 1991, 29:43-51.
    • (1991) Toxicon , vol.29 , pp. 43-51
    • Runnegar, M.T.1    Gerdes, R.G.2    Falconer, I.R.3
  • 143
    • 0023465354 scopus 로고
    • Injury to hepatocytes induced by a peptide toxin from the cyanobacterium Microcystis aeruginosa
    • Runnegar M.T.C., Andrews J., Gerdes R.G., Falconer I.R. Injury to hepatocytes induced by a peptide toxin from the cyanobacterium Microcystis aeruginosa. Toxicon 1987, 25:1235-1239.
    • (1987) Toxicon , vol.25 , pp. 1235-1239
    • Runnegar, M.T.C.1    Andrews, J.2    Gerdes, R.G.3    Falconer, I.R.4
  • 144
    • 0030025617 scopus 로고    scopus 로고
    • Biliary excretion of biochemically active cyanobacteria (blue-green algae) hepatotoxins in fish
    • Sahin A., Tencalla F.G., Dietrich D.R., Naegeli H. Biliary excretion of biochemically active cyanobacteria (blue-green algae) hepatotoxins in fish. Toxicol. 1996, 106:123-130.
    • (1996) Toxicol. , vol.106 , pp. 123-130
    • Sahin, A.1    Tencalla, F.G.2    Dietrich, D.R.3    Naegeli, H.4
  • 145
    • 77951880802 scopus 로고    scopus 로고
    • Metabolomics for functional genomics, systems biology, and biotechnology
    • Saito K., Matsuda F. Metabolomics for functional genomics, systems biology, and biotechnology. Annu. Rev. Plant Biol. 2010, 61:463-489.
    • (2010) Annu. Rev. Plant Biol. , vol.61 , pp. 463-489
    • Saito, K.1    Matsuda, F.2
  • 147
    • 71549121025 scopus 로고    scopus 로고
    • Target gene approaches: Gene expression in Daphnia magna exposed to predator-borne kairomones or to microcystin-producing and microcystin-free Microcystis aeruginosa
    • Schwarzenberger A., Courts C., Von Elert E. Target gene approaches: Gene expression in Daphnia magna exposed to predator-borne kairomones or to microcystin-producing and microcystin-free Microcystis aeruginosa. BMC Genomics 2009, 10:527.
    • (2009) BMC Genomics , vol.10 , pp. 527
    • Schwarzenberger, A.1    Courts, C.2    Von Elert, E.3
  • 149
    • 0018874053 scopus 로고
    • Dynamics of dissolved oxygen during algal bloom in lake Kasumigaura, Japan
    • Seki H., Takahashi M., Hara Y., Ichimura S. Dynamics of dissolved oxygen during algal bloom in lake Kasumigaura, Japan. Water Res. 1980, 14:179-183.
    • (1980) Water Res. , vol.14 , pp. 179-183
    • Seki, H.1    Takahashi, M.2    Hara, Y.3    Ichimura, S.4
  • 150
    • 84863824288 scopus 로고    scopus 로고
    • Recent trends in development of biosensors for detection of microcystin
    • Singh S., Srivastava A., Oh H.M., Ahn C.Y., Choi G.G., Asthana R.K. Recent trends in development of biosensors for detection of microcystin. Toxicon 2012, 60(5):878-894.
    • (2012) Toxicon , vol.60 , Issue.5 , pp. 878-894
    • Singh, S.1    Srivastava, A.2    Oh, H.M.3    Ahn, C.Y.4    Choi, G.G.5    Asthana, R.K.6
  • 151
    • 0034897147 scopus 로고    scopus 로고
    • Time-dependent accumulation of cyanobacterial hepatotoxins in flounders (Platichthys flesus) and mussels (Mytilus edulis) from the Northern Baltic Sea
    • Sipia V.O., Kankaanpa H.T., Flinkman J., Lahti K., Meriluoto J.A.O. Time-dependent accumulation of cyanobacterial hepatotoxins in flounders (Platichthys flesus) and mussels (Mytilus edulis) from the Northern Baltic Sea. Environ. Toxicol. 2001, 16:330-336.
    • (2001) Environ. Toxicol. , vol.16 , pp. 330-336
    • Sipia, V.O.1    Kankaanpa, H.T.2    Flinkman, J.3    Lahti, K.4    Meriluoto, J.A.O.5
  • 154
    • 84876726573 scopus 로고    scopus 로고
    • Longitudinal surface plasmon resonance assay enhanced by magnetosomes for simultaneous detection of Pefloxacin and Microcystin-LR in seafoods
    • Sun X., Wu L., Ji J., Jiang D., Zhang Y., Li Z., Zhang G., Zhang H. Longitudinal surface plasmon resonance assay enhanced by magnetosomes for simultaneous detection of Pefloxacin and Microcystin-LR in seafoods. Biosens. Bioelectron. 2013, 47:318-323.
    • (2013) Biosens. Bioelectron. , vol.47 , pp. 318-323
    • Sun, X.1    Wu, L.2    Ji, J.3    Jiang, D.4    Zhang, Y.5    Li, Z.6    Zhang, G.7    Zhang, H.8
  • 155
    • 43749098985 scopus 로고    scopus 로고
    • DNA methylation landscapes: provocative insights from epigenomics
    • Suzuki M.M., Bird A. DNA methylation landscapes: provocative insights from epigenomics. Nat. Rev. Genet. 2008, 9(6):465-476.
    • (2008) Nat. Rev. Genet. , vol.9 , Issue.6 , pp. 465-476
    • Suzuki, M.M.1    Bird, A.2
  • 157
    • 0028113968 scopus 로고
    • Toxicity of Microc~stis aeruginosa peptide toxin to rainbow trout (Oncorhynchus mykiss)
    • Tencalla F.G., Dietrich D.R., Schlatter C. Toxicity of Microc~stis aeruginosa peptide toxin to rainbow trout (Oncorhynchus mykiss). Toxicon 1994, 30:215-224.
    • (1994) Toxicon , vol.30 , pp. 215-224
    • Tencalla, F.G.1    Dietrich, D.R.2    Schlatter, C.3
  • 158
    • 0030934727 scopus 로고    scopus 로고
    • Biochemical characterization of microcystin toxicity in rainbow trout (Oncorhynchus mykiss)
    • Tencalla F., Dietrich D. Biochemical characterization of microcystin toxicity in rainbow trout (Oncorhynchus mykiss). Toxicon 1997, 35(4):583-595.
    • (1997) Toxicon , vol.35 , Issue.4 , pp. 583-595
    • Tencalla, F.1    Dietrich, D.2
  • 159
    • 0027062881 scopus 로고
    • Substances that protect cultured hepatocytes from the toxic effects of microcystin-LR
    • Thompson W.L., Pace J.G. Substances that protect cultured hepatocytes from the toxic effects of microcystin-LR. Toxicol. In Vitro 1992, 6(6):579-587.
    • (1992) Toxicol. In Vitro , vol.6 , Issue.6 , pp. 579-587
    • Thompson, W.L.1    Pace, J.G.2
  • 160
    • 79955900944 scopus 로고    scopus 로고
    • Label-free immunosensing of microcystin-LR using a gold electrode modified with gold nanoparticles
    • Tong P., Tang S., He Y., Shao Y., Zhang L., Chen G. Label-free immunosensing of microcystin-LR using a gold electrode modified with gold nanoparticles. Microchim. Acta 2011, 173:299-305.
    • (2011) Microchim. Acta , vol.173 , pp. 299-305
    • Tong, P.1    Tang, S.2    He, Y.3    Shao, Y.4    Zhang, L.5    Chen, G.6
  • 162
    • 3042859637 scopus 로고    scopus 로고
    • The effect of intraperitoneally applied pure MC-LR on haematological, biochemical and morphological indices of silver carp (Hypophthalmichthys molitrix Val.)
    • Vajcova V., Navratil S., Palikova M. The effect of intraperitoneally applied pure MC-LR on haematological, biochemical and morphological indices of silver carp (Hypophthalmichthys molitrix Val.). Acta Vet. Brno 1998, 67:281-287.
    • (1998) Acta Vet. Brno , vol.67 , pp. 281-287
    • Vajcova, V.1    Navratil, S.2    Palikova, M.3
  • 163
    • 0003177721 scopus 로고
    • Occurrence of Oscillatoria agardhii and some related species, a survey
    • Van Liere L., Mur L.R. Occurrence of Oscillatoria agardhii and some related species, a survey. Dev. Hydrobiol. 1980, 2:67-77.
    • (1980) Dev. Hydrobiol. , vol.2 , pp. 67-77
    • Van Liere, L.1    Mur, L.R.2
  • 164
    • 0038689221 scopus 로고    scopus 로고
    • Effect of hepatotoxins (microcystin) on ion-regulation and antioxidant system in gills of Chasmagnathus granulatus (Decapoda, Grapsidae)
    • Vinagre T.M., Alciati J.C., Regoli F., Bocchetti R., Yunes J.S., Bianchini A., Monserrat J.M. Effect of hepatotoxins (microcystin) on ion-regulation and antioxidant system in gills of Chasmagnathus granulatus (Decapoda, Grapsidae). Comp. Biochem. Physiol. C 2003, 135:67-75.
    • (2003) Comp. Biochem. Physiol. C , vol.135 , pp. 67-75
    • Vinagre, T.M.1    Alciati, J.C.2    Regoli, F.3    Bocchetti, R.4    Yunes, J.S.5    Bianchini, A.6    Monserrat, J.M.7
  • 165
    • 79954424097 scopus 로고    scopus 로고
    • Rapid surface plasmon resonance immunobiosensor assay for microcystin toxins in blue-green algae food supplements
    • Vinogradova T., Danaher M., Baxter A., Moloney M., Victory D., Haughey S.A. Rapid surface plasmon resonance immunobiosensor assay for microcystin toxins in blue-green algae food supplements. Talanta 2011, 84:638-643.
    • (2011) Talanta , vol.84 , pp. 638-643
    • Vinogradova, T.1    Danaher, M.2    Baxter, A.3    Moloney, M.4    Victory, D.5    Haughey, S.A.6
  • 167
    • 71949095893 scopus 로고    scopus 로고
    • Simple, rapid, sensitive, and versatile SWNTpaper sensor for environmental toxin detection competitive with ELISA
    • Wang L., Chen W., Xu D., Shim B.S., Zhu Y., Sun F., Liu L., Peng C., Jin Z., Xu C., Kotov N.A. Simple, rapid, sensitive, and versatile SWNTpaper sensor for environmental toxin detection competitive with ELISA. Nano Lett. 2009, 9:4147-4152.
    • (2009) Nano Lett. , vol.9 , pp. 4147-4152
    • Wang, L.1    Chen, W.2    Xu, D.3    Shim, B.S.4    Zhu, Y.5    Sun, F.6    Liu, L.7    Peng, C.8    Jin, Z.9    Xu, C.10    Kotov, N.A.11
  • 168
    • 75249106631 scopus 로고    scopus 로고
    • Proteomic analysis of hepatic tissue of zebrafish (Danio rerio) experimentally exposed to chronic microcystin-LR
    • Wang M.H., Chan L.L., Si M.Z., Hong H.S., Wang D.Z. Proteomic analysis of hepatic tissue of zebrafish (Danio rerio) experimentally exposed to chronic microcystin-LR. Toxicol. Sci. 2010, 113:60-69.
    • (2010) Toxicol. Sci. , vol.113 , pp. 60-69
    • Wang, M.H.1    Chan, L.L.2    Si, M.Z.3    Hong, H.S.4    Wang, D.Z.5
  • 169
    • 77957245869 scopus 로고    scopus 로고
    • Protein profiles in zebrafish (Danio rerio) brains exposed to chronic microcystin-LR
    • Wang M., Wang D., Lin L., Hong H. Protein profiles in zebrafish (Danio rerio) brains exposed to chronic microcystin-LR. Chemosphere 2010, 81(6):716-724.
    • (2010) Chemosphere , vol.81 , Issue.6 , pp. 716-724
    • Wang, M.1    Wang, D.2    Lin, L.3    Hong, H.4
  • 170
    • 42049105357 scopus 로고    scopus 로고
    • Gene expression profiles in liver of zebrafish treated with microcystin-LR
    • Wei L., Sun B., Song L., Nie P. Gene expression profiles in liver of zebrafish treated with microcystin-LR. Environ. Toxicol. Pharmacol. 2008, 26(1):6-12.
    • (2008) Environ. Toxicol. Pharmacol. , vol.26 , Issue.1 , pp. 6-12
    • Wei, L.1    Sun, B.2    Song, L.3    Nie, P.4
  • 171
    • 0036048363 scopus 로고    scopus 로고
    • Applications of MALDI-TOF MS analysis in cyanotoxins research
    • Welker M., Fastner J., Erhard M., von Dohren H. Applications of MALDI-TOF MS analysis in cyanotoxins research. Environ. Toxicol. 2002, 17:367-374.
    • (2002) Environ. Toxicol. , vol.17 , pp. 367-374
    • Welker, M.1    Fastner, J.2    Erhard, M.3    von Dohren, H.4
  • 172
    • 33744965454 scopus 로고    scopus 로고
    • Cyanobacterial peptides-nature's own combinatorial biosynthesis
    • Welker M., Von Dohren H. Cyanobacterial peptides-nature's own combinatorial biosynthesis. FEMS Microbiol. Rev. 2006, 30(4):530-563.
    • (2006) FEMS Microbiol. Rev. , vol.30 , Issue.4 , pp. 530-563
    • Welker, M.1    Von Dohren, H.2
  • 174
    • 10644223216 scopus 로고    scopus 로고
    • World Health Organization, Geneva, Switzerland WHO
    • WHO Guidelines for Drinking Water Quality 2003, World Health Organization, Geneva, Switzerland. third ed,.
    • (2003) Guidelines for Drinking Water Quality
  • 176
    • 14644425290 scopus 로고    scopus 로고
    • Ecotoxicological effects of selected cyanobacterial secondary metabolites: a short review
    • Wiegand C., Pflugmacher S. Ecotoxicological effects of selected cyanobacterial secondary metabolites: a short review. Toxicol. Appl. Pharmacol. 2005, 203(3):201-218.
    • (2005) Toxicol. Appl. Pharmacol. , vol.203 , Issue.3 , pp. 201-218
    • Wiegand, C.1    Pflugmacher, S.2
  • 178
    • 20444451257 scopus 로고    scopus 로고
    • Organ distribution and bioaccumulation of microcystins in freshwater fish at different trophic levels from the eutrophic Lake Chaohu
    • Xie L., Xie P., Guo L., Li L., Miyabara Y., Park H. Organ distribution and bioaccumulation of microcystins in freshwater fish at different trophic levels from the eutrophic Lake Chaohu. China. Environ. Toxicol. 2005, 20:293-300.
    • (2005) China. Environ. Toxicol. , vol.20 , pp. 293-300
    • Xie, L.1    Xie, P.2    Guo, L.3    Li, L.4    Miyabara, Y.5    Park, H.6
  • 179
    • 77957170617 scopus 로고    scopus 로고
    • Dynamics of the water bloomforming Microcystis and its relationship with physicochemical factors in Lake Xuanwu (China)
    • Xu Y., Wang G., Yang W., Li R. Dynamics of the water bloomforming Microcystis and its relationship with physicochemical factors in Lake Xuanwu (China). Environ. Sci. Pollut. Res. 2010, 17(9):1581-1590.
    • (2010) Environ. Sci. Pollut. Res. , vol.17 , Issue.9 , pp. 1581-1590
    • Xu, Y.1    Wang, G.2    Yang, W.3    Li, R.4
  • 180
    • 84862829100 scopus 로고    scopus 로고
    • Waterborne exposure to microcystin-LR alters thyroid hormone levels and gene transcription in the hypothalamic-pituitary-thyroid axis in zebrafish larvae
    • Yan W., Zhou Y., Yang J., Li S., Hua D., Wang J., Chen J., Li G. Waterborne exposure to microcystin-LR alters thyroid hormone levels and gene transcription in the hypothalamic-pituitary-thyroid axis in zebrafish larvae. Chemosphere 2012, 87:1301-1307.
    • (2012) Chemosphere , vol.87 , pp. 1301-1307
    • Yan, W.1    Zhou, Y.2    Yang, J.3    Li, S.4    Hua, D.5    Wang, J.6    Chen, J.7    Li, G.8
  • 181
    • 0035978462 scopus 로고    scopus 로고
    • Microcystin-induced down-regulation of lymphocyte functions through reduced IL-2 mRNA stability
    • Yea S.S., Kim H., Oh M., Paik H.M., Yang K.H. Microcystin-induced down-regulation of lymphocyte functions through reduced IL-2 mRNA stability. Toxicol. Lett. 2001, 122:21-31.
    • (2001) Toxicol. Lett. , vol.122 , pp. 21-31
    • Yea, S.S.1    Kim, H.2    Oh, M.3    Paik, H.M.4    Yang, K.H.5
  • 183
    • 0002849692 scopus 로고
    • Springer-Verlag, Berlin, Z.Y. Tang, M.C. Wu, S.S. Xia (Eds.)
    • Yu S.Z. Primary Liver Cancer 1989, 30-37. Springer-Verlag, Berlin. Z.Y. Tang, M.C. Wu, S.S. Xia (Eds.).
    • (1989) Primary Liver Cancer , pp. 30-37
    • Yu, S.Z.1
  • 184
    • 0037212282 scopus 로고    scopus 로고
    • Microcystin-LR induces oxidative DNA damage in human hepatoma cell line HepG2
    • Zegura B., Sedmak B., Filipic M. Microcystin-LR induces oxidative DNA damage in human hepatoma cell line HepG2. Toxicon 2003, 41:41-48.
    • (2003) Toxicon , vol.41 , pp. 41-48
    • Zegura, B.1    Sedmak, B.2    Filipic, M.3
  • 185
    • 40249098704 scopus 로고    scopus 로고
    • Patterns of microcystin-LR induced alteration of the expression of genes involved in response to DNA damage and apoptosis
    • Zegura B., Zajc I., Lah T.T., Filipic M. Patterns of microcystin-LR induced alteration of the expression of genes involved in response to DNA damage and apoptosis. Toxicon 2008, 51:615-623.
    • (2008) Toxicon , vol.51 , pp. 615-623
    • Zegura, B.1    Zajc, I.2    Lah, T.T.3    Filipic, M.4
  • 186
    • 1042286470 scopus 로고    scopus 로고
    • Determination of microcystin-LR in surface water using high-performance liquid chromatography/tandem electrospray ionization mass detector
    • Zhang L., Ping X., Yang Z. Determination of microcystin-LR in surface water using high-performance liquid chromatography/tandem electrospray ionization mass detector. Talanta 2004, 62:191-198.
    • (2004) Talanta , vol.62 , pp. 191-198
    • Zhang, L.1    Ping, X.2    Yang, Z.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.