Identification of an enzymatically formed glutathione conjugate of the cyanobacterial hepatotoxin microcystin-LR: The first step of detoxication

Biochimica et Biophysica Acta - General Subjects

Volumn 1425, Issue 3, 1998, Pages 527-533

  Pflugmacher, Stephan ^a   Wiegand, Claudia ^a   Oberemm, Axel ^a   Beattie, Kenneth A ^b   Krause, Eberhard ^c   Codd, Geoffrey A ^b   Steinberg, Christian E W ^a  

^a LEIBNIZ INSTITUTE OF FRESHWATER ECOLOGY AND INLAND FISHERIES   (Germany)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

^c LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

Author keywords

Cyanobacterial toxin; Detoxication enzyme; Metabolism; Microcystin LR

Indexed keywords

CYANOGINOSIN; GLUTATHIONE;

ARTICLE; CONJUGATE; CONJUGATION; CONTROLLED STUDY; CYANOBACTERIUM; DETOXIFICATION; ECOSYSTEM; ECOTOXICITY; FISH; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; MASS SPECTROMETRY; NONHUMAN; PLANT; PRIORITY JOURNAL;

ANIMALS; BACTERIAL TOXINS; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYANOBACTERIA; DINITROCHLOROBENZENE; FISHES; GLUTATHIONE; GLUTATHIONE TRANSFERASE; MASS SPECTROMETRY; MICROCYSTINS; PEPTIDES, CYCLIC; WATER MICROBIOLOGY;

EID: 0031788805     PISSN: 03044165     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-4165(98)00107-X     Document Type: Article

References (17)

1. G. Francis, Nature 18 (1878) 11-12.
2. G.E. Fogg, W.D.P. Stewart, P. Fay, A.F. Walsby, The Blue-Green Algae, Academic Press, New York, 1973, 459 pp.
3. W.W. Carmichael, J. Appl. Bacteriol. 72 (1992) 445-459.
4. G.A. Codd, Water Sci. Technol. 32 (1995) 149-156.
5. R.W. McKintosh, K.N. Dalby, D.G. Campbell, P.T.W. Cohen, P. Cohen, C. McKintosh, FEBS Lett. 371 (1995) 236-240.
6. F. Kondo, Y. Ikai, H. Oka, M. Okumura, N. Ishikawa, K.-i. Harada, K. Matsuura, H. Murata, M. Suzuki, Chem. Res. Toxicol. 5 (1992) 591-596.
7. D.G. Bourne, G.J. Jones, R.L. Blakeley, A. Jones, A.P. Negri, P. Riddles, Appl. Environ. Microbiol. 62 (1996) 4086-4094.
8. M. Runnegar, N. Berndt, S.-M. Kong, E.Y.C. Lee, L. Zhang, Biochem. Biophys. Res. Commun. 216 (1995) 162-169.
9. S. Pflugmacher, C.E.W. Steinberg, J. Appl. Bot. 71 (1997) 144-146.
10. C. Wiegand, S. Pflugmacher, A. Oberemm, N. Meems, K.A. Beattie, C.E.W. Steinberg, G.A. Codd, Environ. Toxicol. Water Qual. (1999) in press.
11. W. Habig, M.J. Pabst, W.B. Jacoby, J. Biol. Chem. 249 (1974) 7130-7139.
12. M. Bradford, Anal. Biochem. 72 (1976) 248-254.
13. N.R. Bury, F.B. Eddy, G.A. Codd, J. Fish Biol. 46 (1995) 1042-1054.
14. M. Karas, F. Hillenkamp, Anal. Chem. 60 (1988) 2299-2304.
15. B. Mannervik, U.H. Danielson, CRC Crit. Rev. Biochem. 23 (1988) 283-337.
16. J.A. Nimmo, Fish Physiol. Biochem. 3 (1987) 163-172.
17. F. Kondo, H. Matsumoto, S. Yamada, N. Ishikawa, E. Ito, S. Nagata, Y. Ueno, M. Suzuki, K.-i. Harada, Chem. Res. Toxicol. 9 (1996) 1355-1359.