The Cyanotoxins

Advances in Botanical Research

Volumn 27, Issue C, 1997, Pages 211-256

  Carmichael, W W ^a  

^a WRIGHT STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 77956722542     PISSN: 00652296     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0065-2296(08)60282-7     Document Type: Article

References (251)

1. Abdel-Rahman S., El-Ayouty Y.M., and Kamael H.A. Characterization of heptapeptide toxins extracted from Microcystis aeruginosa (Egyptian isolate). International Journal of Peptide Protein Research 41 (1993) 1-7
2. Aggen, J. B., Humphrey, J. M. and Chamberlin, R. A. (1995). Microcystin LA: progress towards the total synthesis of a protein phosphatase inhibiting cyclic heptapeptide. In "American Chemical Society Annual Meeting", Chicago, IL.
3. An J., and Carmichael W.W. Use of a colorimetric protein phosphatase inhibition assay and enzyme linked immunosorbent assay for the study of microcystins and nodularins. Toxicon 32 (1994) 1495-1507
4. Andersen R.J., Luu H.A., Chen D.Z.X., Holmes C.F.B., Kent M., LeBlanc M., Taylor F.J.R., and Williams D.E. Chemical and biological evidence links microcystins to salmon "Netpen Liver Disease". Toxicon 31 (1993) 15-1323
5. Anderson, P. (1996). Design and implementation of harmful algal monitoring systems. Intergovernmental Oceanographic Commission Technical Series No. 44.
6. Arment, A. R. (1995). Evidence that microcystin is the product of a thio-template mechanism. Ph.D. dissertation, Wright State University, Dayton, OH, pp. 143.
7. Arment A.R., and Carmichael W.W. Evidence that microcystin is a thio-template product. Journal of Phycology 32 (1996) 591-597
8. Ash C., MacKintosh C., MacKintosh R., and Fricker C.R. Development of a colorimetric protein phosphorylation assay for detecting cyanobacterial toxins. Water Science Technology 31 (1995) 47-49
9. Bagu J.R., Sonnichsen F.D., Williams D., Anderson R.J., Sykes B.D., and Holmes C.F.B. Comparison of the solution structures of microcystin-LR and motuporin. Structural Biology 2 (1995) 114-116
10. Bateman K.P., Thibault P., Douglas D.J., and White R.L. Mass spectral analyses of microcystins from toxic cyanobacteria using on-line chromatographic and electrophoretic separations. Journal of Chromatography A712 (1995) 253-268
11. Beatty M.F., Jennings-White C., and Avery M.A. Sterocontrolled synthesis of (2S, 3S, 8S, 9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4E, 6E-dienoic acid (ADDA), the characteristic amino acid of microcystins and nodularin. Journal of the Chemical Society 6 (1991) 351-352
12. Bloch C.J.S., Blackburn S.I., Neilan B.A., and Grewe P.M. Genetic characterization of strains of cyanobacteria using PCR-RLP of the cpcBA intergenic spacer and flanking regions. Journal of Phycology 32 (1996) 445-451
13. Blue-Green Algae Task Force (1992). "Blue-green Algae: Final Report of the New South Wales Blue-Green Algae Task Force." Department of Water Resources, Parramatta, New South Wales, Australia.
14. Boland M.P., Smillie M.A., Chen D.Z.X., and Holmes C.F.B. A unified bioscreen for the detection of diarrhetic shellfish toxins and microcystins in marine and freshwater environments. Toxicon 31 (1993) 1393-1405
15. Boland M.P., Taylor M.F.J.R., and Holmes C.F.B. Identification and characterisation of a type-1 protein phosphatase from the okadaic acid-producing marine dinoflagellate Prorocentrum lima. Federation of European Biochemical Societies 334 (1993) 13-17
16. Bonjouklian R., Smitka T.A., Hunt A.H., Occolowitz J.L., Perun Jr. T.J., Doolin L., Stevenson S., Knauss L., Wijayarantne R., Szewczyk S., and Patterson G.M.L. A90720A, a serine protease inhibitor isolated from a terrestrial blue-green alga Microchaete loktakensis. Tetrahedron 52 (1996) 395-404
17. Bourne D.G., Jones G.J., Blakeley R.L., et al. Enzymatic pathway for the bacterial degradation of the cyanobacterial cyclic peptide toxin microcystin-LR. Applied and Environmental Microbiology 62 (1996) 4086-4094
18. Brough P.A., Gallagher T., Thomas P., Wonnacott S., Baker R., Abdul Malik K.M., and Hursthouse M.B. Synthesis and X-ray crystal structure of 2-acetyl-9-azabicyclo[4.2.1]nonan-3-one. A conformationally locked s-cis analogue of anatoxin-a. Journal of the Chemical Society, Chemical Communications 15 (1992) 1087-1089
19. Burlingame A.L., Boyd R.K., and Gaskell S.J. Mass spectrometry. Analytical Chemistry 66 (1994) 634-673
20. Bury N.R., Eddy F.B., and Codd G.A. The effects of the cyanobacterium Microcystis aeruginosa, the cyanobacterial hepatotoxin microcystin-LR, and ammonia on growth rate and ionic regulation of brown trout. Journal of Fish Biology 46 (1995) 1042-1054
21. Campbell D.L., Lawton L.A., Beattie K.A., and Codd G.A. Comparative assessment of the specificity of the brine shrimp and microtox assays to hepatotoxic (microcystin-LR-containing) cyanobacteria. Environmental Toxicology and Water Quality: An International Journal 9 (1994) 71-77
22. Carbis C.R., Waldron D.L., Mitchell G.F., Anderson J.W., and McCauley I. Recovery of hepatic function and latent mortalities in sheep exposed to the blue-green alga Microcystis aeruginosa. Veterinary Record 137 (1995) 12-15
23. Carmichael W.W. Algal toxins. In: Callow J.A. (Ed). Advances in Botanical Research 12 (1986), Academic Press, London 47-101
24. Carmichael W.W. Cyanobacteria secondary metabolites - the cyanotoxins. Journal of Applied Bacteriology 72 (1992) 445-459
25. Carmichael, W. W. (1992b). "A Status Report on Plantonic Cyanobacteria (Blue-Green Algae) and their Toxin." United States Environmental Protection Agency, EPA/600/R-92/079.
26. Carmichael W.W. The toxins of cyanobacteria. Scientific American 270 (1994) 78-86
27. Carmichael W.W. Cyanobacterial toxins. In: Hallegraeff G.M., Anderson D.M., and Cembella A.D. (Eds). Manual on Harmful Marine Microalgae (1995), UNESCO, Paris 165-177 IOC Manuals and Guides no. 33.
28. Carmichael, W. W. and Evans, W. R. (1992). Neurotoxic Lyngbya wollei in Guntersville Reservoir, Alabama. In "North American Lake Management Society 12th Annual International Symposium", November 2-7, Cincinnati, Ohio (abstract).
29. Carmichael, W. W. and Evans, W. R. (1997). "Detection, identification and production of paralytic shellfish poisons (PSP) by the mat forming cyanobac-terium Lyngbya wollei Farlow ex Gomont in Guntersville Reservoir." Final report, Tennessee Valley Authority (TVA) - Joint Agency Guntersville Project, Vicksburg, Mississippi.
30. Carmichael W.W., and Falconer I.R. Diseases related to freshwater blue-green algal toxins, and control measures. In: Falconer I.R. (Ed). Algal Toxins in Seafood and Drinking Water (1993), Academic Press, London 187-209
31. Carmichael W.W., He J.-W., Eschedor J., He Z.-R., and Yu M.-J. Partial structure determination of hepatotoxic peptides from Microcystis aeruginosa (cyanobacterium) collected in ponds of Central China. Toxicon 26 (1988) 1213-1217
32. Casemore D.P. Cyclospora: another "new" pathogen. Journal of Medical Microbiology 41 (1994) 217-219
33. Chu F.S., and Huang X. Production and characterization of antibodies against neosaxitoxin. Journal of AOAC International 75 (1992) 341-345
34. Chu, F. S. and Wedepohl, R. (1994). Algal toxins in drinking water? Research in Wisconsin. Lakeline April, 41-42.
35. Chu F.S., Huang X., and Wei R.D. Enzyme-linked immunosorbent assay for microcystins in blue-green algal blooms. Journal Association Official Analytical Chemists 73 (1990) 451-456
36. Cirirelli M.F. Inhibitors of protein serine/threonine phosphatases. Focus 14 (1992) 16-20
37. Claeyssens S., Francois A., Chedeville A., and Lavoinne A. Microcystin-LR induced an inhibition of protein synthesis in isolated rat hepatocytes. Journal of Biochemistry 306 (1995) 693-696
38. Codd G.A., and Roberts C. Public health aspects of cyanobacteria (blue-green algae). PHLS Microbiology Digest 8 (1991) 80-100
39. In: Codd G.A., Jeffries T.M., Keevil C.W., and Potter E. (Eds). Detection Methods for Cyanobacterial Toxins (1994), The Royal Society of Chemistry, Cambridge
40. Cousins I.T., Bealing D.J., James H.A., and Sutton A. Biodegradation of microcystin-LR by indigenous mixed bacterial populations. Water Research 30 (1996) 481-485
41. Craig M., McCready T.L., Luu H.A., Smillie M.A., Dubord P., and Holmes C.F.B. Identification and characterization of hydrophobic microcystins in Canadian freshwater cyanobacteria. Toxicon 31 (1993) 1541-1549
42. Delaney J.M., and Wilkins R.M. Toxicity of microcystin-LR, isolated from Microcystis aeruginosa, against various insect species. Toxicon 33 (1995) 771-778
43. DeSilva E.D., Williams D.E., Anderson R.J., Klix H., Holmes C.F.B., and Allen T.M. Motuporin, a potent protein phosphatase inhibitor isolated from the Papua New Guinea sponge Theonella swinhoei. Tetrahedron Letters 33 (1992) 1561-1564
44. DeVries S.E., Namikoshi M., Galey F.D., Merritt J.E., Rinehart K.L., and Beasley V.R. Chemical study of the hepatotoxins from Microcystis aeruginosa collected in California. Journal of Veterinary Diagnostic Investigation 5 (1993) 409-412
45. Donati C., Drikas M., Hayes R., and Newcombe G. Microcystin-LR adsorption by powdered activated carbon. Water Research 28 (1994) 1735-1742
46. Done S.H., and Bain M. Hepatic necrosis in sheep associated with ingestion of blue-green algae. Veterinary Record 133 (1993) 600
47. Eckart K. Mass spectrometry of cyclic peptides. Mass Spectrometry Reviews 13 (1994) 13-25
48. Edwards C., Beattie K.A., Scrimgeour C.M., and Codd G.A. Identification of anatoxin-a in benthic cyanobacteria (blue-green algae) and in associated dog poisonings at Loch Insh, Scotland. Toxicon 30 (1992) 1165-1175
49. Falch B.S., König G.M., Wright A.D., Sticher O., Angerhofer C.K., Pezzuto J.M., and Bachmann H. Biological activities of cyanobacteria: evaluation of extracts and pure compounds. Planta Medica 61 (1995) 321-328
50. Falconer I.R. Tumour promotion and liver injury caused by oral consumption of cyanobacteria. Environmental Toxicology and Water Quality 6 (1991) 177-184
51. In: Falconer I.R. (Ed). Algal Toxins in Seafood and Drinking Water. (1993), Academic Press, London
52. Falconer I.R., and Buckley T.H. Tumour promotion by microcystis, a blue-green alga occurring in water supplies. Medical Journal of Australia 150 (1989) 351
53. Falconer I.R., Burch M.D., Steffensen D.A., Choice M., and Coverdale O.R. Toxicity of the blue-green alga (Cyanobacterium) Microcystis aeruginosa in drinking water to growing pigs, as an animal model for human injury and risk assessment. Environmental Toxicology and Water Quality: An International Journal 9 (1994) 131-139
54. Fitzgerald S.D., and Poppenga R.H. Toxicosis due to microcystin hepatotoxins in three Holstein heifers. Journal of Veterinary Diagnostic Investigation 5 (1993) 651-653
55. Francis G. Poisonous Australian lake. Nature 18 (1878) 11-12
56. Frankmolle W.P., Knubel G., Moore R.E., and Patterson G.M.L. Antifungal cyclic peptides from the terrestrial blue-green alga Anabaena laxa. The Journal of Antibiotics 45 (1992) 1458-1466
57. Fujiki H., and Suganuma M. Tumor promotion by inhibitors of protein phosphatases 1 and 2A: The okadaic acid class of compounds. Advances in Cancer Research 61 (1993) 143-194
58. Fujiki H., and Suganuma M. Naturally-derived tumor promoters and inhibitors of carcinogenesis. Journal of Toxicology - Toxins Reviews 15 (1996) 129-156
59. Fujiki H., Suganuma M., and Sugimura T. Significance of new environmen-tal tumor promoters. Environmental Carcinogen Reviews (Journal of Environmental Science and Health) C7 (1989) 1-51
60. Fujiki, H., Suganuma, M., Nishiwaki, S., Yoshizawa, S., Yatsunami, J.r Matsushima, R., Furuya, H., Okabe, S., Matsunaga, S. and Sugimura, T. (1992). Specific mechanistic aspects of animal tumor promoters: the okadaic acid pathway. Relevance of Animal Studies to the Evaluation of Human Cancer Risk 337-350.
61. Gábor S. About the toxicosis caused by blue-green algae. Magyar Allator-vosok Lapja 49 (1994) 96-101
62. Gaete V., Canelo E., Lagos N., and Zambrano F. Inhibitory effects of Microcystis aeruginosa toxin on ion pumps of the gill of freshwater fish. Toxicon 32 (1994) 121-127
63. Gallon J.R., Chit K.N., and Brown E.G. Biosynthesis of the tropane-related cyanobacterial toxin anatoxin-a: Role of ornithine decar-boxylase. Phytochemistry 29 (1990) 1107-1111
64. Gallon J.R., Kittakoop P., and Brown E.G. Biosynthesis of anatoxin-a by Anabaena flos-aquae: examination of primary enzymic steps. Phytochemistry 35 (1994) 1195-1203
65. Gerwick W.H., Jiang Z.D., Agarwal S.K., and Farmer B.T. Total structure of hormothamnin A, a toxic cyclic undecapeptide from the tropical marine cyanobacterium Hormothamnion enteromorphoides. Tetrahedron 48 (1992) 2313-2324
66. Gerwick W.H., Proteau P.J., Nagle D.G., Hamel E., Blokhin A., and Slate D.L. Structure of Curacin A, a novel antimitotic, antiproliferative, and brine shrimp toxic natural product from the marine cyanobacterium Lyngbya majuscula. Journal of Organic Chemistry 59 (1994) 1243-1245
67. Ghosh S., Khan S.A., Wickstrom M., and Beasley V. Effects of microcystin-LR on actin and the actin-associated proteins A-actinin and talin in hepatocytes. Natural Toxins 3 (1995) 405-414
68. Goldberg J., Huang H.-B., Kwon Y.-G., Greengard P., Nairn A.C., and Kuriyan J. Three-dimensional structure of the catalytic subunit of protein serine/threonine phosphatase-1. Nature 376 (1995) 745-753
69. Gunn G.J., Raferty A.G., Rafferty G.C., Cockburn N., Edwards C., Beattie K.A., and Codd G.A. Fatal canine neurotoxicosis attributed to blue-green algae (cyanobacteria). Veterinary Record 130 (1992) 301-302
70. Hallegraeff G.M. A review of harmful algal blooms and their apparent global increase. Phycologia 32 (1993) 79-99
71. Harada K.-I. Chemistry and detection of microcystins. In: Watanabe M.F., Harada K.-I., Carmichael W.W., and Fujiki H. (Eds). Toxic Microcystis (1996), Chemical Rubber Company (CRC) Press, Boca Raton, Florida 103-148
72. Harada K.-I., Ohtani I., Iwamoto K., Suzuki M., Watanabe M.F., Watanabe M., and Terao K. Isolation of cylindrospermopsin from a cyanobacterium Umeazkia natans and its screening method. Toxicon 32 (1993) 73-84
73. Harada K.-I., Ohtani I., Iwamoto K., Suzuki M., Watanabe M.F., Watanabe M., and Terao K. Isolation of cylindrospermopsin from a cyanobacterium Umeazkia natans and its screening method. Toxicon 32 (1994) 73-84
74. Harada K.-I., Fujii K., Shimada T., Suzuki M., Sano H., Adachi K., and Carmichael W.W. Two cyclic peptides, anabaenopeptins, a third group of bioactive compounds from the cyanobacterium Anabaena flos-aquae NRC 525-17. Tetrahedron Letters 36 (1995) 1511-1514
75. Harding W.R., Rowe N., Wessels J.C., Beattie K.A., and Codd G.A. Death of a dog attributed to the cyanobacterial (blue-green algal) hepatotoxin nodularin in South Africa. Journal of South African Veterinary Association 66 (1995) 256-259
76. Hawkins P.R., Runnegar M.T.C., Jackson A.R.B., and Falconer I.R. Severe hepatotoxicity caused by the tropical cyanobacterium (blue-green alga) Cylindrospermopsis raciborskii (Woloszynska) seenaya and Subba Raju isolated from a domestic water supply reservoir. Applied and Environmental Microbiology 50 (1985) 1292-1295
77. Hayakawa K., and Kohama K. Reversible effects of okadaic acid and microcystin-LR on the ATP-dependent interaction between actin and myosin. Journal of Biochemistry 117 (1995) 509-514
78. Hemscheidt, T., Burgoyne, D. L. and Moore, R. E. (1995a). Biosynthesis of anatoxin-a(s). (2S,4S)-4-hydroxyarginine as an intermediate. Journal of Chemical Society 205-206.
79. Hemscheidt, T., Rapala, J., Sivonen, K. and Skulberg, O. M. (1995b). Biosynthesis of anatoxin-a in Anabaena flos-aquae and homoanatoxin-a in Oscillatoria formosa. Journal of Chemical Society, Chemical Communications 1361-1362.
80. Henricksen, P., Kaas, H., Damso, L. and Moestrup, O. (1995). Toxic cyanobacteria (blue-green algae) in Danish fresh waters. In "Proceedings of the First International Congress on Toxic Cyanobacteria (Blue-Green Algae)", Ronne, Denmark, 20-24 August, p. 25 (abstract).
81. Hokama Y., and Smith S. Immunological assessment of marine toxins. Food and Agricultural Immunology 2 (1990) 99-105
82. Holladay M.W., Lebold S.A., and Lin N.-H. Structure-activity relationships of nicotinic acetyicholine receptor agonists as potential treatments for dementia. Drug Development Research 35 (1995) 191-213
83. Honkanen R.E. Cantharidin, another natural toxin that inhibits the activity of serine/threonine protein phosphatases types 1 and 2A. Federation of European Microbiological Societies 330 (1993) 283-286
84. Honkanen R.E., Caplan F.R., Baker K.K., Baldwin C.L., Bobzin S.C., Bolis C.M., Cabrera G.M., Johnson L.A., Jung J.H., Larsen L.K., Levine I.A., Moore R.E., Nelson C.S., Patterson G.M.L., Tschappat K.D., Tuang G.D., Boynton A.L., Arment A.R., An J.S., Carmichael W.W., Rodland K.D., Magun B.E., and Lewin R.A. Protein phosphatase inhibitory activity in extracts of cultured blue-green algae (Cyanophyta). Journal of Phycology 31 (1995) 478-486
85. Hotzel F., and Croome R. Long term phytoplankton monitoring of the Darling River at Burtundy, New South Wales: incidence and significance of cyanobacterial blooms. Australian Journal of Marine and Freshwater Research 45 (1994) 17-29
86. Howard A. SCUM - simulation of cyanobacterial underwater movement. CABIOS 9 (1993) 413-419
87. Howard A., Kirkby M.J., Kneale P.E., and McDonald A.T. Modelling the growth of cyanobacteria (GrowSCUM). Hydrological Processes 9 (1995) 809-820
88. Humpage A.R., Rositano J., Baker P.D., Nicholson B.C., and Steffensen D.A. Paralytic shellfish poisons from freshwater blue-green algae. The Medical Journal of Australia 159 (1993) 423
89. Humpage R.R., Rositano J., Bretag A.H., Brown R., Baker P.D., Nicholson B.C., and Steffensen D.A. Paralytic shellfish poisons from Australian cyanobacterial blooms. Australian Journal of Marine and Freshwater Research 45 (1994) 31-41
90. Hunter P.R. Cyanobacteria and human health. Journal of Medical Microbiology 36 (1992) 301-302
91. Ishida K., Murakami M., Matsuda H., and Yamaguchi K. Micropeptin 90, a plasmin and trypsin inhibitor from the blue-green alga Microcystis aeruginosa (NIES-90). Tetrahedron Letters 36 (1995) 3535-3538
92. Islam M.S., Drasar B.S., and Sack R.B. Probable role of blue-green algae in maintaining endemicity and seasonality of cholera in Bangladesh: a hypothesis. Journal of Diarrhoeal Disease Research 12 (1994) 245-256
93. Jacobs, D., Amanda-Bass, R. and Neilan, B. (1995). Isolation and characterisation of candidate genes responsible for toxin biosynthesis in cyanobacteria. In "Proceedings of the Vth Cyanobacterial Molecular Biology Workshop", July 21-25, Asilomar Conference Center, Pacific Grove, CA.
94. Jakobi C., Oberer L., Quiquerez C., Konig W.A., and Weckesser J. Cyanopeptolin S, a sulfate-containing depsipeptide from a water bloom of Microcystis sp. Federation of European Microbiological Societies Microbiology Letters 129 (1995) 129-134
95. Jones G.J., and Orr P.T. Release and degradation of microcystin following algicide treatment of a Microcystis aeruginosa bloom in a recreational lake, as determined by HPLC and protein phosphatase inhibition assay. Water Research 28 (1994) 871-876
96. Jones, G., Minatol, W., Craig, K. and Naylor, R. (1993). Removal of low level cyanobacterial peptide toxins from drinking water using powdered and granular activated carbon and chlorination - results of laboratory and pilot plant studies. In "Proceedings of the 15th American Water Works Association Convention, Australia", pp. 339-346.
97. Jones G.J., Bourne D.G., Blakeley R.L., and Doelle H. Degradation of the cyanobacterial hepatotoxin microcystin by aquatic bacteria. Natural Toxins 2 (1994) 228-235
98. Jones G.J., Falconer I.R., and Wilkins R.M. Persistence of cyclic peptide toxins in dried Microcystis aeruginosa crusts from Lake Mokoan, Australia. Environmental Toxicology and Water Quality: An International Journal 10 (1995) 19-24
99. In: Jones G.L. (Ed). Cyanobacterial Research in Australia. (1994), Council for Science and Industrial Research (CSIRO), Australia
100. Kangatharalingam N., and Priscu J.C. Isolation and verification of anatoxin-a producing clones of Anabaena flos-aquae (Lyngb.) de Breb. from a eutrophic lake. FEMS Microbiology Ecology 12 (1993) 127-130
101. Kenefick, S. L., Hrudey, S. E., Peterson, H. G. and Prepas, E. E. (1992). Toxin release from Microcystis aeruginosa after chemical treatment. In "Symposium on Health-Related Water Microbiology, Water Quality International '92", Washington, D.C., May.
102. Kiviranta J., and Abdel-Hameed A. Toxicity of the blue-green alga Oscillatoria agarhii to the mosquito Aedes aegypti and the shrimp Anemia salina. World Journal of Microbiology and Biotechnology 10 (1994) 517-520
103. Kleinkauf H., and von Dohren H. Nonribosomal biosynthesis of peptide antibiotics. European Journal of Biochemistry 192 (1990) 1-15
104. Kondo F., Ikai Y., Oka H., Okumura M., Ishikawa N., Harada K.-I., Matsuura K., Murata H., and Suzuki M. Formation, characterization, and toxicity of the glutathione and cysteine conjugates of toxic heptapeptide microcystins. American Chemical Society 5 (1992) 591-596
105. Kós P., Gorzó G., Surányi G., and Borbély G. Simple and efficient method for isolation and measurement of cyanobacterial hepatotoxins by plant test (Sinapis alba L.). Analytical Biochemistry 225 (1995) 49-53
106. Krishnamurthy T. Chirality in microcystins. American Society for Mass Spectrometry 5 (1994) 724-730
107. Kuiper-Goodman, T., Gupta, S., Combley, H. and Thomas, B. H. (1994). Microcystins in drinking water. In "Proceedings of Toxic Cyanobacteria - A Global Perspective, Adelaide, Australia". Australian Centre for Water Quality Research.
108. Kusumi T. NMR characterization of microcystins. In: Watanabe M.F., Harada K.-I., Carmichael W.W., and Fujiki H. (Eds). Toxic Microcystis (1996), CRC Press, Boca Raton, FL. 149-173
109. Lahti K., Ahtiainen J., Rapala J., Sivonen K., and Niemelä S.I. Assessment of rapid bioassays for detecting cyanobacterial toxicity. Letter in Applied Microbiology 21 (1995) 109-114
110. Lam A.K.-Y., Prepas E.E., Spink D., and Hrudey S.E. Chemical control of hepatotoxic phytoplankton blooms: implications for human health. Water Research 29 (1995) 1845-1854
111. Lam A.K.-Y., Fedorak P.M., and Prepas E.E. Biotransformation of the cyanobacterial hepatotoxin microcystin-LR, as determined by HPLC and protein phosphatase bioassay. Environmental Science and Technology 28 (1995) 242-246
112. Lambert T.W., Boland M.P., Holmes C.F.B., and Hrudey S.E. Ouantitation of the microcystin hepatotoxins in water at environmentally relevant concentrations. Environment Science Technology 28 (1994) 753-755
113. Lambert T.W., Holmes C.F.B., and Hrudey S.E. Microcystin class of toxins: health effects and safety of drinking water supplies. Environmental Reviews 2 (1994) 167-186
114. Lambert T.W., Holmes C.F.B., and Hrudey S.E. Adsorption of microcystin-LR by activated carbon and removal in full scale water treatment. Water Research 30 (1996) 1411-1422
115. Lanaras T., and Cook C.M. Toxin extraction from an Anabaenopsis Milleri-dominated bloom. The Science of the Total Environment 142 (1994) 163-169
116. Lanaras T., Cook C.M., Eriksson J.E., Meriluoto J.A.O., and Hotokka M. Computer modelling of the 3-dimensional structures of the cyanobacterial hepatotoxins microcystin-LR and nodularin. Toxicon 29 (1991) 901-906
117. Lawton L.A., Beattie K.A., Hawser S.P., Campbell D.L., and Codd G.A. Evaluation of assay methods for determination of cyanobacterial hepatotoxicity. In: Codd G.A., Jefferies T.M., Keevil C.W., and Potter E. (Eds). Detection Methods for Cyanobacterial Toxins (1994), The Royal Society of Chemistry, London 111-116
118. Lee T., Tsuzuki M., Takeuchi T., Yokoyama K., and Karube I. In vivo fluorometric method for early detection of cyanobacterial waterblooms. Journal of Applied Phycology 6 (1994) 489-495
119. Leppanen J.-M., Rantajarvi E., Halifors S., Kruskopf M., and Laine V. Unattended monitoring of potentially toxic phytoplankton species in the Baltic Sea in 1993. Journal of Plankton Research 17 (1995) 891-902
120. Li M., and Damuni Z. Okadaic acid and microcystin-LR directly inhibit the methylation of protein phosphatase 2A by its specific methyltransferase. Biochemical and Biophysical Research Communications 202 (1994) 1023-1030
121. Lin J.-R., and Chu F.S. In vitro neutralization of the inhibitory effect of microcystin-LR to protein phosphatase 2A by antibody against the toxin. Toxicon 32 (1994) 605-613
122. Lin J.-R., and Chu F.S. Kinetics of distribution of microcystin LR in serum and liver cytosol of mice: an immunochemical analysis. American Chemical Society 94 (1994) 1035-1040
123. Long E.G., White E.H., Carmichael W.W., Quintisk P.M., Raja R., Swisher B.L., Daugharty H., and Cohen M.T. Morphologic and staining characteristics of a cyanobacterium-like organism associated with diarrhea. The Journal of Infectious Diseases 164 (1991) 199-202
124. Lukac M., and Aegerter R. Influence of trace metals on growth and toxin production of Microcystis aeruginosa. Toxicon 31 (1993) 293-305
125. Luu H.A., Chen D.Z.X., Magoon J., Worms J., Smith J., and Holmes C.F.B. Quantification of diarrhetic shellfish toxins and identification of novel protein phosphatase inhibitors in marine phytoplankton and mussels. Toxicon 31 (1993) 75-83
126. MacKintosh R.W., Dalby K.N., Campbell D.G., Cohen P.T.W., Cohen P., and MacKintosh C. The cyanobacterial toxin microcystin binds covalently to cysteine-273 on protein phosphatase 1. Federation of European Biochemical Societies 371 (1995) 236-240
127. Maclean, J. L. (1993). Developing-country aquaculture and harmful algal blooms. In "Environment and Aquaculture in Developing Countries" (R. S. V. Pullin, H. Rosenthal and J. L. Maclean, eds), pp. 252-284. ICLARM Conference Proceedings 31.
128. Manallack D.T., Ellis D.D., Thompson P.E., Gallagher T., and Livingstone D.J. Quantitative structure-activity relationships of (+)-anatoxin-A derivatives. Natural Product Letters 4 (1994) 121-128
129. Manger R.L., Leja L.S., Lee S.Y., Hungerford J.M., Hokama Y., Dickey R.W., Granade H.R., Lewis R., Yasumoto T., and Wekell M.M. Detection of sodium channel toxins: directed cytotoxicity assays of purified ciguatoxins, brevetoxins, saxitoxins, and seafood extracts. Journal AOAC International 78 (1994) 521-527
130. Mansell H.L. Synthetic approaches to anatox Tetrahedron 52 (1996) 6025-6061
131. Maraheil M., Nakana M., and Zuber P. Microreview: regulation of peptide antibiotic formation in Bacillus. Molecular Microbiology 7 (1993) 631-636
132. Matveev V., Matveeva L., and Jones G.J. The ability of Daphnia carinata King to control phytoplankton and resist cyanobacterial toxicity: implications for biomanipulation in Australia. Australian Journal of Marine and Freshwater Research 450 (1994) 889-904
133. Meissner K., Dittmann E., and Borner T. Toxic and non-toxic strains of the cyanobacterium Microcystis aeruginosa contain sequences homologous to peptide synthetase genes. Federation of European Microbiological Societies Microbiology Letters 135 (1995) 295-303
134. Miura G.A., Robinson N.A., Lawrence W.B., and Pace J.G. Hepatotoxicity of microcystin-LR in fed and fasted rats. Toxicon 29 (1991) 337-346
135. Moller A., Norrby A.-M., Gustafsson K., and Jansson J. Luminometry and PCR-based monitoring of gene-tagged cyanobacteria in Baltic Sea microcosms. Federation of European Microbiological Societies Microbiology Letters 129 (1995) 43-50
136. Moore B.S., Ohtani I., de Koning C.B., and Moore R. Biosynthesis of anatoxin-a(s). Origin of the carbons. Tetrahedron Letters 33 (1992) 6595-6598
137. Murakami M., Okita Y., Matsuda H., Okino T., and Yamaguchi K. Aeruginosin 298-A, a thrombin and trypsin inhibitor from the blue-green alga Microcystis aeruginosa (NIES-298). Tetrahedron Letters 35 (1994) 3129-3152
138. Murakami M., Ishida K., Okino T., Okita Y., Matsuda H., and Yamaguchi K. Aeruginosins 98-A and B, trypsin inhibitors from the blue-green alga Microcystis aeruginosa (NIES-98). Tetrahedron Letters 36 (1995) 2785-2788
139. Murata H., Shoji H., Oshikata M., Harada K.-I., Suzuki M., Kondo F., and Goto H. High-performance liquid chromatography with chemiluminescence detection of derivatized microcystins. Journal of Chromatography A 693 (1995) 263-270
140. Nagai H., Yasumoto T., and Hokama Y. Aplysiatoxin and debromoaplysiatozin as the causative agents of a red alga Gracilaria Coronopifolia poisoning in Hawaii. Toxicon 37 (1996) 753-761
141. Nagata S., Tsutsumi T., Hasegawa A., Watanabe M.F., and Ueno Y. Determination of microcystin in environmental water by highly sensitive immunoassay. Japanese Journal of Toxicology and Environmental Health 41 (1995) 10
142. Nagatsu A., Kajitani H., and Sakakibara J. Muscoride A: a new oxazole peptide alkaloid from freshwater cyanobacterium Nostoc muscorum. Tetrahedron Letters 36 (1995) 4097-4100
143. Nagle D.G., and Gerwick W.H. Nakienones A-C and nakitriol, new cytotoxic cyclic Cn metabolites from an Okinawan cyanobacterial (Synechocys- tis sp.) overgrowth of coral. Tetrahedron Letters 36 (1995) 849-852
144. Namikoshi M., Rinehart K.L., Dalhem A.M., Beasley V.R., and Carmichael W.W. Total synthesis of Adda, the unique C20 amino acid of cyanobacterial hepatotoxins. Tetrahedron Letters 30 (1989) 4349-4352
145. Namikoshi M., Sun F., Choi B.W., Rinehart K.L., Carmichael W.W., Evans W.R., and Beasley V.R. Seven more microcystins from Homer Lake cells: application of the general method for structure assignment of peptides containing a,b-dehydroamino acid unit(s). Journal of Organic Chemistry 60 (1995) 3671-3679
146. National Rivers Authority. Toxic Blue-Green Algae. (1990), Stanley L. Hunt Ltd, Rushden, UK.
147. Negri A.P., and Jones G.J. Bioaccumulation of paralytic shellfish poisoning (PSP) toxins from the cyanobacterium Anabaena circinalis by the freshwater mussel Alathyria condola. Toxicon 33 (1995) 667-678
148. Negri A.P., Jones G.J., and Hindmarsh M. Sheep mortality associated with paralytic shellfish poisons from the cyanobacterium Anabaena circinalis. Toxicon 33 (1995) 1321-1329
149. Nehring S. Mortality of dogs associated with a mass development of Nodularia spumigena (Cyanophyceae) in a brackish lake at the German North Sea coast. Journal of Plankton Research 15 (1993) 867-872
150. Neilan, B. A., Jacobs, D., Cox, P. T., Hawkins, P. R. and Goodman, A. E. (1995). 16S rDNA phylogeny and molecular detection of bloom-forming, toxic cyanobacteria. In "Proceedings of the Vth Cyanobacterial Molecular Biology Workshop", July 21-25, Asilimar Conference Center, CA, p. 124.
151. Newman J.R., and Barrett P.R.F. Control of Microcystis aeruginosa by decomposing barley straw. Journal of Aquatic Plant Management 31 (1993) 203-206
152. Nicholson B.C., Rositano J., and Burch M.D. Destruction of cyanobacterial peptide hepatotoxins by chlorine and chloramine. Water Research 28 (1994) 1297-1303
153. Nishiwaki R., Ohta T., Sueoka E., Suganuma M., Harada K.-I., Watanabe M.F., and Fujiki H. Two significant aspects of microcystin-LR: specific binding and liver specificity. Cancer Letters 83 (1994) 283-289
154. Nishiwaki-Matsushima R., Ohta T., Nishiwaki S., Suganuma M., Kohyama K., Ishikawa T., Carmichael W.W., and Fujiki H. Liver tumor promotion by the cyanobacterial cyclic peptide toxin microcystin-LR. Journal of Cancer Research and Clinical Oncology 118 (1992) 420-424
155. Ohta T., Sueoka E., Iida N., Komori A., Suganuma M., Nishiwaki R., Tatematsu M., Kim S.-J., Carmichael W.W., and Fujiki H. Nodularin, a potent inhibitor of protein phosphatases 1 and 2A, is a new environmental carcinogen in male F344 rat liver. Cancer Research 54 (1994) 6402-6406
156. Ohtani I., Moore R.E., and Runnegar M.T.C. Cylindrospermopsin: a potent hepatotoxin from the blue-green alga Cylindrospermopsis raciborskii. Journal of the American Chemical Society 114 (1992) 7942-7944
157. Ojanpera I., Vuori E., Himberg K., Waris M., and Niinivaara K. Facile detection of anatoxin-a in algal material by thin-layer chromatography with fast black K salt. Analyst 116 (1991) 265-267
158. Ojanpera I., Pelander A., Vuori E., Himbert K., Waris M., and Niinivaara K. Detection of cyanobacterial hepatotoxins by TLC. Journal of Planar Chromatography 8 (1995) 69-72
159. Okino T., Matsuda H., Murakami M., and Yamaguchi K. Microginin, an angiotensin-converting enzyme inhibitor from the blue-green alga Microcystis aeruginosa. Tetrahedron Letters 34 (1992) 501-504
160. Okino T., Murakami M., Haraguchi R., Munekata H., Matsuda H., and Yamaguchi K. Micropeptins A and B, plasmin and trypsin inhibitors from the blue-green alga Microcystis aeruginosa. Tetrahedron Letters 34 (1993) 8131-8134
161. Okino T., Matsuda H., Murakami M., and Yamaguchi K. New microviridins, elastase inhibitors from the blue-green alga Microcystis aeruginosa. Tetrahedron 51 (1995) 10679-10686
162. Orjala J., Nagle D., and Gerwick W.H. Malyngamide H, an ichthyotoxic amide possessing a new carbon skeleton from the Caribbean cyanobacterium Lyngbya majuscula. Journal of Natural Products 58 (1995) 764-768
163. Orjala J., Nagle D.G., Hsu V.L., and Gerwick W.H. Antillatoxin: an exceptionally ichthyotoxic cyclic lipopeptide from the tropical cyanobacterium Lyngbya majuscula. Journal of the American Chemical Society 117 (1995) 8281-8282
164. Oxenrider K.A., Rasche M.E., Thorsteinsson M.V., and Kennelly P.J. Inhibition of an archaeal protein phosphatase activity by okadaic acid, microcystin-LR, or calyculin A. Federation of European Biochemical Societies 331 (1993) 291-295
165. Paerl H.W., and Tucker C.S. Ecology of blue-green algae in aquaculture ponds. Journal of World Aquaculture Society 26 (1995) 109-131
166. Park A., Moore R.E., and Patterson G.M.L. Fischerindole L, a new isonitrile from the terrestrial blue-green alga Fischerella muscicola. Tetrahedron Letters 33 (1992) 3257-3260
167. Park H.-D., Watanabe M.F., Harada K.-I., Nagai H., Suzuki M., Watanabe M., and Hayashi H. Hepatotoxin (microcystin) and neurotoxin (anatoxin-a) contained in natural blooms and strains of cyanobacteria from Japanese freshwaters. Natural Toxins 1 (1993) 353-360
168. Patterson G.M.L., and Carmeli S. Biological effects of tolytoxin (6-hydroxy-7-0-methyl-scytophycin b), a potent bioactive metabolite from cyanobacteria. Archives of Microbiology 157 (1992) 406-410
169. Patterson G.M.L., Baker K.K., Baldwin C.L., Bolis C.M., Caplan F.R., Larsen L.K., Levine I.A., Moore R.E., Nelson C.S., Tschappat K.D., Tuang G.D., Boyd M.R., Cardellina II J.H., Collins R.P., Gustafson K.R., Snader K.M., and Weislow O.R. Antiviral activity of cultured blue-green algae (Cyanophyta). Journal of Phycology 29 (1993) 125-130
170. Patterson G.M.L., Larsen L.K., and Moore R.E. Bioactive natural products from blue-green algae. Journal of Applied Phycology 6 (1994) 151-157
171. Pergament I., and Carmeli S. Schizotrin A; a novel antimicrobial cyclic peptide from a cyanobacterium. Tetrahedron Letters 35 (1994) 8473-8476
172. Potts M., Sun H., Mockaitis K., Kennelly P.J., Reed D., and Tonks N.K. A protein-tyrosine/serine phosphatase encoded by the genome of the cyanobacterium Nostoc commune UTEX 584. Journal of Biological Chemistry 268 (1993) 7632-7635
173. Praud A., Vails R., Piovetti L., and Banaigs B. Malyngamide G: proposition de structure pour un nouvel amide chlore d'une algue bleu-verte epiphyte de Cystoseira crinita. Tetrahedron Letters 34 (1993) 5437-5440
174. Provic P., Hayman J., and Falconer I.R. Algal toxins and bellyaches beyond the Barcoo. Medical Journal of Australia 158 (1993) 433-434
175. Ouinn R.J., and Taylor C. The conserved acid binding domain model of inhibitors of protein phosphatases 1 and 2A: molecular modelling aspects. Bioorganic and Medicinal Chemistry Letters 3 (1993) 1029-1034
176. Ouinn R.J., Taylor C., Embrey K.J., and Poulsen S.A. Molecular modeling of microcystins. In: Watanabe M.F., Harada K.-I., Carmichael W.W., and Fujiki H. (Eds). Toxic Microcystis (1996), Chemical Rubber Company (CCR) Press, Boca Raton, Florida 233-253
177. Räbergh C.M.I., Bylund G., and Eriksson J.E. Histopathological effects of microcystin-LR, a cyclic peptide toxin from the cyanobacterium (blue-green alga) Microcystis aeruginosa, on common carp (Cyprinus carpio L.). Aquatic Toxicology 20 (1991) 131-146
178. Rapala J., Sivonen K., Luukkainen R., and Niemela S.I. Anatoxin-a concentration in Anabaena and Aphanizomenon under different environmental conditions and comparison of growth by toxic and non-toxic Anabaena-strains - a laboratory study. Journal of Applied Phycology 5 (1993) 581-591
179. Rapala J., Lahti K., Sivonen K., and Niemela S.I. Biodegradability and adsorption on lake sediments of cyanobacterial hepatotoxins and anatoxin-a. Letters in Applied Microbiology 19 (1994) 423-428
180. Ressom R., Soong F.S., Fitzgerald J., Turczynowiczx L., ElSaadi O., Roder D., Maynard T., and Falconer I.R. Health Effects of Toxic Cyanobacteria (Blue-Green Algae). (1994), National Health and Medical Research Council, Australian Government Publishing Service, Canberra, Australia
181. Rinehart K.L., Namikoshi M., and Choi B.W. Structure and biosynthesis of toxins from blue-green algae (cyanobacteria). Journal Applied Phycology 6 (1994) 159-176
182. Rodger H.D., Turnbull T., Edwards C., and Codd G.A. Cyanobacterial (blue-green algal) bloom associated pathology in brown trout, Salmo trutta L., in Loch Leven, Scotland. Journal of Fish Diseases 17 (1994) 177-181
183. Rouhiainen L., Sivonen K., Buikema W.J., and Haselkorn R. Characterization of toxin-producing cyanobacteria by using an oligonucleotide probe containing a tandemly repeated heptamer. Journal of Bacteriology 177 (1995) 6021-6026
184. Rudolph-Böhner S., Mierke D.F., and Moroder L. Molecular structure of the cyanobacterial tumor-promoting microcystins. Federation of European Biochemical Societies 349 (1994) 319-323
185. Runnegar M.T.C., Andrews J., Gerdes R.G., and Falconer I.R. Injury to hepatocytes induced by a peptide toxin from the cyanobacterium Microcystis aeruginosa. Toxicon 25 (1987) 1235-1239
186. Runnegar M.T., Kong S., and Berndt N. Protein phosphatase inhibition and in vivo hepatotoxicity of microcystins. American Physiological Society 28 (1993) G224-G330
187. Runnegar M.T., Kong S.-M., Zhong Y.-Z., and Lu S.C. Inhibition of reduced glutathione synthesis by cyanobacterial alkaloid cylindrospermopsin in cultured rat hepatocytes. Biochemical Pharmacology 49 (1995) 219-225
188. Runnegar M., Berndt N., and Kaplowitz N. Microcystin uptake and inhibition of protein phosphatases: effects of chemoprotectants and self-inhibition in relation to known hepatic transporters. Toxicology and Applied Pharmacology 134 (1995) 264-272
189. Runnegar M.T., Maddatu T., Deleve L.D., Berndt N., and Govindarajan S. Differential toxicity of the protein phosphatase inhibitors microcystin and calyculin A. Journal of Pharmacology and Experimental Therapeutics 273 (1995) 545-553
190. Runnegar M., Berndt N., Kong S.-M., Lee E.Y.C., and Zhang L. In vivo and in vitro binding of microcystin to protein phosphatases 1 and 2A. Biochemical and Biophysical Research Communications 216 (1995) 162-169
191. Saadi O.E., Esterman A.J., Cameron S., and Roder D.M. Murray River water, raised cyanobacterial cell counts and gastrointestinal and dermatological symptoms. Medical Journal of Australia 162 (1995) 122-125
192. Saario E., Abdel-Hameed A., and Kiviranta J. Larvicidal microcystin toxins of cyanobacteria affect midgut epithelial cells of Aedes aegypti mosquitoes. Medical and Veterinary Entomology 8 (1994) 398-400
193. Sahin A., Tencalla F.G., Dietrich D.R., Mez K., and Haegeli H. Enzymatic analysis of liver samples from rainbow trout for diagnosis of blue-green algae-induced toxicosis. American Journal of Veterinary Research 56 (1995) 1110-1116
194. Saito S., Nakano Y., Kushida K., Shirai M., Harada K.-I., and Nakano M. Cross-reactivity and neutralizing ability of monoclonal antibodies against microcystins. Microbiology Immunology 38 (1994) 389-392
195. Sano T., and Kaya K. Osciliamide Y, a chymotrypsin inhibitor from toxic Oscillatoria agardhii. Tetrahedron Letters 36 (1995) 5933-5936
196. Shi, L. and Carmichael, W. W. (1996). Identification of protein serine/threonine family 1 phosphatase genes from microcystin positive and negative cyanobacteria using polymerase chain reaction. In "Proceedings American Society of Microbiology Annual Meeting", New Orleans, LA.
197. Shima H., Tohda H., Aonuma S., Nakayasu M., Depaoli-Roach A.A., Sugimura T., and Nagao M. Proceedings of the National Academy Sciences (USA) 91 (1994) 9267-9271
198. Shimizu M., Iwasaki Y., and Yamada S. New fluorogenic dienophile: synthesis, reaction with vitamin D, vitamin A and microcystins, and application to fluorometric assays. Journal of the Pharmaceutical Society of Japan 115 (1995) 584-602
199. Shin H.J., Murakami M., Matsuda H., Ishida K., and Yamaguchi K. Oscillapeptin, an elastase and chymotrypsin inhibitor from the cyanobacterium Oscillatoria agardhii (NIES-204). Tetrahedron Letters 36 (1995) 5235-5238
200. Shin H.J., Murakami M., Matsuda H., and Yamaguchi K. Microviridins d-f, serine protease inhibitors from the cyanobacterium Oscillatoria agardhii (NIES-204). Tetrahedron 52 (1996) 8159-8168
201. Sim A.T.R., and Mudge L.-M. Protein phosphatase activity in cyanobac-teria: consequences for microcystin toxicity analysis. Toxicon 31 (1993) 1179-1186
202. Sim A.T.R., and Mudge L.-M. Detection of hepatotoxins by protein phosphatase inhibition assay: advantages, pitfalls and anomalies. In: Codd G.A., Jefferies T.M., Keevil C.W., and Potter E. (Eds). Detection Methods for Cyanobacterial Toxins (1994), The Royal Society of Chemistry, London 100-105
203. Simon J.F., and Vernoux J.P. Highly sensitive assay of okadaic acid using protein phosphatase and paranitrophenyl phosphate. Natural Toxins 2 (1994) 293-301
204. Skulberg O.M., Carmichael W.W., Anderson R., Matsunaya S., Moore R.E., and Skulberg R. Isolation and characterization of homoanatoxin-a, a potent neurotoxin from the freshwater bloom-forming cyanobacteria (blue-green alga) Oscillatoria. Environmental Toxicology and Chemistry 11 (1992) 321-329
205. Skulberg O.M., Carmichael W.W., Codd G.A., and Skulberg R. Taxonomy of toxic cyanophyceae (cyanobacteria). In: Falconer I.R. (Ed). Algal Toxins in Seafood and Drinking Water (1993), Academic Press, London 145-164
206. Smitka T.A., Bonjouklian R., Doolin L., Jones N.D., Deeter J.B., Yoshida W.Y., Prinsep M.R., Moore R.E., and Patterson G.M.L. Ambiguine isonitriles, fungicidal hapalindole-type akaloids from three genera of blue-green algae belonging to the Stigonemataceae. Journal of Organic Chemistry 57 (1992) 857-861
207. Stephen C., Kent M.L., and Dawe S.C. Hepatic megalocytosis in wild and farmed chinook salmon Oncorhynchus tshawytscha in British Columbia, Canada. Diseases of Aquatic Organisms 16 (1993) 35-39
208. Stolerman I.P., Albuquerque E.X., and Garcha H.S. Behavioural effects of anatoxin-a, a potent nicotinic agonist, in rats. Neuropharmacology 31 (1992) 311-314
209. Stolerman I.P., Mirza N.R., and Shoaib M. Nicotine psychopharmacology: addiction, cognition and neuroadaptation. Medical Research Reviews 15 (1995) 47-72
210. Stratmann K., Burgoyne D.L., Moore R.E., and Patterson G.M.L. Hapalosin, a cyanobacterial cyclic depsipeptide with multidrug-resistance reversing activity. Journal of Organic Chemistry 59 (1994) 7219-7226
211. Swanson K.L., and Albuquerque E.X. Nicotinic acetylcholine receptors and low molecular weight toxins. In: Herken H., and Hucho F. (Eds). Handbook of Experimental Pharmacology, Selective Neurotoxicity 102 (1992) 611-657
212. Swanson K.L., and Albuquerque E.X. Progress in understanding the nicotinic acetylcholine receptor function at central and peripheral nervous system synapses through toxin interactions. Maryland Medical Journal (1992) 623-631
213. Swoboda U.K., Dow C.S., Chaivimol J., Smith N., and Pound B.P. Alternatives to the mouse bioassay for cyanobacterial toxicity assessment. In: Codd G.A., Jefferies T.M., Keevil C.W., and Potter E. (Eds). Detection Methods for Cyanobacterial Toxins (1994), The Royal Society of Chemistry, London 106-110
214. Takai A., and Mieskes G. Inhibitory effect of okadaic acid on the p-nitrophenyl phosphate phosphatase activity of protein phosphatases. Biochemistry Journal 275 (1991) 233-239
215. Takai A., Katsunori S., Nagai H., Mieskes G., Isobe M., Isono K., and Yasumoto T. Inhibition of specific binding of okadaic acid to protein phosphatase 2A by microcystin-LR, calyculin-A and tautomycin: method of analysis of interactions of tight-binding ligands with target protein. Biochemistry Journal 306 (1995) 657-665
216. Taylor J.A., Heaney S.I., and Codd G.A. Immunodetection of cyanobacterial picoplankters. Federation of European Microbiological Societies, Microbiology Letters 130 (1995) 159-164
217. Terao K., Ohmori S., Igarashi K., Ohtani I., Watanabe M.F., Harada K.-I., Ito E., and Wantanabe M. Electron microscopic studies on experimental poisoning in mice induced by cylindrospermopsin isolated from blue-green alga Umezakia natans. Toxicon 32 (1994) 833-843
218. Thiel S., and Wiltshire R.J. The automated detection of cyanobacteria using digital image processing techniques. Environment International 21 (1995) 233-236
219. Thiel S., Wiltshire R.J., and Davies L.J. Automated object recognition of blue-green algae for measuring water quality - a premilinary study. Water Research 29 (1995) 2398-2404
220. Thomas P., Stephens M., Wilkie G., Amar M., Lunt G.G., Whiting P., Gallagher T., Pereira E., Alkondon M., Albuquerque E.X., and Wonnacott S. (+)-Anatoxin-a is a potent agonist at neuronal nicotinic acetylcholine receptors. Journal of Neurochemistry 60 (1993) 2308-2311
221. Thompson P.E., Manallack D.T., Blaney F.E., and Gallagher T. Conformational studies on (+)-anatoxin-a and derivatives. Journal of Computer-Aided Molecular Design 6 (1992) 287-298
222. Todorova A.K., Jüttner F., Linden A., Pliiss T., and von Philipsborn W. Nostocyclamide: a new macrocyclic, thiazole-containing allelochemical from Nostoc sp. 31 (Cyanobacteria). Journal of Organic Chemistry 60 (1995) 7891-7895
223. Toivola D.M., Eriksson J.E., and Brautigan D.L. Identification of protein phosphatase 2A as the primary target for microcystin-LR in rat liver homogenates. Federation of European Biochemical Societies 344 (1994) 175-180
224. Tokuda H., Nishio H., Shirahashi H., Murakami N., Nagatsu A., and Sakakibara J. Inhibition of ll-O-tetradecanoylphorbol-13-acetate promoted mouse skin papilloma by digalactosyl diacylglycerols from the fresh water cyanobac-terium Phormidium tenue. Cancer Letters 104 (1996) 91-95
225. Trainer V.L., Baden D.G., and Catterall W.A. Detection of marine toxins using reconstituted sodium channels. Journal of AOAC International 78 (1995) 570-573
226. Trogen G.-B., Annila A., Eriksson J., Kontteli M., Meriluoto J., Sethson I., Zdunek J., and Edlund E. Conformational studies of microcystin-LR using NMR spectroscopy and molecular dynamics calculations. Biochemistry 35 (1996) 3197-3205
227. Tsuji K., Naito S., Kondo F., Ishikawa N., Watanabe M.F., Suzuki M., and Harada K.-I. Stability of microcystins from cyanobacteria: effect of light on decomposition and isomerization. Environmental Science Technology 28 (1993) 173-177
228. Tsukamoto S., Painuly P., Young K.A., Yang X., and Shimizu Y. Microcystilide A: a novel cell-differentiation-promoting depsipeptide from Microcystis aeruginosa NO-15-1840. Journal of the American Chemical Society 115 (1993) 11046-11047
229. Ueno Y., Nagata S., Tsutsumi T., Hasegawa A., Watanabe M.F., Park H.-D., Chen G.-C., Chen G., and Yu S.-Z. Detection of microcystins, a blue-green algal hepatotoxin, in drinking water sampled in Haimen and Fusui, endemic areas of primary liver cancer in China, by highly sensitive immuno-assay. Carcinogenesis 17 (1996) 1317-1321
230. Utkilen H., and Gjølme N. Toxin production by Microcystis aeruginosa as a function of light in continuous cultures and its ecological significance. Applied and Environmental Microbiology 58 (1992) 1321-1325
231. Van Dolah F.M., Finley E.L., Haynes B.L., Doucette G.J., Moeller P.D., and Ramsdell J.S. Development of rapid and sensitive high throughput assays for marine phycotoxins. Natural Toxins 2 (1994) 189-196
232. Van Halderen A., Harding W.R., Wessels J.C., Schneider D.J., Heine E.W.P., Van der Merwe J., and Fourie J.M. Cyanobacterial (blue-green algae) poisoning of livestock in the western Cape Provence of South Africa. Journal of the South African Veterinary Association 66 (1995) 260-264
233. Vasconcelos V.M. Toxic cyanobacteria (blue-green algae) in Portuguese fresh waters. Archives of Hydrobiology 130 (1994) 439-451
234. Vasconcelos V.M. Uptake and depuration of the heptapeptide toxin microcystin-LR in Mytilus galloprovincialis. Aquatic Toxicology 32 (1995) 227-237
235. Vasconcelos V.M., Sivonen K., Evans W.R., Carmichael W.W., and Namikoshi M. Isolation and characterization of microcystins (heptapeptide hepatotoxins) from Portuguese strains of Microcystis aeruginosa Kutz. emend Elekin. Archives of Hydrobiology 134 (1995) 295-305
236. Vieytes M.R., Cabado A.G., Alfonso A., Louzao M.C., Botana A.M., and Botana L.M. Solid-phase radioreceptor assay for paralytic shellfish toxins. Analytical Biochemistry 211 (1993) 87-93
237. Wang H.-B., and Zhu H.-G. Promoting activity of microcystins extracted from waterblooms in SHE cell transformation assay. Biomedical and Environmental Sciences 9 (1996) 46-51
238. Wannemacher, R. W., Dinterman, R. E., Thompson, W. L., Schmidt, M. O. and Burrows, W. D. (1993). Treatment for removal of biotoxins from drinking water. In "U.S. Army Biomedical Research and Development Laboratory, Technical Report 9120". U.S. Army Medical Research and Development Command, Fort Detrick, MA.
239. In: Watanabe M.F., Harada K.-I., Carmichael W.W., and Fujiki H. (Eds). Toxic Microcystis. (1996), CRC Press, Boca Raton, FL.
240. Watanabe M.M., Kaya K., and Takamura N. Fate of the toxic cyclic heptapeptides, the microcystins, from blooms of Microcystis (cyanobacteria) in a hypertrophic lake. Journal of Phycology 28 (1992) 761-767
241. White J.D., Kim T.-S., and Nambu M. Synthesis of curacin A: a powerful antimitotic from the cyanobacterium Lyngbya majuscula. Journal of the American Chemical Society 117 (1995) 5612-5613
242. Wickstrom M.L., Khan S.A., Haschek W.M., Wyman J.F., Eriksson J.E., Schaeffer D.J., and Beasley V.R. Alterations in microtubules, intermediate filaments, and microfilaments induced by microcystin-LR in cultured cells. Toxicologic Pathology 23 (1995) 326-337
243. Wonnacott S., Swanson K.L., Albuquerque E.X., Huby N.J.S., Thompson P., and Gallagher T. Homoanatoxin: a potent analogue of anatoxin-A. Biochemical Pharmacology 43 (1992) 419-423
244. Wurtz R. Cyclospora: a newly identified intestinal pathogen of humans. Clinical Infectious Diseases 18 (1994) 620-623
245. Yoo H.-D., and Gerwick W.H. Curacins B and C, new antimitotic natural products from the marine cyanobacterium Lyngbya majuscula. Journal of Natural Products 58 (1995) 1961-1965
246. Yoo S., Carmichael W.W., Hoehn R.C., and Hrudey S.E. Cyanobacterial (Blue-Green Algal) Toxins: A Resource Guide. (1995), American Waterworks Association Research Foundation, Denver, CO
247. Yoshizawa S., Matsushima R., Watanabe M.F., Harada K.-L., Ichihara A., Carmichael W.W., and Fujiki H. Inhibition of protein phosphatases by microcystin and nodularin associated with hepatotoxicity. Journal of Cancer Research and Clinical Oncology 116 (1990) 609-614
248. Yu S.-H. Drinking water and primary liver cancer. In: Tang Z.Y., Wu M.C., and Xia S.S. (Eds). Primary Liver Cancer (1989), China Academic Publishers, Springer-Verlag, Berlin 30-37
249. Zetterström M., Trogen L., Hammarström L.-G., Juhlin L., Nilsson B., Damberg C., Bartfai T., and Langel U. Synthesis of an N-methyldehydroalanine-containing fragment of microcystin by combination of solid phase peptide synthesis and β-elimination in solution. Acta Chemica Scandinavica 49 (1995) 696-700
250. Zhang L., Zhang Z., Long F., and Lee E.Y.C. Tyrosine-272 is involved in the inhibition of protein phosphatase-1 by multiple toxins. Biochemistry 35 (1996) 1606-1611
251. Zhang Z., Zhao S., Long F., Zhang L., Bai G., Shima H., Nagao M., and Lee E.Y.C. A mutant of protein phosphatase-1 that exhibits altered toxin sensitivity. Journal of Biological Chemistry 269 (1994) 16997-17000