N-aroyl indole thiobarbituric acids as inhibitors of DNA repair and replication stress response polymerases

ACS Chemical Biology

Volumn 8, Issue 8, 2013, Pages 1722-1729

  Coggins, Grace E ^c   Maddukuri, Leena ^a   Penthala, Narsima R ^b   Hartman, Jessica H ^a   Eddy, Sarah ^a   Ketkar, Amit ^a   Crooks, Peter A ^b   Eoff, Robert L ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^c VANDERBILT UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 [(1 (2 BROMOBENZOYL) 5 CHLORO 1H INDOL 3 YL]METHYLENE] 2 THIOXODIHYDROPYRIMIDINE 4,6(1H,5H) DIONE; CISPLATIN; DNA POLYMERASE; DOXORUBICIN; ENZYME INHIBITOR; INDOLE; RNA DIRECTED DNA POLYMERASE INHIBITOR; THIOBARBITURIC ACID; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; COMPETITIVE INHIBITION; DNA REPAIR; DNA REPLICATION; ENZYME INHIBITION; IC 50; KINETICS; MICHAELIS CONSTANT; PRIORITY JOURNAL; RADIOSENSITIVITY; STEADY STATE; STRESS; STRUCTURE ACTIVITY RELATION;

DNA REPAIR; DNA REPLICATION; DNA-DIRECTED DNA POLYMERASE; ENZYME INHIBITORS; HUMANS; INDOLES; INHIBITORY CONCENTRATION 50; SMALL MOLECULE LIBRARIES; STRESS, PHYSIOLOGICAL; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; THIOBARBITURATES;

EID: 84882774240     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb400305r     Document Type: Article

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