-
1
-
-
21744452376
-
Cancer in xeroderma pigmentosum and related disorders of DNA repair
-
Cleaver JE (2005) Cancer in xeroderma pigmentosum and related disorders of DNA repair. Nat Rev Cancer 5:564-573.
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 564-573
-
-
Cleaver, J.E.1
-
2
-
-
0942268166
-
DNA repair-deficient diseases, xeroderma pigmentosum, Cockayne syndrome, and trichothiodystrophy
-
Lehmann AR (2003) DNA repair-deficient diseases, xeroderma pigmentosum, Cockayne syndrome, and trichothiodystrophy. Biochimie 85:1101-1111.
-
(2003)
Biochimie
, vol.85
, pp. 1101-1111
-
-
Lehmann, A.R.1
-
3
-
-
0033578040
-
The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta
-
Masutani C, et al. (1999) The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta. Nature 399:700-704.
-
(1999)
Nature
, vol.399
, pp. 700-704
-
-
Masutani, C.1
-
4
-
-
0033564917
-
Xeroderma pigmentosum variant (XP-V) correcting protein from HeLa cells has a thymine dimer bypass DNA polymerase activity
-
Masutani C, et al. (1999) Xeroderma pigmentosum variant (XP-V) correcting protein from HeLa cells has a thymine dimer bypass DNA polymerase activity. EMBO J 18:3491-3501.
-
(1999)
EMBO J
, vol.18
, pp. 3491-3501
-
-
Masutani, C.1
-
5
-
-
0019196844
-
Similar defects in DNA repair and replication in the pigmented xerodermoid and the xeroderma pigmentosum variants
-
Cleaver JE, et al. (1980) Similar defects in DNA repair and replication in the pigmented xerodermoid and the xeroderma pigmentosum variants. Carcinogenesis 1:647-655.
-
(1980)
Carcinogenesis
, vol.1
, pp. 647-655
-
-
Cleaver, J.E.1
-
6
-
-
0027159226
-
Evidence from mutation spectra that the UV hypermutability of xeroderma pigmentosum variant cells reflects abnormal, error-prone replication on a template containing photoproducts
-
Wang YC, Maher VM, Mitchell DL, McCormick JJ (1993) Evidence from mutation spectra that the UV hypermutability of xeroderma pigmentosum variant cells reflects abnormal, error-prone replication on a template containing photoproducts. Mol Cell Biol 13:4276-4283.
-
(1993)
Mol Cell Biol
, vol.13
, pp. 4276-4283
-
-
Wang, Y.C.1
Maher, V.M.2
Mitchell, D.L.3
McCormick, J.J.4
-
7
-
-
0037202616
-
Replication of damaged DNA in mammalian cells: New solutions to an old problem
-
Lehmann AR (2002) Replication of damaged DNA in mammalian cells: New solutions to an old problem. Mutat Res 509:23-34.
-
(2002)
Mutat Res
, vol.509
, pp. 23-34
-
-
Lehmann, A.R.1
-
8
-
-
33646158472
-
A novel role of DNA polymerase eta in modulating cellular sensitivity to chemotherapeutic agents
-
Chen YW, Cleaver JE, Hanaoka F, Chang CF, Chou KM (2006) A novel role of DNA polymerase eta in modulating cellular sensitivity to chemotherapeutic agents. Mol Cancer Res 4:257-265.
-
(2006)
Mol Cancer Res
, vol.4
, pp. 257-265
-
-
Chen, Y.W.1
Cleaver, J.E.2
Hanaoka, F.3
Chang, C.F.4
Chou, K.M.5
-
9
-
-
2342652151
-
Human DNA polymerase-eta, an A-T mutator in somatic hypermutation of rearranged immunoglobulin genes, is a reverse transcriptase
-
Franklin A, Milburn PJ, Blanden RV, Steele EJ (2004) Human DNA polymerase-eta, an A-T mutator in somatic hypermutation of rearranged immunoglobulin genes, is a reverse transcriptase. Immunol Cell Biol 82:219-225.
-
(2004)
Immunol Cell Biol
, vol.82
, pp. 219-225
-
-
Franklin, A.1
Milburn, P.J.2
Blanden, R.V.3
Steele, E.J.4
-
10
-
-
28444470501
-
Human DNA polymerase eta promotes DNA synthesis from strand invasion intermediates of homologous recombination
-
McIlwraith MJ, et al. (2005) Human DNA polymerase eta promotes DNA synthesis from strand invasion intermediates of homologous recombination. Mol Cell 20:783-792.
-
(2005)
Mol Cell
, vol.20
, pp. 783-792
-
-
McIlwraith, M.J.1
-
11
-
-
34548186415
-
Pol eta is required for DNA replication during nucleotide deprivation by hydroxyurea
-
de Feraudy S, et al. (2007) Pol eta is required for DNA replication during nucleotide deprivation by hydroxyurea. Oncogene 26:5713-5721.
-
(2007)
Oncogene
, vol.26
, pp. 5713-5721
-
-
de Feraudy, S.1
-
12
-
-
0034720285
-
Low fidelity DNA synthesis by human DNA polymerase-eta
-
Matsuda T, Bebenek K, Masutani C, Hanaoka F, Kunkel TA (2000) Low fidelity DNA synthesis by human DNA polymerase-eta. Nature 404:1011-1013.
-
(2000)
Nature
, vol.404
, pp. 1011-1013
-
-
Matsuda, T.1
Bebenek, K.2
Masutani, C.3
Hanaoka, F.4
Kunkel, T.A.5
-
13
-
-
0035862988
-
Domain structure, localization, and function of DNA polymerase eta, defective in xeroderma pigmentosum variant cells
-
Kannouche P, et al. (2001) Domain structure, localization, and function of DNA polymerase eta, defective in xeroderma pigmentosum variant cells. Genes Dev 15:158-172.
-
(2001)
Genes Dev
, vol.15
, pp. 158-172
-
-
Kannouche, P.1
-
14
-
-
33644551556
-
Y-family DNA polymerases respond to DNA damage-independent inhibition of replication fork progression
-
Godoy VG, Jarosz DF, Walker FL, Simmons LA, Walker GC (2006) Y-family DNA polymerases respond to DNA damage-independent inhibition of replication fork progression. EMBO J 25:868-879.
-
(2006)
EMBO J
, vol.25
, pp. 868-879
-
-
Godoy, V.G.1
Jarosz, D.F.2
Walker, F.L.3
Simmons, L.A.4
Walker, G.C.5
-
15
-
-
2442417331
-
Interaction of human DNA polymerase eta with monoubiquitinated PCNA: A possible mechanism for the polymerase switch in response to DNA damage
-
Kannouche PL, Wing J, Lehmann AR (2004) Interaction of human DNA polymerase eta with monoubiquitinated PCNA: A possible mechanism for the polymerase switch in response to DNA damage. Mol Cell 14:491-500.
-
(2004)
Mol Cell
, vol.14
, pp. 491-500
-
-
Kannouche, P.L.1
Wing, J.2
Lehmann, A.R.3
-
16
-
-
33646254420
-
Ubiquitylation of yeast proliferating cell nuclear antigen and its implications for translesion DNA synthesis
-
Haracska L, Unk I, Prakash L, Prakash S (2006) Ubiquitylation of yeast proliferating cell nuclear antigen and its implications for translesion DNA synthesis. Proc Natl Acad Sci USA 103:6477-6482.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 6477-6482
-
-
Haracska, L.1
Unk, I.2
Prakash, L.3
Prakash, S.4
-
17
-
-
3242708425
-
Regulation of DNA replication by ATR: Signaling in response to DNA intermediates
-
Shechter D, Costanzo V, Gautier J (2004) Regulation of DNA replication by ATR: Signaling in response to DNA intermediates. DNA Repair (Amst) 3:901-908.
-
(2004)
DNA Repair (Amst)
, vol.3
, pp. 901-908
-
-
Shechter, D.1
Costanzo, V.2
Gautier, J.3
-
18
-
-
33745755895
-
Opposing effects of the UV lesion repair protein XPA and UV bypass polymerase eta on ATR checkpoint signaling
-
Bomgarden RD, et al. (2006) Opposing effects of the UV lesion repair protein XPA and UV bypass polymerase eta on ATR checkpoint signaling. EMBO J 25:2605-2614.
-
(2006)
EMBO J
, vol.25
, pp. 2605-2614
-
-
Bomgarden, R.D.1
-
19
-
-
0033603630
-
Analysis of DNA replication forks encountering a pyrimidine dimer in the template to the leading strand
-
Cordeiro-Stone M, Makhov AM, Zaritskaya LS, Griffith JD (1999) Analysis of DNA replication forks encountering a pyrimidine dimer in the template to the leading strand. J Mol Biol 289:1207-1218.
-
(1999)
J Mol Biol
, vol.289
, pp. 1207-1218
-
-
Cordeiro-Stone, M.1
Makhov, A.M.2
Zaritskaya, L.S.3
Griffith, J.D.4
-
20
-
-
0030925436
-
Replication fork bypass of a pyrimidine dimer blocking leading strand DNA synthesis
-
Cordeiro-Stone M, Zaritskaya LS, Price LK, Kaufmann WK (1997) Replication fork bypass of a pyrimidine dimer blocking leading strand DNA synthesis. J Biol Chem 272:13945-13954.
-
(1997)
J Biol Chem
, vol.272
, pp. 13945-13954
-
-
Cordeiro-Stone, M.1
Zaritskaya, L.S.2
Price, L.K.3
Kaufmann, W.K.4
-
21
-
-
0014607001
-
Ultraviolet-light irradiation of mouse L cells: Effects on cells in the DNA synthesis phase
-
Domon M, Rauth AM (1969) Ultraviolet-light irradiation of mouse L cells: Effects on cells in the DNA synthesis phase. Radiat Res 40:414-429.
-
(1969)
Radiat Res
, vol.40
, pp. 414-429
-
-
Domon, M.1
Rauth, A.M.2
-
22
-
-
0018611921
-
Abnormal kinetics of DNA synthesis in ultraviolet light-irradiated cells from patients with Cockayne's syndrome
-
Lehmann AR, Kirk-Bell S, Mayne L (1979) Abnormal kinetics of DNA synthesis in ultraviolet light-irradiated cells from patients with Cockayne's syndrome. Cancer Res 39:4237-4241.
-
(1979)
Cancer Res
, vol.39
, pp. 4237-4241
-
-
Lehmann, A.R.1
Kirk-Bell, S.2
Mayne, L.3
-
24
-
-
0033581880
-
ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK
-
Hall-Jackson CA, Cross DA, Morrice N, Smythe C (1999) ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK. Oncogene 18:6707-6713.
-
(1999)
Oncogene
, vol.18
, pp. 6707-6713
-
-
Hall-Jackson, C.A.1
Cross, D.A.2
Morrice, N.3
Smythe, C.4
-
25
-
-
10744219561
-
Caffeine and human DNA metabolism: The magic and the mystery
-
Kaufmann WK, et al. (2003) Caffeine and human DNA metabolism: The magic and the mystery. Mutat Res 532:85-102.
-
(2003)
Mutat Res
, vol.532
, pp. 85-102
-
-
Kaufmann, W.K.1
-
26
-
-
0033199892
-
Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine
-
Sarkaria JN, et al. (1999) Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine. Cancer Res 59:4375-4382.
-
(1999)
Cancer Res
, vol.59
, pp. 4375-4382
-
-
Sarkaria, J.N.1
-
27
-
-
0017080018
-
Metabolism of caffeine to nucleic acid precursors in mammalian cells
-
Goth R, Cleaver JE (1976) Metabolism of caffeine to nucleic acid precursors in mammalian cells. Mutat Res 36:105-114.
-
(1976)
Mutat Res
, vol.36
, pp. 105-114
-
-
Goth, R.1
Cleaver, J.E.2
-
28
-
-
33645845151
-
Protein kinase C (PKC) family in cancer progression
-
Koivunen J, Aaltonen V, Peltonen J (2006) Protein kinase C (PKC) family in cancer progression. Cancer Lett 235:1-10.
-
(2006)
Cancer Lett
, vol.235
, pp. 1-10
-
-
Koivunen, J.1
Aaltonen, V.2
Peltonen, J.3
-
29
-
-
0032491318
-
Protein kinase Cdelta is activated by caspase-dependent proteolysis during ultraviolet radiation-induced apoptosis of human keratinocytes
-
Denning MF, Wang Y, Nickoloff BJ, Wrone-Smith T (1998) Protein kinase Cdelta is activated by caspase-dependent proteolysis during ultraviolet radiation-induced apoptosis of human keratinocytes. J Biol Chem 273:29995-30002.
-
(1998)
J Biol Chem
, vol.273
, pp. 29995-30002
-
-
Denning, M.F.1
Wang, Y.2
Nickoloff, B.J.3
Wrone-Smith, T.4
-
30
-
-
0036144679
-
Caspase activation and disruption of mitochondrial membrane potential during UV radiation-induced apoptosis of human keratinocytes requires activation of protein kinase C
-
Denning MF, et al. (2002) Caspase activation and disruption of mitochondrial membrane potential during UV radiation-induced apoptosis of human keratinocytes requires activation of protein kinase C. Cell Death Differ 9:40-52.
-
(2002)
Cell Death Differ
, vol.9
, pp. 40-52
-
-
Denning, M.F.1
-
31
-
-
0025784927
-
Inhibition of protein kinase C by calphostin C is light-dependent
-
Bruns RF, et al. (1991) Inhibition of protein kinase C by calphostin C is light-dependent. Biochem Biophys Res Commun 176:288-293.
-
(1991)
Biochem Biophys Res Commun
, vol.176
, pp. 288-293
-
-
Bruns, R.F.1
-
32
-
-
0026493815
-
Irreversible oxidative inactivation of protein kinase C by photosensitive inhibitor calphostin C
-
Gopalakrishna R, Chen ZH, Gundimeda U (1992) Irreversible oxidative inactivation of protein kinase C by photosensitive inhibitor calphostin C. FEBS Lett 314:149-154.
-
(1992)
FEBS Lett
, vol.314
, pp. 149-154
-
-
Gopalakrishna, R.1
Chen, Z.H.2
Gundimeda, U.3
-
33
-
-
0028316195
-
Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C
-
Jarvis WD, Turner AJ, Povirk LF, Traylor RS, Grant S (1994) Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C. Cancer Res 54:1707-1714.
-
(1994)
Cancer Res
, vol.54
, pp. 1707-1714
-
-
Jarvis, W.D.1
Turner, A.J.2
Povirk, L.F.3
Traylor, R.S.4
Grant, S.5
-
34
-
-
0024550448
-
Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C
-
Kobayashi E, Nakano H, Morimoto M, Tamaoki T (1989) Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C. Biochem Biophys Res Commun 159:548-553.
-
(1989)
Biochem Biophys Res Commun
, vol.159
, pp. 548-553
-
-
Kobayashi, E.1
Nakano, H.2
Morimoto, M.3
Tamaoki, T.4
-
35
-
-
0027189798
-
Calphostin C, a specific protein kinase C inhibitor, activates human neutrophils: Effect on phospholipase A2 and aggregation
-
Svetlov S, Nigam S (1993) Calphostin C, a specific protein kinase C inhibitor, activates human neutrophils: Effect on phospholipase A2 and aggregation. Biochim Biophys Acta 1177:75-78.
-
(1993)
Biochim Biophys Acta
, vol.1177
, pp. 75-78
-
-
Svetlov, S.1
Nigam, S.2
-
36
-
-
33746855461
-
Regulation of replication protein A functions in DNA mismatch repair by phosphorylation
-
Guo S, et al. (2006) Regulation of replication protein A functions in DNA mismatch repair by phosphorylation. J Biol Chem 281:21607-21616.
-
(2006)
J Biol Chem
, vol.281
, pp. 21607-21616
-
-
Guo, S.1
-
37
-
-
16244377516
-
hMutS alpha is protected from ubiquitin-proteasome-dependent degradation by atypical protein kinase C zeta phosphorylation
-
Hernandez-Pigeon H, et al. (2005) hMutS alpha is protected from ubiquitin-proteasome-dependent degradation by atypical protein kinase C zeta phosphorylation. J Mol Biol 348:63-74.
-
(2005)
J Mol Biol
, vol.348
, pp. 63-74
-
-
Hernandez-Pigeon, H.1
-
38
-
-
1042292696
-
ATM and ATR: Sensing DNA damage
-
Yang J, et al. (2004) ATM and ATR: Sensing DNA damage. World J Gastroenterol 10:155-160.
-
(2004)
World J Gastroenterol
, vol.10
, pp. 155-160
-
-
Yang, J.1
-
39
-
-
0030792007
-
Positioning atypical protein kinase C isoforms in the UV-induced apoptotic signaling cascade
-
Berra E, et al. (1997) Positioning atypical protein kinase C isoforms in the UV-induced apoptotic signaling cascade. Mol Cell Biol 17:4346-4354.
-
(1997)
Mol Cell Biol
, vol.17
, pp. 4346-4354
-
-
Berra, E.1
-
40
-
-
14944339501
-
A caspase-resistant mutant of PKC-delta protects keratinocytes from UV-induced apoptosis
-
D'Costa AM, Denning MF (2005) A caspase-resistant mutant of PKC-delta protects keratinocytes from UV-induced apoptosis. Cell Death Differ 12:224-232.
-
(2005)
Cell Death Differ
, vol.12
, pp. 224-232
-
-
D'Costa, A.M.1
Denning, M.F.2
-
41
-
-
0036203133
-
Protein kinase C-eta regulates resistance to UV- and gamma-irradiation-induced apoptosis in glioblastoma cells by preventing caspase-9 activation
-
Hussaini IM, et al. (2002) Protein kinase C-eta regulates resistance to UV- and gamma-irradiation-induced apoptosis in glioblastoma cells by preventing caspase-9 activation. Neuro Oncol 4:9 -21.
-
(2002)
Neuro Oncol
, vol.4
, pp. 9-21
-
-
Hussaini, I.M.1
-
42
-
-
0038237433
-
Protein kinase Cdelta is responsible for constitutive and DNA damage-induced phosphorylation of Rad9
-
Yoshida K, Wang HG, Miki Y, Kufe D (2003) Protein kinase Cdelta is responsible for constitutive and DNA damage-induced phosphorylation of Rad9. EMBO J 22:1431-1441.
-
(2003)
EMBO J
, vol.22
, pp. 1431-1441
-
-
Yoshida, K.1
Wang, H.G.2
Miki, Y.3
Kufe, D.4
-
43
-
-
18244402410
-
Molecular analysis of mutations in DNA polymerase eta in xeroderma pigmentosum-variant patients
-
Broughton BC, et al. (2002) Molecular analysis of mutations in DNA polymerase eta in xeroderma pigmentosum-variant patients. Proc Natl Acad Sci USA 99:815-820.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 815-820
-
-
Broughton, B.C.1
-
44
-
-
0042674380
-
Recapitulation of the cellular xeroderma pigmentosum-variant phenotypes using short interfering RNA for DNA polymerase H
-
Laposa RR, Feeney L, Cleaver JE (2003) Recapitulation of the cellular xeroderma pigmentosum-variant phenotypes using short interfering RNA for DNA polymerase H. Cancer Res 63:3909-3912.
-
(2003)
Cancer Res
, vol.63
, pp. 3909-3912
-
-
Laposa, R.R.1
Feeney, L.2
Cleaver, J.E.3
-
45
-
-
0017736229
-
Repair of ultraviolet light damage in a variety of human fibroblast cell strains
-
Lehmann AR, et al. (1977) Repair of ultraviolet light damage in a variety of human fibroblast cell strains. Cancer Res 37:904-910.
-
(1977)
Cancer Res
, vol.37
, pp. 904-910
-
-
Lehmann, A.R.1
-
46
-
-
19844366305
-
Alternative recombination pathways in UV-irradiated XP variant cells
-
Limoli CL, Giedzinski E, Cleaver JE (2005) Alternative recombination pathways in UV-irradiated XP variant cells. Oncogene 24:3708-3714.
-
(2005)
Oncogene
, vol.24
, pp. 3708-3714
-
-
Limoli, C.L.1
Giedzinski, E.2
Cleaver, J.E.3
-
47
-
-
6344288785
-
Rad18 guides poleta to replication stalling sites through physical interaction and PCNA monoubiquitination
-
Watanabe K, et al. (2004) Rad18 guides poleta to replication stalling sites through physical interaction and PCNA monoubiquitination. EMBO J 23:3886-3896.
-
(2004)
EMBO J
, vol.23
, pp. 3886-3896
-
-
Watanabe, K.1
-
48
-
-
33745253465
-
A human DNA polymerase eta complex containing Rad18, Rad6 and Rev1; proteomic analysis and targeting of the complex to the chromatin-bound fraction of cells undergoing replication fork arrest
-
Yuasa MS, et al. (2006) A human DNA polymerase eta complex containing Rad18, Rad6 and Rev1; proteomic analysis and targeting of the complex to the chromatin-bound fraction of cells undergoing replication fork arrest. Genes Cells 11:731-744.
-
(2006)
Genes Cells
, vol.11
, pp. 731-744
-
-
Yuasa, M.S.1
-
49
-
-
0036012790
-
Polymerase eta and p53 jointly regulate cell survival, apoptosis and Mre11 recombination during S phase checkpoint arrest after UV irradiation
-
Cleaver JE, et al. (2002) Polymerase eta and p53 jointly regulate cell survival, apoptosis and Mre11 recombination during S phase checkpoint arrest after UV irradiation. DNA Repair (Amst) 1:41-57.
-
(2002)
DNA Repair (Amst)
, vol.1
, pp. 41-57
-
-
Cleaver, J.E.1
-
50
-
-
0034786832
-
DNA polymerase eta undergoes alternative splicing, protects against UV sensitivity and apoptosis, and suppresses Mre11-dependent recombination
-
Thakur M, et al. (2001) DNA polymerase eta undergoes alternative splicing, protects against UV sensitivity and apoptosis, and suppresses Mre11-dependent recombination, Genes Chromosomes Cancer 32:222-235.
-
(2001)
Genes Chromosomes Cancer
, vol.32
, pp. 222-235
-
-
Thakur, M.1
-
51
-
-
0023939007
-
Rapid diagnosis of sensitivity to ultraviolet light in fibroblasts from dermatologic disorders, with particular reference to xeroderma pigmentosum
-
Cleaver JE, Thomas GH (1988) Rapid diagnosis of sensitivity to ultraviolet light in fibroblasts from dermatologic disorders, with particular reference to xeroderma pigmentosum. J Invest Dermatol 90:467-471.
-
(1988)
J Invest Dermatol
, vol.90
, pp. 467-471
-
-
Cleaver, J.E.1
Thomas, G.H.2
|