Megakaryocyte Development and Platelet Formation

Platelets

Volumn , Issue , 2013, Pages 27-49

  Italiano, Joseph E ^a   Hartwig, John H ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84882659599     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-387837-3.00002-X     Document Type: Chapter

References (191)

1. Golde D. The stem cell. Sci Am 1991, 265:86-93.
2. Ogawa M. Differentiation and proliferation of hematopoietic stem cells. Blood 1993, 81:2844-2853.
3. Debili N., Coulombel L., Croisille L. Characterization of a bipotent erythro-megakaryocytic progenitor in human bone marrow. Blood 1996, 88:1284-1296.
4. Hunt P. A bipotential megakaryocyte/erythrocyte progenitor cell: the link between erythropoiesis and megakaryopoiesis becomes stronger. J Lab Clin Med 1995, 125:303-304.
5. McDonald T., Sullivan P. Megakaryocytic and erythrocytic cell lines share a common precursor cell. Exp Hematol 1993, 21:1316-1320.
6. Nakeff A., Daniels-McQueen S. In vitro colony assay for a new class of megakaryocyte precursor: colonyforming unit megakaryocyte (CFU-M). Proc Soc Exp Biol Med 1976, 151:587-590.
7. Levin J. Murine megakaryocytopoiesis in vitro: an analysis of culture systems used for the study of megakaryocyte colony-forming cells and of the characteristics of megakaryocyte colonies. Blood 1983, 61:617-623.
8. Long M., Gragowski L., Heffner C. Phorbol diesters stimulate the development of an early murine progenitor cell. The burst-forming unit-megakaryocyte. J Clin Invest 1985, 76:431-438.
9. Williams N., Eger R., Jackson H. Two-factor requirement for murine megakaryocyte colony formation. J Cell Physiol 1982, 110:101-104.
10. Lev-Lehman E., Deutsh V., Eldor A., Soreq H. Immature human megakaryocytes produce nuclear associated acetylcholinesterase. Blood 1997, 89:3644-3653.
11. Breton-Gorius J., Guichard J. Ultrastructural localization of peroxidase activity in human platelets and megakaryocytes. Am J Pathol 1972, 66:227-293.
12. Jackson C. Cholinesterase as a possible marker for early cells of themegakaryocytic series. Blood 1973, 42:413-421.
13. Briddell R., Brandt J., Stravena J., Srour E., Hoffman R. Characterization of the human burst-forming unit-megakaryocyte. Blood 1989, 74:145-151.
14. Long M., Williams N., Ebbe S. Immature megakaryocytes in the mouse: physical characteristics, cell cycle status, and in vitro responsiveness to thrombopoietic stimulatory factor. Blood 1982, 59:569-575.
15. Odell T., Jackson C.J., Reiter R. Generation cycle of rat megakaryocytes. Exp Cell Res 1968, 53:321.
16. Ebbe S., Stohlman F. Megakaryocytopoiesis in the rat. Blood 1965, 26:20-34.
17. Ebbe S. Biology of megakaryocytes. Prog Hemost Thromb 1976, 3:211-229.
18. Therman E., Sarto G., Stubblefiels P. Endomitosis: a reappraisal. Hum Genet 1983, 63:13-18.
19. Odell T., Jackson C., Friday T. Megakaryocytopoiesis in rats with special reference to polyploidy. Blood 1970, 35:775-782.
20. Raslova H., Roy L., Vourc'h C., et al. Megakaryocyte polyploidization is associated with a functional gene amplification. Blood 2003, 101:541-544.
21. Nagata Y., Muro Y., Todokoro K. Thrombopoietin-induced polyploidization of bone marrow megakaryocytes is due to a unique regulatory mechanism in late mitosis. J Cell Biol 1997, 139:449-457.
22. Vitrat N., Cohen-Solal K., Pique C., et al. Endomitosis of human megakaryocytes are due to abortive mitosis. Blood 1998, 91:3711-3723.
23. Ravid K., Lu J., Zimmet J.M., Jones M.R. Roads to polyploidy: the megakaryocyte example. J Cell Physiol 2002, 190:7-20.
24. Wang Z., Zhang Y., Kamen D., Lee E., Ravid K. Cyclin D3 is essential for megakaryocytopoiesis. Blood 1995, 86:3783-3788.
25. Gu X.F., Allain A., Li L., et al. Expression of cyclin B in megakaryocytes and cells of other hematopoietic lineages. C R Acad Sci III 1993, 316:1438-1445.
26. Hayles J., Fisher D., Woodlard A. Temporal order of S phase and mitosis in fission yeast is determined by the state of the p34cdc22-mitotic B cyclin complex. Cell 1994, 78:813-822.
27. Broek D., Bartlett R., Crawford K. Involvement of p34cdc2 in establishing the dependency of S phase on mitosis. Nature 1991, 349:388-393.
28. Zhang Y., Wang Z., Ravid K. The cell cycle in polyploid megakaryocytes is associated with reduced activity of cyclin B1-dependent cdc2 kinase. J Biol Chem 1996, 271:4266-4272.
29. Datta N.S., Williams J.L., Caldwell J., Curry A.M., Ashcraft E.K., Long M.W. Novel alterations in CDK1/cyclin B1 kinase complex formation occur during the acquisition of a polyploid DNA content. Mol Biol Cell 1996, 7:209-223.
30. Geddis A.E., Fox N.E., Tkachenko E., Kaushansky K. Endomitotic megakaryocytes that form a bipolar spindle exhibit cleavage furrow ingression followed by furrow regression. Cell Cycle 2007, 6:455-460.
31. Geddis A.E., Kaushansky K. Endomitotic megakaryocytes form a midzone in anaphase but have a deficiency in cleavage furrow formation. Cell Cycle 2006, 5:538-545.
32. Leysi-Derilou Y, Robert A, Duchesne C, et al. Polyploid megakaryocytes can complete cytokinesis. Cell Cycle 2010;9:2589-99.
33. Papadantonakis N., Makitalo M, McCrann DJ, et al. Direct visualization of the endomitotic cell cycle in living megakaryocytes: differential patterns in low and high ploidy cells. Cell Cycle 2008, 7:2352-2356.
34. Lordier L., Jalil A, Aurada F, et al. Megakaryocyte endomitosis is a failure of late cytokinesis related to defects in the contractile ring and Rho/Rock signaling. Blood 2008, 112:3164-3174.
35. Zucker-Franklin D. Atlas of blood cells, function and pathology 1988, vol. 2. Lea & Febiger, Structure/Function Relationships of Megakaryocytes and Platelets. Philadelphia, Chapter 10.
36. Kautz J., De Marsh Q.B. Electron microscopy of sectioned blood and bone marrow elements. Rev Hematol 1955, 10:314-323. discussion, 324-344.
37. Yamada F. The fine structure of the megakaryocyte in the mouse spleen. Acta Anat 1957, 29:267-290.
38. Behnke O. An electron microscope study of megakaryocytes of rat bone marrow. I. The development of the demarcation membrane system and the platelet surface coat. J Ultrastruct Res 1968, 24:412-428.
39. Bentfield-Barker M.E., Bainton D. Ultrastructure of rat megakaryocytes after prolonged thrombocytopenia. J Ultrastruct Res 1977, 61:201-214.
40. Behnke O. An electron microscope study of megakaryocytes of rat bone marrow. I. The development of the demarcation membrane system and the platelet surface coat. J Ultrastruct Res 1968, 24:412-433.
41. Nakao K., Angrist A. Membrane surface specialization of blood platelet and megakaryocyte. Nature 1968, 217:960-961.
42. Zucker-Franklin D., Benson K., Myers K. Absence of a surface-connected canalicular system in bovine platelets. Blood 1985, 65:241-244.
43. Daimon T., Gotoh Y. Cytochemical evidence of the origin of the dense tubular system in the mouse platelet. Histochem 1982, 76:189-196.
44. Gerrard J.M., White J.G., Rao G.H., Townsend D. Localization of platelet prostaglandin production in the platelet dense tubular system. Am J Pathol 1976, 101:283-298.
45. Jones O.P. Origin of megakaryocyte granules from Golgi vesicles. Anat Rec 1960, 138:105-114.
46. Handagama P., George J., Shuman M., McEver R., Bainton D.F. Incorporation of circulating protein into megakaryocyte and platelet granules. PNAS 1987, 84:861-865.
47. de Larouziere V., Brouland J.P., Souni F., Drouet L., Cramer E. Inverse immunostaining pattern for synthesized versus endocytosed alpha-granule proteins in human bone marrow megakaryocytes. Br J Haematol 1998, 101:618-625.
48. Coller B.S., Seligsohn U., West S.M., Scudder L.E., Norton K.J. Platelet fibrinogen and vitronectin in Glanzmann thrombasthenia: evidence consistent with specific roles for glycoprotein IIb/IIIA and alpha V beta 3 integrins in platelet protein trafficking. Blood 1991, 78:2603-2610.
49. Handagama P., Bainton D.F., Jacques Y., Conn M.T., Lazarus R.A., Shuman M.A. Kistrin, an integrin antagonist, blocks endocytosis of fibrinogen into guinea pig megakaryocyte and platelet alpha-granules. J Clini Invest 1993, 91:193-200.
50. Handagama P., Scarborough R.M., Shuman M.A., Bainton D.F. Endocytosis of fibrinogen into megakaryocyte and platelet alpha-granules is mediated by alpha IIb beta 3 (glycoprotein IIb-IIIa). Blood 1993, 82:135-138.
51. Heijnen H.F., Debili N., Vainchencker W., Breton-Gorius J., Geuze H.J., Sixma J.J. Multivesicular bodies are an intermediate stage in the formation of platelet alpha granules. Blood 1998, 91:2313-2325.
52. Youssefian T., Cramer E.M. Megakaryocyte dense granule components are sorted in multivesicular bodies. Blood 2000, 95:4004-4007.
53. Djaldetti M., Fishman P., Bessler H., Notti I. SEM observations on the mechanism of platelet release from megakaryocytes. Thromb Haemost 1979, 42:611-620.
54. Ihzumi T., Hattori A., Sanada M., Muto M. Megakaryocyte and platelet formation: a scanning electron microscope study in mouse spleen. Arch Histol Jpon 1977, 40:305-320.
55. Shaklai M., Tavassoli M. Demarcation membrane system in rat megakaryocyte and the mechanism of platelet formation: a membrane reorganization process. J Ultrastruct Res 1978, 62:270-285.
56. Kosaki G. In vivo platelet production from mature megakaryocytes: does platelet release occur via proplatelets?. Int J Hematol 2005, 81:208-219.
57. Radley J., Hatshorm M. Megakaryocyte fragments and the microtubule coil. Blood Cells 1987, 12:603-608.
58. Radley J.M., Haller C.J. The demarcation membrane system of the megakaryocyte: a misnomer?. Blood 1982, 60:213-219.
59. Becker R.P., DeBruyn P.P. The transmural passage of blood cells into myeloid sinusoids and the entry of platelets into the sinusoidal circulation: a scanning electron microscopic investigation. Am J Anat 1976, 145:1046-1052.
60. Wright J. The origin and nature of blood platelets. Boston Med Surg J 1906, 154:643-645.
61. Thiery J.B., Bessis M. Platelet genesis from megakaryocytes observed in live cells. Acad Sci 1956, 242:290.
62. Behnke O. An electron microscope study of the rat megakaryocyte. II. Some aspects of platelet release and microtubules. J Ultrastruct Res 1969, 26:111-129.
63. Zucker-Franklin D., Petursson S. Thrombocytopoiesis: analysis by membrane tracer and freeze-fracture studies on fresh human and cultured mouse megakaryocytes. J Cell Biol 1984, 99:390-402.
64. Hyde P., Zucker-Franklin D. Antigenic differences between human platelets and megakaryocytes. Am J Pathol 1987, 127:349-357.
65. Schultze H., Korpal M, Hurov J, et al. Characterization of the megakaryocyte demarcation membrane system and its role in thrombopoiesis. Blood 2006, 107:3868-3875.
66. Schmitt A., Guichard J., Masse J., Debili N., Cramer E.M. Of mice and men: comparison of the ultrastructure of megakaryocytes and platelets. Exp Hematol 2001, 29:1295-1302.
67. Choi E.S., Nichol J.L., Hokom M.M., Hornkohl A.C., Hunt P. Platelets generated in vitro from proplatelet-displaying human megakaryocytes are functional. Blood 1995, 85:402-413.
68. Cramer E.M., Norol F., Guichard J., et al. Ultrastructure of platelet formation by human megakaryocytes cultured with the Mpl ligand. Blood 1997, 89:2336-2346.
69. Leven R.M. Megakaryocyte motility and platelet formation. Scanning Micros 1987, 1:1701-1709.
70. Tablin F., Castro M., Leven R.M. Blood platelet formation in vitro: the role of the cytoskeleton in megakaryocyte fragmentation. J Cell Sci 1990, 97:59-70.
71. Handagama P.J., Feldman B.F., Jain N.C., Farver T.B., Kono C.S. In vitro platelet release by rat megakaryocytes: effect of metabolic inhibitors and cytoskeletal disrupting agents. Am J Vet Res 1987, 48:1142-1146.
72. Miyazaki H., Inoue H., Yanagida M., et al. Purification of rat megakaryocyte colony-forming cells using monoclonal antibody against rat platelet glycoprotein IIb/IIIa. Exp Hematol 1992, 20:855-861.
73. Choi E. Regulation of proplatelet and platelet formation in vitro. Chapter 17 in Thrombopoiesis and Thrombopoietins: Molecular, Cellular, Pre Clinical, and Clinical Biology. In: Kuter D, Hunt P, Sheridan WP, Zucker-Franklin D, editors. 1997;271-84.
74. Kessal K.G., Kardon R.H. Tissues and organs: a text atlas of scanning electron microscopy 1979, Freeman, San Francisco.
75. Lichtman M.A., Chamberlain J.K., Simon W., Santillo P.A. Parasinusoidal location of megakaryocytes in marrow: a determinant of platelet release. Am J Hematol 1978, 4:303-312.
76. Scurfield G., Radley J.M. Aspects of platelet formation and release. Am J Hematol 1981, 10:285-296.
77. Tavassoli M., Aoki M. Localization of megakaryocytes in the bone marrow. Blood Cells 1989, 15:3-14.
78. Shivdasani R.A., Rosenblatt M.F., Zucker-Franklin D., et al. Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development. Cell 1995, 81:695-704.
79. Shivdasani R.A., Fujiwara Y., McDevitt M.A., Orkin S.H. A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development. EMBO J 1997, 16:3965-3973.
80. Lecine P., Villeval J., Vyas P., Swencki B., Yuhui X., Shivdasani R.A. Mice lacking transcription factor NF-E2 provide in vivo validation of the proplatelet model of thrombocytopoiesis and show a platelet production defect that is intrinsic to megakaryocytes. Blood 1998, 92:1608-1616.
81. Italiano J.E.J., Lecine P., Shivdasani R.A., Hartwig J.H. Blood platelets are assembled principally at the ends of proplatelet processes produced by differentiated megakaryocytes. J Cell Biol 1999, 147:1299-1312.
82. Patel S.R., Hartwig J.H., Italiano J.E. The biogenesis of platelets from megakaryocyte proplatelets. J Clin Invest 2005, 115:3348-3354.
83. Hunt P., Hokom M., Wiemann B., Leven R.M., Arakawa T. Megakaryocyte proplatelet-like process formation in vitro is inhibited by serum prothrombin, a process which is blocked by matrix-bound glycosaminoglycans. Exp Hematol 1993, 21:372-381.
84. Patel S.R., Richardson J., Schulze H., et al. Differential roles of microtubule assembly and sliding in proplatelet formation by megakaryocytes. Blood 2005, 15:4076-4085.
85. Harker L.A., Finch C.A. Thrombokinetics in man. J Clin Invest 1969, 48:963-974.
86. Kaufman R., Airo R., Pollack S. Origin of pulmonary megakaryocytes. Blood 1965, 25:767-775.
87. Trowbridge E.A., Martin J.F., Slater D.N., Kishk Y.T., Warren C.W., Harley P.J., et al. The origin of platelet count and volume. Clin Phys Physiol Meas 1984, 5:145-156.
88. Rojnuckarin P., Kaushansky K. Actin reorganization and proplatelet formation in murine megakaryocytes: the role of protein kinase c alpha. Blood 2001, 97:154-161.
89. Kelley M.J., Jawien W., Ortel T.L., Korczak J.F. Mutation of MYH9, encoding non-muscle myosin heavy chain A, in May-Hegglin anomaly. Nat Gene 2000, 26:106-108.
90. Kunishima S., Kojima T., Matsushita T., et al. Mutations in the NMMHC-A gene cause autosomal dominant macrothrombocytopenia with leukocyte inclusions (May-Hegglin anomaly/Sebastian syndrome). Blood 2001, 97:1147-1149.
91. Richardson J., Shivdasani R., Boers C., Hartwig J., Italiano J.E. Mechanisms of organelle transport and capture along proplatelets during platelet production. Blood 2005, 106:4066-4075.
92. Patel-Hett, S, Wang H, Begonja AJ, et al. The spectrin-based membrane skeleton stabilizes mouse megakaryocyte membrane systems and is essential for proplatelet and platelet formation. Blood 2011;118:1641-52.
93. Junt T., Schultze H, Chen Z, et al. Science 2007, 317(5845):1767-1770.
94. Thon JN, Montalvo A, Patel-Hett S, et al. Cytoskeletal mechanics of proplatelet maturation and platelet release. J Cell Biol 2010;191:861-74.
95. Schwertz H, Köster S, Kahr WH, et al. Anucleate platelets generate progeny. Blood (2010):115;3801-9.
96. Mohandas N., Prenant M. Three-dimensional model of bone marrow. Blood 1978, 51:633-643.
97. Radley J.M. Ultrastructural aspects of platelet formation. Pro Clin Biol Res 1986, 215:387-398.
98. Radley J.M., Scurfield G. The mechanism of platelet release. Blood 1980, 56:996-999.
99. Kopp H.G., Avecilla S.T., Hooper A.T., Rafii S. The bone marrow vascular niche: home of HSC differentiation and mobilization. Physiol 2005, 20:349-356.
100. Avecilla S.T., Hattori K., Heissig B., et al. Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis. Nat Med 2004, 10:64-71.
101. Avraham H., Banu N., Scadden D.T., Abraham J., Groopman J.E. Modulation of megakaryocytopoiesis by human basic fibroblast growth factor. Blood 1994, 83:2126-2132.
102. Avraham H., Cowley S., Chi S.Y., Jiang S., Groopman J.E. Characterization of adhesive interactions between human endothelial cells and megakaryocytes. J Clin Invest 1993, 91:2378-2384.
103. Behnke O., Forer A. From megakaryocytes to platelets: platelet morphogenesis takes place in the bloodstream. Eur J Haematol Suppl 1998, 60:3-23.
104. Minot G. Megakaryocytes in the peripheral circulation. J Exp Med 1922, 36:1-4.
105. Hansen M., Pedersen N.T. Circulating megakaryocytes in blood from the antecubital vein in healthy, adult human. Scan J Haematol 1978, 20:371-376.
106. Efrati P., Rozenszajn L. The morphology of buffy coat in normal human adults. Blood 1960, 16:1012-1019.
107. Melamed M.R., Clifften E.E., Mercer C., Koss G. The megakaryocyte blood count. Am J Med Sci 1966, 252:301-309.
108. Tong M., Seth P., Pennington D.G. Proplatelets and stress platelets. Blood 1987, 69:522-528.
109. Cramer L. Molecular mechanism of actin-dependent retrograde flow in lamellipodia of motile cells. Front Bio 1997, 2:260-270.
110. Howell W., Donahue D. The production of blood platelets in the lungs. J Exp Med 1937, 65:171-203.
111. Kaufman R.M., Airo R., Pollack S., Crosby W.H. Circulating megakaryocytes and platelet release in the lung. Blood 1965, 26:720-728.
112. Pederson N.T. The pulmonary vessels as a filter for circulating megakaryocytes in rats. Scan J Haematol 1974, 13:225-231.
113. Trowbridge E.A., Martin J.F., Slater D.N. Evidence for a theory of physical fragmentation of megakaryocytes, implying that all platelets are produced in the pulmonary circulation. Thromb Res 1982, 28:461-475.
114. Scheinin T., Koivuneimi A. Megakaryocytes in the pulmonary circulation. Blood 1963, 22:82-87.
115. Jordan H. Origin and significance of megakaryocytes of lungs. Anat Rec 1940, 77:91-101.
116. Aschoff L. Ueber capillare embolie von riesenkernhaltigen zellen. Arch Pathol Anat Physiol 1893, 134:11-14.
117. Kinosita R., Ohno S. Biodynamics of thrombopoiesis. Blood Platelets 1958, Little, Brown, Boston. S. Johnson, J. Rebuck, R. Horn (Eds.).
118. Tavassoli M., Aoki M. Migration of entire megakaryocytes through the marrow-blood barrier. Br J Haematol 1981, 48:25-29.
119. Hamada T., Mohle R., Hesselgesser J., et al. Transendothelial migration of megakaryocytes in response to stromal cell-derived factor 1 (SDF-1) enhances platelet formation. J Exp Med 1998, 188:539-548.
120. Rivière C., Subra F., Cohen-Solal K., Cordette-Lagarde V., Letestu R., Auclair C. Phenotypic and functional evidence for the expression of CXCR4 receptor during megakaryocytopoiesis. Blood 1999, 93:1511-1523.
121. Kowalska M.A., Ratajczak J., Hoxie J., et al. Megakaryocyte precursors, megakaryocytes and platelets express the HIV co-receptor CXCR4 on their surface: determination of response to stromal-derived factor-1 by megakaryocytes and platelets. Br J Haematol 1999, 104:220-229.
122. Levine R.F., Eldor A., Shoff P.K., Kirwin S., Tenza D., Cramer E.M. Circulating megakaryocytes. Delivery of large numbers of intact, mature megakaryocytes to the lungs. Eur J Haematol 1993, 51:233-246.
123. Crosby W. Delivery of megakaryocytes by the marrow. The derivation of platelets. Topics in hematology 1976, 416-419. Excerpta Medica, Amsterdam. S. Seno, F. Takaku, S. Irino (Eds.).
124. Pedersen N. Occurrence of megakaryocytes in various vessels and their retention in the pulmonary capillaries in man. Scan J Haematol 1978, 21:369-375.
125. Davis R.E., Stenberg P.E., Levin J., Beckstead J.A. Localization of megakaryocytes in normal mice and following administration of platelet antiserum, 5-fluorouracil, or radiostrontium: evidence for the site of platelet production. Exp Hematol 1997, 25:638-648.
126. Gordge M.P. Megakaryocyte apoptosis: sorting out the signals. Br J Pharmacol 2005, 145:271-273.
127. Radley J.M., Haller C.J. Fate of senescent megakaryocytes in the bone marrow. Br J Haematol 1983, 53:277-287.
128. Falcieri E., Bassini A., Pierpaoli S., et al. Ultrastructural characterization of maturation, platelet release, and senescence of human cultured megakaryocytes. Anat Rec 2000, 258:90-99.
129. Zauli G., Vitale M., Falcieri E., et al. In vitro senescence and apoptotic cell death of human megakaryocytes. Blood 1997, 90:2234-2243.
130. Kaluzhny Y., Ravid K. Role of apoptotic processes in platelet biogenesis. Acta Haematol 2004, 111:67-77.
131. Gaur M, Kamata T, Wang S, et al. Megakaryocytes derived from human embryonic stem cells: a genetically tractable system to study megakaryocytopoiesis and integrin function. J Thromb Haemost 2006, 4:436-442.
132. Nakano T., Kodama H., Honjo T. Generation of lymphohematopoietic cells from embryonic stem cells in culture. Science 1994, 265:1098-1101.
133. Takayama, N, Nishimura S, Nakamura S, et al. Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells. J Exp Med (2010):207;2817-30.
134. Lu SJ. Li F, Yin H, et al. Platelets generated from human embryonic stem cells are functional in vitro and in the microcirculation of living mice. Cell Res 2011;3:530-45.
135. Takahashi K., Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006, 126:663-676.
136. Sullenbarger B., Bahng J.H., Gruner R., Kotov N., Lasky L.C. Prolonged continuous in vitro human platelet production using three-dimensional scaffolds. Exp Hematol 2009, 37:101-110.
137. Fuentes R, Wang Y, Hirsch J, et al. Infusion of mature megakaryocytes into mice yields functional platelets. J Clin Invest 2010;120:3917-22.
138. de Botton S., Sabri S., Daugas E., et al. Platelet formation is the consequence of caspase activation within megakaryocytes. Blood 2002, 100:1310-1317.
139. Kaluzhny Y., Yu G., Sun S., et al. BclxL overexpression in megakaryocytes leads to impaired platelet fragmentation. Blood 2002, 100:1670-1678.
140. Sanz C., Benet I., Richard C., et al. Antiapoptotic protein Bcl-x(L) is up-regulated during megakaryocytic differentiation of CD34(+) progenitors but is absent from senescent megakaryocytes. Exp Hematol 2001, 29:728-735.
141. Battinelli E., Loscalzo J. Nitric oxide induces apoptosis in megakaryocytic cell lines. Blood 2000, 95:3451-3459.
142. Battinelli E., Willoughby S.R., Foxall T., Valeri C.R., Loscalzo J. Induction of platelet formation from megakaryocytoid cells by nitric oxide. Proc Nat Acad Sci USA 2001, 98:14458-14463.
143. Kim J.A., Jung Y.J., Seoh J.Y., Woo S.Y., Seo J.S., Kim H.L. Gene expression profile of megakaryocytes from human cord blood CD34(+) cells ex vivo expanded by thrombopoietin. Stem Cells 2002, 20:402-416.
144. Clarke M.C., Savill J., Jones D.B., Noble B.S., Brown S.B. Compartmentalized megakaryocyte death generates functional platelets committed to caspase-independent death. J Cell Biol 2003, 160:577-587.
145. Brown S.B., Clarke M.C., Magowan L., Sanderson H., Savill J. Constitutive death of platelets leading to scavenger receptor-mediated phagocytosis. A caspase-independent cell clearance program. J Biol Chem 2000, 275:5987-5996.
146. Kerrigan S.W., Gaur M., Murphy R.P., Shattil S.J., Leavitt A.D. Caspase-12: a developmental link between G-protein-coupled receptors and integrin alpha IIb beta3 activation. Blood 2004, 104:1327-1334.
147. Kaushansky K. Regulation of thrombopoiesis. In Loscalzo J, Schafer AI, editors. Thrombosis and Hemorrhage, 2nd edition. Baltimore: Williams and Wilkins. p. 173-94.
148. Segal G., Stueve T., Adamson J. Analysis of murine megakaryocyte ploidy and size: effects of interleukin-3. J Cell Physiol 1988, 137:537-544.
149. Yang Y., Ciarletta A., Temple P. Human IL-3 (multi-CSF): identification by expression cloning of a novel hematopoietic growth factor related to murine IL-3. Cell 1986, 47:3-10.
150. Kaushansky K. Thrombopoietin: the primary regulator of platelet production. Blood 1995, 85:419-431.
151. Martin F., Suggs S., Langley K. Primary structure and functional expression of rat and human stem cell factor. Cell 1990, 63:203-210.
152. Flanagan J., Leder P. The kit ligand: a cell surface molecule altered in steel mutant fibroblasts. Cell 1990, 63:185-194.
153. Briddell R., Bruno E., Cooper R. Effect of c-kit ligand on in vitro human megakaryocytopoiesis. Blood 1991, 78:2854-2859.
154. Ito T., Ishida Y., Kashiwagi R., Kuriya S. Recombinant human c-Mpl ligand is not a direct stimulator of proplatelet formation of human megakaryocytes. Br J Haematol 1996, 94:387-390.
155. Pevny L., Simon M., Robertson E., et al. Erythroid differentiation in chimeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1. Nature 1991, 349(6306):257-260.
156. Centurione L., Di Baldassarre A., Zingariello M., et al. Increased and pathologic emperipolesis of neutrophils within megakaryocytes associated with marrow fibrosis in GATA-1(low) mice. Blood 2004, 104:3573-3580.
157. Visvader J., Elefanty A., Strasser A., Adams J. GATA-1 but not SCL induces megakaryocytic differentiation in an early myeloid line. EMBO 1992, 11:4557-4564.
158. Vyas P., Ault K., Jackson C., Orkin S.H., Shivdasani R.A. Consequences of GATA-1 deficiency in megakaryocytes and platelets. Blood 1999, 93:2867-2875.
159. Nichols K.E., Crispino J.D., Poncz M., et al. Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA1. Nat Gene 2000, 3:266-270.
160. Mehaffey M.G., Newton A.L., Gandhi M.J., Crossley M., Drachman J.G. X-linked thrombocytopenia caused by a novel mutation of GATA-1. Blood 2001, 98:2681-2688.
161. Tsang A.P., Fujiwara Y., Hom D.B., Orkin S.H. Failure of megakaryopoiesis and arrested erythropoiesis in mice lacking the GATA-1 transcriptional cofactor FOG. Genes Dev 1998, 12:1176-1188.
162. Andrews N., Erdjument-Bromage H., Davidson M., Tempst P., Orkin S. Erythroid transcription factor NF-E2 is a hematopoietic-specific basic-leucine zipper protein. Nature 1993, 362:722-728.
163. Shavit J., Motohashi H., Onodera K., Akasaka J., Yamamoto M., Engel J. Impaired megakaryopoiesis and behavioral defects in mafG-null mutant mice. Genes Dev 1998, 12:2164-2174.
164. Tiwari S., Italiano J.E., Barral D.C., et al. A role for Rab27b in NF-E2-dependent pathways of platelet formation. Blood 2003, 102:3970-3979.
165. Novak E.K., Reddington M., Zhen L., et al. Inherited thrombocytopenia caused by reduced platelet production in mice with the gunmetal pigment gene mutation. Blood 1995, 85:1781-1789.
166. Lecine P., Italiano J.E.J., Kim S., Villeval J., Shivdasani R.A. Hematopoietic-specific B1 tubulin participates in a pathway of platelet biogenesis dependent on the transcription factor NF-E2. Blood 2000, 96:1366-1373.
167. Wang D., Villasante A., Lewis S.A., Cowan N.J. The mammalian B-tubulin repertoire: hematopoietic expression of a novel B-tubulin isotype. J Cell Biol 1985, 103:1903-1910.
168. Schwer H.D., Lecine P., Tiwari S., Italiano J.E., Hartwig J.H., Shivdasani R.A. A lineage-restricted and divergent B-tubulin isoform is essential for the biogenesis, structure and function of blood platelets. Curr Biol 2001, 11:579-586.
169. Freson K., De Vos R., Wittevrongel C., et al. The TUBB1 Q43P functional polymorphism reduces the risk of cardiovascular disease in men by modulating platelet function and structure. Blood 2005, 106:2356-2362.
170. Andrews R., Shen Y., Gardiner E., Dong J., Lopez J., Berndt M. The glycoprotein Ib-IX-V complex in platelet adhesion and signaling. Thromb Haemost 1999, 82:357-364.
171. Lopez J.A., Andrews R.K., Afshar-Kharghan V., Berndt M. Bernard-Soulier syndrome. Blood 1998, 91:4397-4418.
172. Clemetson K.J., McGregor J.L., James E., Dechavanne M., Luscher E.F. Characterization of the platelet membrane glycoprotein abnormalities in Bernard-Soulier syndrome and comparison with normal by surface-labeling techniques and high-resolution two-dimensional gel electrophoresis. J Clin Invest 1982, 70:304-311.
173. Tomer A., Scharf R., McMillan R., Ruggeri Z., Harker L. Bernard-Soulier syndrome: quantitative characterization of megakaryocytes and platelets by flow cytometric and platelet kinetic measurements. Eur J Haematol 1994, 52:193-200.
174. Nurden P., Nurden A. Giant platelets, megakaryocytes and the expression of glycoprotein Ib-IX complexes. CR Acad Sci Paris 1996, 319:717-726.
175. Kass L., Leichtman D.A., Beals T.F. Megakaryocytes in the giant platelet syndrome. A cytochemical and ultrastructural study. Thromb Haemost 1977, 38:652-659.
176. Ware J., Russell S., Ruggeri Z.M. Generation and rescue of a murine model of platelet dysfunction: the Bernard-Soulier syndrome. Blood 2000, 97:2803-2808.
177. Begonja A.J., Hoffmeister K., Hartwig J., Falet H. FlnA-null megakaryocytes prematurely release large and fragile platelets that circulate poorly. Blood 2011, 118:2285-2295.
178. May R. Leokozyteneinschlusse. Deutsch Arch Klin Med 1909, 96:1-6.
179. Hegglin R. Gleichzeitige konstitutionelle veranderungen an neurtophilen und thrombocyten. Helv Med Acta 1945, 12:439-440.
180. Seri M., Cusano R., Gangarossa S., et al. Mutations in MYH9 result in the May-Hegglin anomaly, and Fechtner and Sebastian syndromes. The May-Hegglin/Fechtner Syndrome Consortium. Nat Gene 2000, 26:103-105.
181. Franke J.D., Dong F., Rickoll W.L., Kelley M.J., Kiehart D.P. Rod mutations associated with MYH9-related disorders disrupt nonmuscle myosin-IIA assembly. Blood 2005, 105:161-169.
182. Peterson L., Rao K., Crosson J., White J. Fechtner syndrome-A variant of Alport's syndrome with leukocyte inclusions and macrothrombocytopenia. Blood 1985, 65:397-406.
183. Greinacher A., Nieuwenhuis H., White J. Sebastian platelet syndrome: A new variant of the hereditary macrothrombocytopenia with leukocyte inclusions. Blut 1990, 61:282-288.
184. Chen Z., Naveiras O, Balduini A, et al. The May-Hegglin anomaly gene MYH9 is a negative regulator of platelet biogenesis modulated by the Rho-ROCK pathway. Blood 2007, 110:171-179.
185. Eckly A., Strassel C, Freund M, et al. Abnormal megakaryocyte morphology and proplatelet formation in mice with megakaryocyte-restricted MYH9 inactivation. Blood 2009, 113:3182-3189.
186. Leon C., Eckly A, Hechler B, et al. Megakaryocyte-restricted MYH9 inactivation dramatically affects hemostasis while preserving platelet aggregation and secretion. Blood 2007, 110:3183-3191.
187. Chen Z., Shivdasani R.A. Regulation of platelet biogenesis: Insights from the May-Hegglin anomaly and other MYH9-related disorders. J Thromb Haemost 2009, 7(Suppl. 1):272-276.
188. Bender M, Eckly A, Hartwig JH, et al. ADF/n-cofilin-dependent actin turnover determines platelet formation and sizing. Blood 1767-75;116.
189. Novak E., Reddington M., Zhen L., et al. Inherited thrombocytopenia caused by reduced platelet production in mice with the gunmetal pigment gene mutation. Blood 1995, 85:1781-1789.
190. Swank R., Jiang S., Reddington M., et al. Inherited abnormalities in platelet organelles and plated formation and associated altered expression of low molecular weight gaunosine triphosphate-binding proteins in the mouse pigment mutant gunmetal. Blood 1993, 81:2626-2635.
191. Detter J., Zhang Q., Mules E., et al. Rab geranylgeranyl transferase alpha mutation in the gunmetal mouse reduces Rab prenylation and platelet synthesis. Blood 2000, 97:4144-4149.