Endomitosis of human megakaryocytes are due to abortive mitosis

Blood

Volumn 91, Issue 10, 1998, Pages 3711-3723

  Vitrat, Natacha ^a   Cohen Solal, Karine ^a   Pique, Claudine ^a   Le Couedic, Jean Pierre ^a   Norol, Françoise ^a   Larsen, Annette K ^a   Katz, André ^a   Vainchenker, William ^a   Debili, Najet ^a  

^a INSTITUT GUSTAVE ROUSSY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CELL SPECIFICITY; CYTOKINESIS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MEGAKARYOPOIESIS; METAPHASE; MICROTUBULE; MITOSIS; MITOSIS SPINDLE; PRIORITY JOURNAL;

EID: 0032525078     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v91.10.3711     Document Type: Article

References (60)

1. Hoffman R: Regulation of megakaryocytopoiesis. Blood 74:1196, 1989
2. Odell TT, Jackson CW Jr, Reiter RS: Generation cycle of rat megakaryocytes. Exp Cell Res 53:321, 1968
3. Debili N, Massé J, Katz A, Guichard J, Breton-Gorius J, Vainchenker W: Effects of recombinant hematopoietic growth factors (IL-3, IL-6, SCF, LlF) on the megakaryocyte differentiation of CD34 positive cells. Blood 82:84, 1993
4. Debili N, Wendling N, Katz A, Guichard J, Breton-Gorius J, Hunt P, Vainchenker W: The Mpl-ligand or thrombopoietin or megakaryocyte growth and differentiative factor has both direct proliferative and differentiative activities on human megakaryocyte progenitors. Blood 86:2516, 1995
5. Kaushansky K: Thrombopoietin, the primary regulator of platelet production. Blood 86:419, 1995
6. Jackson CW: Cholinesterase as a possible marker for early cells of the megakaryocytic series. Blood 42:413, 1973
7. Long MW, Williams N, McDonald TP: Immature megakaryocytes in the mouse: In vitro relationship to megakaryocyte progenitor cells and mature megakaryocytes. J Cell Physiol 112:339, 1982
8. Rabellino EM, Levene RB, Leung LLK, Nachman RL: Human megakaryocytes. II. Expression of platelet proteins in early marrow megakaryocytes. J Exp Med 154:85, 1981
9. Vinci G, Tabilio A, Deschamps J, Van Haeke D, Henri A, Guichard J, Tetteroo P, Lansdorp PM, Hercend T, Vainchenker W, Breton-Gorius J: Immunological study of in vitro maturation of human megakaryocytes. Br J Haematol 56:589, 1984
10. Debili N, Issaad C, Massé JM, Guichard J, Katz A, Breton-Gorius J, Vainchenker W: Expression of CD34 and platelet glycoproteins during human megakaryocytic differentiation. Blood 80:3022, 1992
11. Jackson CW, Brown LK, Sommerville BC, Lytes SA, Look AT: Two-color flow cytometric measurement of DNA distributions of rat megakaryocytes in unfixed, unfractionated marrow cell suspensions. Blood 63:768, 1984
12. Bartley TD, Bogenberger J, Hunt P, Li YS, Lu HS, Martin F, Chang MS, Samal B, Nichol JL, Swift S, Johnson MJ, Hsu RY, Parker VP, Suggs S, Skrine JD, Merewether LA, Clogston C, Hsu E, Hokom MM, Hornkohl A, Choi E, Pangelinan M, Sun Y, Mar V, McNinch J, Simonet L, Jacobsen F, Xie C, Shutter J, Chute H, Basu R, Selander L, Trollinger D, Sieu L, Padilla D, Trail G, Elliot G, Izumi R, Covey T, Crouse J, Garcia A, Xu W, Del Castillo J, Biron J, Cole S, Hu CT, Pacifici R, Ponting I, Saris C, Wen D, Yung YP, Lin H, Bosselman RA: Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl. Cell 77:1117, 1994
13. de Sauvage FJ, Hass PE, Spencer SD, Malloy BE, Gurney AL, Spencer SA, Darbonne WC, Henzel WJ, Wong SC, Kuang W-J, Oles KJ, Hultgren B, Solberg LA Jr, Goeddel DV, Eaton DL: Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand. Nature 369:533, 1994
14. Lok S, Kaushansky K, Holly RD, Kuijper JL, Lofton-Day CE, Oort PJ, Grant FJ, Heipel MD, Burhead SK, Kramer JM, Bell LA, Sprecher CA, Blumberg H, Johnson R, Prunkard D, Ching AFT, Bailey MC, Forstrom JW, Buddle MM, Osborn SG, Evans SJ, Sheppard PO, Presnell SR, O'Hara PJ, Hagen HS, Roth GR, Foster DC: Murine thrombopoietin: Expression cloning, cDNA sequence and Stimulation of platelet production in vivo. Nature 369:565, 1994
15. Wendling F, Maraskovsky E, Debili N, Florindo C, Teepe M, Titeux M, Methia N, Breton-Gorius J, Cosman D, Vainchenker W: The Mpl ligand is a humoral regulator of megakaryocytopoiesis. Nature 369:571, 1994
16. Banu N, Wang J, Deng B, Groopman JE, Avraham H: Modulation of megakaryocytopoiesis by thrombopoietin: The c-mpl ligand. Blood 86:1331, 1995
17. Kaushansky K, Lok S, Holly RD, Broudy VC, Lin N, Bailey MC, Forstrom JW, Buddle MM, Oort PJ, Hagen FS, Roth GR, Papayannopoulou T, Foster DC: Murine thrombopoietin: The ligand for c-mpl expands megakaryocyte progenitors, induces their differentition and stimulates platelet production. Nature 369:568, 1994
18. Handeli S, Weintraub H: The ts41 mutation in Chinese hamster cells leads to successive S phases in the absence of intervening G2, M, and G1. Cell 71:599, 1992
19. Wang Z, Zhang Y, Kamen D, Lees E, Ravid K: Cyclin D3 is essential for megakaryocytopoiesis. Blood 86:3783, 1995
20. Datta NS, Williams JL, Caldwell J, Curry AM, Ashcraft EK, Long MW: Novel alteration in CDK1/Cyclin B1 kinase complex formation occur during the acquisition of a polyploid DNA content. Mol Biol Cell 7:209, 1996
21. Garcia P, Calés C: Endoreplication in megakaryoblastic cell lines is accompanied by sustained expression of G1/S cyclins and downregulation of cdc25C. Oncogene 13:695, 1996
22. Gu XF, Allain A, LI L, Cramer-Martin E, Tenza D, Caen JP, Han ZC: Expression of cyclin B in megakaryocytes and cells of other hematopoietic lines. C R Acad Sci 316:1438, 1993
23. Zhang Y, Wang Z, Ravid K: The cell cycle in polyploid megakaryocytes is associated with reduced activity of cyclin-B1-dependent cdc2 kinase. J Biol Chem 271:4266, 1996
24. King RW, Jackson PK, Kirschner MW: Mitosis in transition. Cell 79:563, 1994
25. Lewin B: Driving the cell cycle: M phase kinase, its partners and substrates. Cell 61:743, 1990
26. Long MW, Heffner CH, Williams JL, Peters C, Prochownik EV: Regulation of megakaryocyte phenotype in human erythroleukemia cells. J Clin Invest 85:1072, 1990
27. Therman E, Sarto GE, Stubblefled PA: Endomitosis: A reappraisal. Hum Genet 63:13, 1983
28. Goyanes-Villaescuca V: Cycles of reduplication in megakaryocyte nuclei. Cell Tissue Kinet 2:165, 1969
29. Radley JM, Green SL: Ultrastructure of endomitosis in megakaryocytes. Nouv Rev Fr Hematol 31:232, 1989
30. Mariette X, Brouet JC, Danon F, Tsapis A, Lassoued K: Nucleotide sequence analysis of the VL and VH domains of five human IgM directed to lamin B. Evidence for an antigen-driven process in the generation of human autoantibodies to lamin B. Arthritis Rheum 36:1345, 1993
31. Choi E, Nichol J, Hokom M, Hornkohl A, Hunt P: Platelets generated in vitro from proplatelet-displaying human megakaryocytes are functional. Blood 85:402, 1995
32. Komatsu N, Nakauchi H, Miwa A, Ishihara T, Eguchi M, Moroi M, Okada M, Sato Y, Wada H, Yawata Y, Suda T, Miura Y: Establishment and characterization of a human leukemic cell line with megakaryocytic features: Dependency on granulocyte-macrophage colonystimulating factor, interleukin-3, or erythropoietin for growth and survival. Cancer Res 51:341, 1991
33. Carter KC, Bowman D, Carrington W, Fogarty K, McNeil A, Fay FS, Lawrence JB: A three-dimensional view of precursor messenger RNA metabolism within the mammalian nucleus. Science 259:1330, 1993
34. Gong J, Traganos F, Darzynkiewicz Z: Expression of cyclins B and E in individual MOLT-4 cells and in stimulated lymphocytes during their progression through the cell cycle. Int J Oncol 3:1037, 1993
35. Gong J, Traganos F, Darzynkiewicz Z: Simultaneous analysis of cell cycle kinetics at two different DNA ploidy levels bases on DNA content and cyclin B measurements? Cancer Res 53:5096, 1993
36. Gong J, Ardelt B, Traganos F, Darzynkiewicz Z: Unscheduled expression of cyclin B1 and cyclin E in several leukemic and solid tumor cell lines. Cancer Res 54:4285, 1994
37. McIntosch RJ, Koonce MP: Mitosis. Science 246:622, 1989
38. Breton-Gorius J, Reyes F: Ultrastructure of human bone marrow cell maturation. Int Rev Cytol 46:251, 1976
39. Moskwin-Taerkhanov MI, Onishenko GE: Centrioles in megakaryocytes of mouse bone marrow. Tsilogiia 20:1436, 1978
40. Gorbsky GJ, Ricketts WA: Differential expression of a phosphoepitope at the kinetochores of moving chromosomes. J Cell Biol 122:1311, 1993
41. Campbell MS, Gorbsky GJ: Microinjection of mitotic cells with the 3F3/2 anti-phosphoepitope antibody delays the onset of anaphase. J Cell Biol 129:1195, 1995
42. Nicklas BR, Ward SC, Gorbsky GJ: Kinetochore chemistry is sensitive to tension and may link mitotic forces to a cell cycle checkpoint. J Cell Biol 130:929, 1995
43. Karess RE, Chang X, Edwards KA, Kulkarni S, Aguilera I, Kiehart DP: The regulatory light chain of nonmuscle myosin is encoded by spaghetti-squash, a gene required for cytokinesis in Drosophilia. Cell 65:1177, 1991
44. Lehner CF: The pebble gene is required for cytokinesis in Drosophilia. J Cell Sci 103:1021, 1992
45. Neufeld TP, Rubin GM: The drosophilia peanut gene is required for cytokinesis and encodes a protein similar to yeast putative bud neck filament proteins. Cell 77:371, 1994
46. Nurse P: Ordering S phase and M phase in the cell cycle. Cell 79:547, 1994
47. Grafi G, Larkins BA: Endoreduplication in maize endosperm: Involvement of M phase-promoting factor inhibition and induction of S phase-related kinases. Science 269:1262, 1995
48. Ookata K, Hisanaga S-i, Bulinski JC, Murofushi H, Aizawa T, Itoh TJ, Hotani H, Okumura E, Tachibana K, Kishimoto T: Cyclin B interaction with microtubule-associated protein 4 (MAP4) targets p34cdc2 kinase to microtubules and is a potential regulator of M-phase microtubule dynamics. J Cell Biol 128:849, 1995
49. Carow CE, Fox NE, Kaushansky K: Purified endomitotic megakaryocytes display a functional cyclin B1-associated mitotic kinase. Blood 88:287a, 1996 (abstr, suppl 1)
50. Blangy A, Lane HA, d'Hérin P, Harper M, Kress M, Nigg EA: Phosphorylation by p34 cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo. Cell 83:1159, 1995
51. Bai C, Sen P, Hofman K, Ma L, Goebl M, Harper W, Elledge J: SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box. Cell 86:263, 1996
52. Connelly C, Hieter P: Budding yeast SKP1 encodes an evolutionary conserved kinetochore protein required for cell cycle progression. Cell 86:275, 1996
53. Irniger S, Piatti S, Michaelis C, Nasmyth K: Genes involved in sister chromatid separation are needed for B-type cyclin proteolysis. Cell 81:269, 1995
54. Li Y, Benezra R: Identification of a human mitotic checkpoint gene: hsMAD2. Science 274:246, 1996
55. Tugendreich S, Tomkiel J, Earnshaw W, Hieter P: CDC27Hs colocalizes with the CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition. Cell 81:261, 1995
56. Holloway SL, Glotzer M, King RW, Murray AW: Anaphase is initiated by proteolysis rather than by the inactivation of maturation-promoting factor. Cell 73:1393, 1993
57. Murray AW, Desai AB, Salmon ED: Real time observation of anaphase in vitro. Proc Natl Acad Sci USA 93:12327, 1996
58. Wheatley SP, Hinchcliffe EH, Glotzer M, Hyman AA, Sluder G, Wang Y-1: CDK1 inactivation regulates anaphase spindle dynamics and cytokinesis in vitro. J Cell Biol 138:385, 1997
59. wAF1/Cip1 by STAT5. Mol Cell Biol 17:2933, 1997
60. Nagata Y, Muro Y, Todokoro K: Thrombopoietin-induced polyploidization of bone marrow megakaryocytes is due to a unique regulatory mechanism in late mitosis. J Cell Biol 139:449, 1997