Blood platelets are assembled principally at the ends of proplatelet processes produced by differentiated megakaryocytes

Journal of Cell Biology

Volumn 147, Issue 6, 1999, Pages 1299-1312

  Italiano Jr , Joseph E ^a,b   Lecine, Patrick ^b,c   Shivdasani, Ramesh A ^b,c   Hartwig, John H ^a,b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

Actin cytoskeleton; Blood platelet; Megakaryocyte; Microtubules; Thrombopoiesis

Indexed keywords

ACTIN;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL STRUCTURE; CYTOSKELETON; ELECTRON MICROSCOPY; FETUS; MEGAKARYOCYTE; MICROTUBULE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PSEUDOPODIUM; THROMBOCYTE; THROMBOCYTOPOIESIS;

ACTINS; ANIMALS; BLOOD PLATELETS; CELL DIFFERENTIATION; CELL SIZE; CELLS, CULTURED; CYTOCHALASIN B; CYTOPLASM; HEMATOPOIETIC STEM CELLS; MEGAKARYOCYTES; MICE; MICROSCOPY, ELECTRON; MICROSCOPY, VIDEO; MICROTUBULES; MODELS, BIOLOGICAL; NOCODAZOLE; PSEUDOPODIA; TIME FACTORS;

ANIMALIA;

EID: 0033552631     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.147.6.1299     Document Type: Article

References (48)

1. An, E., K. Ogata, S. Kuriya, and T. Nomura. 1994. Interleukin-6 and erythropoietin act as direct potentiators and inducers of in vitro cytoplasmic process formation on purified mouse megakaryocytes. Exp. Hematol. 22:149-156.
2. Andrews, R.K., and J.B. Fox. 1991. Interaction of purified actin-binding protein with glycoprotein Ib-IX complex. J. Biol. Chem. 266:7144-7147.
3. Becker, R.P., and P.P. DeBruyn. 1976. The transmural passage of blood cells into myeloid sinusoids and the entry of platelets into the sinusoidal circulation: a scanning electron microscopic investigation. Am. J. Anat. 145:1046-1052.
4. Behnke, O. 1968. An electron microscope study of megakaryocytes of rat bone marrow. I. The development of the demarcation membrane system and the platelet surface coat. J. Ultrastruct. Res. 24:412-428.
5. Behnke, O. 1969. An electron microscope study of the rat megakaryocyte. II. Some aspects of platelet release and microtubules. J. Ultrastruct. Res. 26: 111-129.
6. Carlsson, L., F. Markey, I. Blikstad, T. Persson, and U. Lindberg. 1979. Reorganization of actin in platelets stimulated by thrombin as measured by the DNase I inhibition assay. Proc. Natl. Acad. Sci. USA. 76:6376-6380.
7. Choi, E.S., J.L. Nichol, M.M. Hokom, A.C. Hornkohl, and P. Hunt. 1995. Platelets generated in vitro from proplatelet-displaying human megakaryocytes are functional. Blood. 85:402-413.
8. Cramer, E., F. Norol, J. Guichard, J. Breton-Gorius, W. Vainchenker, J.M. Massé, and N. Debili. 1997. Ultrastructure of platelet formation by human megakaryocytes cultured with the Mpl ligand. Blood. 89:2336-2346.
9. Drachman, J., D. Sabath, N. Fox, and K. Kaushansky. 1997. Thrombopoietin signal transduction in purified murine megakaryocytes. Blood. 89:483-492.
10. Ebbe, S., and F. Stohlman. 1965. Megakaryocytopoiesis in the rat. Blood. 26: 20-34.
11. Falet, H., S. Pain, and F. Rendu. 1998. Tyrosine unphosphorylated platelet SHP-1 is a substrate for calpain. Biochem. Biophys. Res. Commun. 252:51-55.
12. Fox, J., and D.R. Phillips. 1981. Inhibition of actin polymerization in blood platelets by cytochalasins. Nature. 292:650-652.
13. Fox, J., J. Koyles, C. Reynolds, and J. Phillips. 1984. Actin filament content and organization in unstimulated platelets. J. Cell Biol. 98:1985-1991.
14. Fox, J., L. Aggerbeck, and M. Berndt. 1988. Structure of the glycoprotein Ib-IX complex from platelet membranes. J. Biol. Chem. 263:4882-4890.
15. Fox, J., S. Shattil, R. Kinlough-Rathbone, M. Richardson, M. Packham, and D. Sanan. 1996. The platelet cytoskeleton stabilizes the interaction between αIIbβ3 and its ligand and induces selective movement of ligand-occupied integrin. J. Biol. Chem. 271:7004-7011.
16. Haller, C., and J. Radley. 1983. Time-lapse cinemicrography and scanning electron microscopy of platelet formation by megakaryocytes. Blood Cells. 9:407-418.
17. Handagama, P., B. Feldman, N. Jain, T. Farver, and C. Kono. 1987. In vitro platelet release by rat megakaryocytes: effect of metabolic inhibitors and cyloskeletal disrupting agents. Am. J. Vet. Res. 48:1142-1146.
18. Harker, L.A., and C.A. Finch. 1969. Thrombokinetics in man. J. Clin. Invest. 48: 963-974.
19. Hartwig, J. 1992. Mechanism of actin rearrangements mediating platelet activation. J. Cell Biol. 118:1421-1442.
20. Hartwig, J., and M. DeSisto. 1991. The cytoskeleton of the resting human blood platelet: structure of the membrane skeleton and its attachment to actin filaments. J. Cell Biol. 112:407-425.
21. Haydon, G., and D. Taylor. 1965. Microtubules in hamster platelets. J. Cell Sci. 26:673-676.
22. Howard, T., and C. Oresajo. 1985. A method for quantifying F-actin in chemolactic peptide activated neutrophils: study of the effect of tBOC peptide. Cell Motil. 5:545-557.
23. Karlsson, R., I. Lassing, A.-S. Hoglund, and U. Lindberg. 1984. The organization of microfilaments in spreading platelets: a comparison with fibroblasts and glial cells. J. Cell Physiol. 121:96-113.
24. Kaufman, R.M., R. Airo, S. Pollack, and W.U. Crosby. 1965. Circulating megakaryocytes and platelet release in the lung. Blood. 26:720-728.
25. Kaushansky, K. 1995. Thrombopoietin: the primary regulator of platelet production. Blood. 85:419-131.
26. Kenney, D., and R. Linck. 1985. The cytoskeleton of unstimulated blood platelets: structure and composition of the isolated marginal microtubular band. J. Cell Sci. 78:1-22.
27. Kovacsovics, T.J., and J.H. Hartwig. 1996. Thrombin-induced GPIb-IX centralization on the platelet surface requires actin assembly and myosin II activation. Blood. 87:618-629.
28. Lecine, P., J. Villeval, P. Vyas, B. Swencki, Y. Xu, and R.A. Shivdasani. 1998. Mice lacking transcription factor NF-E2 provide in vivo validation of the proplatelet model of thrombocytopoiesis and show a platelet production defect that is intrinsic to megakaryocytes. Blood. 92:1608-1616.
29. Leven, R.M., and M.K. Yee. 1987. Megakaryocyte morphogenesis stimulated in vitro by whole or partially fractionated thrombocytopenic plasma: a model system for the study of platelet formation. Blood. 69:1046-1052.
30. Lichtman, M., J. Chamberlain, W. Simon, and P. Santillo. 1978. Parasinusoidal location of megakaryocytes in marrow: a determinant of platelet release. Am. J. Hematol. 4:303-312.
31. Nachmias, V.T., and K.-I. Yoshida. 1988. The cytoskeleton of the blood platelet: a dynamic structure. Adv. Cell Biol. 2:181-211.
32. Paulus, J. 1970. DNA metabolism and development of organelles in guinea-pig megakaryocytes: a combined ultrastructural, autoradiographic and cytophotometric study. Blood. 35:298-311.
33. Radley, J.M., and G. Scurfield. 1980. The mechanism of platelet release. Blood. 56:996-999.
34. Radley, J.M., and C.J. Haller. 1982. The demarcation membrane system of the megakaryocyte: a misnomer? Blood. 60:213-219.
35. Radley, J.M., and M. Hatshorn. 1987. Megakaryocyte fragments and the microtubule coil. Blood Cells. 12:603-608.
36. Radley, J.M., M. Hatshorn, and S. Green. 1987. The response of megakaryocytes with processes to thrombin. Thromb. Haemostasis. 58:732-736.
37. Radley, J.M., J. Rogerson, S. Ellis, and S. Hasthorpe. 1991. Megakaryocyte maturation in long-term marrow culture. Exp. Hematol. 19:1075-1078.
38. Scurfield, G., and J.M. Radley. 1981. Aspects of platelet formation and release. Am. J. Hematol. 10:285-296.
39. Stenberg, P.E., and J. Levin. 1989. Mechanisms of platelet production. Blood Cells. 15:23-31.
40. Tablin, F., M. Castro, and R.M. Leven. 1990. Blood platelet formation in vitro: the role of the cytoskeleton in megakaryocyte fragmentation. J. Cell Sci. 97: 59-70.
41. Topp, K., F. Tablin, and J. Levin. 1990. Culture of isolated bovine megakaryocytes on reconstituted basement membrane matrix leads to proplatelet process formation. Blood. 76:912-924.
42. Trowbridge, E.A., J.F. Martin, D.N. Slater, Y.T. Kishk, C.W. Warren, P.J. Harley, and W. Woodcock. 1984. The origin of platelet count and volume. Clin. Phys. Physiol. Meas. 5:145-156.
43. White, J. 1968. Effects of colchicine and vinca alkaloids on human platelets. Am. J. Pathol. 53:281-291.
44. White, J., and W. Krivit. 1967. An ultrastructural basis for the shape changes induced in platelets by chilling. Blood. 30:625-635.
45. Yamada, F. 1957. The fine structure of the megakaryocyte in the mouse spleen. Acta Anat. 29:267-290.
46. Zucker-Franklin, D. 1970. The ultrastructure of megakaryocytes and platelets. In Regulation of Hematopoiesis. Vol. 55. A. Gordon, editor. Appleton-Century-Crofts, New York. 1553-1586.
47. Zucker-Franklin, D. 1997. Platelet structure and function. In Thrombopoiesis and Thrombopoietins. D. Kuter, P. Hunt, W. Sheridan, and D. Zucker-Franklin, editors. Humana Press, Totowa, NJ. 41-62.
48. Zucker-Franklin, D., and S. Petursson. 1984. Thrombocytopoiesis - analysis by membrane tracer and freeze-fracture studies on fresh human and cultured mouse megakaryocytes. J. Cell Biol. 99:390-402.