ADF/n-cofilin-dependent actin turnover determines platelet formation and sizing

Blood

Volumn 116, Issue 10, 2010, Pages 1767-1775

  Bender, Markus ^a,b   Eckly, Anita ^c   Hartwig, John H ^d   Elvers, Margitta ^a,b   Pleines, Irina ^a,b   Gupta, Shuchi ^a,b   Krohne, Georg ^e   Jeanclos, Elisabeth ^a,e   Gohla, Antje ^a,e   Gurniak, Christine ^f   Gachet, Christian ^c   Witke, Walter ^f   Nieswandt, Bernhard ^a,b  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

^c UNIVERSITÉ DE STRASBOURG   (France)

^d HARVARD UNIVERSITY   (United States)

^e UNIVERSITY OF WÜRZBURG   (Germany)

^f UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; ACTIN DEPOLYMERIZING FACTOR; COFILIN 1; DSTN PROTEIN, MOUSE; FIBRINOGEN; THROMBIN;

ACTIN FILAMENT; ANIMAL; CELL SHAPE; CELL SIZE; CELL SURVIVAL; CYTOLOGY; CYTOSKELETON; DRUG EFFECTS; GENETICS; KNOCKOUT MOUSE; MEGAKARYOCYTE; METABOLISM; MOUSE; PATHOLOGY; SCANNING ELECTRON MICROSCOPY; SPLENOMEGALY; THROMBOCYTE; THROMBOCYTE COUNT; TIME; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE; WESTERN BLOTTING;

ACTIN CYTOSKELETON; ACTINS; ANIMALS; BLOOD PLATELETS; BLOTTING, WESTERN; CELL SHAPE; CELL SIZE; CELL SURVIVAL; COFILIN 1; CYTOSKELETON; DESTRIN; FIBRINOGEN; MEGAKARYOCYTES; MICE; MICE, KNOCKOUT; MICROSCOPY, ELECTRON, SCANNING; MICROSCOPY, ELECTRON, TRANSMISSION; PLATELET COUNT; SPLENOMEGALY; THROMBIN; TIME FACTORS;

EID: 77956607977     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2010-03-274340     Document Type: Article

References (50)

1. Italiano JE Jr, Lecine P, Shivdasani RA, Hartwig JH. Blood platelets are assembled principally at the ends of proplatelet processes produced by differentiated megakaryocytes. J Cell Biol. 1999;147(6):1299-1312. (Pubitemid 30012814)
2. Hartwig JH, Italiano JE Jr. Cytoskeletal mechanisms for platelet production. Blood Cells Mol Dis. 2006;36(2):99-103.
3. Junt T, Schulze H, Chen Z, et al. Dynamic visualization of thrombopoiesis within bone marrow. Science. 2007;317(5845):1767-1770. (Pubitemid 47461844)
4. Schwertz H, Koster S, Kahr WH, et al. Anucleate platelets generate progeny. Blood. 2010;115(18):3801-3809.
5. Hartwig J, Italiano J Jr. The birth of the platelet. J Thromb Haemost. 2003;1(7):1580-1586.
6. Barkalow K, Witke W, Kwiatkowski DJ, Hartwig JH. Coordinated regulation of platelet actin filament barbed ends by gelsolin and capping protein. J Cell Biol. 1996;134(2):389-399. (Pubitemid 26250707)
7. Witke W, Sharpe AH, Hartwig JH, et al. Hemostatic, inflammatory, and fibroblast responses are blunted in mice lacking gelsolin. Cell. 1995;81(1):41-51.
8. Ghosh M, Song X, Mouneimne G, et al. Cofilin promotes actin polymerization and defines the direction of cell motility. Science. 2004;304(5671):743-746. (Pubitemid 38560882)
9. Pak CW, Flynn KC, Bamburg JR. Actin-binding proteins take the reins in growth cones. Nat Rev Neurosci. 2008;9(2):136-147.
10. Stossel TP, Fenteany G, Hartwig JH. Cell surface actin remodeling. J Cell Sci. 2006;119(16):3261-3264.
11. Bamburg JR. Proteins of the ADF/cofilin family: essential regulators of actin dynamics. Annu Rev Cell Dev Biol. 1999;15:185-230.
12. Vartiainen MK, Mustonen T, Mattila PK, et al. The three mouse actin-depolymerizing factor/cofilins evolved to fulfill cell-type-specific requirements for actin dynamics. Mol Biol Cell. 2002;13(1):183-194. (Pubitemid 34106068)
13. Gurniak CB, Perlas E, Witke W. The actin depolymerizing factor n-cofilin is essential for neural tube morphogenesis and neural crest cell migration. Dev Biol. 2005;278(1):231-241. (Pubitemid 40092863)
14. Abe H, Obinata T, Minamide LS, Bamburg JR. Xenopus laevis actin-depolymerizing factor/cofilin: a phosphorylation-regulated protein essential for development. J Cell Biol. 1996;132(5):871-885. (Pubitemid 26085502)
15. Carlier MF, Laurent V, Santolini J, et al. Actin depolymerizing factor (ADF/cofilin) enhances the rate of filament turnover: implication in actin-based motility. J Cell Biol. 1997;136(6):1307-1322. (Pubitemid 27421917)
16. Maciver SK. How ADF/cofilin depolymerizes actin filaments. Curr Opin Cell Biol. 1998;10(1):140-144.
17. Andrianantoandro E, Pollard TD. Mechanism of actin filament turnover by severing and nucleation at different concentrations of ADF/cofilin. Mol Cell. 2006;24(1):13-23. (Pubitemid 44466682)
18. McGough A, Pope B, Chiu W, Weeds A. Cofilin changes the twist of F-actin: implications for actin filament dynamics and cellular function. J Cell Biol. 1997;138(4):771-781. (Pubitemid 27365041)
19. Maciver SK, Zot HG, Pollard TD. Characterization of actin filament severing by actophorin from Acanthamoeba castellanii. J Cell Biol. 1991;115(6):1611-1620.
20. Gunsalus KC, Bonaccorsi S, Williams E, et al. Mutations in twinstar, a Drosophila gene encoding a cofilin/ADF homologue, result in defects in centrosome migration and cytokinesis. J Cell Biol. 1995;131(5):1243-1259.
21. Iida K, Moriyama K, Matsumoto S, et al. Isolation of a yeast essential gene, COF1, that encodes a homologue of mammalian cofilin, a low-M (r) actin-binding and depolymerizing protein. Gene. 1993;124(1):115-120. (Pubitemid 23065976)
22. Moon AL, Janmey PA, Louie KA, Drubin DG. Cofilin is an essential component of the yeast cortical cytoskeleton. J Cell Biol. 1993;120(2):421-435.
23. McKim KS, Matheson C, Marra MA, Wakarchuk MF, Baillie DL. The Caenorhabditis elegans unc-60 gene encodes proteins homologous to a family of actin-binding proteins. Mol Gen Genet. 1994;242(3):346-357. (Pubitemid 24061216)
24. Ono S, Benian GM. Two Caenorhabditis elegans actin depolymerizing factor/cofilin proteins, encoded by the unc-60 gene, differentially regulate actin filament dynamics. J Biol Chem. 1998;273(6):3778-3783. (Pubitemid 28109808)
25. Bellenchi GC, Gurniak CB, Perlas E, et al. N-cofilin is associated with neuronal migration disorders and cell cycle control in the cerebral cortex. Genes Dev. 2007;21(18):2347-2357. (Pubitemid 47443340)
26. Ikeda S, Cunningham LA, Boggess D, et al. Aberrant actin cytoskeleton leads to accelerated proliferation of corneal epithelial cells in mice deficient for destrin (actin depolymerizing factor). Hum Mol Genet. 2003;12(9):1029-1037.
27. Tiedt R, Schomber T, Hao-Shen H, Skoda RC. Pf4-Cre transgenic mice allow the generation of lineage-restricted gene knockouts for studying megakaryocyte and platelet function in vivo. Blood. 2007;109(4):1503-1506. (Pubitemid 46239582)
28. Nieswandt B, Bergmeier W, Rackebrandt K, Gessner JE, Zirngibl H. Identification of critical antigen-specific mechanisms in the development of immune thrombocytopenic purpura in mice. Blood. 2000;96(7):2520-2527.
29. Strassel C, Eckly A, Leon C, et al. Intrinsic impaired proplatelet formation and microtubule coil assembly of megakaryocytes in a mouse model of Bernard-Soulier syndrome. Haematologica. 2009;94(6):800-810.
30. Illes I, Pfueller SL, Hussein S, Chesterman CN, Martin JF. Platelets in idiopathic thrombocytopenic purpura are increased in size but are of normal density. Br J Haematol. 1987;67(2):173-176. (Pubitemid 18029649)
31. Nurden AT, Nurden P. Inherited thrombocytopenias. Haematologica. 2007;92(9):1158-1164.
32. Grosse J, Braun A, Varga-Szabo D, et al. An EF hand mutation in Stim1 causes premature platelet activation and bleeding in mice. J Clin Invest. 2007;117(11):3540-3550. (Pubitemid 350097009)
33. Falet H, Chang G, Brohard-Bohn B, Rendu F, Hartwig JH. Integrin alpha(IIb)beta3 signals lead cofilin to accelerate platelet actin dynamics. Am J Physiol Cell Physiol. 2005;289(4):C819-C825.
34. Van TM, Huyck L, Leyman S, et al. Ins and outs of ADF/cofilin activity and regulation. Eur J Cell Biol. 2008;87(8):649-667.
35. Shivdasani RA, Schulze H. Culture, expansion, and differentiation of murine megakaryocytes. Curr Protoc Immunol. 2005;Chapter 22:Unit 22F6.
36. Patel SR, Hartwig JH, Italiano JE Jr. The biogenesis of platelets from megakaryocyte proplatelets. J Clin Invest. 2005;115(12):3348-3354.
37. Schwer HD, Lecine P, Tiwari S, et al. A lineage-restricted and divergent beta-tubulin isoform is essential for the biogenesis, structure and function of blood platelets. Curr Biol. 2001;11(8):579-586. (Pubitemid 32324760)
38. Shivdasani RA, Fujiwara Y, McDevitt MA, Orkin SH. A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development. EMBO J. 1997;16(13):3965-3973. (Pubitemid 27281012)
39. Goerge T, Ho-Tin-Noe B, Carbo C, et al. Inflammation induces hemorrhage in thrombocytopenia. Blood. 2008;111(10):4958-4964.
40. Rodgers RP, Levin J. A critical reappraisal of the bleeding time. Semin Thromb Hemost. 1990;16(1):1-20.
41. Patel SR, Richardson JL, Schulze H, et al. Differential roles of microtubule assembly and sliding in proplatelet formation by megakaryocytes. Blood. 2005;106(13):4076-4085. (Pubitemid 41775912)
42. Levin J, Levin FC, Penington DG, Metcalf D. Measurement of ploidy distribution in megakaryocyte colonies obtained from culture: with studies of the effects of thrombocytopenia. Blood. 1981;57(2):287-297. (Pubitemid 11174890)
43. Kile BT, Panopoulos AD, Stirzaker RA, et al. Mutations in the cofilin partner Aip1/Wdr1 cause autoinflammatory disease and macrothrombocytopenia. Blood. 2007;110(7):2371-2380.
44. Schulze H, Korpal M, Hurov J, et al. Characterization of the megakaryocyte demarcation membrane system and its role in thrombopoiesis. Blood. 2006;107(10):3868-3875. (Pubitemid 43726790)
45. Yamada E. The fine structure of the megakaryocyte in the mouse spleen. Acta Anat (Basel). 1957;29(3):267-290.
46. Becker RP, De Bruyn PP. The transmural passage of blood cells into myeloid sinusoids and the entry of platelets into the sinusoidal circulation; a scanning electron microscopic investigation. Am J Anat. 1976;145(2):183-205.
47. Behnke O, Forer A. From megakaryocytes to platelets: platelet morphogenesis takes place in the bloodstream. Eur J Haematol Suppl. 1998;613-623.
48. Amano T, Kaji N, Ohashi K, Mizuno K. Mitosis-specific activation of LIM motif-containing protein kinase and roles of cofilin phosphorylation and dephosphorylation in mitosis. J Biol Chem. 2002;277(24):22093-22102. (Pubitemid 34952364)
49. Gohla A, Birkenfeld J, Bokoch GM. Chronophin, a novel HAD-type serine protein phosphatase, regulates cofilin-dependent actin dynamics. Nat Cell Biol. 2005;7(1):21-29. (Pubitemid 40123379)
50. Kaji N, Ohashi K, Shuin M, et al. Cell cycle-associated changes in Slingshot phosphatase activity and roles in cytokinesis in animal cells. J Biol Chem. 2003;278(35):33450-33455. (Pubitemid 37055799)