메뉴 건너뛰기




Volumn , Issue , 2011, Pages 457-472

Premalignant Hepatocellular Lesions

Author keywords

[No Author keywords available]

Indexed keywords


EID: 84882464632     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-443-06803-4.00033-2     Document Type: Chapter
Times cited : (2)

References (81)
  • 1
    • 21344450714 scopus 로고    scopus 로고
    • Characterization of small nodules in cirrhosis by assessment of vascularity: the problem of hypovascular hepatocellular carcinoma
    • Bolondi L., Gaiani S., Celli N., et al. Characterization of small nodules in cirrhosis by assessment of vascularity: the problem of hypovascular hepatocellular carcinoma. Hepatology 2005, 42:27-34.
    • (2005) Hepatology , vol.42 , pp. 27-34
    • Bolondi, L.1    Gaiani, S.2    Celli, N.3
  • 2
    • 1842426695 scopus 로고    scopus 로고
    • Increased survival of cirrhotic patients with a hepatocellular carcinoma detected during surveillance
    • Sangiovanni A., Del Ninno E., Fasani P., et al. Increased survival of cirrhotic patients with a hepatocellular carcinoma detected during surveillance. Gastroenterology 2004, 126:1005-1014.
    • (2004) Gastroenterology , vol.126 , pp. 1005-1014
    • Sangiovanni, A.1    Del Ninno, E.2    Fasani, P.3
  • 3
    • 28844480321 scopus 로고    scopus 로고
    • Management of hepatocellular carcinoma
    • Bruix J., Sherman M. Management of hepatocellular carcinoma. Hepatology 2005, 42:1208-1236.
    • (2005) Hepatology , vol.42 , pp. 1208-1236
    • Bruix, J.1    Sherman, M.2
  • 4
    • 0042093775 scopus 로고    scopus 로고
    • Impact of large regenerative, low grade and high grade dysplastic nodules in hepatocellular carcinoma development
    • Borzio M., Fargion S., Borzio F., et al. Impact of large regenerative, low grade and high grade dysplastic nodules in hepatocellular carcinoma development. J Hepatol 2003, 39:208-214.
    • (2003) J Hepatol , vol.39 , pp. 208-214
    • Borzio, M.1    Fargion, S.2    Borzio, F.3
  • 5
    • 4344573456 scopus 로고    scopus 로고
    • Ultrasound-guided fine needle biopsy of early hepatocellular carcinoma complicating liver cirrhosis: a multicentre study
    • Caturelli E., Solmi L., Anti M., et al. Ultrasound-guided fine needle biopsy of early hepatocellular carcinoma complicating liver cirrhosis: a multicentre study. Gut 2004, 53:1356-1362.
    • (2004) Gut , vol.53 , pp. 1356-1362
    • Caturelli, E.1    Solmi, L.2    Anti, M.3
  • 6
    • 38649114052 scopus 로고    scopus 로고
    • Diagnosis of hepatic nodules 20 mm or smaller in cirrhosis: prospective validation of the noninvasive diagnostic criteria for hepatocellular carcinoma
    • Forner A., Vilana R., Ayuso C., et al. Diagnosis of hepatic nodules 20 mm or smaller in cirrhosis: prospective validation of the noninvasive diagnostic criteria for hepatocellular carcinoma. Hepatology 2008, 47:97-104.
    • (2008) Hepatology , vol.47 , pp. 97-104
    • Forner, A.1    Vilana, R.2    Ayuso, C.3
  • 7
    • 11944266041 scopus 로고
    • Histological features and clinical course of large regenerative nodules: evaluation of their precancerous potentiality
    • Kondo F., Ebara M., Sugiura N., et al. Histological features and clinical course of large regenerative nodules: evaluation of their precancerous potentiality. Hepatology 1990, 12:592-598.
    • (1990) Hepatology , vol.12 , pp. 592-598
    • Kondo, F.1    Ebara, M.2    Sugiura, N.3
  • 8
    • 0036788274 scopus 로고    scopus 로고
    • Progression to hypervascular hepatocellular carcinoma: correlation with intranodular blood supply evaluated with CT during intraarterial injection of contrast material
    • Hayashi M., Matsui O., Ueda K., et al. Progression to hypervascular hepatocellular carcinoma: correlation with intranodular blood supply evaluated with CT during intraarterial injection of contrast material. Radiology 2002, 225:143-149.
    • (2002) Radiology , vol.225 , pp. 143-149
    • Hayashi, M.1    Matsui, O.2    Ueda, K.3
  • 9
    • 0034856294 scopus 로고    scopus 로고
    • Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona-2000 EASL conference. European Association for the Study of the Liver
    • Bruix J., Sherman M., Llovet J.M., et al. Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona-2000 EASL conference. European Association for the Study of the Liver. J Hepatol 2001, 35:421-430.
    • (2001) J Hepatol , vol.35 , pp. 421-430
    • Bruix, J.1    Sherman, M.2    Llovet, J.M.3
  • 10
    • 0029155354 scopus 로고
    • Terminology of nodular hepatocellular lesions
    • International Working Party
    • International Working Party Terminology of nodular hepatocellular lesions. Hepatology 1995, 22:983-993.
    • (1995) Hepatology , vol.22 , pp. 983-993
  • 11
    • 0030663989 scopus 로고    scopus 로고
    • Large cell change (liver cell dysplasia) and hepatocellular carcinoma in cirrhosis: matched case-control study, pathological analysis, and pathogenetic hypothesis
    • Lee R.G., Tsamandas A.C., Demetris A.J. Large cell change (liver cell dysplasia) and hepatocellular carcinoma in cirrhosis: matched case-control study, pathological analysis, and pathogenetic hypothesis. Hepatology 1997, 26:1415-1422.
    • (1997) Hepatology , vol.26 , pp. 1415-1422
    • Lee, R.G.1    Tsamandas, A.C.2    Demetris, A.J.3
  • 12
    • 34247400156 scopus 로고    scopus 로고
    • Telomere shortening and inactivation of cell cycle checkpoints characterize human hepatocarcinogenesis
    • Plentz R.R., Park Y.N., Lechel A., et al. Telomere shortening and inactivation of cell cycle checkpoints characterize human hepatocarcinogenesis. Hepatology 2007, 45:968-976.
    • (2007) Hepatology , vol.45 , pp. 968-976
    • Plentz, R.R.1    Park, Y.N.2    Lechel, A.3
  • 13
    • 70349249505 scopus 로고    scopus 로고
    • Large liver cell changes in hepatitis B virus-related liver cirrhosis
    • Kim H., Oh B.K., Roncalli M., et al. Large liver cell changes in hepatitis B virus-related liver cirrhosis. Hepatology 2009, 50:752-762.
    • (2009) Hepatology , vol.50 , pp. 752-762
    • Kim, H.1    Oh, B.K.2    Roncalli, M.3
  • 14
    • 0033933955 scopus 로고    scopus 로고
    • The immunohistochemical phenotype of dysplastic foci in human liver: correlation with putative progenitor cells
    • Libbrecht L., Desmet V., Van Damme B., et al. The immunohistochemical phenotype of dysplastic foci in human liver: correlation with putative progenitor cells. J Hepatol 2000, 33:76-84.
    • (2000) J Hepatol , vol.33 , pp. 76-84
    • Libbrecht, L.1    Desmet, V.2    Van Damme, B.3
  • 15
    • 0033812451 scopus 로고    scopus 로고
    • Outcomes of dysplastic nodules in human cirrhotic liver: a clinicopathological study
    • Seki S., Sakaguchi H., Kitada T., et al. Outcomes of dysplastic nodules in human cirrhotic liver: a clinicopathological study. Clin Cancer Res 2000, 6:3469-3473.
    • (2000) Clin Cancer Res , vol.6 , pp. 3469-3473
    • Seki, S.1    Sakaguchi, H.2    Kitada, T.3
  • 16
    • 20344399151 scopus 로고    scopus 로고
    • Early hepatocellular carcinoma and dysplastic nodules
    • Kojiro M., Roskams T. Early hepatocellular carcinoma and dysplastic nodules. Semin Liver Dis 2005, 25:133-142.
    • (2005) Semin Liver Dis , vol.25 , pp. 133-142
    • Kojiro, M.1    Roskams, T.2
  • 17
    • 0028958050 scopus 로고
    • Liver cell dysplasia is a major risk factor for hepatocellular carcinoma in cirrhosis: a prospective study
    • Borzio M., Bruno S., Roncalli M., et al. Liver cell dysplasia is a major risk factor for hepatocellular carcinoma in cirrhosis: a prospective study. Gastroenterology 1995, 108:812-817.
    • (1995) Gastroenterology , vol.108 , pp. 812-817
    • Borzio, M.1    Bruno, S.2    Roncalli, M.3
  • 18
    • 15844411099 scopus 로고    scopus 로고
    • Predictive score for the development of hepatocellular carcinoma and additional value of liver large cell dysplasia in Western patients with cirrhosis
    • Ganne-Carrie N., Chastang C., Chapel F., et al. Predictive score for the development of hepatocellular carcinoma and additional value of liver large cell dysplasia in Western patients with cirrhosis. Hepatology 1996, 23:1112-1118.
    • (1996) Hepatology , vol.23 , pp. 1112-1118
    • Ganne-Carrie, N.1    Chastang, C.2    Chapel, F.3
  • 19
    • 54749121355 scopus 로고    scopus 로고
    • Predictive value of liver cell dysplasia for development of hepatocellular carcinoma in patients with chronic hepatitis B
    • Koo J.S., Kim H., Park B.K., et al. Predictive value of liver cell dysplasia for development of hepatocellular carcinoma in patients with chronic hepatitis B. J Clin Gastroenterol 2008, 42:738-743.
    • (2008) J Clin Gastroenterol , vol.42 , pp. 738-743
    • Koo, J.S.1    Kim, H.2    Park, B.K.3
  • 20
    • 33749067406 scopus 로고    scopus 로고
    • Large liver cell dysplasia: a controversial entity
    • Park Y.N., Roncalli M. Large liver cell dysplasia: a controversial entity. J Hepatol 2006, 45:734-743.
    • (2006) J Hepatol , vol.45 , pp. 734-743
    • Park, Y.N.1    Roncalli, M.2
  • 21
    • 61949171989 scopus 로고    scopus 로고
    • Pathologic diagnosis of early hepatocellular carcinoma: a report of the International Consensus Group for Hepatocellular Neoplasia
    • ICGHN
    • ICGHN Pathologic diagnosis of early hepatocellular carcinoma: a report of the International Consensus Group for Hepatocellular Neoplasia. Hepatology 2008, 49:658-664.
    • (2008) Hepatology , vol.49 , pp. 658-664
  • 22
    • 0035986529 scopus 로고    scopus 로고
    • Dysplastic nodules and hepatocarcinogenesis
    • Theise N.D., Park Y.N., Kojiro M. Dysplastic nodules and hepatocarcinogenesis. Clin Liver Dis 2002, 6:497-512.
    • (2002) Clin Liver Dis , vol.6 , pp. 497-512
    • Theise, N.D.1    Park, Y.N.2    Kojiro, M.3
  • 23
    • 1942487260 scopus 로고    scopus 로고
    • Morphological changes of early human hepatocarcinogenesis
    • Hytiroglou P. Morphological changes of early human hepatocarcinogenesis. Semin Liver Dis 2004, 24:65-75.
    • (2004) Semin Liver Dis , vol.24 , pp. 65-75
    • Hytiroglou, P.1
  • 24
    • 14544292426 scopus 로고    scopus 로고
    • Preneoplastic lesions in human hepatocarcinogenesis
    • Libbrecht L., Desmet V., Roskams T. Preneoplastic lesions in human hepatocarcinogenesis. Liver Int 2005, 25:16-27.
    • (2005) Liver Int , vol.25 , pp. 16-27
    • Libbrecht, L.1    Desmet, V.2    Roskams, T.3
  • 25
    • 35748945421 scopus 로고    scopus 로고
    • Hepatic precancerous lesions and small hepatocellular carcinoma
    • vii
    • Hytiroglou P., Park Y.N., Krinsky G., et al. Hepatic precancerous lesions and small hepatocellular carcinoma. Gastroenterol Clin North Am 2007, 36:867-887. vii.
    • (2007) Gastroenterol Clin North Am , vol.36 , pp. 867-887
    • Hytiroglou, P.1    Park, Y.N.2    Krinsky, G.3
  • 26
    • 0027198036 scopus 로고
    • A clinicopathologic study of adenomatous hyperplasia of the liver in 209 consecutive cirrhotic livers examined by autopsy
    • Terada T., Terasaki S., Nakanuma Y. A clinicopathologic study of adenomatous hyperplasia of the liver in 209 consecutive cirrhotic livers examined by autopsy. Cancer 1993, 72:1551-1556.
    • (1993) Cancer , vol.72 , pp. 1551-1556
    • Terada, T.1    Terasaki, S.2    Nakanuma, Y.3
  • 27
    • 0023869660 scopus 로고
    • Macroregenerative nodule of the liver. A clinicopathologic study of 345 autopsy cases of chronic liver disease
    • Furuya K., Nakamura M., Yamamoto Y., et al. Macroregenerative nodule of the liver. A clinicopathologic study of 345 autopsy cases of chronic liver disease. Cancer 1988, 61:99-105.
    • (1988) Cancer , vol.61 , pp. 99-105
    • Furuya, K.1    Nakamura, M.2    Yamamoto, Y.3
  • 28
    • 0026027904 scopus 로고
    • Early stages of multistep hepatocarcinogenesis: adenomatous hyperplasia and early hepatocellular carcinoma
    • Sakamoto M., Hirohashi S., Shimosato Y. Early stages of multistep hepatocarcinogenesis: adenomatous hyperplasia and early hepatocellular carcinoma. Hum Pathol 1991, 22:172-178.
    • (1991) Hum Pathol , vol.22 , pp. 172-178
    • Sakamoto, M.1    Hirohashi, S.2    Shimosato, Y.3
  • 29
    • 0026697979 scopus 로고
    • Macroregenerative nodules and hepatocellular carcinoma in forty-four sequential adult liver explants with cirrhosis
    • Theise N.D., Schwartz M., Miller C., et al. Macroregenerative nodules and hepatocellular carcinoma in forty-four sequential adult liver explants with cirrhosis. Hepatology 1992, 16:949-955.
    • (1992) Hepatology , vol.16 , pp. 949-955
    • Theise, N.D.1    Schwartz, M.2    Miller, C.3
  • 30
    • 0026452895 scopus 로고
    • Incidence and diagnostic features of macroregenerative nodules vs. small hepatocellular carcinoma in cirrhotic livers
    • Ferrell L., Wright T., Lake J., et al. Incidence and diagnostic features of macroregenerative nodules vs. small hepatocellular carcinoma in cirrhotic livers. Hepatology 1992, 16:1372-1381.
    • (1992) Hepatology , vol.16 , pp. 1372-1381
    • Ferrell, L.1    Wright, T.2    Lake, J.3
  • 31
    • 0025155659 scopus 로고
    • Malignant transformation of adenomatous hyperplasia to hepatocellular carcinoma
    • Takayama T., Makuuchi M., Hirohashi S., et al. Malignant transformation of adenomatous hyperplasia to hepatocellular carcinoma. Lancet 1990, 336:1150-1153.
    • (1990) Lancet , vol.336 , pp. 1150-1153
    • Takayama, T.1    Makuuchi, M.2    Hirohashi, S.3
  • 32
    • 0022474895 scopus 로고
    • Emergence of malignant lesions within an adenomatous hyperplastic nodule in a cirrhotic liver. Observations in five cases
    • Arakawa M., Kage M., Sugihara S., et al. Emergence of malignant lesions within an adenomatous hyperplastic nodule in a cirrhotic liver. Observations in five cases. Gastroenterology 1986, 91:198-208.
    • (1986) Gastroenterology , vol.91 , pp. 198-208
    • Arakawa, M.1    Kage, M.2    Sugihara, S.3
  • 33
    • 0032712149 scopus 로고    scopus 로고
    • The vascular profile of regenerative and dysplastic nodules of the cirrhotic liver: implications for diagnosis and classification
    • Roncalli M., Roz E., Coggi G., et al. The vascular profile of regenerative and dysplastic nodules of the cirrhotic liver: implications for diagnosis and classification. Hepatology 1999, 30:1174-1178.
    • (1999) Hepatology , vol.30 , pp. 1174-1178
    • Roncalli, M.1    Roz, E.2    Coggi, G.3
  • 34
    • 0031778206 scopus 로고    scopus 로고
    • Clinical significance of microvessel density and vascular endothelial growth factor expression in hepatocellular carcinoma and surrounding liver: possible involvement of vascular endothelial growth factor in the angiogenesis of cirrhotic liver
    • El-Assal O.N., Yamanoi A., Soda Y., et al. Clinical significance of microvessel density and vascular endothelial growth factor expression in hepatocellular carcinoma and surrounding liver: possible involvement of vascular endothelial growth factor in the angiogenesis of cirrhotic liver. Hepatology 1998, 27:1554-1562.
    • (1998) Hepatology , vol.27 , pp. 1554-1562
    • El-Assal, O.N.1    Yamanoi, A.2    Soda, Y.3
  • 35
    • 0004623809 scopus 로고    scopus 로고
    • Increased expression of vascular endothelial growth factor and angiogenesis in the early stage of multistep hepatocarcinogenesis
    • Park Y.N., Kim Y.B., Yang K.M., et al. Increased expression of vascular endothelial growth factor and angiogenesis in the early stage of multistep hepatocarcinogenesis. Arch Pathol Lab Med 2000, 124:1061-1065.
    • (2000) Arch Pathol Lab Med , vol.124 , pp. 1061-1065
    • Park, Y.N.1    Kim, Y.B.2    Yang, K.M.3
  • 36
    • 0031866348 scopus 로고    scopus 로고
    • Neoangiogenesis and sinusoidal "capillarization" in dysplastic nodules of the liver
    • Park Y.N., Yang C.P., Fernandez G.J., et al. Neoangiogenesis and sinusoidal "capillarization" in dysplastic nodules of the liver. Am J Surg Pathol 1998, 22:656-662.
    • (1998) Am J Surg Pathol , vol.22 , pp. 656-662
    • Park, Y.N.1    Yang, C.P.2    Fernandez, G.J.3
  • 37
    • 0028792192 scopus 로고
    • Arterial elements and perisinusoidal cells in borderline hepatocellular nodules and small hepatocellular carcinomas
    • Terada T., Nakanuma Y. Arterial elements and perisinusoidal cells in borderline hepatocellular nodules and small hepatocellular carcinomas. Histopathology 1995, 27:333-339.
    • (1995) Histopathology , vol.27 , pp. 333-339
    • Terada, T.1    Nakanuma, Y.2
  • 38
    • 0033754784 scopus 로고    scopus 로고
    • Molecular changes in hepatocellular dysplastic nodules on microdissected liver biopsies
    • Maggioni M., Coggi G., Cassani B., et al. Molecular changes in hepatocellular dysplastic nodules on microdissected liver biopsies. Hepatology 2000, 32:942-946.
    • (2000) Hepatology , vol.32 , pp. 942-946
    • Maggioni, M.1    Coggi, G.2    Cassani, B.3
  • 39
    • 0034991865 scopus 로고    scopus 로고
    • An early lesion in hepatic carcinogenesis: loss of heterozygosity in human cirrhotic livers and dysplastic nodules at the 1p36-p34 region
    • Sun M., Eshleman J.R., Ferrell L.D., et al. An early lesion in hepatic carcinogenesis: loss of heterozygosity in human cirrhotic livers and dysplastic nodules at the 1p36-p34 region. Hepatology 2001, 33:1415-1424.
    • (2001) Hepatology , vol.33 , pp. 1415-1424
    • Sun, M.1    Eshleman, J.R.2    Ferrell, L.D.3
  • 40
    • 0036091657 scopus 로고    scopus 로고
    • Chromosomal alterations in hepatocellular nodules by comparative genomic hybridization: high-grade dysplastic nodules represent early stages of hepatocellular carcinoma
    • Tornillo L., Carafa V., Sauter G., et al. Chromosomal alterations in hepatocellular nodules by comparative genomic hybridization: high-grade dysplastic nodules represent early stages of hepatocellular carcinoma. Lab Invest 2002, 82:547-553.
    • (2002) Lab Invest , vol.82 , pp. 547-553
    • Tornillo, L.1    Carafa, V.2    Sauter, G.3
  • 41
    • 38849119717 scopus 로고    scopus 로고
    • Molecular pathogenesis of hepatocellular carcinoma
    • Wong C.M., Ng I.O. Molecular pathogenesis of hepatocellular carcinoma. Liver Int 2008, 28:160-174.
    • (2008) Liver Int , vol.28 , pp. 160-174
    • Wong, C.M.1    Ng, I.O.2
  • 42
    • 0033765496 scopus 로고    scopus 로고
    • Genetic instability and aberrant DNA methylation in chronic hepatitis and cirrhosis-a comprehensive study of loss of heterozygosity and microsatellite instability at 39 loci and DNA hypermethylation on 8 CpG islands in microdissected specimens from patients with hepatocellular carcinoma
    • Kondo Y., Kanai Y., Sakamoto M., et al. Genetic instability and aberrant DNA methylation in chronic hepatitis and cirrhosis-a comprehensive study of loss of heterozygosity and microsatellite instability at 39 loci and DNA hypermethylation on 8 CpG islands in microdissected specimens from patients with hepatocellular carcinoma. Hepatology 2000, 32:970-979.
    • (2000) Hepatology , vol.32 , pp. 970-979
    • Kondo, Y.1    Kanai, Y.2    Sakamoto, M.3
  • 43
    • 31544459554 scopus 로고    scopus 로고
    • Dysplastic nodules frequently develop into hepatocellular carcinoma in patients with chronic viral hepatitis and cirrhosis
    • Kobayashi M., Ikeda K., Hosaka T., et al. Dysplastic nodules frequently develop into hepatocellular carcinoma in patients with chronic viral hepatitis and cirrhosis. Cancer 2006, 106:636-647.
    • (2006) Cancer , vol.106 , pp. 636-647
    • Kobayashi, M.1    Ikeda, K.2    Hosaka, T.3
  • 44
    • 0031732647 scopus 로고    scopus 로고
    • Histological features predicting malignant transformation of nonmalignant hepatocellular nodules: a prospective study
    • Terasaki S., Kaneko S., Kobayashi K., et al. Histological features predicting malignant transformation of nonmalignant hepatocellular nodules: a prospective study. Gastroenterology 1998, 115:1216-1222.
    • (1998) Gastroenterology , vol.115 , pp. 1216-1222
    • Terasaki, S.1    Kaneko, S.2    Kobayashi, K.3
  • 45
    • 1242329819 scopus 로고    scopus 로고
    • Focus on dysplastic nodules and early hepatocellular carcinoma: an Eastern point of view
    • Kojiro M. Focus on dysplastic nodules and early hepatocellular carcinoma: an Eastern point of view. Liver Transpl 2004, 10:S3-S8.
    • (2004) Liver Transpl , vol.10
    • Kojiro, M.1
  • 46
    • 41249092035 scopus 로고    scopus 로고
    • Diagnostic discrepancy of early hepatocellular carcinoma between Japan and West
    • Kojiro M. Diagnostic discrepancy of early hepatocellular carcinoma between Japan and West. Hepatol Res 2007, 37(suppl 2):S121-S124.
    • (2007) Hepatol Res , vol.37 , Issue.SUPPL. 2
    • Kojiro, M.1
  • 47
    • 1242329815 scopus 로고    scopus 로고
    • Hepatocellular nodules in cirrhosis: focus on diagnostic criteria on liver biopsy. A Western experience
    • Roncalli M. Hepatocellular nodules in cirrhosis: focus on diagnostic criteria on liver biopsy. A Western experience. Liver Transpl 2004, 10:S9-S15.
    • (2004) Liver Transpl , vol.10
    • Roncalli, M.1
  • 48
    • 61749083279 scopus 로고    scopus 로고
    • Hepatocellular dysplastic nodules
    • Roncalli M., Borzio M., Di Tommaso L. Hepatocellular dysplastic nodules. Hepatol Res 2007, 37(suppl 2):S125-S134.
    • (2007) Hepatol Res , vol.37 , Issue.SUPPL. 2
    • Roncalli, M.1    Borzio, M.2    Di Tommaso, L.3
  • 49
    • 84983725887 scopus 로고    scopus 로고
    • Chromosomal allelic imbalance evolving from liver cirrhosis to hepatocellular carcinoma
    • Yeh S.H., Chen P.J., Shau W.Y., et al. Chromosomal allelic imbalance evolving from liver cirrhosis to hepatocellular carcinoma. Gastroenterology 2001, 121:699-709.
    • (2001) Gastroenterology , vol.121 , pp. 699-709
    • Yeh, S.H.1    Chen, P.J.2    Shau, W.Y.3
  • 50
    • 0031681247 scopus 로고    scopus 로고
    • Clonal analysis of macronodules in cirrhosis
    • Paradis V., Laurendeau I., Vidaud M., et al. Clonal analysis of macronodules in cirrhosis. Hepatology 1998, 28:953-958.
    • (1998) Hepatology , vol.28 , pp. 953-958
    • Paradis, V.1    Laurendeau, I.2    Vidaud, M.3
  • 51
    • 0034025348 scopus 로고    scopus 로고
    • Fractional allelic loss in non-end-stage cirrhosis: correlations with hepatocellular carcinoma development during follow-up
    • Roncalli M., Bianchi P., Grimaldi G.C., et al. Fractional allelic loss in non-end-stage cirrhosis: correlations with hepatocellular carcinoma development during follow-up. Hepatology 2000, 31:846-850.
    • (2000) Hepatology , vol.31 , pp. 846-850
    • Roncalli, M.1    Bianchi, P.2    Grimaldi, G.C.3
  • 53
    • 0029041691 scopus 로고
    • Overexpression of p53 in hepatocellular carcinomas: a clinicopathological and prognostic correlation
    • Ng I.O., Lai E.C., Chan A.S., et al. Overexpression of p53 in hepatocellular carcinomas: a clinicopathological and prognostic correlation. J Gastroenterol Hepatol 1995, 10:250-255.
    • (1995) J Gastroenterol Hepatol , vol.10 , pp. 250-255
    • Ng, I.O.1    Lai, E.C.2    Chan, A.S.3
  • 54
    • 34548044683 scopus 로고    scopus 로고
    • Loss of p53 and Ink4a/Arf cooperate in a cell autonomous fashion to induce metastasis of hepatocellular carcinoma cells
    • Chen Y.W., Klimstra D.S., Mongeau M.E., et al. Loss of p53 and Ink4a/Arf cooperate in a cell autonomous fashion to induce metastasis of hepatocellular carcinoma cells. Cancer Res 2007, 67:7589-7596.
    • (2007) Cancer Res , vol.67 , pp. 7589-7596
    • Chen, Y.W.1    Klimstra, D.S.2    Mongeau, M.E.3
  • 55
    • 0034495080 scopus 로고    scopus 로고
    • Beta-catenin mutations are associated with a subset of low-stage hepatocellular carcinoma negative for hepatitis B virus and with favorable prognosis
    • Hsu H.C., Jeng Y.M., Mao T.L., et al. Beta-catenin mutations are associated with a subset of low-stage hepatocellular carcinoma negative for hepatitis B virus and with favorable prognosis. Am J Pathol 2000, 157:763-770.
    • (2000) Am J Pathol , vol.157 , pp. 763-770
    • Hsu, H.C.1    Jeng, Y.M.2    Mao, T.L.3
  • 56
    • 0032761853 scopus 로고    scopus 로고
    • Beta-catenin mutations are frequent in human hepatocellular carcinomas associated with hepatitis C virus infection
    • Huang H., Fujii H., Sankila A., et al. Beta-catenin mutations are frequent in human hepatocellular carcinomas associated with hepatitis C virus infection. Am J Pathol 1999, 155:1795-1801.
    • (1999) Am J Pathol , vol.155 , pp. 1795-1801
    • Huang, H.1    Fujii, H.2    Sankila, A.3
  • 57
    • 0034088858 scopus 로고    scopus 로고
    • AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1
    • Satoh S., Daigo Y., Furukawa Y., et al. AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1. Nat Genet 2000, 24:245-250.
    • (2000) Nat Genet , vol.24 , pp. 245-250
    • Satoh, S.1    Daigo, Y.2    Furukawa, Y.3
  • 58
    • 0037130449 scopus 로고    scopus 로고
    • Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas
    • Taniguchi K., Roberts L.R., Aderca I.N., et al. Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas. Oncogene 2002, 21:4863-4871.
    • (2002) Oncogene , vol.21 , pp. 4863-4871
    • Taniguchi, K.1    Roberts, L.R.2    Aderca, I.N.3
  • 59
    • 33846463379 scopus 로고    scopus 로고
    • Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets
    • Boyault S., Rickman D.S., de Reynies A., et al. Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets. Hepatology 2007, 45:42-52.
    • (2007) Hepatology , vol.45 , pp. 42-52
    • Boyault, S.1    Rickman, D.S.2    de Reynies, A.3
  • 60
    • 18644363653 scopus 로고    scopus 로고
    • Bi-allelic inactivation of TCF1 in hepatic adenomas
    • Bluteau O., Jeannot E., Bioulac-Sage P., et al. Bi-allelic inactivation of TCF1 in hepatic adenomas. Nat Genet 2002, 32:312-315.
    • (2002) Nat Genet , vol.32 , pp. 312-315
    • Bluteau, O.1    Jeannot, E.2    Bioulac-Sage, P.3
  • 61
    • 20044388328 scopus 로고    scopus 로고
    • PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas
    • Lee J.W., Soung Y.H., Kim S.Y., et al. PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas. Oncogene 2005, 24:1477-1480.
    • (2005) Oncogene , vol.24 , pp. 1477-1480
    • Lee, J.W.1    Soung, Y.H.2    Kim, S.Y.3
  • 62
    • 18344372735 scopus 로고    scopus 로고
    • M6P/IGF2R tumor suppressor gene mutated in hepatocellular carcinomas in Japan
    • Oka Y., Waterland R.A., Killian J.K., et al. M6P/IGF2R tumor suppressor gene mutated in hepatocellular carcinomas in Japan. Hepatology 2002, 35:1153-1163.
    • (2002) Hepatology , vol.35 , pp. 1153-1163
    • Oka, Y.1    Waterland, R.A.2    Killian, J.K.3
  • 63
    • 0242438080 scopus 로고    scopus 로고
    • Telomere shortening and telomerase reactivation in dysplastic nodules of human hepatocarcinogenesis
    • Oh B.K., Jo Chae K., Park C., et al. Telomere shortening and telomerase reactivation in dysplastic nodules of human hepatocarcinogenesis. J Hepatol 2003, 39:786-792.
    • (2003) J Hepatol , vol.39 , pp. 786-792
    • Oh, B.K.1    Jo Chae, K.2    Park, C.3
  • 64
    • 33645452432 scopus 로고    scopus 로고
    • Quantitative assessment of hTERT mRNA expression in dysplastic nodules of HBV-related hepatocarcinogenesis
    • Oh B.K., Kim Y.J., Park Y.N., et al. Quantitative assessment of hTERT mRNA expression in dysplastic nodules of HBV-related hepatocarcinogenesis. Am J Gastroenterol 2006, 101:831-838.
    • (2006) Am J Gastroenterol , vol.101 , pp. 831-838
    • Oh, B.K.1    Kim, Y.J.2    Park, Y.N.3
  • 65
    • 0141648473 scopus 로고    scopus 로고
    • Aberrant CpG island hypermethylation along multistep hepatocarcinogenesis
    • Lee S., Lee H.J., Kim J.H., et al. Aberrant CpG island hypermethylation along multistep hepatocarcinogenesis. Am J Pathol 2003, 163:1371-1378.
    • (2003) Am J Pathol , vol.163 , pp. 1371-1378
    • Lee, S.1    Lee, H.J.2    Kim, J.H.3
  • 66
    • 0037455979 scopus 로고    scopus 로고
    • P16 Hypermethylation in the early stage of hepatitis B virus-associated hepatocarcinogenesis
    • Shim Y.H., Yoon G.S., Choi H.J., et al. p16 Hypermethylation in the early stage of hepatitis B virus-associated hepatocarcinogenesis. Cancer Lett 2003, 190:213-219.
    • (2003) Cancer Lett , vol.190 , pp. 213-219
    • Shim, Y.H.1    Yoon, G.S.2    Choi, H.J.3
  • 67
    • 33745088298 scopus 로고    scopus 로고
    • Quantitative evaluation of RASSF1A methylation in the non-lesional, regenerative and neoplastic liver
    • Di Gioia S., Bianchi P., Destro A., et al. Quantitative evaluation of RASSF1A methylation in the non-lesional, regenerative and neoplastic liver. BMC Cancer 2006, 6:89.
    • (2006) BMC Cancer , vol.6 , pp. 89
    • Di Gioia, S.1    Bianchi, P.2    Destro, A.3
  • 68
    • 34548645031 scopus 로고    scopus 로고
    • Alterations of DNA methylation and histone modifications contribute to gene silencing in hepatocellular carcinomas
    • Kondo Y., Shen L., Suzuki S., et al. Alterations of DNA methylation and histone modifications contribute to gene silencing in hepatocellular carcinomas. Hepatol Res 2007, 37:974-983.
    • (2007) Hepatol Res , vol.37 , pp. 974-983
    • Kondo, Y.1    Shen, L.2    Suzuki, S.3
  • 69
    • 0032513884 scopus 로고    scopus 로고
    • Irregular regeneration of hepatocytes and risk of hepatocellular carcinoma in chronic hepatitis and cirrhosis with hepatitis C virus infection
    • Shibata M., Morizane T., Uchida T., et al. Irregular regeneration of hepatocytes and risk of hepatocellular carcinoma in chronic hepatitis and cirrhosis with hepatitis C virus infection. Lancet 1998, 351:1773-1777.
    • (1998) Lancet , vol.351 , pp. 1773-1777
    • Shibata, M.1    Morizane, T.2    Uchida, T.3
  • 70
    • 0031059533 scopus 로고    scopus 로고
    • Stromal and blood vessel wall invasion in well-differentiated hepatocellular carcinoma
    • Nakano M., Saito A., Yamamoto M., et al. Stromal and blood vessel wall invasion in well-differentiated hepatocellular carcinoma. Liver 1997, 17:41-46.
    • (1997) Liver , vol.17 , pp. 41-46
    • Nakano, M.1    Saito, A.2    Yamamoto, M.3
  • 71
    • 33847387209 scopus 로고    scopus 로고
    • Ductular reaction is helpful in defining early stromal invasion, small hepatocellular carcinomas, and dysplastic nodules
    • Park Y.N., Kojiro M., Di Tommaso L., et al. Ductular reaction is helpful in defining early stromal invasion, small hepatocellular carcinomas, and dysplastic nodules. Cancer 2007, 109:915-923.
    • (2007) Cancer , vol.109 , pp. 915-923
    • Park, Y.N.1    Kojiro, M.2    Di Tommaso, L.3
  • 72
    • 0035395236 scopus 로고    scopus 로고
    • Beta-catenin mutation and overexpression in hepatocellular carcinoma: clinicopathologic and prognostic significance
    • Wong C.M., Fan S.T., Ng I.O. Beta-catenin mutation and overexpression in hepatocellular carcinoma: clinicopathologic and prognostic significance. Cancer 2001, 92:136-145.
    • (2001) Cancer , vol.92 , pp. 136-145
    • Wong, C.M.1    Fan, S.T.2    Ng, I.O.3
  • 73
    • 0036379830 scopus 로고    scopus 로고
    • Beta-catenin expression in hepatocellular carcinoma: a possible participation of beta-catenin in the dedifferentiation process
    • Suzuki T., Yano H., Nakashima Y., et al. Beta-catenin expression in hepatocellular carcinoma: a possible participation of beta-catenin in the dedifferentiation process. J Gastroenterol Hepatol 2002, 17:994-1000.
    • (2002) J Gastroenterol Hepatol , vol.17 , pp. 994-1000
    • Suzuki, T.1    Yano, H.2    Nakashima, Y.3
  • 74
    • 0034995765 scopus 로고    scopus 로고
    • Genetic alterations associated with hepatocellular carcinomas define distinct pathways of hepatocarcinogenesis
    • Laurent-Puig P., Legoix P., Bluteau O., et al. Genetic alterations associated with hepatocellular carcinomas define distinct pathways of hepatocarcinogenesis. Gastroenterology 2001, 120:1763-1773.
    • (2001) Gastroenterology , vol.120 , pp. 1763-1773
    • Laurent-Puig, P.1    Legoix, P.2    Bluteau, O.3
  • 75
    • 0037223571 scopus 로고    scopus 로고
    • Expression profiling in multistage hepatocarcinogenesis: identification of HSP70 as a molecular marker of early hepatocellular carcinoma
    • Chuma M., Sakamoto M., Yamazaki K., et al. Expression profiling in multistage hepatocarcinogenesis: identification of HSP70 as a molecular marker of early hepatocellular carcinoma. Hepatology 2003, 37:198-207.
    • (2003) Hepatology , vol.37 , pp. 198-207
    • Chuma, M.1    Sakamoto, M.2    Yamazaki, K.3
  • 76
    • 0041343280 scopus 로고    scopus 로고
    • Molecular profiling of hepatocellular carcinomas (HCC) using a large-scale real-time RT-PCR approach: determination of a molecular diagnostic index
    • Paradis V., Bieche I., Dargere D., et al. Molecular profiling of hepatocellular carcinomas (HCC) using a large-scale real-time RT-PCR approach: determination of a molecular diagnostic index. Am J Pathol 2003, 163:733-741.
    • (2003) Am J Pathol , vol.163 , pp. 733-741
    • Paradis, V.1    Bieche, I.2    Dargere, D.3
  • 77
    • 25844461787 scopus 로고    scopus 로고
    • Molecular changes from dysplastic nodule to hepatocellular carcinoma through gene expression profiling
    • Nam S.W., Park J.Y., Ramasamy A., et al. Molecular changes from dysplastic nodule to hepatocellular carcinoma through gene expression profiling. Hepatology 2005, 42:809-818.
    • (2005) Hepatology , vol.42 , pp. 809-818
    • Nam, S.W.1    Park, J.Y.2    Ramasamy, A.3
  • 78
    • 33845790499 scopus 로고    scopus 로고
    • A molecular signature to discriminate dysplastic nodules from early hepatocellular carcinoma in HCV cirrhosis
    • Llovet J.M., Chen Y., Wurmbach E., et al. A molecular signature to discriminate dysplastic nodules from early hepatocellular carcinoma in HCV cirrhosis. Gastroenterology 2006, 131:1758-1767.
    • (2006) Gastroenterology , vol.131 , pp. 1758-1767
    • Llovet, J.M.1    Chen, Y.2    Wurmbach, E.3
  • 79
    • 34247549347 scopus 로고    scopus 로고
    • Genome-wide molecular profiles of HCV-induced dysplasia and hepatocellular carcinoma
    • Wurmbach E., Chen Y.B., Khitrov G., et al. Genome-wide molecular profiles of HCV-induced dysplasia and hepatocellular carcinoma. Hepatology 2007, 45:938-947.
    • (2007) Hepatology , vol.45 , pp. 938-947
    • Wurmbach, E.1    Chen, Y.B.2    Khitrov, G.3
  • 80
    • 33947396135 scopus 로고    scopus 로고
    • Diagnostic value of HSP70, glypican 3, and glutamine synthetase in hepatocellular nodules in cirrhosis
    • Di Tommaso L., Franchi G., Park Y.N., et al. Diagnostic value of HSP70, glypican 3, and glutamine synthetase in hepatocellular nodules in cirrhosis. Hepatology 2007, 45:725-734.
    • (2007) Hepatology , vol.45 , pp. 725-734
    • Di Tommaso, L.1    Franchi, G.2    Park, Y.N.3
  • 81
    • 38149004217 scopus 로고    scopus 로고
    • Glypican-3 expression in benign liver tissue with active hepatitis C: implications for the diagnosis of hepatocellular carcinoma
    • Abdul-Al H.M., Makhlouf H.R., Wang G., et al. Glypican-3 expression in benign liver tissue with active hepatitis C: implications for the diagnosis of hepatocellular carcinoma. Hum Pathol 2008, 39:209-212.
    • (2008) Hum Pathol , vol.39 , pp. 209-212
    • Abdul-Al, H.M.1    Makhlouf, H.R.2    Wang, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.