Neoangiogenesis and sinusoidal 'capillarization' in dysplastic nodules of the liver

American Journal of Surgical Pathology

Volumn 22, Issue 6, 1998, Pages 656-662

  Park, Young Nyun ^b   Yang, Chang Pei ^b   Fernandez, Gerardo J ^b   Cubukcu, Olcay ^b   Thung, Swan N ^b   Theise, Neil D ^a  

^a NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^b NONE

Author keywords

Adenomatous hyperplasia; Angiogenesis; Dysplastic nodules; Hepatocellular carcinoma; Liver; Macroregenerative nodules

Indexed keywords

ADENOMA; ANGIOGENESIS; ARTICLE; DISEASE CLASSIFICATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCHEMISTRY; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER NODULE; LIVER SINUSOID; PRECANCER; TOPOGRAPHY; TUMOR VASCULARIZATION;

ACTINS; ANTIGENS, CD34; CARCINOMA, HEPATOCELLULAR; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LIVER CIRRHOSIS; LIVER NEOPLASMS; MALE; MIDDLE AGED; NEOVASCULARIZATION, PATHOLOGIC; PRECANCEROUS CONDITIONS;

EID: 0031866348     PISSN: 01475185     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000478-199806000-00002     Document Type: Article

References (35)

1. Anthony PP, Vogel CL, Barker LF. Liver cell dysplasia: a premalignant condition. J Clin Pathol 1973;26:217-23.
2. Arakawa M, Kage M, Sugihara S, Nakashima T, Suenaga M, Okuda K. Emergence of malignant lesions within an adenomatous hyperplastic nodule in a cirrhotic liver: observation in five cases. Gastroenterology 1986;91:198-208.
3. Couvelard A, Scoazec JY, Dauge MC, Bringuier AF, Potet F, Feldmann G. Structural and functional differentiation of sinusoidal endothelial cells during liver organogenesis in humans. Blood 1996;87:4568-80.
4. Couvelard A, Scoazec JY, Feldmann G. Expression of cell-cell and cell-matrix adhesion proteins by sinusoidal endothelial cells in the normal and cirrhotic human liver. Am J Pathol 1993;143:738-52.
5. Dhillon A, Colombari R, Savage K, Scheuer P. An immunohistochemical study of the blood vessels within primary hepatocellular tumors. Liver 1992;12:311-8.
6. Eguchi A, Nakashima O, Okudaira S, Sugihara S, Kojiro M. Ad- enomatous hyperplasia in the vicinity of small hepatocellular carcinoma. Hepatology 1992;15:843-8.
7. Ferrell L, Wright T, Lake J, Roberts J, Ascher N. Incidence and diagnostic features of dysplastic nodules vs small hepatocellular carcinoma in cirrhotic livers. Hepatology 1992;16:1372-81.
8. Fina L, Molgaard HV, Robertson D, et al. Expression of the CD34 gene in vascular endothelial cells. Blood 1990;75:2417-26.
9. Folkman J, Watson K, Ingber D, Hanahan D. Induction of angiogenesis during the transition from hyperplasia to neoplasia. Nature 1989;339:58-61.
10. Furuya K, Nakamura M, Yamamoto Y, Togei K, Otsuka H. Dysplastic nodule of the liver. A clinicopathologic study of 345 autopsy cases of chronic liver disease. Cancer 1988;61:99-105.
11. Haratake J, Hisaoka M, Yamamoto O, Horie A. An ultrastructural comparison of sinusoids in hepatocellular carcinoma, adenomatous hyperplasia, and fetal liver. Arch Pathol Lab Med 1992;116:67-70.
12. Himeno H, Enzan H, Saibara T, Onishi S, Yamamoto Y. Hitherto unrecognized arterioles within hepatocellular carcinoma. J Pathol 1994;174:217-22.
13. Hytiroglou P, Theise ND, Schwartz M, Mor E, Miller C, Thung SN. Dysplastic nodules in a series of adult cirrhotic liver explants: issues of classification and nomenclature. Hepatology 1995;21:703-8.
14. Matsui O, Kadoya M, Kameyama T, et al. Benign and malignant nodules in cirrhotic livers: distinction based on blood supply. Radiology 1991;178:493-7.
15. Muro H, Shrasawa H, Kosugi I, Nakamura S. Defect of Fc receptors and phenotypical changes in sinusoidal endothelial cells in human liver cirrhosis. Am J Pathol 1993;143:105-20.
16. Nakanuma Y, Terada T, Terasaki S, et al. "Atypical adenomatous hyperplasia" in liver cirrhosis: low-grade hepatocellular carcinoma or borderline lesion? Histopathology 1990;17:27-35.
17. Nakanuma Y, Terada T, Ueda K, Terasaki S, Nonomura A, Matsui O. Adenomatous hyperplasia of the liver as a precancerous lesion. Liver 1993;13:1-9.
18. Ruck P, Xiao JC, Kaiserling E. Immunoreactivity of sinusoids in hepatocellular carcinoma. An immunohistochemical study using lectin UEA-1 and antibodies against endothelial markers. Arch Pathol Lab Med 1995;119:173-8.
19. Ruck P, Xiao JC, Kaiserling E. Immunoreactivity of sinusoids in hepatoblastoma: an immunohistochemical study using lectin UEA-1 and antibodies against endothelium-associated antigens, including CD34. Histopathology 1995;26:451-5.
20. Schaffner F, Popper H. Capillarization of hepatic sinusoids in man. Gastroenterology 1963;44:239-42.
21. Schlingemann RO, Rietveld F Jr, de Waal R, et al. Leukocyte antigen CD34 is expressed by a subset of cultured endothelial cells and on endothelial abluminal microprocesses in the tumor stroma. Lab Invest 1990;62:690-6.
22. Schmitt-Gräff A, Krüger S, Bochard F, Gabbiani G, Denk H. Modulation of alpha smooth muscle actin and desmin expression in stellatecells of normal and diseased human livers. Am J Pathol 1991;138:1233-42.
23. Terada T, Hoso M, Nakanuma Y. Mallory body clustering in adenomatous hyperplasia in human cirrhotic livers: report of four cases. Hum Pathol 1989;20:886-90.
24. Terada T, Nakanuma Y. Expression of ABH blod group antigens, receptors of Ulex europaeus agglutinin I, and factor VIII-related antigen on sinusoidal endothelial cells in adenomatous hyperplasia in human cirrhotic livers. Hum Pathol 1991;22:486-93.
25. Terada T, Nakanuma Y. Survey of iron-accumulative dysplastic nodules in cirrhotic livers. Hepatology 1989;5:851-4.
26. Terada T, Nakanuma Y, Hoso M, Saito K, Sasaki M, Nonomura A. Fatty dysplastic nodule in non-steatotic liver cirrhosis: a morphologic study. Virchows Arch [A] 1989;415:131-6.
27. Terada T, Terasaki S, Nakanuma Y. A clinicopathologic study of adenomatous hyperplasia of the liver in 209 consecutive cirrhotic livers examined by autopsy. Cancer 1993;72:1551-6.
28. Theise ND. Dysplastic (dysplastic) nodules and human hepatocarcinogenesis: theoretical and clinical implications. Semin Liver Dis 1995;15:360-71.
29. Theise ND, Lapook J, Thung SN. A macroregenerative nodule containing multiple foci of hepatocellular carcinoma in a noncirrhotic liver. Hepatology 1993;17:993-6.
30. Theise ND, Schwartz M, Miller C, Thung SN. Dysplastic nodules and hepatocellular carcinoma in forty-four sequential adult liver explants with cirrhosis. Hepatology 1992;16:949-55.
31. Ueda K, Terada T, Nakanuma Y, Matsui O. Vascular supply in adenomatous hyperplasia of the liver and hepatocellular carcinoma: a morhometric study. Hum Pathol 1992;23:619-26.
32. Wanless IR. Large regenerative nodules, dysplastic nodules (adenomatous hyperplasia) and hepatocellular dysplasia in cirrhosis: criteria for diagnosis based on histologic analysis of 124 cirrhotic livers [Abstract]. Hepatology 1994;20:412.
33. Wanless I, Callea R, Craig JR, et al. Terminology of nodular lesions of the liver: recommendations of the World Congress of Gastroenterology Working Party. Hepatology 1995;22:983-93.
34. Wisse E, DeZanger RB, Charles K, Van der Smissen P, McCuskey RS. The liver sieve: considerations concerning the structure and function of endothelial fenestrae, the sinusoidal wall, and the space of Disse. Hepatology 1985;5:683-92.
35. Watanabe S, Okita K, Harada T, et al. Morphologic studies of the liver cell dysplasia. Cancer 1983;51:2197-205.