메뉴 건너뛰기




Volumn 45, Issue 5, 2006, Pages 734-743

Large liver cell dysplasia: A controversial entity

Author keywords

Cirrhosis; Hepatocellular carcinoma; Large liver cell change; Large liver cell dysplasia

Indexed keywords

CYTOKERATIN; DNA; FERRITIN; GENE PRODUCT; HEPATITIS B SURFACE ANTIGEN; IRON; PROTEIN P53;

EID: 33749067406     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2006.08.002     Document Type: Review
Times cited : (51)

References (58)
  • 1
    • 0015598739 scopus 로고
    • Liver cell dysplasia: a premalignant condition
    • Anthony P.P., Vogel C.L., and Barker L.F. Liver cell dysplasia: a premalignant condition. J Clin Path 26 (1973) 217-223
    • (1973) J Clin Path , vol.26 , pp. 217-223
    • Anthony, P.P.1    Vogel, C.L.2    Barker, L.F.3
  • 3
    • 0029155354 scopus 로고    scopus 로고
    • International Working Party. Terminology of nodular hepatocellular lesions. Hepatology 1995;22:983-93.
  • 4
    • 14544292426 scopus 로고    scopus 로고
    • Preneoplastic lesions in human hepatocarcinogenesis
    • Libbrecht L., Desmet V., and Roskams T. Preneoplastic lesions in human hepatocarcinogenesis. Liver Int 25 (2005) 16-27
    • (2005) Liver Int , vol.25 , pp. 16-27
    • Libbrecht, L.1    Desmet, V.2    Roskams, T.3
  • 5
    • 0034897714 scopus 로고    scopus 로고
    • Chromosomal abnormalities in liver cell dysplasia detected by comparative genomic hybridisation
    • Marchio A., Terris B., Meddeb M., Pineau P., Duverger A., Tiollais P., et al. Chromosomal abnormalities in liver cell dysplasia detected by comparative genomic hybridisation. Mol Pathol 54 (2001) 270-274
    • (2001) Mol Pathol , vol.54 , pp. 270-274
    • Marchio, A.1    Terris, B.2    Meddeb, M.3    Pineau, P.4    Duverger, A.5    Tiollais, P.6
  • 7
    • 0023181157 scopus 로고
    • Morphological precursors of hepatocellular carcinoma: a morphometrical analysis
    • Giannini A., Zampi G., Bartoloni F., and Omer S. Morphological precursors of hepatocellular carcinoma: a morphometrical analysis. Hepatogastroenterology 34 (1987) 95-97
    • (1987) Hepatogastroenterology , vol.34 , pp. 95-97
    • Giannini, A.1    Zampi, G.2    Bartoloni, F.3    Omer, S.4
  • 8
    • 0021954724 scopus 로고
    • Karyometric analysis of liver cell dysplasia and hepatocellular carcinoma. Evidence against precancerous nature of liver cell dysplasia
    • Henmi A., Uchida T., and Shikata T. Karyometric analysis of liver cell dysplasia and hepatocellular carcinoma. Evidence against precancerous nature of liver cell dysplasia. Cancer 55 (1985) 2594-2599
    • (1985) Cancer , vol.55 , pp. 2594-2599
    • Henmi, A.1    Uchida, T.2    Shikata, T.3
  • 9
    • 0028129288 scopus 로고
    • Immunohistochemical analysis of p53 protein overexpression in liver cell dysplasia and in hepatocellular carcinoma
    • Zhao M., Zhang N.X., Laissue J.A., and Zimmermann A. Immunohistochemical analysis of p53 protein overexpression in liver cell dysplasia and in hepatocellular carcinoma. Virchows Arch 424 (1994) 613-621
    • (1994) Virchows Arch , vol.424 , pp. 613-621
    • Zhao, M.1    Zhang, N.X.2    Laissue, J.A.3    Zimmermann, A.4
  • 10
    • 0028958050 scopus 로고
    • Liver cell dysplasia is a major risk factor for hepatocellular carcinoma in cirrhosis: a prospective study
    • Borzio M., Bruno S., Roncalli M., Mels G.C., Ramella G., Borzio F., et al. Liver cell dysplasia is a major risk factor for hepatocellular carcinoma in cirrhosis: a prospective study. Gastroenterology 108 (1995) 812-817
    • (1995) Gastroenterology , vol.108 , pp. 812-817
    • Borzio, M.1    Bruno, S.2    Roncalli, M.3    Mels, G.C.4    Ramella, G.5    Borzio, F.6
  • 11
    • 15844411099 scopus 로고    scopus 로고
    • Predictive score for the development of hepatocellular carcinoma and additional value of liver large cell dysplasia in Western patients with cirrhosis
    • Ganne-Carrie N., Chastang C., Chapel F., Munz C., Pateron D., Sibony M., et al. Predictive score for the development of hepatocellular carcinoma and additional value of liver large cell dysplasia in Western patients with cirrhosis. Hepatology 23 (1996) 1112-1118
    • (1996) Hepatology , vol.23 , pp. 1112-1118
    • Ganne-Carrie, N.1    Chastang, C.2    Chapel, F.3    Munz, C.4    Pateron, D.5    Sibony, M.6
  • 12
    • 0034856920 scopus 로고    scopus 로고
    • Predictive value of liver cell dysplasia for development of hepatocellular carcinoma in patients with non-cirrhotic and cirrhotic chronic viral hepatitis
    • Libbrecht L., Craninx M., Nevens F., Desmet V., and Roskams T. Predictive value of liver cell dysplasia for development of hepatocellular carcinoma in patients with non-cirrhotic and cirrhotic chronic viral hepatitis. Histopathology 39 (2001) 66-73
    • (2001) Histopathology , vol.39 , pp. 66-73
    • Libbrecht, L.1    Craninx, M.2    Nevens, F.3    Desmet, V.4    Roskams, T.5
  • 13
    • 0025069745 scopus 로고
    • The morphological characteristics of hepatocyte dysplasia
    • Serov V.V., and Beketora T.P. The morphological characteristics of hepatocyte dysplasia. Arkh Patol 52 (1990) 36-42
    • (1990) Arkh Patol , vol.52 , pp. 36-42
    • Serov, V.V.1    Beketora, T.P.2
  • 14
    • 0030663989 scopus 로고    scopus 로고
    • Large cell change (liver cell dysplasia) and hepatocellular carcinoma in cirrhosis: matched case-control study, pathological analysis, and pathogenetic hypothesis
    • Lee R.G., Tsamandas A.C., and Demetris A.J. Large cell change (liver cell dysplasia) and hepatocellular carcinoma in cirrhosis: matched case-control study, pathological analysis, and pathogenetic hypothesis. Hepatology 26 (1997) 1415-1422
    • (1997) Hepatology , vol.26 , pp. 1415-1422
    • Lee, R.G.1    Tsamandas, A.C.2    Demetris, A.J.3
  • 15
    • 0022641365 scopus 로고
    • Liver cell dysplasia in cirrhosis. A serologic and immunohistochemical study
    • Roncalli M., Borzio M., De Biagi G., Ferrari A.R., Macchi R., Tombesi V.M., et al. Liver cell dysplasia in cirrhosis. A serologic and immunohistochemical study. Cancer 57 (1986) 1515-1521
    • (1986) Cancer , vol.57 , pp. 1515-1521
    • Roncalli, M.1    Borzio, M.2    De Biagi, G.3    Ferrari, A.R.4    Macchi, R.5    Tombesi, V.M.6
  • 16
    • 0343145738 scopus 로고    scopus 로고
    • Prevalence of liver cell dysplasia and association with HCC in series of 100 cirrhotic liver explants
    • Le Bail B., Bernard P.H., Carles J., Balabaud C., and Bioulac-Sage P. Prevalence of liver cell dysplasia and association with HCC in series of 100 cirrhotic liver explants. J Hepatol 27 (1997) 835-842
    • (1997) J Hepatol , vol.27 , pp. 835-842
    • Le Bail, B.1    Bernard, P.H.2    Carles, J.3    Balabaud, C.4    Bioulac-Sage, P.5
  • 17
    • 0028898433 scopus 로고
    • Macroregenerative nodules in a series of adult cirrhotic liver explants: issues of classification and nomenclature
    • Hytrioglou P., Theise N.D., Schwartz M., Mor E., Miller C., and Thung S.N. Macroregenerative nodules in a series of adult cirrhotic liver explants: issues of classification and nomenclature. Hepatology 21 (1995) 703-708
    • (1995) Hepatology , vol.21 , pp. 703-708
    • Hytrioglou, P.1    Theise, N.D.2    Schwartz, M.3    Mor, E.4    Miller, C.5    Thung, S.N.6
  • 19
    • 0019401667 scopus 로고
    • Liver cell dysplasia in association with hepatocellular carcinoma, cirrhosis and hepatitis B surface antigen in Hong Kong
    • Ho J.C., Wu P.C., and Mak T.K. Liver cell dysplasia in association with hepatocellular carcinoma, cirrhosis and hepatitis B surface antigen in Hong Kong. Int J Cancer 28 (1981) 571-574
    • (1981) Int J Cancer , vol.28 , pp. 571-574
    • Ho, J.C.1    Wu, P.C.2    Mak, T.K.3
  • 20
    • 0032513884 scopus 로고    scopus 로고
    • Irregular regeneration of hepatocytes and risk of hepatocellular carcinoma in chronic hepatitis and cirrhosis with hepatitis C-virus infection
    • Shibata M., Morizane T., Uchida T., Yamagami T., Onozuka Y., Nakano M., et al. Irregular regeneration of hepatocytes and risk of hepatocellular carcinoma in chronic hepatitis and cirrhosis with hepatitis C-virus infection. Lancet 351 (1998) 1773-1777
    • (1998) Lancet , vol.351 , pp. 1773-1777
    • Shibata, M.1    Morizane, T.2    Uchida, T.3    Yamagami, T.4    Onozuka, Y.5    Nakano, M.6
  • 21
    • 0024545594 scopus 로고
    • Liver cell dysplasia accompanying hepatocellular carcinoma in southern Africa. Differences between urban and rural populations
    • Paterson A.C., Kew M.C., Duskeiko G.M., and Isaacson C. Liver cell dysplasia accompanying hepatocellular carcinoma in southern Africa. Differences between urban and rural populations. J Hepatol 8 (1989) 241-248
    • (1989) J Hepatol , vol.8 , pp. 241-248
    • Paterson, A.C.1    Kew, M.C.2    Duskeiko, G.M.3    Isaacson, C.4
  • 22
    • 0033788977 scopus 로고    scopus 로고
    • Can large cell change and high proliferative activity predict hepatocellular carcinoma in patients with hereditary hemochromatosis?
    • Fracanzani A.L., Borzio M., Roncalli M., Derenzini M., Trere D., Mattioli M., et al. Can large cell change and high proliferative activity predict hepatocellular carcinoma in patients with hereditary hemochromatosis?. Am J Gastroenterol 95 (2000) 2940-2945
    • (2000) Am J Gastroenterol , vol.95 , pp. 2940-2945
    • Fracanzani, A.L.1    Borzio, M.2    Roncalli, M.3    Derenzini, M.4    Trere, D.5    Mattioli, M.6
  • 24
    • 0028187932 scopus 로고
    • Liver cell dysplasia in alpha-1-antitrypsin deficiency
    • Cohen C., and DeRose P.B. Liver cell dysplasia in alpha-1-antitrypsin deficiency. Mod Pathol 7 (1994) 31-36
    • (1994) Mod Pathol , vol.7 , pp. 31-36
    • Cohen, C.1    DeRose, P.B.2
  • 25
  • 26
    • 0020323914 scopus 로고
    • Hepatitis B virus antigens in liver tissue in hepatocellular carcinoma and advanced chronic liver disease-relationship to liver cell dysplasia
    • Omata M., Mori J., Yokosuka O., Iwama S., Ito Y., and Okuda K. Hepatitis B virus antigens in liver tissue in hepatocellular carcinoma and advanced chronic liver disease-relationship to liver cell dysplasia. Liver 2 (1982) 125-132
    • (1982) Liver , vol.2 , pp. 125-132
    • Omata, M.1    Mori, J.2    Yokosuka, O.3    Iwama, S.4    Ito, Y.5    Okuda, K.6
  • 27
    • 0018189621 scopus 로고
    • Liver cell dysplasia and hepatitis B surface and core antigens in cirrhosis and hepatocellular carcinoma of autopsy cases
    • Sakurai M. Liver cell dysplasia and hepatitis B surface and core antigens in cirrhosis and hepatocellular carcinoma of autopsy cases. Acta Pathol Jpn 28 (1978) 705-719
    • (1978) Acta Pathol Jpn , vol.28 , pp. 705-719
    • Sakurai, M.1
  • 28
    • 0018901093 scopus 로고
    • Hepatitis-B surface antigen in tumour tissue and non-tumorous liver in black patients with hepatocellular carcinoma
    • Kew M.C., Ray M.B., Desmet V.J., and Desmyter J. Hepatitis-B surface antigen in tumour tissue and non-tumorous liver in black patients with hepatocellular carcinoma. Br J Cancer 41 (1980) 399-406
    • (1980) Br J Cancer , vol.41 , pp. 399-406
    • Kew, M.C.1    Ray, M.B.2    Desmet, V.J.3    Desmyter, J.4
  • 29
    • 0020696332 scopus 로고
    • Pathology of hepatocellular carcinoma in Japan. 232 Consecutive cases autopsied in ten years
    • Nakashima T., Okuda K., Kojiro M., Jimi A., Yamaguchi R., Sakamoto K., et al. Pathology of hepatocellular carcinoma in Japan. 232 Consecutive cases autopsied in ten years. Cancer 51 (1983) 863-877
    • (1983) Cancer , vol.51 , pp. 863-877
    • Nakashima, T.1    Okuda, K.2    Kojiro, M.3    Jimi, A.4    Yamaguchi, R.5    Sakamoto, K.6
  • 30
    • 0028453008 scopus 로고
    • Immunohistochemical p53 in hepatocellular carcinoma and liver cell dysplasia
    • Cohen C., and DeRose P.B. Immunohistochemical p53 in hepatocellular carcinoma and liver cell dysplasia. Mod Pathol 7 (1994) 536-539
    • (1994) Mod Pathol , vol.7 , pp. 536-539
    • Cohen, C.1    DeRose, P.B.2
  • 31
    • 0028060647 scopus 로고
    • Overexpression of p53 protein and Ki67 proliferative index in hepatocellular carcinoma: an immunohistochemical study on 109 Italian patients
    • D'Errico A., Grigioni W.F., Fiorentino M., Baccarini P., Grazi G.L., and Mancini A.M. Overexpression of p53 protein and Ki67 proliferative index in hepatocellular carcinoma: an immunohistochemical study on 109 Italian patients. Pathol Int 44 (1994) 682-687
    • (1994) Pathol Int , vol.44 , pp. 682-687
    • D'Errico, A.1    Grigioni, W.F.2    Fiorentino, M.3    Baccarini, P.4    Grazi, G.L.5    Mancini, A.M.6
  • 32
    • 0027423064 scopus 로고
    • Hepatitis B and alterations of the p53 tumor suppressor gene in hepatocellular carcinoma
    • Goldblum J.R., Bartos R.E., Carr K.A., and Frank T.S. Hepatitis B and alterations of the p53 tumor suppressor gene in hepatocellular carcinoma. Am J Surg Pathol 17 (1993) 1244-1251
    • (1993) Am J Surg Pathol , vol.17 , pp. 1244-1251
    • Goldblum, J.R.1    Bartos, R.E.2    Carr, K.A.3    Frank, T.S.4
  • 33
    • 0031846563 scopus 로고    scopus 로고
    • Liver cell dysplasia: reactivities for c-met protein, Rb protein, E-cadherin and transforming growth factor-beta 1 in comparison with hepatocellular carcinoma
    • Zhao M., and Zimmermann A. Liver cell dysplasia: reactivities for c-met protein, Rb protein, E-cadherin and transforming growth factor-beta 1 in comparison with hepatocellular carcinoma. Histol Histopathol 13 (1998) 657-670
    • (1998) Histol Histopathol , vol.13 , pp. 657-670
    • Zhao, M.1    Zimmermann, A.2
  • 34
    • 0028145762 scopus 로고
    • Immunohistochemical detection of bcl-2 protein in liver lesions: bcl-2 protein is expressed in hepatocellular carcinomas but not in liver cell dysplasia
    • Zhao M., Zhang N.X., Economou M., Blaha I., Laissue J.A., and Zimmermann A. Immunohistochemical detection of bcl-2 protein in liver lesions: bcl-2 protein is expressed in hepatocellular carcinomas but not in liver cell dysplasia. Histopathology 25 (1994) 237-245
    • (1994) Histopathology , vol.25 , pp. 237-245
    • Zhao, M.1    Zhang, N.X.2    Economou, M.3    Blaha, I.4    Laissue, J.A.5    Zimmermann, A.6
  • 35
    • 0021929242 scopus 로고
    • Liver cell dysplasia and hepatocellular carcinoma: a histological and immunohistochemical study
    • Roncalli M., Borzio M., de Biagi G., Servida E., Cantaboni A., Sironi M., et al. Liver cell dysplasia and hepatocellular carcinoma: a histological and immunohistochemical study. Histopathology 9 (1985) 209-221
    • (1985) Histopathology , vol.9 , pp. 209-221
    • Roncalli, M.1    Borzio, M.2    de Biagi, G.3    Servida, E.4    Cantaboni, A.5    Sironi, M.6
  • 36
    • 0033933955 scopus 로고    scopus 로고
    • The immunohistochemical phenotype of dysplastic foci in human liver: correlation with putative progenitor cells
    • Libbrecht L., Desmet V., Van Damme B., and Roskams T. The immunohistochemical phenotype of dysplastic foci in human liver: correlation with putative progenitor cells. J Hepatol 33 (2000) 76-84
    • (2000) J Hepatol , vol.33 , pp. 76-84
    • Libbrecht, L.1    Desmet, V.2    Van Damme, B.3    Roskams, T.4
  • 37
    • 17244382225 scopus 로고    scopus 로고
    • Large liver cell dysplasia in hepatitis B virus X transgenic mouse liver and human chronic hepatitis B virus-infected liver
    • Koo J.S., Seong J.K., Park C., Yu D.Y., Oh B.K., Oh S.H., et al. Large liver cell dysplasia in hepatitis B virus X transgenic mouse liver and human chronic hepatitis B virus-infected liver. Intervirology 48 (2005) 16-22
    • (2005) Intervirology , vol.48 , pp. 16-22
    • Koo, J.S.1    Seong, J.K.2    Park, C.3    Yu, D.Y.4    Oh, B.K.5    Oh, S.H.6
  • 38
    • 0024443569 scopus 로고
    • Abnormal DNA content in liver-cell dysplasia: a flow cytometric study
    • Roncalli M., Borzio M., Brando B., Colloredo G., and Servida E. Abnormal DNA content in liver-cell dysplasia: a flow cytometric study. Int J Cancer 44 (1989) 204-207
    • (1989) Int J Cancer , vol.44 , pp. 204-207
    • Roncalli, M.1    Borzio, M.2    Brando, B.3    Colloredo, G.4    Servida, E.5
  • 39
    • 0026691205 scopus 로고
    • Liver cell dysplasia: a DNA aneuploid lesion with distinct morphologic features
    • Thomas R.M., Berman J.J., Yetter R.A., Moore G.W., and Hutchins G.M. Liver cell dysplasia: a DNA aneuploid lesion with distinct morphologic features. Hum Pathol 23 (1992) 496-503
    • (1992) Hum Pathol , vol.23 , pp. 496-503
    • Thomas, R.M.1    Berman, J.J.2    Yetter, R.A.3    Moore, G.W.4    Hutchins, G.M.5
  • 40
    • 0027513261 scopus 로고
    • DNA image cytometric analysis of macroregenerative nodules (adenomatous hyperplasia) of the liver: evidence in support of their preneoplastic nature
    • Orsatti G., Theise N.D., Thung S.N., and Paronetto F. DNA image cytometric analysis of macroregenerative nodules (adenomatous hyperplasia) of the liver: evidence in support of their preneoplastic nature. Hepatology 17 (1993) 621-627
    • (1993) Hepatology , vol.17 , pp. 621-627
    • Orsatti, G.1    Theise, N.D.2    Thung, S.N.3    Paronetto, F.4
  • 41
    • 0028492109 scopus 로고
    • Comparative image cytometric DNA ploidy of liver cell dysplasia and hepatocellular carcinoma
    • Rubin E.M., DeRose P.B., and Cohen C. Comparative image cytometric DNA ploidy of liver cell dysplasia and hepatocellular carcinoma. Mod Pathol 7 (1994) 677-680
    • (1994) Mod Pathol , vol.7 , pp. 677-680
    • Rubin, E.M.1    DeRose, P.B.2    Cohen, C.3
  • 43
    • 0030758205 scopus 로고    scopus 로고
    • Interphase cytogenetic analysis reveals numerical chromosome aberrations in large liver cell dysplasia
    • Terris B., Ingster O., Rubbia L., Dubois S., Belghiti J., Feldmann G., et al. Interphase cytogenetic analysis reveals numerical chromosome aberrations in large liver cell dysplasia. J Hepatol 27 (1997) 313-319
    • (1997) J Hepatol , vol.27 , pp. 313-319
    • Terris, B.1    Ingster, O.2    Rubbia, L.3    Dubois, S.4    Belghiti, J.5    Feldmann, G.6
  • 44
    • 0033772078 scopus 로고    scopus 로고
    • Molecular cytogenetic evaluation of virus-associated and non-viral hepatocellular carcinoma: analysis of 26 carcinomas and 12 concurrent dysplasias
    • Zondervan P.E., Wink J., Alers J.C., IJzermans J.N., Schalm S.W., de Man R.A., et al. Molecular cytogenetic evaluation of virus-associated and non-viral hepatocellular carcinoma: analysis of 26 carcinomas and 12 concurrent dysplasias. J Pathol 192 (2000) 207-215
    • (2000) J Pathol , vol.192 , pp. 207-215
    • Zondervan, P.E.1    Wink, J.2    Alers, J.C.3    IJzermans, J.N.4    Schalm, S.W.5    de Man, R.A.6
  • 47
    • 0036789184 scopus 로고    scopus 로고
    • Colorectal adenoma to carcinoma progression follows multiple pathways of chromosomal instability
    • Hermsen M., Postma C., Baak J., Weiss M., Rapallo A., Sciutto A., et al. Colorectal adenoma to carcinoma progression follows multiple pathways of chromosomal instability. Gastroenterology 123 (2002) 1109-1119
    • (2002) Gastroenterology , vol.123 , pp. 1109-1119
    • Hermsen, M.1    Postma, C.2    Baak, J.3    Weiss, M.4    Rapallo, A.5    Sciutto, A.6
  • 48
    • 0034861522 scopus 로고    scopus 로고
    • High rates of hepatocellular carcinoma in cirrhotic patients with high liver cell proliferative activity
    • Donato M.F., Arosio E., Del Ninno E., Ronchi G., Lampertico P., Morabito A., et al. High rates of hepatocellular carcinoma in cirrhotic patients with high liver cell proliferative activity. Hepatology 34 (2001) 523-528
    • (2001) Hepatology , vol.34 , pp. 523-528
    • Donato, M.F.1    Arosio, E.2    Del Ninno, E.3    Ronchi, G.4    Lampertico, P.5    Morabito, A.6
  • 49
    • 0042093775 scopus 로고    scopus 로고
    • Impact of large regenerative, low grade and high grade dysplastic nodules in hepatocellular carcinoma development
    • Borzio M., Fargion S., Borzio F., Fracanzani A.L., Croce A.M., Stroffolini T., et al. Impact of large regenerative, low grade and high grade dysplastic nodules in hepatocellular carcinoma development. J Hepatol 39 (2003) 208-214
    • (2003) J Hepatol , vol.39 , pp. 208-214
    • Borzio, M.1    Fargion, S.2    Borzio, F.3    Fracanzani, A.L.4    Croce, A.M.5    Stroffolini, T.6
  • 50
    • 0030036244 scopus 로고    scopus 로고
    • Evolution of neoplastic development in the liver of transgenic mice co-expressing c-myc and transforming growth factor-alpha
    • Santoni-Rugiu E., Nagy P., Jensen M.R., Factor V.M., and Thorgeirsson S.S. Evolution of neoplastic development in the liver of transgenic mice co-expressing c-myc and transforming growth factor-alpha. Am J Pathol 149 (1996) 407-428
    • (1996) Am J Pathol , vol.149 , pp. 407-428
    • Santoni-Rugiu, E.1    Nagy, P.2    Jensen, M.R.3    Factor, V.M.4    Thorgeirsson, S.S.5
  • 51
    • 0035879040 scopus 로고    scopus 로고
    • Hepatocellular carcinoma results from chronic cyclin D1 overexpression in transgenic mice
    • Deane N.G., Parker M.A., Aramandla R., Diehl L., Lee W.J., Washington M.K., et al. Hepatocellular carcinoma results from chronic cyclin D1 overexpression in transgenic mice. Cancer Res 61 (2001) 5389-5395
    • (2001) Cancer Res , vol.61 , pp. 5389-5395
    • Deane, N.G.1    Parker, M.A.2    Aramandla, R.3    Diehl, L.4    Lee, W.J.5    Washington, M.K.6
  • 52
    • 1642535593 scopus 로고    scopus 로고
    • Hepatocarcinogenesis in mice with beta-catenin and Ha-ras gene mutations
    • Harada N., Oshima H., Katoh M., Tamai Y., Oshima M., and Taketo M.M. Hepatocarcinogenesis in mice with beta-catenin and Ha-ras gene mutations. Cancer Res 64 (2004) 48-54
    • (2004) Cancer Res , vol.64 , pp. 48-54
    • Harada, N.1    Oshima, H.2    Katoh, M.3    Tamai, Y.4    Oshima, M.5    Taketo, M.M.6
  • 53
    • 0033058294 scopus 로고    scopus 로고
    • Incidence of hepatocellular carcinoma in transgenic mice expressing the hepatitis B virus X-protein
    • Yu D.Y., Moon H.B., Son J.K., Jeong S., Yu S.L., Yoon H., et al. Incidence of hepatocellular carcinoma in transgenic mice expressing the hepatitis B virus X-protein. J Hepatol 31 (1999) 123-132
    • (1999) J Hepatol , vol.31 , pp. 123-132
    • Yu, D.Y.1    Moon, H.B.2    Son, J.K.3    Jeong, S.4    Yu, S.L.5    Yoon, H.6
  • 54
    • 0026673779 scopus 로고
    • Development of liver tumors in transforming growth factor alpha transgenic mice
    • Lee G.H., Merlino G., and Fausto N. Development of liver tumors in transforming growth factor alpha transgenic mice. Cancer Res 52 (1992) 5162-5170
    • (1992) Cancer Res , vol.52 , pp. 5162-5170
    • Lee, G.H.1    Merlino, G.2    Fausto, N.3
  • 55
    • 0025766290 scopus 로고
    • Selective ampilification of periportal transitional cells precedes formation of hepatocellular carcinoma in SV40 large tag transgenic mice
    • Schirmacher P., Held W.A., Yang D., Biempica L., and Rogler C.E. Selective ampilification of periportal transitional cells precedes formation of hepatocellular carcinoma in SV40 large tag transgenic mice. Am J Pathol 139 (1991) 231-241
    • (1991) Am J Pathol , vol.139 , pp. 231-241
    • Schirmacher, P.1    Held, W.A.2    Yang, D.3    Biempica, L.4    Rogler, C.E.5
  • 56
    • 0029926712 scopus 로고    scopus 로고
    • Ploidy and karyotypic alterations associated with early events in the development of hepatocarcinogenesis in transgenic mice harboring c-myc and transforming growth factor alpha transgenes
    • Sargent L.M., Sanderson N.D., and Thorgeirsson S.S. Ploidy and karyotypic alterations associated with early events in the development of hepatocarcinogenesis in transgenic mice harboring c-myc and transforming growth factor alpha transgenes. Cancer Res 56 (1996) 2137-2142
    • (1996) Cancer Res , vol.56 , pp. 2137-2142
    • Sargent, L.M.1    Sanderson, N.D.2    Thorgeirsson, S.S.3
  • 57
    • 0028023372 scopus 로고
    • Overexpression of transforming growth factor-α causes liver enlargement and increased hepatocyte proliferation in transgenic mice
    • Webber E.M., Wu J.C., Wang L., Merlino G., and Fausto N. Overexpression of transforming growth factor-α causes liver enlargement and increased hepatocyte proliferation in transgenic mice. Am J Pathol 145 (1994) 398-408
    • (1994) Am J Pathol , vol.145 , pp. 398-408
    • Webber, E.M.1    Wu, J.C.2    Wang, L.3    Merlino, G.4    Fausto, N.5
  • 58
    • 12244281113 scopus 로고    scopus 로고
    • Hepatocellular carcinoma in a hepatitis B 'x' transgenic mouse model: a sequential pathological evaluation
    • Lakhtakia R., Kumar V., Reddi H., Mathur M., Dattagupta S., and Panda S.K. Hepatocellular carcinoma in a hepatitis B 'x' transgenic mouse model: a sequential pathological evaluation. J Gastroenterol Hepatol 18 (2003) 80-91
    • (2003) J Gastroenterol Hepatol , vol.18 , pp. 80-91
    • Lakhtakia, R.1    Kumar, V.2    Reddi, H.3    Mathur, M.4    Dattagupta, S.5    Panda, S.K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.