Diagnostic value of HSP70, glypican 3, and glutamine synthetase in hepatocellular nodules in cirrhosis

Hepatology

Volumn 45, Issue 3, 2007, Pages 725-734

  Di Tommaso, Luca ^a   Franchi, Giada ^b   Young, Nyun Park ^c   Fiamengo, Barbara ^a   Destro, Annarita ^b   Morenghi, Emanuela ^b   Montorsi, Marco ^a   Torzilli, Guido ^a   Tommasini, Maurizio ^b   Terracciano, Luigi ^d   Tornillo, Luigi ^d   Vecchione, Raffaella ^e   Roncalli, Massimo ^a,f  

^a UNIVERSITY OF MILAN   (Italy)

^b HUMANITAS CLINICAL AND RESEARCH CENTER   (Italy)

^c Yonsei University College of Medicine   (South Korea)

^d UNIVERSITY HOSPITAL BASEL   (Switzerland)

^e UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^f UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMATE AMMONIA LIGASE; GLYPICAN 3; HEAT SHOCK PROTEIN 70;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; DIAGNOSTIC TEST; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LIVER CIRRHOSIS; LIVER NODULE; MALE; PHENOTYPE; PRIORITY JOURNAL;

ADULT; AGED; BIOLOGICAL MARKERS; DIAGNOSIS, DIFFERENTIAL; FEMALE; GLUTAMATE-AMMONIA LIGASE; GLYPICANS; HEPATOCYTES; HSP70 HEAT-SHOCK PROTEINS; HUMANS; LIVER CIRRHOSIS; MALE; MIDDLE AGED; SENSITIVITY AND SPECIFICITY;

EID: 33947396135     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.21531     Document Type: Article

References (29)

1. Bruix J, Sherman M; Practice Guidelines Committee, American Association for the Study of Liver Disease. Management of hepatocellular carcinoma. HEPATOLOGY 2005;42:1208-1236.
2. Terminology of nodular hepatocellular lesions. International Working Party. HEPATOLOGY 1995;22:983-993.
3. Roncalli M. Hepatocellular nodules in cirrhosis: focus on diagnostic criteria on liver biopsy. A Western experience. Liver Transpl 2004;10:S9-S15.
4. Llovet JM, Chen Y, Wurmbach E, Roayaie S, Fiel MI, Schwartz M, et al. A molecular signature to discriminate dysplastic nodules from early hepatocellular carcinoma in HCV cirrhosis. Gastroenterology (2006), doi: 10.1053/j.gastro. 2006.09.014
5. Capurro M, Wanless IR, Sherman M, Deboer G, Shi W, Miyoshi E, et al. Glypican-3: a novel serum and histochemical marker for hepatocellular carcinoma. Gastroenterology 2003;125:89-97.
6. Chuma M, Sakamoto M, Yamazaki K, Ohta T, Ohiki M, Asaka M, et al. Expression profiling in multistage hepatocarcinogenesis: identification of HSP70 as a molecular marker of early hepatocellular carcinoma. HEPATOLOGY 2003;37:198-207.
7. Osada T, Sakamoto M, Nagawa H, Yamamoto J, Matsuno Y, Iwamatsu A, et al. Acquisition of glutamine synthetase expression in human hepatocarcinogenesis: relation to disease recurrence and possible regulation by ubiquitin-dependent proteolysis. Cancer 1999;85:819-831.
8. Garrido C, Gurbuxani S, Ravagnan L, Kroemer G. Heat shock proteins: endogenous modulators of apoptotic cell death. Biochem Biophys Res Commun 2001;286:433-442.
9. Helmbrecht K, Zeise E, Rensing L. Chaperones in cell cycle regulation and mitogenic signal transduction: a review. Cell Prolif 2000;33:341-365.
10. Jolly C, Morimoto RI. Role of the heat shock response and molecular chaperones in oncogenesis and cell death. J Natl Cancer Inst 2000;92:1564-1572.
11. Filmus J. Glypicans in growth control and cancer. Glycobiology 2001;11:19R-23R.
12. Cano-Gauci DF, Song HH, Yang H, Mckerlie C, Choo B, Shi W, et al. Glypican-3-deficient mice exhibit developmental overgrowth and some of the abnormalities typical of Simpson-Golabi-Behmel syndrome. J Cell Biol 1999;146:255-264.
13. Lin H, Huber R, Schlessinger D, Morin PJ. Frequent silencing of the GPC3 gene in ovarian cancer cell lines. Cancer Res 1999;59:807-810.
14. Murthy SS, Shen T, De Rienzo A, Lee WC, Ferriola PC, Jhanwar SC, et al. Expression of GPC3, an X-linked recessive overgrowth gene, is silenced in malignant mesothelioma. Oncogene 2000;19:410-416.
15. Xiang YY, Ladeda V, Filmus J. Glypican-3 expression is silenced in human breast cancer. Oncogene 2001;20:7408-7412.
16. Zhu ZW, Friess H, Wang L, Abou-Shady M, Zimmermann A, Lander AD, et al. Enhanced glypican-3 expression differentiates the majority of hepatocellular carcinomas from benign hepatic disorders. Gut 2001;48:558-564.
17. Sung YK, Hwang SY, Park MK, Farooq M, Han IS, Bae HI, et al. Glypican-3 is overexpressed in human hepatocellular carcinoma. Cancer Sci 2003;94:259-262.
18. Yamauchi N, Watanabe A, Hishinuma M, Ohashi K, Midorikawa Y, Morishita Y, et al. The glypican 3 oncofetal protein is a promising diagnostic marker for hepatocellular carcinoma. Mod Pathol 2005;18:1591-1598.
19. Haussinger D, Sies H, Gerok W. Functional hepatocyte heterogeneity in ammonia metabolism. The intercellular glutamine cycle. J Hepatol 1985;1:3-14.
20. Moorman AF, de Boer PA, Geerts WJ, van de Zande L, Lamers WH, Charles R. Complementary distribution of carbamoylphosphate synthetase (ammonia) and glutamine synthetase in rat liver acinus is regulated at a pretranslational level. J Histochem Cytochem 1988;36:751-755.
21. Moorman AF, Vermeulen JL, Charles R, Lamers WH. Localization of ammonia-metabolizing enzymes in human liver: ontogenesis of eterogeneity. HEPATOLOGY 1989;9:367-372.
22. Reitzer LJ, Wice BM, Kennell D. Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells. J Biol Chem 1979;254:2669-2676.
23. Gebhardt R, Tanaka T, Williams GM. Glutamine synthetase heterogeneous expression as a marker for the cellular lineage of preneoplastic and neoplastic liver populations. Carcinogenesis 1989;10:1917-1923.
24. Christa L, Simon MT, Flinois JP, Gebhardt R, Brechot C, Lasserre C. Overexpression of glutamine synthetase in human primary liver cancer. Gastroenterology 1994;106:1312-1320.
25. Kojiro M. Focus on dysplastic nodules and early hepatocellular carcinoma: an Eastern point of view. Liver Transpl 2004;10(Suppl 1):S3-S8.
26. Kojiro M. Pathology of early HCC. In: Jordi Bruix, ed. Hepatocellular Carcinoma. Barcelona, Spain: Permanyer Publications, 2004:41-54.
27. Roncalli M, Roz E, Coggi G, Di Rocco MG, Bossi P, Minola E, et al. The vascular profile of regenerative and dysplastic nodules of the cirrhotic liver: implications for diagnosis and classification. HEPATOLOGY 1999;30:1174-1178.
28. Edmondson HA, Steiner PE. Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. Cancer 1954;7:462-503.
29. Tornillo L, Carafa V, Sauter G, Moch H, Minola E, Gambacorta M, et al. Chromosomal alterations in hepatocellular nodules by comparative genomic hybridization: high-grade dysplastic nodules represent early stages of hepatocellular carcinoma. Lab Invest 2002;82:547-553.