Impact of large regenerative, low grade and high grade dysplastic nodules in hepatocellular carcinoma development

Journal of Hepatology

Volumn 39, Issue 2, 2003, Pages 208-214

  Borzio, Mauro ^a   Fargion, Silvia ^b   Borzio, Franco ^a   Fracanzani, Anna Ludovica ^b   Croce, Anna Maria ^a   Stroffolini, Tommaso ^c   Oldani, Silvia ^a   Cotichini, Rodolfo ^d   Roncalli, Massimo ^b  

^a FATEBENEFRATELLI HOSPITAL   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c San Giacomo Hospital   (Italy)

^d ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

Cirrhosis; High grade dysplastic nodule hepatocellular carcinoma; Large regenerative nodule; Low grade dysplastic nodule

Indexed keywords

ADULT; AGED; ARTICLE; CANCER RISK; CARCINOGENESIS; CELL SUBPOPULATION; CONTROLLED STUDY; DYSPLASIA; ECHOGRAPHY; FEMALE; FOLLOW UP; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CELL CARCINOMA; LIVER REGENERATION; MAJOR CLINICAL STUDY; MALE; MALIGNANT TRANSFORMATION; MORPHOLOGY; PREDICTION; PRIORITY JOURNAL; REGRESSION ANALYSIS; RISK ASSESSMENT; TUMOR CLASSIFICATION;

EID: 0042093775     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(03)00190-9     Document Type: Article

References (27)

1. Bruix J, Llovet MJ. Prognostic prediction and treatment strategy in hepatocellular carcinoma. Hepatology 2002;35:519-524.
2. International Working Party, Terminology of nodular lesions of the liver. Hepatology 1995;22:983-993.
3. Theise N. Macroregenerative (Dysplastic) nodules and hepatocarcinogenesis: theoretical and clinical consideration. Sem Liver Dis 1995;15:360-371.
4. Kondo F, Ebara M, Sugiura N, Wada K, Kita K, Hirooka N, et al. Histological features and clinical course of large regenerative nodules: evaluation of their precancerous potentiality. Hepatology 1990;12:592-598.
5. Takayama T, Makuuchi M, Hirohashi S, Sakamoto M, Okazaki N, Takayasu K, et al. Malignant transformation of adenomatous hyperplasia to hepatocellular carcinoma. Lancet 1990;336:1150-1153.
6. Rapaccini L, Pompili M, Caturelli E, Anti M, Aliotta A, Cedrone A, et al. Focal ultrasound lesions in liver cirrhosis diagnosed as regenerating nodules by fine-needle biopsy. Follow-up of 12 cases. Dig Dis Sci 1990;35:422-427.
7. Seki S, Sakaguchi H, Kitada T, Tamori A, Takeda T, Kawada N, et al. Outcomes of dysplastic nodules in human cirrhotic liver: a clinicopathological study. Clin Cancer Res 2000;6:3469-3473.
8. Borzio M, Borzio F, Croce A, Sala M, Salmi A, Leandro G, et al. Ultrasonography-detected macroregenerative nodules in cirrhosis: a prospective study. Gastroenterology 1997;112:1617-1623.
9. Gibson JB, Sobin LH. Histological typing of tumors of the liver, biliary tract and pancreas. International histological classification of tumors, no. 20. Geneva: World Health Organization; 1978. p. 12-30.
10. Anthony PP, Vogel CL, Barker LF. Liver cell dysplasia: a premalignant condition. J Clin Pathol 1973;26:217-223.
11. Watanabe S, Okita K, Harada T, Kodama T, Numa Y, Takemoto T, et al. Morphologic studies of the liver cell dysplasia. Cancer 1983;51:2197-2205.
12. Kaplan EL, Meier P. Non-parametric estimation for incomplete observation. J Am Star Assoc 1958;53:457-481.
13. Cox DR. Regression models and life tables. J R Star Soc 1972;34:187-220.
14. Colombo M, De Franchis R, Del Ninno E, Sangiovanni A, De Fazio C, Tommasini M, et al. Hepatocellular carcinoma in Italian patients with cirrhosis. N Engl J Med 1991;325:675-680.
15. Chiaramonte M, Stroffolini T, Vian A, Stazi MA, Floreani A, Lorenzoni U, et al. Rate of incidence of hepatocellular carcinoma in patients with compensated viral cirrhosis. Cancer 1999;85:2132-2137.
16. Terasaki S, Kanedo S, Kobayashi K, Nonamoura A, Nakanuma Y, Histological features predicting malignant transformation of non-malignant hepatocellular nodules: a prospective study. Gastroenterology 1998;115:1216-1222.
17. Earls JP, Theise ND, Weinreb JC, DeCorato DR, Krinsky GA, Rofsky NM, et al. Dysplastic nodules and hepatocellular carcinoma: thin-section MR imaging of explanted cirrhotic livers with pathologic correlation. Radiology 1996;201:207-214.
18. Lim JH, Cho JM, Kim EY, Park CK. Dysplastic nodules in liver cirrhosis: evaluation of hemodynamics with CT during arterial portography and CT hepatic arteriography. Radiology 2000;214:869-874.
19. Fracanzani AL, Burdick L, Borzio M, Roncalli M, Bonelli N, Borzio F, et al. Contrast-enhanced doppler ultrasonography in the diagnosis of hepatocellular carcinoma and premalignant lesions in patients with cirrhosis. Hepatology 2001;34:1109-1112.
20. Park YN, Yang CP, Fernandez GJ, Cubukcu O, Thung S, Theise N. Neoangiogenesis and sinusoidal capillarization in dysplastic nodules of the liver. Am J Surg Pathol 1998;22:656-662.
21. Roncalli M, Roz E, Coggi G, Di Rocco MG, Bossi P, Minola E, et al. The vascular profile of regenerative and dysplastic nodules of the cirrhotic liver: implication for diagnosis and classification. Hepatology 1999;30:1174-1178.
22. Le Bail B, Bellannèe G, Bernard P-H, Saric J, Balabaud C, Bioulac-Sage P. Adenomatous hyperplasia in cirrhotic livers: histological evaluation, cellular density, and proliferative activity of 35 macronodular lesions in cirrhotic explants of 10 adult French patients. Hum Pathol 1995;26:897-906.
23. Maggioni M, Coggi G, Cassani B, Bianchi P, Romagnoli S, Mandelli A, et al. Molecular changes in hepatocellular dysplastic nodules on microdissected liver biopsies. Hepatology 2000;32:942-946.
24. Borzio M, Bruno S, Roncalli M, Colloredo Mels G, Ramella G, Borzio F, et al. Liver cell dysplasia is a major risk factor for hepatocellular carcinoma in cirrhosis: a prospective study. Gastroenterology 1995;108:812-817.
25. Ganne-Carrié N, Chastang C, Chapel F, Munz C, Pateron D, Sibony M, et al. Predictive score for the development of hepatocellular carcinoma and additional value of liver large cell dysplasia in Western patients with cirrhosis. Hepatology 1996;23:1112-1118.
26. Lee RG, Tsamandas AC, Demetris AJ. Large cell change (liver cell dysplasia) and hepatocellular carcinoma in cirrhosis: matched case-control study, pathological analysis, and pathogenetic hypothesis. Hepatology 1997;26:1415-1422.
27. Fracanzani AL, Borzio M, Roncalli M, Derenzini M, Trerè D, Mattioli M, et al. Can large cell change and high proliferative activity predict hepatocellular carcinoma in patients with hereditary hemochromatosis. Am J Gastroenterol 2000;95:2940-2945.