Quantitative assessment of hTERT mRNA expression in dysplastic nodules of HBV-related hepatocarcinogenesis

American Journal of Gastroenterology

Volumn 101, Issue 4, 2006, Pages 831-838

  Oh, Bong Kyeong ^a   Kim, Young Joo ^a   Park, Young Nyun ^a   Choi, Jinsub ^b   Kim, Kyung Sik ^b   Park, Chanil ^a  

^a Yonsei University College of Medicine   (South Korea)

^b Yonsei University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; TELOMERASE REVERSE TRANSCRIPTASE;

ADULT; AGED; ARTICLE; CARCINOGENESIS; CHRONIC HEPATITIS; CLINICAL ARTICLE; FEMALE; GENE DOSAGE; HEPATITIS B; HUMAN; HUMAN TISSUE; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER NODULE; MALE; ONCOGENE C MYC; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOUTHERN BLOTTING;

ADULT; AGED; CARCINOMA, HEPATOCELLULAR; DNA-BINDING PROTEINS; FEMALE; GENE DOSAGE; HEPATITIS B; HUMANS; LIVER; LIVER DISEASES; LIVER NEOPLASMS; MALE; MIDDLE AGED; PRECANCEROUS CONDITIONS; PROTO-ONCOGENE PROTEINS C-MYC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TELOMERASE;

EID: 33645452432     PISSN: 00029270     EISSN: 15720241     Source Type: Journal    
DOI: 10.1111/j.1572-0241.2006.00532.x     Document Type: Article

References (50)

1. Nowak AK Chow PK Findlay M. Systemic therapy for advanced hepatocellular carcinoma: A review. Eur J Cancer 2004 40 1474 84.
2. International working party Terminology of nodular hepatocellular lesions. Hepatology 1995 22 983 93.
3. Theise ND Park YN Kojiro M. Dysplastic nodules and hepatocarcinogenesis. Clinics in liver disease. Liver histopathology 1st Ed. Philadelphia W.B. Saunders 2002.
4. Kojiro M. Focus on dysplastic nodules and early hepatocellular carcinoma: An eastern point of view. Liver Transpl 2004 10 S3 8.
5. Ishikawa F. Breakthrough and views. Telomere crisis, the driving force in cancer cell evolution. Biochem Biophys Res Commun 1997 230 1 6.
6. Satyanarayana A Manns MP Rudolph KL. Telomeres and telomerase: A dual role in hepatocarcinogenesis. Hepatology 2004 40 276 83.
7. Feng J Funk WD Wang SS et al. The RNA component of human telomerase. Science 1995 269 1236 41.
8. Harrington L McPhail T Mar V et al. A mammalian telomerase-associated protein. Science 1997 275 973 7.
9. Nakamura TM Morin GB Chapman KB et al. Telomerase catalytic subunit homologs from fission yeast and human. Science 1997 277 955 9.
10. Nakayama J Tahara H Tahara E et al. Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas. Nat Genet 1998 18 65 8.
11. Zhang A Zheng C Hou M et al. Amplification of the telomerase reverse transcriptase (hTERT) gene in cervical carcinomas. Genes Chromosomes Cancer 2002 34 269 75.
12. Reardon DA Michalkiewicz E Boyett JM et al. Extensive genomic abnormalities in childhood medulloblastoma by comparative genomic hybridization. Cancer Res 1997 57 4042 7.
13. Zhang A Zheng C Lindvall C et al. Frequent amplification of the telomerase reverse transcriptase gene in human tumors. Cancer Res 2000 60 6230 5.
14. Eberhart CG Kratz JE Schuster A et al. Comparative genomic hybridization detects an increased number of chromosomal alterations in large cell/anaplastic medulloblastomas. Brain Pathol 2002 12 36 44.
15. Saretzki G Petersen S Petersen I et al. hTERT gene dosage correlates with telomerase activity in human lung cancer cell lines. Cancer Lett 2002 176 81 91.
16. Fan X Wang Y Kratz J et al. hTERT gene amplification and increased mRNA expression in central nervous system embryonal tumors. Am J Pathol 2003 162 1763 9.
17. Wu KJ Grandori C Amacker M et al. Direct activation of TERT transcription by c-MYC. Nat Genet 1999 21 220 4.
18. Wang J Xie LY Allan S et al. Myc activates telomerase. Genes Dev 1998 12 1769 74.
19. Miura N Horikawa I Nishimoto A et al. Progressive telomere shortening and telomerase reactivation during hepatocellular carcinogenesis. Cancer Genet Cytogenet 1997 93 56 62.
20. Oh BK Chae KJ Park C et al. Telomere shortening and telomerase reactivation in dysplastic nodules of human hepatocarcinogenesis. J Hepatol 2003 39 786 92.
21. Hytiroglou P Kotoula V Thung SN et al. Telomerase activity in precancerous hepatic nodules. Cancer 1998 82 1831 8.
22. Chae KJ Rha SY Oh BK et al. Expression of matrix metalloproteinase-2 and -9 and tissue inhibitor of metalloproteinase-1 and -2 in intraductal and nonintraductal growth type of cholangiocarcinoma. Am J Gastroenterol 2004 99 68 75.
23. Marchetti A Pellegrini C Buttitta F et al. Prediction of survival in stage I lung carcinoma patients by telomerase function evaluation. Lab Invest 2002 82 729 36.
24. Lehmann U Glockner S Kleeberger W et al. Detection of gene amplification in archival breast cancer specimens by laser-assisted microdissection and quantitative real-time polymerase chain reaction. Am J Pathol 2000 156 1855 64.
25. Konigshoff M Wilhelm J Bohle RM et al. HER-2/neu gene copy number quantified by real-time PCR: Comparison of gene amplification, heterozygosity, and immunohistochemical status in breast cancer tissue. Clin Chem 2003 49 219 29.
26. Oh BK Kim YJ Park C et al. Upregulation of telomere binding proteins, TRF1, TRF2 and TIN2 is related to telomere shortening during human multistep hepatocarcinogenesis. Am J Pathol 2005 166 73 80.
27. Nishimura T Nishida N Itoh T et al. Comprehensive allelotyping of well-differentiated human hepatocellular carcinoma with semiquantitative determination of chromosomal gain or loss. Genes Chromosomes Cancer 2002 35 329 39.
28. Kusano N Shiraishi K Kubo K et al. Genetic aberrations detected by comparative genomic hybridization in hepatocellular carcinomas: Their relationship to clinicopathological features. Hepatology 1999 29 1858 62.
29. Zimonjic DB Keck CL Thorgeirsson SS et al. Novel recurrent genetic imbalances in human hepatocellular carcinoma cell lines identified by comparative genomic hybridization. Hepatology 1999 29 1208 14.
30. Takeo S Arai H Kusano N et al. Examination of oncogene amplification by genomic DNA microarray in hepatocellular carcinomas: Comparison with comparative genomic hybridization analysis. Cancer Genet Cytogenet 2001 130 127 32.
31. Chang J Kim NG Piao Z et al. Assessment of chromosomal losses and gains in hepatocellular carcinoma. Cancer Lett 2002 182 193 202.
32. Hackett JA Greider CW. Balancing instability: Dual roles for telomerase and telomere dysfunction in tumorigenesis. Oncogene 2002 21 619 26.
33. Satyanarayana A Manns MP Rudolph KL. Telomeres and telomerase: A dual role in hepatocarcinogenesis. Hepatology 2004 40 276 83.
34. Borzio M Fargion S Borzio F et al. Impact of large regenerative, low-grade and high-grade dysplastic nodules in hepatocellular carcioma development. J Hepatol 2003 39 208 14.
35. Yi X Shay JW Wright WE. Quantitation of telomerase components and hTERT mRNA splicing patterns in immortal human cells. Nucleic Acids Res 2001 29 4818 25.
36. Kotoula V Hytiroglou P Pyrpasopoulou A et al. Expression of human telomerase reverse transcriptase in regenerative and precancerous lesions of cirrhotic livers. Liver 2002 22 57 69.
37. Ulaner GA Hu JF Vu TH et al. Telomerase activity in human development is regulated by human telomerase reverse transcriptase (hTERT) transcription and by alternate splicing of hTERT transcripts. Cancer Res 1998 58 4168 72.
38. Ulaner GA Hu JF Vu TH et al. Regulation of telomerase by alternate splicing of human telomerase reverse transcriptase (hTERT) in normal and neoplastic ovary, endometrium and myometrium. Int J Cancer 2000 85 330 5.
39. Takuma Y Nouso K Kobayashi Y et al. Telomerase reverse transcriptase gene amplification in hepatocellular carcinoma. J Gastroenterol Hepatol 2004 19 1300 4.
40. Bryce LA Morrison N Hoare SF et al. Mapping of the gene for the human telomerase reverse transcriptase, hTERT, to chromosome 5p15.33 by fluorescence in situ hybridization. Neoplasia 2000 2 197 201.
41. Szutorisz H Palmqvist R Roos G et al. Rearrangements of minisatellites in the human telomerase reverse transcriptase gene are not correlated with its expression in colon carcinomas. Oncogene 2001 20 2600 5.
42. Ducrest AL Szutorisz H Lingner J et al. Regulation of the human telomerase reverse transcriptase gene. Oncogene 2002 21 541 52.
43. Greenberg RA O'Hagan RC Deng H et al. Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation. Oncogene 1999 18 1219 26.
44. Wu KJ Grandori C Amacker M et al. Direct activation of TERT transcription by c-MYC. Nat Genet 1999 21 220 4.
45. Liu YC Chen CJ Wu HS et al. Telomerase and c-myc expression in hepatocellular carcinomas. Eur J Surg Oncol 2004 30 384 90.
46. Kirkpatrick KL Newbold RF Mokbel K. There is no correlation between c-Myc mRNA expression and telomerase activity in human breast cancer. Int Semin Surg Oncol 2004 1 2 6.
47. Devereux TR Horikawa I Anna CH et al. DNA methylation analysis of the promoter region of the human telomerase reverse transcriptase (hTERT) gene. Cancer Res 1999 59 6087 90.
48. Dessain SK Yu H Reddel RR et al. Methylation of the human telomerase gene CpG island. Cancer Res 2000 60 537 41.
49. Horikawa I Barrett JC. cis-Activation of the human telomerase gene (hTERT) by the hepatitis B virus genome. J Natl Cancer Inst 2001 93 1171 3.
50. Horikawa I Barrett JC. Transcriptional regulation of the telomerase hTERT gene as a target for cellular and viral oncogenic mechanisms. Carcinogenesis 2003 24 1167 76.