Ensemble perspective for catalytic promiscuity: Calorimetric analysis of the active site conformational landscape of a detoxification enzyme

Journal of Biological Chemistry

Volumn 286, Issue 49, 2011, Pages 42770-42776

  Honaker, Matthew T ^a   Acchione, Mauro ^a   Sumida, John P ^a   Atkins, William M ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; BIMODAL DISTRIBUTION; C TERMINUS; CALORIMETRIC ANALYSIS; DETOXIFICATION ENZYMES; ENERGY LANDSCAPE; GLUTATHIONE TRANSFERASE; GLUTATHIONE-S-TRANSFERASE; HIGH SPECIFICITY; INTERMEDIATE TEMPERATURES; ISOFORMS; LANDAU THEORY; LOW TEMPERATURES; MACROSTATES; PARTITION FUNCTIONS; THERMODYNAMIC TREATMENT; UNIMODAL DISTRIBUTION;

DETOXIFICATION; DICHROISM; DIFFERENTIAL SCANNING CALORIMETRY; ENZYMES; PEPTIDES; TEMPERATURE;

POLYPEPTIDES;

GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE A1; GLUTATHIONE TRANSFERASE A4; ISOENZYME;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CATALYTIC PROMISCUITY; CONTROLLED STUDY; DETOXIFICATION; DIFFERENTIAL SCANNING CALORIMETRY; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME CONFORMATION; ENZYME SPECIFICITY; ENZYME SUBSTRATE; ENZYME SUBUNIT; ESCHERICHIA COLI; LIGAND BINDING; LOW TEMPERATURE; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN UNFOLDING; RAT;

CALORIMETRY, DIFFERENTIAL SCANNING; CATALYSIS; CATALYTIC DOMAIN; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HUMANS; KINETICS; MODELS, MOLECULAR; MODELS, STATISTICAL; MOLECULAR CONFORMATION; PROTEIN CONFORMATION; SPECTROPHOTOMETRY; THERMODYNAMICS;

EID: 82755163096     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.304386     Document Type: Article

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