Impaired homocysteine transsulfuration is an indicator of alcoholic liver disease

Journal of Hepatology

Volumn 53, Issue 3, 2010, Pages 551-557

  Medici, Valentina ^a   Peerson, Janet M ^a   Stabler, Sally P ^b   French, Samuel W ^c   Gregory III, Jesse F ^d   Virata, Maria Catrina ^a   Albanese, Antony ^e   Bowlus, Christopher L ^a   Devaraj, Sridevi ^a   Panacek, Edward A ^a   Rahim, Nazir ^a   Richards, John R ^a   Rossaro, Lorenzo ^a   Halsted, Charles H ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c HARBOR UCLA MEDICAL CENTER   (United States)

^d UNIVERSITY OF FLORIDA   (United States)

^e VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Alcohol; Cystathionine; Methionine; Vitamin B6

Indexed keywords

2 AMINOBUTYRIC ACID; BIOCHEMICAL MARKER; CYANOCOBALAMIN; CYSTATHIONINE; CYSTATHIONINE BETA LYASE; CYSTEINE; DIMETHYLGLYCINE; FOLIC ACID; GLYCINE; HOMOCYSTEINE; METHIONINE; PYRIDOXINE; S ADENOSYLHOMOCYSTEINE; S ADENOSYLMETHIONINE; SERINE;

ADULT; AGED; ALCOHOL LIVER DISEASE; ALCOHOLISM; ARTICLE; BLOOD LEVEL; CHEMICAL REACTION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LIVER BIOPSY; LIVER FIBROSIS; LIVER FUNCTION; MALE; PATHOGENESIS; PRIORITY JOURNAL; RISK FACTOR; SULFURATION;

ADULT; AGED; ALCOHOLISM; AMINOBUTYRIC ACIDS; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CYSTATHIONINE; DISEASE PROGRESSION; FEMALE; HOMOCYSTEINE; HUMANS; LIVER; LIVER CIRRHOSIS, ALCOHOLIC; LIVER DISEASES, ALCOHOLIC; MALE; METHIONINE; MIDDLE AGED; SULFUR; YOUNG ADULT;

EID: 77955849533     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2010.03.029     Document Type: Article

References (37)

1. K.K. Kharbanda Alcoholic liver disease and methionine metabolism Semin Liver Dis 29 2009 155 165
2. S.H. Kenyon, A. Nicolaou, and W.A. Gibbons The effect of ethanol and its metabolites upon methionine synthase activity in vitro Alcohol 15 1998 305 309
3. M.A. Avila, M.V. Carretero, E.N. Rodriguez, and J.M. Mato Regulation by hypoxia of methionine adenosyltransferase activity and gene expression in rat hepatocytes Gastroenterology 114 1998 364 371
4. C.H. Halsted, J.A. Villanueva, A.M. Devlin, O. Niemelä, S. Parkkila, and T.A. Garrow Folate deficiency disturbs hepatic methionine metabolism and promotes liver injury in the ethanol-fed micropig Proc Natl Acad Sci USA 99 2002 10072 10077
5. F. Esfandiari, V. Medici, D.H. Wong, S. Jose, M. Dolatshahi, and E. Quinlivan Epigenetic regulation of hepatic endoplasmic reticulum stress pathways in the ethanol-fed cystathionine beta synthase deficient mouse Hepatology 51 2010 932 941
6. Z. Song, Z. Zhou, S. Uriarte, L. Wang, Y.J. Kang, and T. Chen S-adenosylhomocysteine sensitizes to TNF-alpha hepatotoxicity in mice and liver cells: a possible etiological factor in alcoholic liver disease Hepatology 40 2004 989 997
7. J.A. Villanueva, F. Esfandiari, M.E. White, S. Devaraj, S.W. French, and C.H. Halsted S-adenosylmethionine attenuates oxidative liver injury in micropigs fed ethanol with a folate-deficient diet Alcohol Clin Exp Res 31 2007 1934 1943 (Pubitemid 47609648)
8. F. Esfandiari, M. You, J.A. Villanueva, D.H. Wong, S.W. French, and C.H. Halsted S-adenosylmethionine attenuates hepatic lipid synthesis in micropigs fed ethanol with a folate-deficient diet Alcohol Clin Exp Res 31 2007 1231 1239 (Pubitemid 46934391)
9. P.G. O'Connor, and R.S. Schottenfeld Patients with alcohol problems N Engl J Med 338 1998 592 602
10. R.N. Pugh, I.M. Murray-Lyon, J.L. Dawson, M.C. Pietroni, and R. Williams Transection of the oesophagus for bleeding oesophageal varices Br J Surg 60 1973 646 649
11. R. Wiesner, E. Edwards, R. Freeman, A. Harper, R. Kim, and P. Kamath Model for end-stage liver disease (MELD) and allocation of donor livers Gastroenterology 124 2003 91 96
12. J.B. Ubbink, W.J. Serfontein, and L.S. de Villiers Stability of pyridoxal-5-phosphate semicarbazone: applications in plasma vitamin B6 analysis and population surveys of vitamin B6 nutritional status J Chromatogr 342 1985 277 284
13. H. Myrick, S. Henderson, and R.F. Anton Utility of a new assay for carbohydrate-deficient transferrin (Biorad %CDT TIA) to monitor abstinence during a treatment outcome study Alcohol Clin Exp Res 25 2001 1330 1334
14. S.P. Stabler, and R.H. Allen Quantification of serum and urinary S-adenosylmethionine and S-adenosylhomocysteine by stable isotope dilution liquid chromatography mass spectrometry Clin Chem 50 2004 365 372
15. S.W. French, J. Nash, P. Shitabata, K. Kachi, C. Hara, and A. Chedid Pathology of alcoholic liver disease. VA Cooperative Study Group 119 Semin Liver Dis 13 1993 154 169
16. G.A. Berlakovich, T. Soliman, E. Freundorfer, T. Windhager, M. Bodingbauer, and P. Wamser Pretransplant screening of sobriety with carbohydrate-deficient transferrin in patients suffering from alcoholic cirrhosis Transpl Int 17 2004 617 621
17. M.P. Look, R. Riezler, C. Reichel, K.A. Brensing, J.K. Rockstroh, and S.P. Stabler Is the increase in serum cystathionine levels in patients with liver cirrhosis a consequence of impaired homocysteine transsulfuration at the level of gamma-cystathionase? Scand J Gastroenterol 35 2000 866 872
18. V. Herbert, R. Zalusky, and C.S. Davidson Correlation of folate deficiency with alcoholism and associated macrocystosis, anemia, and liver disease Ann Intern Med 58 1963 977 988
19. C.H. Halsted, V. Medici, and F. Esfandiari Influence of alcohol on folate status and methionine metabolism in relation to alcoholic liver disease L. Bailey, Folate in health and disease 2nd ed. 2010 CRC Press Boca Raton, FL 429 448
20. S. Kanazawa, and V. Herbert Total corrinoid, cobalamin (vitamin B12), and cobalamin analogue levels may be normal in serum despite cobalamin in liver depletion in patients with alcoholism Lab Invest 53 1985 108 110
21. H. Baker, O. Frank, R.K. Zetterman, K.S. Rajan, W. ten Hove, and C.M. Leevy Inability of chronic alcoholics with liver disease to use food as a source of folates, thiamin and vitamin B6 Am J Clin Nutr 28 1975 1377 1380
22. L. Lumeng The role of acetaldehyde in mediating the deleterious effect of ethanol on pyridoxal 5′-phosphate J Clin Invest 62 1978 286 293
23. A. González-Quintela, M.J. Dominguez-Santalla, L.F. Pérez, C. Vidal, S. Lojo, and E. Barrio Influence of acute alcohol intake and alcohol withdrawal on circulating levels of IL-6, IL-8, IL-10 and IL-12 Cytokine 12 2000 1437 1440
24. N. Sheron, G. Bird, J. Goka, G. Alexander, and R. Williams Elevated plasma interleukin-6 and increased severity and mortality in alcoholic hepatitis Clin Exp Immunol 84 1991 449 453
25. M. Marcos, M. Gómez-Munuera, I. Pastor, R. González- Sarmiento, and F.J. Laso Tumor necrosis factor polymorphisms and alcoholic liver disease: a HuGE review and meta-analysis Am J Epidemiol 170 2009 948 956
26. S. Naveau, A. Balian, F. Capron, B. Raynard, D. Fallik, and H. Agostini Balance between pro and anti-inflammatory cytokines in patients with acute alcoholic hepatitis Gastroenterol Clin Biol 29 2005 269 274
27. V. von Baehr, W.D. Döcke, M. Plauth, C. Liebenthal, S. Küpferling, and H. Lochs Mechanisms of endotoxin tolerance in patients with alcoholic liver cirrhosis: role of interleukin 10, interleukin 1 receptor antagonist, and soluble tumour necrosis factor receptors as well as effector cell desensitisation Gut 47 2000 281 287
28. J. Grove, A.K. Daly, M.F. Bassendine, E. Gilvarry, and C.P. Day Interleukin 10 promoter region polymorphisms and susceptibility to advanced alcoholic liver disease Gut 46 2000 540 545
29. T.D. Lee, M.R. Sadda, M.H. Mendler, T. Bottiglieri, G. Kanel, and J.M. Mato Abnormal hepatic methionine and glutathione metabolism in patients with alcoholic hepatitis Alcohol Clin Exp Res 28 2004 173 181
30. C. Blasco, J. Caballería, R. Deulofeu, A. Lligoña, A. Parés, and J.M. Lluis Prevalence and mechanisms of hyperhomocysteinemia in chronic alcoholics Alcohol Clin Exp Res 29 2005 1044 1048
31. S.P. Stabler, J. Sekhar, R.H. Allen, H.C. O'Neill, and C.W. White Alpha-lipoic acid induces elevated S-adenosylhomocysteine and depletes S-adenosylmethionine Free Radic Biol Med 47 2009 1147 1153
32. M.A. Avila, C. Berasain, L. Torres, A. Martín-Duce, F.J. Corrales, and H. Yang Reduced mRNA abundance of the main enzymes involved in methionine metabolism in human liver cirrhosis and hepatocellular carcinoma J Hepatol 33 2000 907 914
33. J.W. Miller, J.D. Ribaya-Mercado, R.M. Russell, D.C. Shepard, F.D. Morrow, and E.F. Cochary Effect of vitamin B-6 deficiency on fasting plasma homocysteine concentrations Am J Clin Nutr 55 1992 1154 1160
34. J.B. Ubbink, A. van der Merwe, R. Delport, R.H. Allen, S.P. Stabler, and R. Riezler The effect of a subnormal vitamin B-6 status on homocysteine metabolism J Clin Invest 98 1996 177 184
35. S.P. Stabler, D.A. Sampson, L.P. Wang, and R.H. Allen Elevations of serum cystathionine and total homocysteine in pyridoxine-, folate-, and cobalamin-deficient rats J Nutr Biochem 8 1997 279 289
36. M.H. Stipanuk, I. Ueki, J.E. Dominy Jr., C.R. Simmons, and L.L. Hirschberger Cysteine dioxygenase: a robust system for regulation of cellular cysteine levels Amino Acids 37 2009 55 63
37. S.W. French Effect of chronic ethanol ingestion on liver enzyme changes induced by thiamine, riboflavin, pyridoxine, or choline deficiency J Nutr 88 1966 291 302