S-adenosylmethionine attenuates oxidative liver injury in micropigs fed ethanol with a folate-deficient diet

Alcoholism: Clinical and Experimental Research

Volumn 31, Issue 11, 2007, Pages 1934-1943

  Villanueva, Jesus A ^a   Esfandiari, Farah ^a   White, Mollie E ^a   Devaraj, Sridevi ^a   French, Samuel W ^b   Halsted, Charles H ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b HARBOR UCLA MEDICAL CENTER   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Alcohol; Micropig; Oxidative Liver Injury; S Adenosylmethionine

Indexed keywords

3 NITROTYROSINE; ALCOHOL; CYTOCHROME P450 2E1; GLUTATHIONE; INDUCIBLE NITRIC OXIDE SYNTHASE; MALONALDEHYDE; METHIONINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; S ADENOSYLHOMOCYSTEINE; S ADENOSYLMETHIONINE;

ALCOHOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FOLIC ACID DEFICIENCY; FOOD INTAKE; HISTOPATHOLOGY; LIVER INJURY; LIVER NECROSIS; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; SUPPLEMENTATION; SWINE;

ANIMALS; BODY WEIGHT; DISEASE MODELS, ANIMAL; ETHANOL; FATTY LIVER; FEMALE; FOLIC ACID; FOLIC ACID DEFICIENCY; LINEAR MODELS; LIVER; LIVER DISEASES, ALCOHOLIC; MALE; METHIONINE; NECROSIS; OXIDATIVE STRESS; S-ADENOSYLMETHIONINE; SWINE; SWINE, MINIATURE;

EID: 35348932181     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2007.00511.x     Document Type: Article

References (60)

1. Arteel GE (2003) Oxidants and antioxidants in alcohol-induced liver disease. Gastroenterology 124 : 778 790.
2. Austin RC, Lentz SR, Werstuck GH (2004) Role of hyperhomocysteinemia in endothelial dysfunction and atherothrombotic disease. Cell Death Differ 11 (Suppl. 1 S56 S64.
3. Avila MA, Mingorance J, Martinez-Chantar ML, Casado M, Martin-Sanz P, Bosca L, Mato JM (1997) Regulation of rat liver S-adenosylmethionine synthetase during septic shock: role of nitric oxide. Hepatology 25 : 391 396.
4. Bailey SM, Robinson G, Pinner A, Chamlee L, Ulasova E, Pompilius M, Page GP, Chhieng D, Jhala N, Landar A, Kharbanda KK, Ballinger S, Darley-Usmar V (2006) S-adenosylmethionine prevents chronic alcohol-induced mitochondrial dysfunction in the rat liver. Am J Physiol Gastrointest Liver Physiol 291 : G857 G867.
5. Bailey AL, Wortley G, Southon S (1997) Measurement of aldehydes in low density lipoprotein by high performance liquid chromatography. Free Radic Biol Med 23 : 1078 1085.
6. Barak AJ, Beckenhauer HC, Junnila M, Tuma DJ (1993) Dietary betaine promotes generation of hepatic S-adenosylmethionine and protects the liver from ethanol-induced fatty infiltration. Alcohol Clin Exp Res 17 : 552 555.
7. Barak AJ, Beckenhauer HC, Tuma DJ, Badakhsh S (1987) Effects of prolonged ethanol feeding on methionine metabolism in rat liver. Biochem Cell Biol 65 : 230 233.
8. Cederbaum AI, Wu D, Mari M, Bai J (2001) CYP2E1-dependent toxicity and oxidative stress in HepG2 cells. Free Radic Biol Med 31 : 1539 1543.
9. Clarke S, Banfield K (2001) S-adenosylmethionine-dependent methyltransferases, in Homocysteine in Health and Disease (Carmel R, Jacobsen D eds pp 63 78. Cambridge University Press, Cambridge.
10. Colell A, Garcia-Ruiz C, Morales A, Ballesta A, Ookhtens M, Rodes J, Kaplowitz N, Fernandez-Checa JC (1997) Transport of reduced glutathione in hepatic mitochondria and mitoplasts from ethanol-treated rats: effect of membrane physical properties and S-adenosyl-L-methionine. Hepatology 26 : 699 708.
11. Devaraj S, Glaser N, Griffen S, Wang-Polagruto J, Miguelino E, Jialal I (2006) Increased monocytic activity and biomarkers of inflammation in patients with type 1 diabetes. Diabetes 55 : 774 779.
12. Esfandiari F, Villanueva JA, Wong DH, French SW, Halsted CH (2005) Chronic ethanol feeding and folate deficiency activate hepatic endoplasmic reticulum stress pathway in micropigs. Am J Physiol Gastrointest Liver Physiol 289 : G54 G63.
13. Esfandiari F, You M, Villanueva JA, Wong DH, French SW, Halsted CH (2007) S-adenosylmethionine attenuates hepatic lipid synthesis in micropigs fed ethanol with a folate-deficient diet. Alcohol Clin Exp Res 31 : 1231 1239.
14. Finkelstein JD (2000) Pathways and regulation of homocysteine metabolism in mammals [In Process Citation]. Semin Thromb Hemost 26 : 219 225.
15. Finkelstein JD (2006) Inborn errors of sulfur-containing amino acid metabolism. J Nutr 136 (Suppl. 6 1750S 1754S.
16. Finkelstein JD, Kyle WE, Martin JL, Pick AM (1975) Activation of cystathionine synthase by adenosylmethionine and adenosylethionine. Biochem Biophys Res Commun 66 : 81 87.
17. Foster MW, McMahon TJ, Stamler JS (2003) S-nitrosylation in health and disease. Trends Mol Med 9 : 160 168.
18. French SW, Nash J, Shitabata P, Kachi K, Hara C, Chedid A, Mendenhall CL (1993) Pathology of alcoholic liver disease. VA Cooperative Study Group 119. Semin Liver Dis 13 : 154 169.
19. Gasso M, Rubio M, Varela G, Cabre M, Caballeria J, Alonso E, Deulofem R, Camps J, Gimenez A, Pajares M, Pares A, Mato JM, Rodes J (1996) Effects of S-adenosylmethionine on lipid peroxidation and liver fibrogenesis in carbon tetrachloride-induced cirrhosis. J Hepatol 25 : 200 205.
20. Halsted CH (2004) Nutrition and alcoholic liver disease. Semin Liver Dis 24 : 289 304.
21. Halsted CH, Villanueva J, Chandler CJ, Ruebner B, Munn RJ, Parkkila S, Niemela O (1993) Centrilobular distribution of acetaldehyde and collagen in the ethanol-fed micropig. Hepatology 18 : 954 960.
22. Halsted CH, Villanueva J, Chandler CJ, Stabler SP, Allen RH, Muskhelishvili L, James SJ, Poirier L (1996) Ethanol feeding of micropigs alters methionine metabolism and increases hepatocellular apoptosis and proliferation. Hepatology 23 : 497 505.
23. Halsted CH, Villanueva JA, Devlin AM, Niemela O, Parkkila S, Garrow TA, Wallock LM, Shigenaga MK, Melnyk S, James SJ (2002) Folate deficiency disturbs hepatic methionine metabolism and promotes liver injury in the ethanol-fed micropig. Proc Natl Acad Sci U S A 99 : 10072 10077.
24. Jaeschke H, Gores GJ, Cederbaum AI, Hinson JA, Pessayre D, Lemasters JJ (2002) Mechanisms of hepatotoxicity. Toxicol Sci 65 : 166 176.
25. Ji C, Kaplowitz N (2003) Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice. Gastroenterology 124 : 1488 1499.
26. Kanbagli O, Balkan J, Aykac-Toker G, Uysal M (2002) Hepatic mitochondrial prooxidant and antioxidant status in ethanol-induced liver injury in rats. Biol Pharm Bull 25 : 1482 1484.
27. Kenyon SH, Nicolaou A, Gibbons WA (1998) The effect of ethanol and its metabolites upon methionine synthase activity in vitro. Alcohol 15 : 305 309.
28. Kharbanda KK, Rogers DD II., Mailliard ME, Siford GL, Barak AJ, Beckenhauer HC, Sorrell MF, Tuma DJ (2005) Role of elevated S- adenosylhomocysteine in rat hepatocyte apoptosis: protection by betaine. Biochem Pharmacol 70 : 1883 1890.
29. Koch OR, De Leo ME, Borrello S, Palombini G, Galeotti T (1994) Ethanol treatment up-regulates the expression of mitochondrial manganese superoxide dismutase in rat liver. Biochem Biophys Res Commun 201 : 1356 1365.
30. Kono H, Rusyn I, Yin M, Gabele E, Yamashina S, Dikalova A, Kadiiska MB, Connor HD, Mason RP, Segal BH, Bradford BU, Holland SM, Thurman RG (2000) NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease. J Clin Invest 106 : 867 872.
31. Lee TD, Sadda MR, Mendler MH, Bottiglieri T, Kanel G, Mato JM, Lu SC (2004) Abnormal hepatic methionine and glutathione metabolism in patients with alcoholic hepatitis. Alcohol Clin Exp Res 28 : 173 181.
32. Leusen JH, Meischl C, Eppink MH, Hilarius PM, de Boer M, Weening RS, Ahlin A, Sanders L, Goldblatt D, Skopczynska H, Bernatowska E, Palmblad J, Verhoeven AJ, van Berkel WJ, Roos D (2000) Four novel mutations in the gene encoding gp91-phox of human NADPH oxidase: consequences for oxidase assembly. Blood 95 : 666 673.
33. Lieber CS, Casini A, DeCarli LM, Kim CI, Lowe N, Sasaki R, Leo MA (1990) S-adenosyl-L-methionine attenuates alcohol-induced liver injury in the baboon. Hepatology 11 : 165 172.
34. Marklund S, Marklund G (1974) Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem 47 : 469 474.
35. Mato JM, Corrales FJ, Lu SC, Avila MA (2002) S-adenosylmethionine: a control switch that regulates liver function. FASEB J 16 : 15 26.
36. Melnyk S, Pogribna M, Pogribny IP, Yi P, James SJ (2000) Measurement of plasma and intracellular S-adenosylmethionine and S-adenosylhomocysteine utilizing coulometric electrochemical detection: alterations with plasma homocysteine and pyridoxal 5′-phosphate concentrations. Clin Chem 46 : 265 272.
37. Nakamura MT, Tang AB, Villanueva J, Halsted CH, Phinney SD (1993) The body composition and lipid metabolic effects of long-term ethanol feeding during a high omega 6 polyunsaturated fatty acid diet in micropigs. Metabolism 42 : 1340 1350.
38. Niemela O, Parkkila S, Pasanen M, Viitala K, Villanueva JA, Halsted CH (1999) Induction of cytochrome P450 enzymes and generation of protein-aldehyde adducts are associated with sex-dependent sensitivity to alcohol-induced liver disease in micropigs. Hepatology 30 : 1011 1017.
39. Prudova A, Bauman Z, Braun A, Vitvitsky V, Lu SC, Banerjee R (2006) S-adenosylmethionine stabilizes cystathionine beta-synthase and modulates redox capacity. Proc Natl Acad Sci U S A 103 : 6489 6494.
40. Quijano C, Hernandez-Saavedra D, Castro L, McCord JM, Freeman BA, Radi R (2001) Reaction of peroxynitrite with Mn-superoxide dismutase. Role of the metal center in decomposition kinetics and nitration. J Biol Chem 276 : 11631 11638.
41. Selhub J (1999) Homocysteine metabolism. Annu Rev Nutr 19 : 217 246.
42. Song Z, McClain CJ, Chen T (2004a) S-adenosylmethionine protects against acetaminophen-induced hepatotoxicity in mice. Pharmacology 71 : 199 208.
43. Song Z, Zhou Z, Uriarte S, Wang L, Kang YJ, Chen T, Barve S, McClain CJ (2004b) S-adenosylhomocysteine sensitizes to TNF-alpha hepatotoxicity in mice and liver cells: a possible etiological factor in alcoholic liver disease. Hepatology 40 : 989 997.
44. Spitzer JA, Zheng M, Kolls JK, Vande Stouwe C, Spitzer JJ (2002) Ethanol and LPS modulate NF-kappaB activation, inducible NO synthase and COX-2 gene expression in rat liver cells in vivo. Front Biosci 7 : a99 a108.
45. Subcommittee on Swine Nutrition (1998) Nutrient Requirements of Swine. 10th ed. National Academy of Sciences, Washington, DC.
46. Tambyrajah WS, Doran E, Wood JD, McGivan JD (2004) The pig CYP2E1 promoter is activated by COUP-TF1 and HNF-1 and is inhibited by androstenone. Arch Biochem Biophys 431 : 252 260.
47. Tamura T (1990) Microbiological assay of folates, in Folic Acid Metabolism in Health and Disease (Picciano M, Stokstad ELR, Gregory JF III. eds) Vol 13, pp 121 138. Wiley-Liss, New York, NY.
48. Trimble KC, Molloy AM, Scott JM, Weir DG (1993) The effect of ethanol on one-carbon metabolism: increased methionine catabolism and lipotrope methyl-group wastage. Hepatology 18 : 984 989.
49. Vendemiale G, Altomare E, Trizio T, Le Grazie C, Di Padova C, Salerno MT, Carrieri V, Albano O (1989) Effects of oral S-adenosyl-L-methionine on hepatic glutathione in patients with liver disease. Scand J Gastroenterol 24 : 407 415.
50. Villanueva JA, Esfandiari F, Wong DH, Ahmad I, Melnyk S, James SJ, Halsted CH (2006) Abnormal transsulfuration and glutathione metabolism in the micropig model of alcoholic liver disease. Alcohol Clin Exp Res 30 : 1262 1270.
51. Villanueva JA, Halsted CH (2004) Hepatic transmethylation reactions in micropigs with alcoholic liver disease. Hepatology 39 : 1303 1310.
52. Wang YZ, Cao YQ, Wu JN, Chen M, Cha XY (2005) Expression of nitric oxide synthase in human gastric carcinoma and its relation to p53, PCNA. World J Gastroenterol 11 : 46 50.
53. Wang X, Cederbaum AI (2006) S-adenosyl-L-methionine attenuates hepatotoxicity induced by agonistic Jo2 Fas antibody following CYP2E1 induction in mice. J Pharmacol Exp Ther 317 : 44 52.
54. Wu D, Cederbaum AI (2005) Oxidative stress mediated toxicity exerted by ethanol-inducible CYP2E1. Toxicol Appl Pharmacol 207 (Suppl. 2 70 76.
55. Yamakura F, Taka H, Fujimura T, Murayama K (1998) Inactivation of human manganese-superoxide dismutase by peroxynitrite is caused by exclusive nitration of tyrosine 34 to 3-nitrotyrosine. J Biol Chem 273 : 14085 14089.
56. Yi P, Melnyk S, Pogribna M, Pogribny IP, Hine RJ, James SJ (2000) Increase in plasma homocysteine associated with parallel increases in plasma S-adenosylhomocysteine and lymphocyte DNA hypomethylation. J Biol Chem 275 : 29318 29323.
57. Yu Z, Kone BC (2004) Hypermethylation of the inducible nitric-oxide synthase gene promoter inhibits its transcription. J Biol Chem 279 : 46954 46961.
58. Zhang X, Chen J, Graham SH, Du L, Kochanek PM, Draviam R, Guo F, Nathaniel PD, Szabo C, Watkins SC, Clark RS (2002) Intranuclear localization of apoptosis-inducing factor (AIF) and large scale DNA fragmentation after traumatic brain injury in rats and in neuronal cultures exposed to peroxynitrite. J Neurochem 82 : 181 191.
59. Zidenberg-Cherr S, Halsted CH, Olin KL, Reisenauer AM, Keen CL (1990) The effect of chronic alcohol ingestion on free radical defense in the miniature pig. J Nutr 120 : 213 217.
60. Zidenberg-Cherr S, Olin KL, Villanueva J, Tang A, Phinney SD, Halsted CH, Keen CL (1991) Ethanol-induced changes in hepatic free radical defense mechanisms and fatty-acid composition in the miniature pig. Hepatology 13 : 1185 1192.