Acute ethanol exposure inhibits renal folate transport, but repeated exposure upregulates folate transport proteins in rats and human cells

Journal of Nutrition

Volumn 137, Issue 5, 2007, Pages 1260-1265

  Romanoff, Rachelle L ^a   Ross, Donna M ^a   McMartin, Kenneth E ^a  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 METHYLTETRAHYDROFOLIC ACID; ALCOHOL; FOLATE RECEPTOR; FOLIC ACID; REDUCED FOLATE CARRIER;

ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIETARY INTAKE; EXPOSURE; FOLATE METABOLISM; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR TRANSPORT; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE ABSORPTION; KIDNEY TUBULE CELL; MALE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RAT; UPREGULATION; URINARY EXCRETION; WESTERN BLOTTING;

RATTUS;

EID: 34247847680     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.1093/jn/137.5.1260     Document Type: Article

References (40)

1. Eichner ER, Hillman RS. The evolution of anemia in alcoholic patients. Am J Med. 1971;50:218-32.
2. Halsted CH. Folate deficiency in alcoholism. Am J Clin Nutr. 1980;33:2736-40.
3. Czeizel AE, Dudas I. Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. N Engl J Med. 1992;327:1832-5.
4. MRC Vitamin Study Research Group. Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. Lancet. 1991;338:131-7.
5. Brattström LE, Israelsson B, Jeppsson JO, Hultberg BL. Folic acid: an innocuous means to reduce plasma homocysteine. Scand J Clin Lab Invest. 1998;48:215-21.
6. Selhub J, Jacques PF, Boston AG, D'Agostino RB, Wilson PWF, Belanger AJ, O'Leary DH, Wolf PA, Rush D, et al. Relationship between plasma homocysteine, vitamin status and extracranial carotid-artery stenosis in the Framingham Study population. J Nutr. 1996;126:S1258-65.
7. Herbert V, Zalusky R, Davidson CS. Correlation of folate deficiency with alcoholism and associated macrocytosis, anemia and liver disease. Ann Intern Med. 1963;58:977-88.
8. 3[H] folic acid in the chronic alcoholic monkey. Gastroenterology. 1981;80:99-102.
9. Tamura T, Romero JJ, Watson JE, Gong EJ, Halsted CH. Hepatic folate metabolism in the chronic alcoholic monkey. J Lab Clin Med. 1981;97:654-61.
10. Weir DG, McGing PG, Scott JM. Folate metabolism, the enterohepatic circulation and alcohol. Biochem Pharmacol. 1985;34:1-7.
11. Lindenbaum J, Lieber CS. Hematologic effects of alcohol in man in the absence of nutritional deficiency. N Engl J Med. 1969;281:333-8.
12. Tamura T, Halsted CH. Folate turnover in chronically alcoholic monkeys. J Lab Clin Med. 1983;101:623-8.
13. McMartin KE. Increased urinary folate excretion and decreased plasma folate levels in the rat after acute ethanol treatment. Alcohol Clin Exp Res. 1984;8:172-8.
14. Eichner ER, Hillman RS. Effect of alcohol on serum folate level. J Clin Invest. 1973;52:584-91.
15. Paine CJ, Eichner ER, Dickson V. Concordance of radioassay and microbiological assay in the study of the ethanol-induced fall in serum folate level. Am J Med Sci. 1973;266:134-8.
16. McMartin KE, Collins TD. Role of ethanol metabolism in the alcohol-induced increase in urinary folate excretion in rats. Biochem Pharmacol. 1983;32:2549-55.
17. McMartin KE, Collins TD, Eisenga BH, Fortney T, Bates WR, Bairnsfather L. Effects of chronic ethanol and diet treatment on urinary folate excretion and development of folate deficiency in the rat. J Nutr. 1989;119:1490-7.
18. Russell RM, Rosenberg IH, Wilson DP, Iber FL, Oaks EB, Giovetti AC, Otradovec CL, Karwoski PA, Press AW. Increased urinary excretion and prolonged turnover time of folic acid during ethanol ingestion. Am J Clin Nutr. 1983;38:64-70.
19. McMartin KE, Collins TD, Shiao CQ, Vidrine L, Redetzki HM. Study of dose-dependence and urinary folate excretion produced by ethanol in humans and rats. Alcohol Clin Exp Res. 1986;10:419-24.
20. Eisenga BH, Collins TD, McMartin KE. Differential effects of acute ethanol on urinary excretion of folate derivatives in the rat. J Pharmacol Exp Ther. 1989;248:916-22.
21. Muldoon RT, McMartin KE. Ethanol acutely impairs the renal conservation of 5-methyltetrahydrofolate in the isolated perfused rat kidney. Alcohol Clin Exp Res. 1994;18:333-9.
22. Jansen G. Receptor- and carrier-mediated transport systems for folates and antifolates. In: Jackman AL, editor. Anticancer drug development guide: antifolate drugs in cancer therapy. Totowa (NJ): Humana Press; 1999.
23. Antony AC. Folate receptors. Annu Rev Nutr. 1996;16:501-21.
24. Kamen BA, Johnson CA, Wang M-T, Anderson RGW. The folate receptor works in tandem with a probenecid-sensitive carrier in MA104 cells in vitro. J Clin Invest. 1991;87:1442-9.
25. Rothberg KG, Ying Y, Kolhouse JF, Kamen BA, Anderson RGW. The glycophospholipid-linked folate receptor internalizes folate without entering the clathrin-coated pit endocytic pathway. J Cell Biol. 1990;110:637-49.
26. Morshed KM, Ross DM, McMartin KE. Folate transport proteins mediate the bi-directional transport of 5-methyltetrahydrofolate in cultured human proximal tubule cells. J Nutr. 1997;127:1137-47.
27. Morshed KM, McMartin KE. Transient alterations in cellular permeability in cultured human proximal tubule cells: implications for transport studies. In Vitro Cell Dev Biol Anim. 1995;31:107-14.
28. Todd JH, McMartin KE, Sens DA. Enzymatic isolation and serum-free culture of human renal cells retaining properties of proximal tubule cells. In: Jones GE, editor. Human cell culture protocols. New York: Humana Press; 1996. p. 431-5.
29. Detrisac CJ, Sens MA, Garvin AJ, Spicer SS, Sens DA. Tissue culture of human kidney epithelial cells of proximal tubule origin. Kidney Int. 1984;25:383-90.
30. Morshed KM, McMartin KE. Reabsorptive and secretory 5- methyltetrahydrofolate transport pathways in cultured human proximal tubule cells. Am J Physiol. 1997;272:F380-8.
31. Baker RN, Alenty AL, Zack JF Jr. Simultaneous determination of lower alcohols, acetone and acetaldehyde in blood by gas chromatography. J Chromatogr Sci. 1969;7:312-4.
32. Horne DW. Microbiological assay of folates in 96-well microtiter plates. Methods Enzymol. 1997;281:38-43.
33. Bhandari SD, Joshi SK, McMartin KE. Folate binding and transport by rat kidney brush-border membrane vesicles. Biochim Biophys Acta. 1988;937:211-8.
34. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970;227:680-5.
35. Da Costa M, Rothenberg SP. Purification and characterization of folate binding proteins from rat placenta. Biochim Biophys Acta. 1996;1292:23-30.
36. Wong SC, Zhang L, Witt TL, Proefke SA, Bhushan A, Matherly LH. Impaired methotrexate transport in methotrexate-resistant CCRF-CEM cells involves early translation termination and increased turnover of a mutant reduced folate carrier. J Biol Chem. 1999;274:10388-94.
37. Villanueva J, Ling E-H, Chandler CJ, Halsted CH. Membrane and tissue distribution of folate binding protein in pig. Am J Physiol. 1998;275:R1503-10.
38. Kempson SA, McAteer JA, Al-Mahrouq HA, Dousa TP, Dougherty GS, Evan AP. Proximal tubule characteristics of cultured human renal cortex epithelium. J Lab Clin Med. 1989;113:285-96.
39. Hamid A, Kaur J. Kinetic characteristics of folate binding to rat renal brush border membrane in chronic alcoholism. Mol Cell Biochem. 2005;280:219-25.
40. Hamid A, Kaur J. Chronic alcoholism alters the transport characteristics of folate in rat renal brush border membrane. Alcohol. 2006;38:59-66.