-
1
-
-
0025247229
-
Autosomal dominant polycystic kidney disease-more than a renal disease
-
Gabow PA. Autosomal dominant polycystic kidney disease-more than a renal disease. Am J Kidney Dis 1990; 16: 403-413.
-
(1990)
Am J Kidney Dis
, vol.16
, pp. 403-413
-
-
Gabow, P.A.1
-
2
-
-
0030582668
-
The molecular basis of focal cyst formation in human autosomal dominant polycystic kidney disease type i
-
Qian F, Watnick TJ, Onuchic LF et al. The molecular basis of focal cyst formation in human autosomal dominant polycystic kidney disease type I. Cell 1996; 87: 979-987.
-
(1996)
Cell
, vol.87
, pp. 979-987
-
-
Qian, F.1
Watnick, T.J.2
Onuchic, L.F.3
-
3
-
-
0030887477
-
Molecular basis of renal cyst formation-one hit or two?
-
Ong AC, Harris PC. Molecular basis of renal cyst formation-one hit or two? Lancet 1997; 349: 1039-1040.
-
(1997)
Lancet
, vol.349
, pp. 1039-1040
-
-
Ong, A.C.1
Harris, P.C.2
-
4
-
-
63949086532
-
Incompletely penetrant PKD1 alleles suggest a role for gene dosage in cyst initiation in polycystic kidney disease
-
Rossetti S, Kubly VJ, Consugar MB et al. Incompletely penetrant PKD1 alleles suggest a role for gene dosage in cyst initiation in polycystic kidney disease. Kidney Int 2009; 75: 848-855.
-
(2009)
Kidney Int
, vol.75
, pp. 848-855
-
-
Rossetti, S.1
Kubly, V.J.2
Consugar, M.B.3
-
5
-
-
77954598398
-
Incompletely penetrant PKD1 alleles mimic the renal manifestations of ARPKD
-
Vujic M, Heyer CM, Ars E et al. Incompletely penetrant PKD1 alleles mimic the renal manifestations of ARPKD. J Am Soc Nephrol 2010; 21: 1097-1102.
-
(2010)
J Am Soc Nephrol
, vol.21
, pp. 1097-1102
-
-
Vujic, M.1
Heyer, C.M.2
Ars, E.3
-
6
-
-
84856019824
-
Neonatal onset autosomal dominant polycystic kidney disease (ADPKD) in a patient homozygous for a PKD2 missense mutation due to uniparental disomy
-
Losekoot M, Ruivenkamp CAL, Tholens AP et al. Neonatal onset autosomal dominant polycystic kidney disease (ADPKD) in a patient homozygous for a PKD2 missense mutation due to uniparental disomy. J Med Genet 2012; 49: 37-40.
-
(2012)
J Med Genet
, vol.49
, pp. 37-40
-
-
Losekoot, M.1
Ruivenkamp, C.A.L.2
Tholens, A.P.3
-
7
-
-
0026786024
-
Renal histology in polycystic kidney disease with incipient and advanced renal failure
-
Zeier M, Fehrenbach P, Geberth S et al. Renal histology in polycystic kidney disease with incipient and advanced renal failure. Kidney Int 1992; 42: 1259-1265.
-
(1992)
Kidney Int
, vol.42
, pp. 1259-1265
-
-
Zeier, M.1
Fehrenbach, P.2
Geberth, S.3
-
8
-
-
0033865917
-
Progressive renal fibrosis in murine polycystic kidney disease: An immunohistochemical observation
-
Okada H, Ban S, Nagao S et al. Progressive renal fibrosis in murine polycystic kidney disease: an immunohistochemical observation. Kidney Int 2000; 58: 587-597.
-
(2000)
Kidney Int
, vol.58
, pp. 587-597
-
-
Okada, H.1
Ban, S.2
Nagao, S.3
-
9
-
-
0028869162
-
Polycystic kidney disease: Etiology, pathogenesis, and treatment
-
Martinez JR, Grantham JJ. Polycystic kidney disease: etiology, pathogenesis, and treatment. Dis Mon 1995; 41: 693-765.
-
(1995)
Dis Mon
, vol.41
, pp. 693-765
-
-
Martinez, J.R.1
Grantham, J.J.2
-
10
-
-
19944406428
-
Lowering of Pkd1 expression is sufficient to cause polycystic kidney disease
-
Lantinga-van Leeuwen IS, Dauwerse JG, Baelde HJ et al. Lowering of Pkd1 expression is sufficient to cause polycystic kidney disease. Hum Mol Genet 2004; 13: 3069-3077.
-
(2004)
Hum Mol Genet
, vol.13
, pp. 3069-3077
-
-
Lantinga-Van Leeuwen, I.S.1
Dauwerse, J.G.2
Baelde, H.J.3
-
11
-
-
35148840431
-
Pathogenic sequence for dissecting aneurysm formation in a hypomorphic polycystic kidney disease 1 mouse model
-
Hassane S, Claij N, Lantinga-van Leeuwen IS et al. Pathogenic sequence for dissecting aneurysm formation in a hypomorphic polycystic kidney disease 1 mouse model. Arterioscler Thromb Vasc Biol 2007; 27: 2177-2183.
-
(2007)
Arterioscler Thromb Vasc Biol
, vol.27
, pp. 2177-2183
-
-
Hassane, S.1
Claij, N.2
Lantinga-Van Leeuwen, I.S.3
-
12
-
-
77955494879
-
Elevated TGFbeta-Smad signalling in experimental Pkd1 models and human patients with polycystic kidney disease
-
Hassane S, Leonhard WN, van der Wal A et al. Elevated TGFbeta-Smad signalling in experimental Pkd1 models and human patients with polycystic kidney disease. J Pathol 2010; 222: 21-31.
-
(2010)
J Pathol
, vol.222
, pp. 21-31
-
-
Hassane, S.1
Leonhard, W.N.2
Van Der Wal, A.3
-
13
-
-
0028278058
-
The polycystic kidney disease 1 gene encodes a 14 kb transcript and lies within a duplicated region on chromosome
-
The European Polycystic Kidney Disease Consortium
-
The European Polycystic Kidney Disease Consortium. The polycystic kidney disease 1 gene encodes a 14 kb transcript and lies within a duplicated region on chromosome. Cell 1994; 77: 881-894.
-
(1994)
Cell
, vol.77
, pp. 881-894
-
-
-
14
-
-
77958456505
-
Association of urinary biomarkers with disease severity in patients with autosomal dominant polycystic kidney disease: A cross-sectional analysis
-
Meijer E, Boertien WE, Nauta FL et al. Association of urinary biomarkers with disease severity in patients with autosomal dominant polycystic kidney disease: a cross-sectional analysis. Am J Kidney Dis 2010; 56: 883-895.
-
(2010)
Am J Kidney Dis
, vol.56
, pp. 883-895
-
-
Meijer, E.1
Boertien, W.E.2
Nauta, F.L.3
-
15
-
-
34447565155
-
Neutrophil gelatinaseassociated lipocalin in patients with autosomal-dominant polycystic kidney disease
-
Bolignano D, Coppolino G, Campo S et al. Neutrophil gelatinaseassociated lipocalin in patients with autosomal-dominant polycystic kidney disease. Am J Nephrol 2007; 27: 373-378.
-
(2007)
Am J Nephrol
, vol.27
, pp. 373-378
-
-
Bolignano, D.1
Coppolino, G.2
Campo, S.3
-
16
-
-
49749086512
-
Neutrophil gelatinaseassociated lipocalin (NGAL) as a marker of kidney damage
-
Bolignano D, Donato V, Coppolino G et al. Neutrophil gelatinaseassociated lipocalin (NGAL) as a marker of kidney damage. Am J Kidney Dis 2008; 52: 595-605.
-
(2008)
Am J Kidney Dis
, vol.52
, pp. 595-605
-
-
Bolignano, D.1
Donato, V.2
Coppolino, G.3
-
17
-
-
50849141709
-
Characterization of the renal cyst fluid proteome in autosomal dominant polycystic kidney disease (ADPKD) patients
-
Lai X, Bacallao RL, Blazer-Yost BL et al. Characterization of the renal cyst fluid proteome in autosomal dominant polycystic kidney disease (ADPKD) patients. Proteomics Clin Appl 2008; 2: 1140-1152.
-
(2008)
Proteomics Clin Appl
, vol.2
, pp. 1140-1152
-
-
Lai, X.1
Bacallao, R.L.2
Blazer-Yost, B.L.3
-
18
-
-
37249025309
-
Overexpression of innate immune response genes in a model of recessive polycystic kidney disease
-
Mrug M, Zhou J, Woo Y et al. Overexpression of innate immune response genes in a model of recessive polycystic kidney disease. Kidney Int 2008; 73: 63-76.
-
(2008)
Kidney Int
, vol.73
, pp. 63-76
-
-
Mrug, M.1
Zhou, J.2
Woo, Y.3
-
19
-
-
0035834136
-
Cardiovascular, skeletal, and renal defects in mice with a targeted disruption of the Pkd1 gene
-
Boulter C, Mulroy S, Webb S et al. Cardiovascular, skeletal, and renal defects in mice with a targeted disruption of the Pkd1 gene. Proc Natl Acad Sci USA 2001; 98: 12174-12179.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 12174-12179
-
-
Boulter, C.1
Mulroy, S.2
Webb, S.3
-
20
-
-
0034652247
-
Polycystin 1 is required for the structural integrity of blood vessels
-
Kim K, Drummond I, Ibraghimov-Beskrovnaya O et al. Polycystin 1 is required for the structural integrity of blood vessels. Proc Natl Acad Sci USA 2000; 97: 1731-1736.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 1731-1736
-
-
Kim, K.1
Drummond, I.2
Ibraghimov-Beskrovnaya, O.3
-
21
-
-
0037098955
-
Pioglitazone improves the phenotype and molecular defects of a targeted Pkd1 mutant
-
Muto S, Aiba A, Saito Y et al. Pioglitazone improves the phenotype and molecular defects of a targeted Pkd1 mutant. Hum Mol Genet 2002; 11: 1731-1742.
-
(2002)
Hum Mol Genet
, vol.11
, pp. 1731-1742
-
-
Muto, S.1
Aiba, A.2
Saito, Y.3
-
22
-
-
0033989173
-
Cardiac defects and renal failure in mice with targeted mutations in Pkd2
-
Wu G, Markowitz GS, Li L et al. Cardiac defects and renal failure in mice with targeted mutations in Pkd2. Nat Genet 2000; 24: 75-78.
-
(2000)
Nat Genet
, vol.24
, pp. 75-78
-
-
Wu, G.1
Markowitz, G.S.2
Li, L.3
-
23
-
-
0035504102
-
Comparison of Pkd1-targeted mutants reveals that loss of polycystin-1 causes cystogenesis and bone defects
-
Lu W, Shen X, Pavlova A et al. Comparison of Pkd1-targeted mutants reveals that loss of polycystin-1 causes cystogenesis and bone defects. Hum Mol Genet 2001; 10: 2385-2396.
-
(2001)
Hum Mol Genet
, vol.10
, pp. 2385-2396
-
-
Lu, W.1
Shen, X.2
Pavlova, A.3
-
24
-
-
84892933118
-
Toward understanding Pkd1 cystogenetic mechanism
-
Trudel M, Kurbegovic A. Toward understanding Pkd1 cystogenetic mechanism. J Am Soc Nephrol 2011; 22: 59A.
-
(2011)
J Am Soc Nephrol
, vol.22
-
-
Trudel, M.1
Kurbegovic, A.2
-
25
-
-
77950256964
-
Glomerular and proximal tubule cysts as early manifestations of Pkd1 deletion
-
Ahrabi AK, Jouret F, Marbaix E et al. Glomerular and proximal tubule cysts as early manifestations of Pkd1 deletion. Nephrol Dial Transplant 2010; 25: 1067-1078.
-
(2010)
Nephrol Dial Transplant
, vol.25
, pp. 1067-1078
-
-
Ahrabi, A.K.1
Jouret, F.2
Marbaix, E.3
-
26
-
-
30344471203
-
Defining a link with autosomaldominant polycystic kidney disease in mice with congenitally low expression of Pkd1
-
Jiang ST, Chiou YY, Wang E et al. Defining a link with autosomaldominant polycystic kidney disease in mice with congenitally low expression of Pkd1. Am J Pathol 2006; 168: 205-220.
-
(2006)
Am J Pathol
, vol.168
, pp. 205-220
-
-
Jiang, S.T.1
Chiou, Y.Y.2
Wang, E.3
-
27
-
-
77958016655
-
Progressive renal distortion by multiple cysts in transgenic mice expressing artificial microRNAs against Pkd1
-
Wang E, Hsieh-Li HM, Chiou YY et al. Progressive renal distortion by multiple cysts in transgenic mice expressing artificial microRNAs against Pkd1. J Pathol 2010; 222: 238-248.
-
(2010)
J Pathol
, vol.222
, pp. 238-248
-
-
Wang, E.1
Hsieh-Li, H.M.2
Chiou, Y.Y.3
-
28
-
-
0034970744
-
Potential role of modifier genes influencing transforming growth factor-beta1 levels in the development of vascular defects in endoglin heterozygous mice with hereditary hemorrhagic telangiectasia
-
Bourdeau A, Faughnan ME, McDonald ML et al. Potential role of modifier genes influencing transforming growth factor-beta1 levels in the development of vascular defects in endoglin heterozygous mice with hereditary hemorrhagic telangiectasia. Am J Pathol 2001; 158: 2011-2020.
-
(2001)
Am J Pathol
, vol.158
, pp. 2011-2020
-
-
Bourdeau, A.1
Faughnan, M.E.2
McDonald, M.L.3
-
29
-
-
33646462753
-
Selective cyclooxygenase-2 inhibition with celecoxib decreases angiotensin II-induced abdominal aortic aneurysm formation in mice
-
King VL, Trivedi DB, Gitlin JM et al. Selective cyclooxygenase-2 inhibition with celecoxib decreases angiotensin II-induced abdominal aortic aneurysm formation in mice. Arterioscler Thromb Vasc Biol 2006; 26: 1137-1143.
-
(2006)
Arterioscler Thromb Vasc Biol
, vol.26
, pp. 1137-1143
-
-
King, V.L.1
Trivedi, D.B.2
Gitlin, J.M.3
-
30
-
-
65349114100
-
Inhibition of autoregulated TGFbeta signaling simultaneously enhances proliferation and differentiation of kidney epithelium and promotes repair following renal ischemia
-
Geng H, Lan R, Wang G et al. Inhibition of autoregulated TGFbeta signaling simultaneously enhances proliferation and differentiation of kidney epithelium and promotes repair following renal ischemia. Am J Pathol 2009; 174: 1291-1308.
-
(2009)
Am J Pathol
, vol.174
, pp. 1291-1308
-
-
Geng, H.1
Lan, R.2
Wang, G.3
-
31
-
-
0037884961
-
Kidney-specific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease
-
Lin F, Hiesberger T, Cordes K et al. Kidney-specific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease. Proc Natl Acad Sci USA 2003; 100: 5286-5291.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 5286-5291
-
-
Lin, F.1
Hiesberger, T.2
Cordes, K.3
-
32
-
-
67649884993
-
Toxic tubular injury in kidneys from Pkd1-deletion mice accelerates cystogenesis accompanied by dysregulated planar cell polarity and canonical Wnt signaling pathways
-
Happé H, Leonhard WN, van der Wal A et al. Toxic tubular injury in kidneys from Pkd1-deletion mice accelerates cystogenesis accompanied by dysregulated planar cell polarity and canonical Wnt signaling pathways. Hum Mol Genet 2009; 18: 2532-2542.
-
(2009)
Hum Mol Genet
, vol.18
, pp. 2532-2542
-
-
Happé, H.1
Leonhard, W.N.2
Van Der Wal, A.3
-
33
-
-
67249125789
-
Systems biology of autosomal dominant polycystic kidney disease (ADPKD): Computational identification of gene expression pathways and integrated regulatory networks
-
Song X, Di G V, He N et al. Systems biology of autosomal dominant polycystic kidney disease (ADPKD): computational identification of gene expression pathways and integrated regulatory networks. Hum Mol Genet 2009; 18: 2328-2343.
-
(2009)
Hum Mol Genet
, vol.18
, pp. 2328-2343
-
-
Song, X.1
Di, G.V.2
He, N.3
-
34
-
-
79953787286
-
Altered Hippo signalling in polycystic kidney disease
-
Happé H, van der Wal AM, Leonhard WN et al. Altered Hippo signalling in polycystic kidney disease. J Pathol 2011; 224: 133-142.
-
(2011)
J Pathol
, vol.224
, pp. 133-142
-
-
Happé, H.1
Van Der Wal, A.M.2
Leonhard, W.N.3
-
35
-
-
80053557318
-
Macrophages promote cyst growth in polycystic kidney disease
-
Karihaloo A, Koraishy F, Huen SC et al. Macrophages promote cyst growth in polycystic kidney disease. J Am Soc Nephrol 2011; 22: 1809-1814.
-
(2011)
J Am Soc Nephrol
, vol.22
, pp. 1809-1814
-
-
Karihaloo, A.1
Koraishy, F.2
Huen, S.C.3
-
36
-
-
56749174940
-
Exploring the full spectrum of macrophage activation
-
Mosser DM, Edwards JP. Exploring the full spectrum of macrophage activation. Nat Rev Immunol 2008; 8: 958-969.
-
(2008)
Nat Rev Immunol
, vol.8
, pp. 958-969
-
-
Mosser, D.M.1
Edwards, J.P.2
-
37
-
-
77953304171
-
Correlation of kidney function, volume and imaging findings, and PKHD1 mutations in 73 patients with autosomal recessive polycystic kidney disease
-
Gunay-Aygun M, Font-Montgomery E, Lukose L et al. Correlation of kidney function, volume and imaging findings, and PKHD1 mutations in 73 patients with autosomal recessive polycystic kidney disease. Clin J Am Soc Nephrol 2010; 5: 972-984.
-
(2010)
Clin J Am Soc Nephrol
, vol.5
, pp. 972-984
-
-
Gunay-Aygun, M.1
Font-Montgomery, E.2
Lukose, L.3
-
38
-
-
20144375384
-
Clinical consequences of PKHD1 mutations in 164 patients with autosomal-recessive polycystic kidney disease (ARPKD)
-
Bergmann C, Senderek J, Windelen E et al. Clinical consequences of PKHD1 mutations in 164 patients with autosomal-recessive polycystic kidney disease (ARPKD). Kidney Int 2005; 67: 829-848.
-
(2005)
Kidney Int
, vol.67
, pp. 829-848
-
-
Bergmann, C.1
Senderek, J.2
Windelen, E.3
-
39
-
-
0029035757
-
Apoptosis and loss of renal tissue in polycystic kidney diseases
-
Woo D. Apoptosis and loss of renal tissue in polycystic kidney diseases. N Engl J Med 1995; 333: 18-25.
-
(1995)
N Engl J Med
, vol.333
, pp. 18-25
-
-
Woo, D.1
-
40
-
-
44349088262
-
Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1
-
Shibazaki S, Yu Z, Nishio S et al. Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1. Hum Mol Genet 2008; 17: 1505-1516.
-
(2008)
Hum Mol Genet
, vol.17
, pp. 1505-1516
-
-
Shibazaki, S.1
Yu, Z.2
Nishio, S.3
-
41
-
-
79955780675
-
Curcumin inhibits cystogenesis by simultaneous interference of multiple signaling pathways: In vivo evidence from a Pkd1-deletion model
-
Leonhard WN, van der Wal A, Novalic Z et al. Curcumin inhibits cystogenesis by simultaneous interference of multiple signaling pathways: in vivo evidence from a Pkd1-deletion model. Am J Physiol Renal Physiol 2011; 300: F1193-F1202.
-
(2011)
Am J Physiol Renal Physiol
, vol.300
-
-
Leonhard, W.N.1
Van Der Wal, A.2
Novalic, Z.3
-
42
-
-
80052450816
-
Intermediate volume on computed tomography imaging defines a fibrotic compartment that predicts glomerular filtration rate decline in autosomal dominant polycystic kidney disease patients
-
Caroli A, Antiga L, Conti S et al. Intermediate volume on computed tomography imaging defines a fibrotic compartment that predicts glomerular filtration rate decline in autosomal dominant polycystic kidney disease patients. Am J Pathol 2011; 179: 619-627.
-
(2011)
Am J Pathol
, vol.179
, pp. 619-627
-
-
Caroli, A.1
Antiga, L.2
Conti, S.3
-
43
-
-
0025380629
-
Polycystic kidney disease: Neoplasia in disguise
-
Grantham JJ. Polycystic kidney disease: neoplasia in disguise. Am J Kidney Dis 1990; 15: 110-116.
-
(1990)
Am J Kidney Dis
, vol.15
, pp. 110-116
-
-
Grantham, J.J.1
-
44
-
-
77956048123
-
MTOR inhibitors in polycystic kidney disease
-
Watnick T, Germino GG. mTOR inhibitors in polycystic kidney disease. N Engl J Med 2010; 363: 879-881.
-
(2010)
N Engl J Med
, vol.363
, pp. 879-881
-
-
Watnick, T.1
Germino, G.G.2
-
45
-
-
77956029702
-
Sirolimus and kidney growth in autosomal dominant polycystic kidney disease
-
Serra AL, Poster D, Kistler AD et al. Sirolimus and kidney growth in autosomal dominant polycystic kidney disease. N Engl J Med 2010; 363: 820-829.
-
(2010)
N Engl J Med
, vol.363
, pp. 820-829
-
-
Serra, A.L.1
Poster, D.2
Kistler, A.D.3
-
46
-
-
77956035166
-
Everolimus in patients with autosomal dominant polycystic kidney disease
-
Walz G, Budde K, Mannaa M et al. Everolimus in patients with autosomal dominant polycystic kidney disease. N Engl J Med 2010; 363: 830-840.
-
(2010)
N Engl J Med
, vol.363
, pp. 830-840
-
-
Walz, G.1
Budde, K.2
Mannaa, M.3
-
47
-
-
84860633618
-
Dose-dependent effects of sirolimus on mTOR signaling and polycystic kidney disease
-
Novalic Z, van der Wal AM, Leonhard WN et al. Dose-dependent effects of sirolimus on mTOR signaling and polycystic kidney disease. J Am Soc Nephrol 2012; 23: 842-853.
-
(2012)
J Am Soc Nephrol
, vol.23
, pp. 842-853
-
-
Novalic, Z.1
Van Der Wal, A.M.2
Leonhard, W.N.3
-
48
-
-
0028932828
-
Segmental distribution of the endocytosis receptor gp330 in renal proximal tubules
-
Christensen EI, Nielsen S, Moestrup SK et al. Segmental distribution of the endocytosis receptor gp330 in renal proximal tubules. Eur J Cell Biol 1995; 66: 349-364.
-
(1995)
Eur J Cell Biol
, vol.66
, pp. 349-364
-
-
Christensen, E.I.1
Nielsen, S.2
Moestrup, S.K.3
|