Pioglitazone improves the phenotype and molecular defects of a targeted Pkd1 mutant

Human Molecular Genetics

Volumn 11, Issue 15, 2002, Pages 1731-1742

  Muto, Satoru ^a   Aiba, Atsu ^b   Saito, Yuichirou ^c   Nakao, Kazuki ^d   Nakamura, Kenji ^e   Tomita, Kyoichi ^a   Kitamura, Tadaichi ^a   Kurabayashi, Masahiko ^c   Nagai, Ryozo ^a   Higashihara, Eiji ^f   Harris, Peter C ^g   Katsuki, Motoya ^h   Horie, Shigeo ^a,f,i  

^a UNIVERSITY OF TOKYO   (Japan)

^b KOBE UNIVERSITY   (Japan)

^c GUNMA UNIVERSITY   (Japan)

^d RIKEN   (Japan)

^e MITSUBISHI KASEI INST OF LIFE SCI   (Japan)

^f KYORIN UNIVERSITY   (Japan)

^g MAYO CLINIC   (United States)

^h NATIONAL INSTITUTE FOR BASIC BIOLOGY   (Japan)

ⁱ KYORIN UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; CD31 ANTIGEN; EPIDERMAL GROWTH FACTOR RECEPTOR; GENE PRODUCT; MUTANT PROTEIN; MYC PROTEIN; PIOGLITAZONE; POLYCYSTIN; POLYCYSTIN 1; POLYCYSTIN 2; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; UVOMORULIN; 2,4 THIAZOLIDINEDIONE DERIVATIVE; CATNB PROTEIN, MOUSE; CYTOSKELETON PROTEIN; POLYCYSTIC KIDNEY DISEASE 1 PROTEIN; PROTEIN; TRANSACTIVATOR PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; AUTOSOMAL DOMINANT DISORDER; BASOLATERAL MEMBRANE; CONGENITAL HEART MALFORMATION; CONTROLLED STUDY; DRUG EFFECT; EMBRYO; EMBRYO DEVELOPMENT; ENDOTHELIUM; EXON; GENE DELETION; GENETIC DISORDER; HEART; HOMOZYGOTE; HYDROPS; KIDNEY CYST; KIDNEY POLYCYSTIC DISEASE; KIDNEY TUBULE; LONG TERM CARE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; ONCOGENE C MYC; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; SURVIVAL RATE; TISSUE DISTRIBUTION; ANIMAL; GENETICS; KIDNEY; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHENOTYPE;

ANIMALIA; HYDROPS;

ANIMALS; BETA CATENIN; CYTOSKELETAL PROTEINS; ENDOTHELIUM; KIDNEY; MICE; PHENOTYPE; POLYCYSTIC KIDNEY, AUTOSOMAL DOMINANT; PROTEINS; PROTO-ONCOGENE PROTEINS C-MYC; SEQUENCE DELETION; THIAZOLES; THIAZOLIDINEDIONES; TRANS-ACTIVATORS; TRPP CATION CHANNELS;

EID: 0037098955     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/11.15.1731     Document Type: Article

References (45)

1. Autosomal dominant polycystic kidney disease
2. The polycystic kidney disease 1 (PKD1) gene encodes a novel protein with multiple cell recognition domains
3. PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein
4. Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents
5. Polycystin-1, the gene product of PKD1, induces resistance to apoptosis and spontaneous tubulogenesis in MDCK cells
6. Polycystin 1 is required for the structural integrity of blood vessels
7. Cardiovascular, skeletal, and renal defects in mice with a targeted disruption of the Pkd1 gene
8. Comparison of Pkd1-targeted mutants reveals that loss of polycystin-1 causes cystogenesis and bone defects
9. Perinatal lethality with kidney and pancreas defects in mice with a targetted Pkd1 mutation
10. Late onset of renal and hepatic cysts in Pkd1-targeted heterozygotes
11. Polycystic kidney disease: In danger of being X-rated?
12. Compromised cytoarchitecture and polarized trafficking in autosomal dominant polycystic kidney disease cells
13. Autocrine, endocrine and paracrine regulation of growth abnormalities in autosomal dominant polycystic kidney disease
14. Expression of transforming growth factor alpha and epidermal growth factor receptor in adult polycystic kidney disease
15. Mediation of renal cyst formation by hepatocyte growth factor
16. Renal tubular hyperplasia, polycystic disease, and glomerulosclerosis in transgenic mice overexpressing hepatocyte growth factor/scatter factor
17. The polycystic kidney disease 1 gene product modulates Wnt signaling
18. Identification of c-MYC as a target of the APC pathway
19. A Grb2-associated docking protein in EGF- and insulin-receptor signalling
20. Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis
21. Activation of the peroxisome proliferator-activated receptor gamma promotes the development of colon tumors in C57BL/6J-APCMin/+ mice
22. Ligands for peroxisome proliferator-activated receptor gamma inhibit growth and induce apoptosis of human papillary thyroid carcinoma cells
23. Neural crest cells contribute to normal aorticopulmonary septation
24. Endothelium-dependent relaxation of small resistance vessels is impaired in patients with autosomal dominant polycystic kidney disease
25. Vascular endothelium: Vasoactive mediators
26. Characterization of conotruncal malformations following ablation of 'cardiac' neural crest
27. Decreased neural crest stem cell expansion is responsible for the conotruncal heart defects within the splotch (Sp(2H))/Pax3 mouse mutant
28. Mechanism and function of signal transduction by the Wnt/β-catenin and Wnt/Ca2+ pathways
29. RXR alpha deficiency confers genetic susceptibility for aortic sac, conotruncal, atrioventricular cushion, and ventricular muscle defects in mice
30. PPAR: A nuclear regulator of metabolism, differentiation, and cell growth
31. Early development of polycystic kidney disease in transgenic mice expressing an activated mutant of the β-catenin gene
32. -/- mouse
33. -/- mice
34. Polycystin-1, the PKD1 gene product, is in a complex containing E-cadherin and the catenins
35. ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini
36. Treatment of polycystic kidney disease with a novel tyrosine kinase inhibitor
37. 2+ -permeable nonselective cation channel
38. Polycystin-2 is an intracellular calcium release channel
39. Vascular expression of polycystin
40. Polycystin: In vitro synthesis, in vivo tissue expression, and subcellular localization identifies a large membrane-associated protein
41. The mouse homolog of PKD1: Sequence analysis and alternative splicing
42. Homologous recombination at c-fyn locus of mouse embryonic stem cells with use of diphtheria toxin A-fragment gene in negative selection
43. K-ras is essential for the development of the mouse embryo
44. Polycystin-1 expression in PKD1, early-onset PKD1, and TSC2/PKD1 cystic tissue
45. Klotho protein protects against endothelial dysfunction