Intermediate volume on computed tomography imaging defines a fibrotic compartment that predicts glomerular filtration rate decline in autosomal dominant polycystic kidney disease patients

American Journal of Pathology

Volumn 179, Issue 2, 2011, Pages 619-627

  Caroli, Anna ^a,b   Antiga, Luca ^a   Conti, Sara ^a   Sonzogni, Aurelio ^c   Fasolini, Giorgio ^c   Ondei, Patrizia ^c   Perico, Norberto ^a   Remuzzi, Giuseppe ^a,c   Remuzzi, Andrea ^a,d  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^b IRCCS ISTITUTO CENTRO SAN GIOVANNI DI DIO FATEBENEFRATELLI   (Italy)

^c OSPEDALI RIUNITI   (Italy)

^d UNIVERSITY OF BERGAMO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

EOSIN; HEMATOXYLIN; IOMEPROL;

ADULT; AGED; ARTICLE; ATROPHY; CELL INFILTRATION; CHOLELITHIASIS; CLINICAL ARTICLE; COHORT ANALYSIS; COMPUTER ASSISTED TOMOGRAPHY; CONTRAST ENHANCEMENT; DISEASE COURSE; FEMALE; FOLLOW UP; GLOMERULUS FILTRATION RATE; HEMODIALYSIS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; INFLAMMATORY CELL; INFLAMMATORY INFILTRATE; KIDNEY ATROPHY; KIDNEY CYST; KIDNEY FAILURE; KIDNEY FIBROSIS; KIDNEY FUNCTION; KIDNEY INTERMEDIATE VOLUME; KIDNEY MICROCYST; KIDNEY POLYCYSTIC DISEASE; KIDNEY SIZE; KIDNEY TUBULE; MALE; NEPHRECTOMY; NEPHROSCLEROSIS; PREDICTIVE VALUE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; STAINING;

ADULT; AGED; COHORT STUDIES; FEMALE; FIBROSIS; GLOMERULAR FILTRATION RATE; HUMANS; KIDNEY; MALE; MIDDLE AGED; PHENOTYPE; POLYCYSTIC KIDNEY, AUTOSOMAL DOMINANT; RETROSPECTIVE STUDIES; TIME FACTORS; TOMOGRAPHY, X-RAY COMPUTED;

EID: 80052450816     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2011.04.036     Document Type: Article

References (37)

1. J.J. Grantham, B.J. Cowley, and V.E. Torres Progression of autosomal dominant polycystic kidney disease (ADPKD) to renal failure The Kidney: Physiology & Pathophysiology D.W. Seldin, G. Giebisch, 2000 Lippincott Williams & Wilkins Philadelphia 2513 2536
2. P.A. Gabow Autosomal dominant polycystic kidney disease N Engl J Med 329 1993 332 342 (Pubitemid 23210687)
3. N. Hateboer, M.A. v Dijk, N. Bogdanova, E. Coto, A.K. Saggar-Malik, J.L. San Millan, R. Torra, M. Breuning, and D. Ravine Comparison of phenotypes of polycystic kidney disease types 1 and 2 European PKD1-PKD2 Study Group Lancet 353 1999 103 107 (Pubitemid 29088079)
4. J.J. Grantham Polycystic kidney disease: neoplasia in disguise Am J Kidney Dis 15 1990 110 116
5. G. Choukroun, Y. Itakura, G. Albouze, J.L. Christophe, N.K. Man, J.P. Grunfeld, and P. Jungers Factors influencing progression of renal failure in autosomal dominant polycystic kidney disease J Am Soc Nephrol 6 1995 1634 1642 (Pubitemid 26184577)
6. J.J. Grantham Mechanisms of progression in autosomal dominant polycystic kidney disease Kidney Int Suppl 63 1997 S93 S97
7. P.A. Gabow, A.M. Johnson, W.D. Kaehny, W.J. Kimberling, D.C. Lezotte, I.T. Duley, and R.H. Jones Factors affecting the progression of renal disease in autosomal-dominant polycystic kidney disease Kidney Int 41 1992 1311 1319
8. A.B. Chapman Cystic disease in women: clinical characteristics and medical management Adv Ren Replace Ther 10 2003 24 30 (Pubitemid 36278327)
9. J.J. Grantham, A.B. Chapman, and V.E. Torres Volume progression in autosomal dominant polycystic kidney disease: the major factor determining clinical outcomes Clin J Am Soc Nephrol 1 2006 148 157
10. K.A. Franz, and F.C. Reubi Rate of functional deterioration in polycystic kidney disease Kidney Int 23 1983 526 529 (Pubitemid 13117121)
11. J.J. Grantham, V.E. Torres, A.B. Chapman, L.M. Guay-Woodford, K.T. Bae, B.F. King Jr., L.H. Wetzel, D.A. Baumgarten, P.J. Kenney, P.C. Harris, S. Klahr, W.M. Bennett, G.N. Hirschman, C.M. Meyers, X. Zhang, F. Zhu, and J.P. Miller Volume progression in polycystic kidney disease N Engl J Med 354 2006 2122 2130 (Pubitemid 43736612)
12. K.T. Bae, P.K. Commean, and J. Lee Volumetric measurement of renal cysts and parenchyma using MRI: phantoms and patients with polycystic kidney disease J Comput Assist Tomogr 24 2000 614 619 (Pubitemid 32204335)
13. A.B. Chapman, L.M. Guay-Woodford, J.J. Grantham, V.E. Torres, K.T. Bae, D.A. Baumgarten, P.J. Kenney, B.F. King Jr., J.F. Glockner, L.H. Wetzel, M.E. Brummer, W.C. O'Neill, M.L. Robbin, W.M. Bennett, S. Klahr, G.H. Hirschman, P.L. Kimmel, P.A. Thompson, and J.P. Miller Renal structure in early autosomal-dominant polycystic kidney disease (ADPKD): the Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) cohort Kidney Int 64 2003 1035 1045 (Pubitemid 37013840)
14. K.T. Bae, F. Zhu, A.B. Chapman, V.E. Torres, J.J. Grantham, L.M. Guay-Woodford, D.A. Baumgarten, B.F. King Jr., L.H. Wetzel, P.J. Kenney, M.E. Brummer, W.M. Bennett, S. Klahr, C.M. Meyers, X. Zhang, P.A. Thompson, and J.P. Miller Magnetic resonance imaging evaluation of hepatic cysts in early autosomal-dominant polycystic kidney disease: the Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease cohort Clin J Am Soc Nephrol 1 2006 64 69
15. L. Antiga, M. Piccinelli, G. Fasolini, B. Ene-Iordache, P. Ondei, S. Bruno, G. Remuzzi, and A. Remuzzi Computed tomography evaluation of autosomal dominant polycystic kidney disease progression: a progress report Clin J Am Soc Nephrol 1 2006 754 760
16. A.B. Chapman Improving clinical trial design for inquiries into the mechanisms of cyst growth in ADPKD Kidney Int 75 2009 139 141
17. M.Y. Chang, E. Parker, S. Ibrahim, J.R. Shortland, M.E. Nahas, J.L. Haylor, and A.C. Ong Haploinsufficiency of Pkd2 is associated with increased tubular cell proliferation and interstitial fibrosis in two murine Pkd2 models Nephrol Dial Transplant 21 2006 2078 2084 (Pubitemid 44295032)
18. S. Hassane, W.N. Leonhard, A. van der Wal, L.J. Hawinkels, I.S. Lantinga-van Leeuwen, P. ten Dijke, M.H. Breuning, E. de Heer, and D.J. Peters Elevated TGFbeta-Smad signalling in experimental Pkd1 models and human patients with polycystic kidney disease J Pathol 222 2010 21 31
19. E.Y. Park, M.J. Seo, and J.H. Park Effects of specific genes activating RAGE on polycystic kidney disease Am J Nephrol 32 2010 169 178
20. M. Zeier, P. Fehrenbach, S. Geberth, K. Mohring, R. Waldherr, and E. Ritz Renal histology in polycystic kidney disease with incipient and advanced renal failure Kidney Int 42 1992 1259 1265
21. N. Perico, L. Antiga, A. Caroli, P. Ruggenenti, G. Fasolini, M. Cafaro, P. Ondei, N. Rubis, O. Diadei, G. Gherardi, S. Prandini, A. Panozo, R.F. Bravo, S. Carminati, F.R. De Leon, F. Gaspari, M. Cortinovis, N. Motterlini, B. Ene-Iordache, A. Remuzzi, and G. Remuzzi Sirolimus therapy to halt the progression of ADPKD J Am Soc Nephrol 21 2010 1031 1040
22. P. Ruggenenti, A. Remuzzi, P. Ondei, G. Fasolini, L. Antiga, B. Ene-Iordache, G. Remuzzi, and F.H. Epstein Safety and efficacy of long-acting somatostatin treatment in autosomal-dominant polycystic kidney disease Kidney Int 68 2005 206 216 (Pubitemid 43181378)
23. Zhang Y, Kong J, Deb DK, Chang A, Li YC: VitaminDreceptor attenuates renal fibrosis by suppressing the renin-angiotensin system. J Am Soc Nephrol, 21:966973
24. F. Gaspari, N. Perico, P. Ruggenenti, L. Mosconi, C.S. Amuchastegui, E. Guerini, E. Daina, and G. Remuzzi Plasma clearance of nonradioactive iohexol as a measure of glomerular filtration rate J Am Soc Nephrol 6 1995 257 263
25. A.S. Levey, T. Greene, J. Kusek, G.J. Beck Group: for the MDRD Study A simplified equation to predict glomerular filtration rate from serum creatinine (abstract) J Am Soc Nephrol 11 2000 155A
26. N. Perico, A. Benigni, and G. Remuzzi Present and future drug treatments for chronic kidney diseases: evolving targets in renoprotection Nat Rev Drug Discov 7 2008 936 953
27. D. Joly, S. Berissi, A. Bertrand, L. Strehl, N. Patey, and B. Knebelmann Laminin 5 regulates polycystic kidney cell proliferation and cyst formation J Biol Chem 281 2006 29181 29189 (Pubitemid 44507062)
28. D.P. Wallace, M.T. Quante, G.A. Reif, E. Nivens, F. Ahmed, S.J. Hempson, G. Blanco, and T. Yamaguchi Periostin induces proliferation of human autosomal dominant polycystic kidney cells through alphaV-integrin receptor Am J Physiol Renal Physiol 295 2008 F1463 F1471
29. P.D. Wilson, J. Du, and J.T. Norman Autocrine, endocrine and paracrine regulation of growth abnormalities in autosomal dominant polycystic kidney disease Eur J Cell Biol 61 1993 131 138 (Pubitemid 23221791)
30. V. Gupta, and K.J. Grande-Allen Effects of static and cyclic loading in regulating extracellular matrix synthesis by cardiovascular cells Cardiovasc Res 72 2006 375 383 (Pubitemid 44755053)
31. A.B. Chapman, A. Johnson, P.A. Gabow, and R.W. Schrier The renin-angiotensin-aldosterone system and autosomal dominant polycystic kidney disease N Engl J Med 323 1990 1091 1096 (Pubitemid 20370729)
32. J.J. Grantham Clinical practice Autosomal dominant polycystic kidney disease N Engl J Med 359 2008 1477 1485
33. G. Walz, K. Budde, M. Mannaa, J. Nurnberger, C. Wanner, C. Sommerer, U. Kunzendorf, B. Banas, W.H. Horl, N. Obermuller, W. Arns, H. Pavenstadt, J. Gaedeke, M. Buchert, C. May, H. Gschaidmeier, S. Kramer, and K.U. Eckardt Everolimus in patients with autosomal dominant polycystic kidney disease N Engl J Med 363 2010 830 840
34. K.A. Nath Tubulointerstitial changes as a major determinant in the progression of renal damage Am J Kidney Dis 20 1992 1 17
35. R.A. Risdon, J.C. Sloper, and H.E. De Wardener Relationship between renal function and histological changes found in renal-biopsy specimens from patients with persistent glomerular nephritis Lancet 2 1968 363 366
36. L.I. Schainuck, G.E. Striker, R.E. Cutler, and E.P. Benditt Structural-functional correlations in renal disease II. The correlations Hum Pathol 1 1970 631 641
37. R.W. Katzberg, and C. Haller Contrast-induced nephrotoxicity: clinical landscape Kidney Int 69 2006 S3 S7