Pathogenic sequence for dissecting aneurysm formation in a hypomorphic polycystic kidney disease 1 mouse model

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 27, Issue 10, 2007, Pages 2177-2183

  Hassane, Sabrine ^a   Claij, Nanna ^a   Lantinga Van Leeuwen, Irma S ^a   Van Munsteren, J Conny ^a   Van Lent, Natascha ^b   Hanemaaijer, Roeland ^b   Breuning, Martijn H ^a   Peters, Dorien J M ^a   DeRuiter, Marco C ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b TNO   (Netherlands)

Author keywords

Aorta; Dissecting aneurysm; Extracellular matrix; Pkd1; Polycystic kidney disease

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CALCIUM; COLLAGEN; COLLAGEN TYPE 1; COLLAGEN TYPE 3; ELASTIN; FIBRILLIN 1; FIBRONECTIN; GELATINASE A; GELATINASE B; KI 67 ANTIGEN; LECTIN; OSTEOPONTIN; PERLECAN; POLYCYSTIN 1; PROTEOGLYCAN; VERSICAN; MESSENGER RNA; POLYCYSTIC KIDNEY DISEASE 1 PROTEIN; POLYCYSTIN; UNCLASSIFIED DRUG;

ABDOMINAL AORTA; ANIMAL MODEL; ANIMAL TISSUE; AORTA; AORTA DISSECTING ANEURYSM; AORTA INTIMA; AORTA MEDIA; ARTERY INTIMA PROLIFERATION; ARTERY RUPTURE; ARTICLE; BLEEDING; CELL COUNT; CONTROLLED STUDY; DISEASE MODEL; ENDOTHELIUM CELL; FEMALE; IMMUNOHISTOCHEMISTRY; KIDNEY POLYCYSTIC DISEASE; MACROPHAGE; MALE; MOUSE; NICK END LABELING; NONHUMAN; PATHOGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; RETROPERITONEAL HEMORRHAGE; SMOOTH MUSCLE FIBER; THORACIC AORTA; TISSUE REGENERATION; ANIMAL; AORTA ANEURYSM; C57BL MOUSE; DISEASE COURSE; DISSECTING ANEURYSM; EXTRACELLULAR MATRIX; GENETICS; GENOTYPE; HOSPITALIZATION; INTIMA; METABOLISM; MOUSE MUTANT; MUTATION; PATHOLOGY; PHENOTYPE; TUNICA MEDIA;

ANEURYSM, DISSECTING; ANIMALS; AORTA; AORTIC ANEURYSM; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; ENDOTHELIAL CELLS; EXTRACELLULAR MATRIX; GENOTYPE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUTATION; MYOCYTES, SMOOTH MUSCLE; PHENOTYPE; POLYCYSTIC KIDNEY DISEASES; RNA, MESSENGER; SEVERITY OF ILLNESS INDEX; TRPP CATION CHANNELS; TUNICA INTIMA; TUNICA MEDIA;

EID: 35148840431     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/ATVBAHA.107.149252     Document Type: Article

References (32)

1. Chapman AB, Rubinstein D, Hughes R, Stears JC, Earnest MP, Johnson AM, Gabow PA, Kaehny WD. Intracranial aneurysms in autosomal dominant polycystic kidney disease. N Engl J Med. 1992;327:916-920.
2. Ruggieri PM, Poulos N, Masaryk TJ, Ross JS, Obuchowski NA, Awad IA, Braun WE, Nally J, Lewin JS, Modic MT. Occult intracranial aneurysms in polycystic kidney disease: screening with MR angiography. Radiology. 1994;191:33-39.
3. Torra R, Nicolau C, Badenas C, Bru C, Perez L, Estivill X, Darnell A. Abdominal aortic aneurysms and autosomal dominant polycystic kidney disease. J Am Soc Nephrol. 1996;7:2483-2486.
4. Chapman JR, Hilson AJ. Polycystic kidneys and abdominal aortic aneurysms. Lancet. 1980;1:646-647.
5. Roodvoets AP. Aortic aneurysms in presence of kidney disease. Lancet. 1980;1:1413-1414.
6. Muller BT, Modlich O, Prisack HB, Bojar H, Schipke JD, Goecke T, Feindt P, Petzold T, Gams E, Muller W, Hort W, Sandmann W. Gene expression profiles in the acutely dissected human aorta. Eur J Vasc Endovasc Surg. 2002;24:356-364.
7. Griffin MD, Torres VE, Grande JP, Kumar R. Vascular expression of polycystin. J Am Soc Nephrol. 1997;8:616-626.
8. Peters DJM, van de WA, Spruit L, Saris JJ, Breuning MH, Bruijn JA, De Heer E. Cellular localization and tissue distribution of polycystin-1. J Pathol. 1999;188:439-446.
9. Boulter C, Mulroy S, Webb S, Fleming S, Brindle K, Sandford R. Cardiovascular, skeletal, and renal defects in mice with a targeted disruption of the Pkd1 gene. Proc Natl Acad Sci U S A. 2001;98:12174-12179.
10. Kim K, Drummond I, Ibraghimov-Beskrovnaya O, Klinger K, Arnaout MA. Polycystin 1 is required for the structural integrity of blood vessels. Proc Natl Acad Sci U S A. 2000;97:1731-1736.
11. Muto S, Aiba A, Saito Y, Nakao K, Nakamura K, Tomita K, Kitamura T, Kurabayashi M, Nagai R, Higashihara E, Harris PC, Katsuki M, Horie S. Pioglitazone improves the phenotype and molecular defects of a targeted Pkd1 mutant. Hum Mol Genet. 2002;11:1731-1742.
12. Wu G, Markowitz GS, Li L, D'Agati VD, Factor SM, Geng L, Tibara S, Tuchman J, Cai Y, Park JH, van Adelsberg J, Hou H Jr, Kucherlapati R, Edelmann W, Somlo S. Cardiac defects and renal failure in mice with targeted mutations in Pkd2. Nat Genet. 2000;24:75-78.
13. Lantinga-van Leeuwen IS, Dauwerse JG, Baelde HJ, Leonhard WN, van der Wal A, Ward CJ, Verbeek S, Deruiter MC, Breuning MH, De Heer E, Peters DJ. Lowering of Pkd1 expression is sufficient to cause polycystic kidney disease. Hum Mol Genet. 2004;13:3069-3077.
14. Bergwerff M, Deruiter MC, Hall S, Poelmann RE, Gittenberger-de Groot AC. Unique vascular morphology of the fourth aortic arches: possible implications for pathogenesis of type-B aortic arch interruption and anomalous right subclavian artery. Cardiovasc Res. 1999;44:185-196.
15. Melrose J, Whitelock J, Xu Q, Ghosh P. Pathogenesis of abdominal aortic aneurysms: possible role of differential production of proteoglycans by smooth muscle cells. J Vasc Surg. 1998;28:676-686.
16. Qian Q, Hunter LW, Li M, Marin-Padilla M, Prakash YS, Somlo S, Harris PC, Torres VE, Sieck GC. Pkd2 haploinsufficiency alters intracellular calcium regulation in vascular smooth muscle cells. Hum Mol Genet. 2003;12:1875-1880.
17. Basalyga DM, Simionescu DT, Xiong WF, Baxter T, Starcher BC, Vyavahare NR. Elastin degradation and calcification in an abdominal aorta injury model - Role of matrix metalloproteinases. Circulation. 2004;110:3480-3487.
18. Bunton TE, Biery NJ, Myers L, Gayraud B, Ramirez F, Dietz HC. Phenotypic alteration of vascular smooth muscle cells precedes elastolysis in a mouse model of Marfan syndrome. Circ Res. 2001;88:37-43.
19. Ibraghimov-Beskrovnaya O, Bukanov NO, Donohue LC, Dackowski WR, Klinger KW, Landes GM. Strong homophilic interactions of the Ig-like domains of polycystin-1, the protein product of an autosomal dominant polycystic kidney disease gene, PKD1. Hum Mol Genet. 2000;9:1641-1649.
20. Scheffers MS, van der Bent P, Prins F, Spruit L, Breuning MH, Litvinov SV, De Heer E, Peters DJM. Polycystin-1, the product of the polycystic kidney disease 1 gene, co-localizes with desmosomes in MDCK-cells. Hum Mol Genet. 2000;9:2743-2750.
21. Geng L, Burrow CR, Li HP, Wilson PD. Modification of the composition of polycystin-1 multiprotein complexes by calcium and tyrosine phosphorylation. Biochim Biophys Acta. 2000;1535:21-35.
22. Davis EC. Smooth-muscle cell to elastic lamina connections in developing mouse aorta - role in aortic medial organization. Lab Invest. 1993;68:89-99.
23. Qian Q, Li M, Cai Y, Ward CJ, Somlo S, Harris PC, Torres VE. Analysis of the polycystins in aortic vascular smooth muscle cells. J Am Soc Nephrol. 2003;14:2280-2287.
24. Halayko AJ, Solway J. Molecular mechanisms of phenotypic plasticity in smooth muscle cells. J Appl Physiol. 2001;90:358-368.
25. Li DY, Brooke B, Davis EC, Mecham RP, Sorensen LK, Boak BB, Eichwald E, Keating MT. Elastin is an essential determinant of arterial morphogenesis. Nature. 1998;393:276-280.
26. Molin DG, Poelmann RE, Deruiter MC, Azhar M, Doetschman T, Gittenberger-de Groot AC. Transforming growth factor beta-SMAD2 signaling regulates aortic arch innervation and development. Circ Res. 2004;95:1109-1117.
27. Nauli SM, Alenghat FJ, Luo Y, Williams E, Vassilev P, Li X, Elia AE, Lu W, Brown EM, Quinn SJ, Ingber DE, Zhou J. Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nat Genet. 2003;33:129-137.
28. Iomini C, Tejada K, Mo WJ, Vaananen H, Piperno G. Primary cilia of human endothelial cells disassemble under laminar shear stress. Journal of Cell Biology. 2004;164:811-817.
29. Van der Heiden K, Groenendijk BC, Hierck BP, Hogers B, Koerten HK, Mommaas AM, Gittenberger-de Groot AC, Poelmann RE. Monocilia on chicken embryonic endocardium in low shear stress areas. Dev Dyn. 2006;235:19-28.
30. Ibraghimov-Beskrovnaya O, Dackowski WR, Foggensteiner L, Coleman N, Thiru S, Petry LR, Burn TC, Connors TD, Van Raay TJ, Bradley J, Qian F, Onuchic LF, Watnick TJ, Piontek K, Hakim RM, Landes GM, Germino GG, Sandford R, Klinger KW. Polycystin: In vitro synthesis, in vivo tissue expression, and subcellular localization identifies a large membrane-associated protein. Proc Natl Acad Sci U S A. 1997;94:6397-6402.
31. Ilan N, Madri JA. PECAM-1: old friend, new partners. Curr Opin Cell Biol. 2003;15:515-524.
32. Isogai Z, Aspberg A, Keene DR, Ono RN, Reinhardt DP, Sakai LY. Versican interacts with fibrillin-1 and links extracellular microfibrils to other connective tissue networks. J Biol Chem. 2002;277:4565-4572.